UA99140C2 - Способ получения 4'-[[4-метил-6-(1-метил-1h-бензимидазол-2-ил)-2-пропил-1h-бензимидазол-1-ил]метил]бифенил-2-карбоновой кислоты (телмисартан) - Google Patents

Способ получения 4'-[[4-метил-6-(1-метил-1h-бензимидазол-2-ил)-2-пропил-1h-бензимидазол-1-ил]метил]бифенил-2-карбоновой кислоты (телмисартан)

Info

Publication number
UA99140C2
UA99140C2 UAA201001360A UAA201001360A UA99140C2 UA 99140 C2 UA99140 C2 UA 99140C2 UA A201001360 A UAA201001360 A UA A201001360A UA A201001360 A UAA201001360 A UA A201001360A UA 99140 C2 UA99140 C2 UA 99140C2
Authority
UA
Ukraine
Prior art keywords
methyl
benzimidazol
telmisartan
carboxylic acid
biphenyl
Prior art date
Application number
UAA201001360A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ян Стах
Станислав Радл
Йозеф Цинибулк
Иво Стрелец
Камаль Яррах
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of UA99140C2 publication Critical patent/UA99140C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Карбоновую кислоту общей формулы RCOOH, где Rявляется атомом водорода или С-Салкил, добавляют к раствору калиевой соли телмисартана в спирте формулы ROH с содержанием воды ниже чем 2 %, где Rявляется этилом или метилом.
UAA201001360A 2007-07-09 2008-07-08 Способ получения 4'-[[4-метил-6-(1-метил-1h-бензимидазол-2-ил)-2-пропил-1h-бензимидазол-1-ил]метил]бифенил-2-карбоновой кислоты (телмисартан) UA99140C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20070457A CZ302272B6 (cs) 2007-07-09 2007-07-09 Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)

Publications (1)

Publication Number Publication Date
UA99140C2 true UA99140C2 (ru) 2012-07-25

Family

ID=40229130

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201001360A UA99140C2 (ru) 2007-07-09 2008-07-08 Способ получения 4'-[[4-метил-6-(1-метил-1h-бензимидазол-2-ил)-2-пропил-1h-бензимидазол-1-ил]метил]бифенил-2-карбоновой кислоты (телмисартан)

Country Status (13)

Country Link
US (1) US20100222402A1 (ru)
EP (1) EP2176235B1 (ru)
AT (1) ATE554074T1 (ru)
CZ (1) CZ302272B6 (ru)
EA (1) EA015790B1 (ru)
ES (1) ES2386678T3 (ru)
HR (1) HRP20120501T1 (ru)
PL (1) PL2176235T3 (ru)
PT (1) PT2176235E (ru)
RS (1) RS52426B (ru)
SI (1) SI2176235T1 (ru)
UA (1) UA99140C2 (ru)
WO (1) WO2009006860A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010004385A1 (en) * 2008-06-17 2010-01-14 Aurobindo Pharma Limited Process for the preparation of pure 4'-[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
WO2010018441A2 (en) * 2008-08-11 2010-02-18 Cadila Pharmaceuticals Ltd. An improved process for the preparation of substantially pure telmisartan
EP2632438A1 (en) 2010-10-27 2013-09-04 KRKA, tovarna zdravil, d.d., Novo mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
ITMI20102416A1 (it) * 2010-12-27 2012-06-28 Chemelectiva S R L Intermedio per la preparazione di un principio attivo e processo per la sua preparazione
JP6147546B2 (ja) * 2013-04-10 2017-06-14 株式会社トクヤマ 酢酸が低減されたテルミサルタンａ型結晶の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614519A (en) * 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
US6358986B1 (en) * 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
DE10314702A1 (de) 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
KR20070061583A (ko) * 2004-10-15 2007-06-13 테바 파마슈티컬 인더스트리즈 리미티드 텔미사르탄의 제조 방법
US7943781B2 (en) * 2004-10-18 2011-05-17 Dr. Reddy's Laboratories Limited Process for preparing telmisartan
US20060211866A1 (en) * 2005-03-21 2006-09-21 Glenmark Pharmaceuticals Limited Process for the preparation of angiotensin receptor blockers and intermediates thereof

Also Published As

Publication number Publication date
EA015790B1 (ru) 2011-12-30
PL2176235T3 (pl) 2012-09-28
CZ2007457A3 (cs) 2009-02-11
US20100222402A1 (en) 2010-09-02
EP2176235A2 (en) 2010-04-21
EP2176235B1 (en) 2012-04-18
WO2009006860A3 (en) 2009-04-16
WO2009006860A2 (en) 2009-01-15
ES2386678T3 (es) 2012-08-24
CZ302272B6 (cs) 2011-01-19
SI2176235T1 (sl) 2012-10-30
HRP20120501T1 (hr) 2012-10-31
EA201000065A1 (ru) 2010-06-30
PT2176235E (pt) 2012-07-02
ATE554074T1 (de) 2012-05-15
RS52426B (en) 2013-02-28

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