JP2004532102A - 集中音響エネルギーを使用する薬剤粒子の生成 - Google Patents
集中音響エネルギーを使用する薬剤粒子の生成 Download PDFInfo
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- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/823,899 US6596206B2 (en) | 2001-03-30 | 2001-03-30 | Generation of pharmaceutical agent particles using focused acoustic energy |
| PCT/US2002/010266 WO2002078863A1 (en) | 2001-03-30 | 2002-04-01 | Generation of pharmaceutical agent particles using focused acoustic energy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004532102A true JP2004532102A (ja) | 2004-10-21 |
| JP2004532102A5 JP2004532102A5 (https=) | 2005-12-22 |
Family
ID=25240048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002577117A Pending JP2004532102A (ja) | 2001-03-30 | 2002-04-01 | 集中音響エネルギーを使用する薬剤粒子の生成 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6596206B2 (https=) |
| EP (1) | EP1379337B1 (https=) |
| JP (1) | JP2004532102A (https=) |
| AT (1) | ATE556788T1 (https=) |
| WO (1) | WO2002078863A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009119363A (ja) * | 2007-11-14 | 2009-06-04 | Nikkiso Co Ltd | 微粒子化方法 |
| JP2009535399A (ja) * | 2006-05-04 | 2009-10-01 | バイオ−シネクティクス インク. | ナノスケールの活物質粒子の製造方法 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620351B2 (en) * | 2000-05-24 | 2003-09-16 | Auburn University | Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer |
| US6642061B2 (en) * | 2000-09-25 | 2003-11-04 | Picoliter Inc. | Use of immiscible fluids in droplet ejection through application of focused acoustic energy |
| US6869551B2 (en) * | 2001-03-30 | 2005-03-22 | Picoliter Inc. | Precipitation of solid particles from droplets formed using focused acoustic energy |
| US20050260273A1 (en) * | 2001-06-07 | 2005-11-24 | Chinea Vanessa I | Applicatin of a bioactive agent in a solvent composition to produce a target particle morphology |
| US7354141B2 (en) * | 2001-12-04 | 2008-04-08 | Labcyte Inc. | Acoustic assessment of characteristics of a fluid relevant to acoustic ejection |
| US20050244508A1 (en) * | 2002-06-12 | 2005-11-03 | Messer Griesheim | Anti-spasmodic comprising xenon |
| JP2005533062A (ja) * | 2002-06-12 | 2005-11-04 | メツサー グリースハイム ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | キセノン含有ガスによる脳保護 |
| US7070260B2 (en) * | 2003-01-09 | 2006-07-04 | Labcyte Inc. | Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge |
| WO2004091571A2 (en) * | 2003-04-08 | 2004-10-28 | New Jersey Institute Of Technology (Njit) | Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process |
| WO2005051511A1 (ja) * | 2003-11-28 | 2005-06-09 | Mitsubishi Chemical Corporation | 有機化合物微粒子の製造方法 |
| KR100603974B1 (ko) | 2003-12-05 | 2006-07-25 | 김갑식 | 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법 |
| CA2548281C (en) * | 2003-12-09 | 2013-11-12 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| US20060210443A1 (en) | 2005-03-14 | 2006-09-21 | Stearns Richard G | Avoidance of bouncing and splashing in droplet-based fluid transport |
| US20070120281A1 (en) * | 2005-11-08 | 2007-05-31 | Boris Khusid | Manufacture of fine particles and nano particles and coating thereof |
| WO2008030473A2 (en) * | 2006-09-05 | 2008-03-13 | University Of Wyoming | Process for forming nanoparticles by micellization of blocky copolymers in subcritical and supercritical solvents |
| KR20090077066A (ko) * | 2006-10-06 | 2009-07-14 | 뉴사우스 이노베이션즈 피티와이 리미티드 | 입자 형성 |
| WO2011118960A2 (ko) | 2010-03-22 | 2011-09-29 | (주)바이오시네틱스 | 나노입자 제조방법 |
| CN102058996A (zh) * | 2010-10-29 | 2011-05-18 | 华侨大学 | 非溶剂法改进超临界抗溶剂过程制备药物超细微粒的方法 |
| WO2014007771A2 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising muscarinic receptor antagonist |
| WO2014007772A2 (en) * | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising glucose anhydrous |
| WO2014078258A1 (en) * | 2012-11-16 | 2014-05-22 | Merck Sharp & Dohme Corp. | Process for making agglomerates using acoustic mixing technology |
| GB201402556D0 (en) | 2014-02-13 | 2014-04-02 | Crystec Ltd | Improvements relating to inhalable particles |
| US11344496B2 (en) | 2017-08-25 | 2022-05-31 | Merck Sharp & Dohme Corp. | Methods for preparing stabilized amorphous drug formulations using acoustic fusion |
| JP7503781B2 (ja) * | 2018-07-30 | 2024-06-21 | 株式会社リコー | 粒子の製造方法、並びに、それにより製造された粒子及び医薬 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4308547A (en) | 1978-04-13 | 1981-12-29 | Recognition Equipment Incorporated | Liquid drop emitter |
| US5041849A (en) | 1989-12-26 | 1991-08-20 | Xerox Corporation | Multi-discrete-phase Fresnel acoustic lenses and their application to acoustic ink printing |
| US6063910A (en) | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
| DK0863202T3 (da) * | 1995-11-01 | 2010-09-27 | Dnavec Research Inc | Rekombinant Sendai-virus |
| EP0885038B1 (en) * | 1996-03-01 | 2011-06-15 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
| US5874029A (en) | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
| GB9828204D0 (en) | 1998-12-21 | 1999-02-17 | Smithkline Beecham Plc | Process |
| DK1173265T3 (da) | 1999-01-29 | 2006-04-10 | Bristol Myers Squibb Co | Apparat og fremgangsmåde til krystallisation med ultralydstråler |
| US6620351B2 (en) | 2000-05-24 | 2003-09-16 | Auburn University | Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer |
| GB0016002D0 (en) | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| US7121275B2 (en) | 2000-12-18 | 2006-10-17 | Xerox Corporation | Method of using focused acoustic waves to deliver a pharmaceutical product |
| US6622720B2 (en) | 2000-12-18 | 2003-09-23 | Xerox Corporation | Using capillary wave driven droplets to deliver a pharmaceutical product |
| US8122880B2 (en) | 2000-12-18 | 2012-02-28 | Palo Alto Research Center Incorporated | Inhaler that uses focused acoustic waves to deliver a pharmaceutical product |
| JPWO2003029475A1 (ja) * | 2001-09-28 | 2005-01-20 | 株式会社ディナベック研究所 | エピトープ結合β2mをコードする哺乳動物細胞感染性ウイルスベクターおよびその利用 |
-
2001
- 2001-03-30 US US09/823,899 patent/US6596206B2/en not_active Expired - Fee Related
-
2002
- 2002-04-01 EP EP02725473A patent/EP1379337B1/en not_active Expired - Lifetime
- 2002-04-01 AT AT02725473T patent/ATE556788T1/de active
- 2002-04-01 JP JP2002577117A patent/JP2004532102A/ja active Pending
- 2002-04-01 WO PCT/US2002/010266 patent/WO2002078863A1/en not_active Ceased
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009535399A (ja) * | 2006-05-04 | 2009-10-01 | バイオ−シネクティクス インク. | ナノスケールの活物質粒子の製造方法 |
| JP4830019B2 (ja) * | 2006-05-04 | 2011-12-07 | バイオ−シネクティクス インク. | ナノスケールの活物質粒子の製造方法 |
| JP2009119363A (ja) * | 2007-11-14 | 2009-06-04 | Nikkiso Co Ltd | 微粒子化方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US6596206B2 (en) | 2003-07-22 |
| EP1379337B1 (en) | 2012-05-09 |
| US20020142049A1 (en) | 2002-10-03 |
| WO2002078863A1 (en) | 2002-10-10 |
| ATE556788T1 (de) | 2012-05-15 |
| EP1379337A1 (en) | 2004-01-14 |
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