SI2176235T1 - Postopek za proizvodnjo 4'-((4-metil-6-(1-metil-1h-benzimidazol-2-il)-2-propil-1h-benzimidazol- 1il)metil)bifenil-2-karboksilne kisline (telmisartan) - Google Patents

Postopek za proizvodnjo 4'-((4-metil-6-(1-metil-1h-benzimidazol-2-il)-2-propil-1h-benzimidazol- 1il)metil)bifenil-2-karboksilne kisline (telmisartan)

Info

Publication number
SI2176235T1
SI2176235T1 SI200830664T SI200830664T SI2176235T1 SI 2176235 T1 SI2176235 T1 SI 2176235T1 SI 200830664 T SI200830664 T SI 200830664T SI 200830664 T SI200830664 T SI 200830664T SI 2176235 T1 SI2176235 T1 SI 2176235T1
Authority
SI
Slovenia
Prior art keywords
methyl
benzimidazol
telmisartan
carboxylic acid
åmethyl
Prior art date
Application number
SI200830664T
Other languages
English (en)
Inventor
Jan Stach
Stanislav Radl
Josef Cinibulk
Ivo Strelec
Kamal Jarrah
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Publication of SI2176235T1 publication Critical patent/SI2176235T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200830664T 2007-07-09 2008-07-08 Postopek za proizvodnjo 4'-((4-metil-6-(1-metil-1h-benzimidazol-2-il)-2-propil-1h-benzimidazol- 1il)metil)bifenil-2-karboksilne kisline (telmisartan) SI2176235T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20070457A CZ302272B6 (cs) 2007-07-09 2007-07-09 Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
PCT/CZ2008/000080 WO2009006860A2 (en) 2007-07-09 2008-07-08 A method of manufacturing 4'-[[4-methyl-6-(1-methyl-1h-benzimidazol-2-yl)-2-propyl-1h-benzimidazol-1yl]methyl]biphenyl-2-carboxylic acid (telmisartan)
EP08773249A EP2176235B1 (en) 2007-07-09 2008-07-08 A method of manufacturing 4'-[[4-methyl-6-(1-methyl-1h-benzimidazol-2-yl)-2-propyl-1h-benzimidazol-1yl]methyl]biphenyl-2-carboxylic acid (telmisartan)

Publications (1)

Publication Number Publication Date
SI2176235T1 true SI2176235T1 (sl) 2012-10-30

Family

ID=40229130

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200830664T SI2176235T1 (sl) 2007-07-09 2008-07-08 Postopek za proizvodnjo 4'-((4-metil-6-(1-metil-1h-benzimidazol-2-il)-2-propil-1h-benzimidazol- 1il)metil)bifenil-2-karboksilne kisline (telmisartan)

Country Status (13)

Country Link
US (1) US20100222402A1 (sl)
EP (1) EP2176235B1 (sl)
AT (1) ATE554074T1 (sl)
CZ (1) CZ302272B6 (sl)
EA (1) EA015790B1 (sl)
ES (1) ES2386678T3 (sl)
HR (1) HRP20120501T1 (sl)
PL (1) PL2176235T3 (sl)
PT (1) PT2176235E (sl)
RS (1) RS52426B (sl)
SI (1) SI2176235T1 (sl)
UA (1) UA99140C2 (sl)
WO (1) WO2009006860A2 (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010004385A1 (en) * 2008-06-17 2010-01-14 Aurobindo Pharma Limited Process for the preparation of pure 4'-[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
WO2010018441A2 (en) * 2008-08-11 2010-02-18 Cadila Pharmaceuticals Ltd. An improved process for the preparation of substantially pure telmisartan
WO2012055941A1 (en) 2010-10-27 2012-05-03 Krka,Tovarna Zdravil, D. D., Novo Mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
ITMI20102416A1 (it) * 2010-12-27 2012-06-28 Chemelectiva S R L Intermedio per la preparazione di un principio attivo e processo per la sua preparazione
JP6147546B2 (ja) * 2013-04-10 2017-06-14 株式会社トクヤマ 酢酸が低減されたテルミサルタンａ型結晶の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614519A (en) * 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
US6358986B1 (en) * 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
KR20080112424A (ko) * 2004-10-15 2008-12-24 테바 파마슈티컬 인더스트리즈 리미티드 텔미사르탄의 제조 방법
WO2006044754A2 (en) * 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
US20060211866A1 (en) * 2005-03-21 2006-09-21 Glenmark Pharmaceuticals Limited Process for the preparation of angiotensin receptor blockers and intermediates thereof

Also Published As

Publication number Publication date
HRP20120501T1 (hr) 2012-10-31
CZ302272B6 (cs) 2011-01-19
CZ2007457A3 (cs) 2009-02-11
ATE554074T1 (de) 2012-05-15
EA201000065A1 (ru) 2010-06-30
US20100222402A1 (en) 2010-09-02
EP2176235A2 (en) 2010-04-21
ES2386678T3 (es) 2012-08-24
UA99140C2 (ru) 2012-07-25
PL2176235T3 (pl) 2012-09-28
EA015790B1 (ru) 2011-12-30
PT2176235E (pt) 2012-07-02
WO2009006860A2 (en) 2009-01-15
EP2176235B1 (en) 2012-04-18
WO2009006860A3 (en) 2009-04-16
RS52426B (en) 2013-02-28

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