ATE554074T1 - Verfahren zur herstellung von 4'-ää4-methyl-6-(1- methyl-1h-benzimidazol-2-yl)-2-propyl-1h- - Google Patents

Verfahren zur herstellung von 4'-ää4-methyl-6-(1- methyl-1h-benzimidazol-2-yl)-2-propyl-1h-

Info

Publication number
ATE554074T1
ATE554074T1 AT08773249T AT08773249T ATE554074T1 AT E554074 T1 ATE554074 T1 AT E554074T1 AT 08773249 T AT08773249 T AT 08773249T AT 08773249 T AT08773249 T AT 08773249T AT E554074 T1 ATE554074 T1 AT E554074T1
Authority
AT
Austria
Prior art keywords
methyl
benzimidazole
propyl
producing
telmisartan
Prior art date
Application number
AT08773249T
Other languages
English (en)
Inventor
Jan Stach
Stanislav Radl
Josef Cinibulk
Ivo Strelec
Kamal Jarrah
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Application granted granted Critical
Publication of ATE554074T1 publication Critical patent/ATE554074T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
AT08773249T 2007-07-09 2008-07-08 Verfahren zur herstellung von 4'-ää4-methyl-6-(1- methyl-1h-benzimidazol-2-yl)-2-propyl-1h- ATE554074T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20070457A CZ302272B6 (cs) 2007-07-09 2007-07-09 Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
PCT/CZ2008/000080 WO2009006860A2 (en) 2007-07-09 2008-07-08 A method of manufacturing 4'-[[4-methyl-6-(1-methyl-1h-benzimidazol-2-yl)-2-propyl-1h-benzimidazol-1yl]methyl]biphenyl-2-carboxylic acid (telmisartan)

Publications (1)

Publication Number Publication Date
ATE554074T1 true ATE554074T1 (de) 2012-05-15

Family

ID=40229130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08773249T ATE554074T1 (de) 2007-07-09 2008-07-08 Verfahren zur herstellung von 4'-ää4-methyl-6-(1- methyl-1h-benzimidazol-2-yl)-2-propyl-1h-

Country Status (13)

Country Link
US (1) US20100222402A1 (de)
EP (1) EP2176235B1 (de)
AT (1) ATE554074T1 (de)
CZ (1) CZ302272B6 (de)
EA (1) EA015790B1 (de)
ES (1) ES2386678T3 (de)
HR (1) HRP20120501T1 (de)
PL (1) PL2176235T3 (de)
PT (1) PT2176235E (de)
RS (1) RS52426B (de)
SI (1) SI2176235T1 (de)
UA (1) UA99140C2 (de)
WO (1) WO2009006860A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010004385A1 (en) * 2008-06-17 2010-01-14 Aurobindo Pharma Limited Process for the preparation of pure 4'-[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
WO2010018441A2 (en) * 2008-08-11 2010-02-18 Cadila Pharmaceuticals Ltd. An improved process for the preparation of substantially pure telmisartan
EA025946B1 (ru) 2010-10-27 2017-02-28 Крка, Товарна Здравил, Д. Д., Ново Место Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
ITMI20102416A1 (it) * 2010-12-27 2012-06-28 Chemelectiva S R L Intermedio per la preparazione di un principio attivo e processo per la sua preparazione
JP6147546B2 (ja) * 2013-04-10 2017-06-14 株式会社トクヤマ 酢酸が低減されたテルミサルタンａ型結晶の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591762A (en) * 1991-02-06 1997-01-07 Dr. Karl Thomae Gmbh Benzimidazoles useful as angiotensin-11 antagonists
US6358986B1 (en) * 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
DE10314702A1 (de) 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
CA2581723A1 (en) * 2004-10-15 2006-04-27 Teva Pharmaceutical Industries Ltd. Process for preparing telmisartan
WO2006044754A2 (en) * 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
US20060211866A1 (en) * 2005-03-21 2006-09-21 Glenmark Pharmaceuticals Limited Process for the preparation of angiotensin receptor blockers and intermediates thereof

Also Published As

Publication number Publication date
CZ2007457A3 (cs) 2009-02-11
EA015790B1 (ru) 2011-12-30
EP2176235A2 (de) 2010-04-21
WO2009006860A3 (en) 2009-04-16
US20100222402A1 (en) 2010-09-02
SI2176235T1 (sl) 2012-10-30
EP2176235B1 (de) 2012-04-18
PT2176235E (pt) 2012-07-02
EA201000065A1 (ru) 2010-06-30
PL2176235T3 (pl) 2012-09-28
CZ302272B6 (cs) 2011-01-19
ES2386678T3 (es) 2012-08-24
WO2009006860A2 (en) 2009-01-15
UA99140C2 (ru) 2012-07-25
HRP20120501T1 (hr) 2012-10-31
RS52426B (en) 2013-02-28

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