JP2005533062A - キセノン含有ガスによる脳保護 - Google Patents
キセノン含有ガスによる脳保護 Download PDFInfo
- Publication number
- JP2005533062A JP2005533062A JP2004512773A JP2004512773A JP2005533062A JP 2005533062 A JP2005533062 A JP 2005533062A JP 2004512773 A JP2004512773 A JP 2004512773A JP 2004512773 A JP2004512773 A JP 2004512773A JP 2005533062 A JP2005533062 A JP 2005533062A
- Authority
- JP
- Japan
- Prior art keywords
- xenon
- manufacture
- drugs
- volume
- brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (7)
- キセノン又はキセノン含有ガス混合物を含有する脳保護用の薬剤。
- キセノンが薬理学的に有効な量で含まれている、請求項1記載の薬剤。
- 脳保護用の薬剤が残分として酸素又は酸素と不活性ガスとを含有する、請求項1又は2記載の薬剤。
- 薬剤を、同時に、別々に又は時間的に区別して使用するために、NO源を含有するガス状、液状又は固体の製剤を含有する組み合わせ製剤として使用する、請求項1から3までのいずれか1項記載の薬剤。
- キセノン及びNO源又はキセノン含有ガス混合物及びNO源を含有し、その際、キセノンとNO源とが薬理学的に有効な濃度で含まれている薬剤。
- 脳内の血行障害の治療用の薬剤の製造のため、脳血流欠損の治療用の薬剤の製造のため、認知障害の治療用の薬剤の製造のため、脳保護用の薬剤の製造のため、認知機能障害の予防及び/又は治療用の薬剤の製造のため、術後にも、卒中発作の治療用の薬剤の製造のため、卒中発作の予防用の薬剤の製造のため、脳内の酸素供給の改善用の薬剤の製造のため、虚血後症候群の治療用の薬剤の製造のため、脳内の血行促進用の薬剤の製造のための、術後認知不全の治療又は予防用の薬剤の製造のため又は脳血管拡張用の薬剤の製造のための、キセノン又はキセノン含有ガス混合物及び場合によりNO源の使用。
- 脳保護のため、脳血管拡張のため又は認知機能障害又は認知不全の治療、療治又は予防のための、キセノン又はキセノン含有ガス混合物及び場合によりNO源の使用。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10226191 | 2002-06-12 | ||
DE10227975 | 2002-06-22 | ||
DE10236765 | 2002-08-10 | ||
PCT/EP2003/006157 WO2003105871A1 (de) | 2002-06-12 | 2003-06-12 | Cerebrale protektion mit einem xenonhaltigen gas |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005533062A true JP2005533062A (ja) | 2005-11-04 |
Family
ID=29740361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004512773A Pending JP2005533062A (ja) | 2002-06-12 | 2003-06-12 | キセノン含有ガスによる脳保護 |
Country Status (11)
Country | Link |
---|---|
US (1) | US7235264B2 (ja) |
EP (1) | EP1515732B1 (ja) |
JP (1) | JP2005533062A (ja) |
CN (1) | CN1668315A (ja) |
AT (1) | ATE420650T1 (ja) |
AU (1) | AU2003246415A1 (ja) |
DE (1) | DE50311092D1 (ja) |
DK (1) | DK1515732T3 (ja) |
ES (1) | ES2321185T3 (ja) |
PT (1) | PT1515732E (ja) |
WO (1) | WO2003105871A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010091376A2 (en) * | 2009-02-08 | 2010-08-12 | Blaise Baxter | Devices and methods for perfusion therapy |
US9526863B2 (en) * | 2009-02-08 | 2016-12-27 | Neuronal Protection System, Llc | Devices and methods for perfusion therapy |
FR2964876B1 (fr) * | 2010-09-22 | 2013-04-12 | Air Liquide Sante Int | Composition anesthesique gazeuse a base de xenon utilisable pendant une endarteriectomie avec clampage de l'artere carotide |
CN110464709A (zh) | 2012-08-10 | 2019-11-19 | 德克萨斯州大学系统董事会 | 用于治疗中风的神经保护性脂质体组合物和方法 |
US20160030472A1 (en) * | 2013-03-05 | 2016-02-04 | Air Liquide Santé (International) | Xenon-based anesthetic gas composition usable during an endarterectomy involving the clamping of the carotid artery |
CA3132914C (en) | 2013-03-15 | 2023-11-07 | The Board Of Regents Of The University Of Texas System | Liquids rich in noble gas and methods of their preparation and use |
FR3022456B1 (fr) * | 2014-06-20 | 2016-07-15 | Air Liquide | Xenon associe a un antagoniste des recepteurs nmda pour lutter contre une proliferation tumorale dans le systeme nerveux central |
CA3106611A1 (en) * | 2018-07-18 | 2020-01-23 | Likeminds, Inc. | Method for accelerated tissue penetration of compounds into brain |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11513703A (ja) * | 1995-10-20 | 1999-11-24 | レール・リキード・ソシエテ・アノニム・プール・レテュード・エ・レクスプロワタシオン・デ・プロセデ・ジョルジュ・クロード | 医薬として用いられる一酸化窒素に基づく組成物 |
WO2000053192A1 (en) * | 1999-03-11 | 2000-09-14 | Aga Ab | Use of xenon for treating neurointoxications |
DE19933704A1 (de) * | 1999-07-19 | 2001-01-25 | Michael Georgieff | Verwendung einer lipophile Gase enthaltenden Präparation zur Neuroprotektion und Neuroregeneration |
WO2002009731A1 (fr) * | 2000-07-27 | 2002-02-07 | L'air Liquide Sante (International) | Utilisation de co dans le traitement de l'inflammation des voies aeriennes superieures ou des bronches |
WO2002022141A2 (de) * | 2000-09-14 | 2002-03-21 | Messer Griesheim Gmbh | Xenon als arzneimittel |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1601366A (en) | 1977-06-21 | 1981-10-28 | Nat Res Dev | Lasers |
FR2538704B1 (fr) | 1983-01-03 | 1986-02-28 | France Prod Oxygenes Co | Produit de contraste des images en tomodensitometrie |
US5228434A (en) * | 1991-07-16 | 1993-07-20 | Praxair Technology, Inc. | Mixture for anesthesia |
US5099834A (en) | 1991-07-16 | 1992-03-31 | Union Carbide Industrial Gases Technology Corporation | Method for anesthesia |
DE19709704C2 (de) | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
GB9913677D0 (en) | 1999-06-11 | 1999-08-11 | Imperial College | Formulation |
DE19938800A1 (de) | 1999-08-16 | 2001-02-22 | Stefan Huebner | Medizinisches Präperat zur Verabreichung flüchtiger Stoffe |
FR2812545B1 (fr) | 2000-08-03 | 2003-03-28 | Air Liquide Sante Int | Aerosol medicamenteux inhalable dans le traitement ou la prevention de la douceur |
DE10045829A1 (de) | 2000-09-14 | 2002-04-04 | Messer Griesheim Gmbh | Volatile Anästhesiemittel mit Xenon |
US6596206B2 (en) | 2001-03-30 | 2003-07-22 | Picoliter Inc. | Generation of pharmaceutical agent particles using focused acoustic energy |
-
2003
- 2003-06-12 AT AT03759935T patent/ATE420650T1/de active
- 2003-06-12 WO PCT/EP2003/006157 patent/WO2003105871A1/de active Application Filing
- 2003-06-12 CN CNA038165767A patent/CN1668315A/zh active Pending
- 2003-06-12 ES ES03759935T patent/ES2321185T3/es not_active Expired - Lifetime
- 2003-06-12 AU AU2003246415A patent/AU2003246415A1/en not_active Abandoned
- 2003-06-12 US US10/517,723 patent/US7235264B2/en not_active Expired - Lifetime
- 2003-06-12 DE DE50311092T patent/DE50311092D1/de not_active Expired - Lifetime
- 2003-06-12 PT PT03759935T patent/PT1515732E/pt unknown
- 2003-06-12 DK DK03759935T patent/DK1515732T3/da active
- 2003-06-12 JP JP2004512773A patent/JP2005533062A/ja active Pending
- 2003-06-12 EP EP03759935A patent/EP1515732B1/de not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11513703A (ja) * | 1995-10-20 | 1999-11-24 | レール・リキード・ソシエテ・アノニム・プール・レテュード・エ・レクスプロワタシオン・デ・プロセデ・ジョルジュ・クロード | 医薬として用いられる一酸化窒素に基づく組成物 |
WO2000053192A1 (en) * | 1999-03-11 | 2000-09-14 | Aga Ab | Use of xenon for treating neurointoxications |
DE19933704A1 (de) * | 1999-07-19 | 2001-01-25 | Michael Georgieff | Verwendung einer lipophile Gase enthaltenden Präparation zur Neuroprotektion und Neuroregeneration |
WO2002009731A1 (fr) * | 2000-07-27 | 2002-02-07 | L'air Liquide Sante (International) | Utilisation de co dans le traitement de l'inflammation des voies aeriennes superieures ou des bronches |
WO2002022141A2 (de) * | 2000-09-14 | 2002-03-21 | Messer Griesheim Gmbh | Xenon als arzneimittel |
Non-Patent Citations (2)
Title |
---|
JPN6009035523, Horn P et al, The Keio Journal of Medicine, 2000, Vol.49, Suppl.1, pA161−A163 * |
JPN6009035525, Horn P, AJNR Am J Neuroradiol, 2001, Vol.22, p1543−1549 * |
Also Published As
Publication number | Publication date |
---|---|
EP1515732B1 (de) | 2009-01-14 |
DE50311092D1 (de) | 2009-03-05 |
ATE420650T1 (de) | 2009-01-15 |
DK1515732T3 (da) | 2009-05-11 |
EP1515732A1 (de) | 2005-03-23 |
PT1515732E (pt) | 2009-04-14 |
ES2321185T3 (es) | 2009-06-03 |
WO2003105871A1 (de) | 2003-12-24 |
CN1668315A (zh) | 2005-09-14 |
AU2003246415A1 (en) | 2003-12-31 |
US20050255168A1 (en) | 2005-11-17 |
US7235264B2 (en) | 2007-06-26 |
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