ATE544344T1 - Therapeutische pyrazolochinolinderivate - Google Patents
Therapeutische pyrazolochinolinderivateInfo
- Publication number
- ATE544344T1 ATE544344T1 AT08770402T AT08770402T ATE544344T1 AT E544344 T1 ATE544344 T1 AT E544344T1 AT 08770402 T AT08770402 T AT 08770402T AT 08770402 T AT08770402 T AT 08770402T AT E544344 T1 ATE544344 T1 AT E544344T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- gabaa
- pyrazolochinoline
- therapeutic
- derivatives
- Prior art date
Links
- UXYHZIYEDDINQH-UHFFFAOYSA-N C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=NN=C3C=CC2=C1 UXYHZIYEDDINQH-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 2
- 108091008681 GABAA receptors Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94300507P | 2007-06-08 | 2007-06-08 | |
| PCT/US2008/066201 WO2008154438A1 (en) | 2007-06-08 | 2008-06-06 | Therapeutic pyrazoloquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE544344T1 true ATE544344T1 (de) | 2012-02-15 |
Family
ID=40096440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08770402T ATE544344T1 (de) | 2007-06-08 | 2008-06-06 | Therapeutische pyrazolochinolinderivate |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7872002B2 (enExample) |
| EP (1) | EP2166852B1 (enExample) |
| JP (1) | JP2010529143A (enExample) |
| KR (1) | KR20100039331A (enExample) |
| CN (1) | CN101742908A (enExample) |
| AT (1) | ATE544344T1 (enExample) |
| AU (1) | AU2008261884A1 (enExample) |
| BR (1) | BRPI0812366A2 (enExample) |
| CA (1) | CA2688395A1 (enExample) |
| ES (1) | ES2386168T3 (enExample) |
| IL (1) | IL202270A0 (enExample) |
| MX (1) | MX2009013202A (enExample) |
| WO (1) | WO2008154438A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010529144A (ja) * | 2007-06-08 | 2010-08-26 | ヘリコン・セラピューティクス・インコーポレーテッド | 治療用ピラゾロキノリン尿素誘導体 |
| ATE544344T1 (de) * | 2007-06-08 | 2012-02-15 | Helicon Therapeutics Inc | Therapeutische pyrazolochinolinderivate |
| KR20100036306A (ko) * | 2007-06-08 | 2010-04-07 | 헬리콘 테라퓨틱스 인코퍼레이티드 | 치료용 피라졸로나프티리딘 유도체 |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| US10407423B2 (en) | 2015-11-16 | 2019-09-10 | Fundación Para La Investigación Médica Aplicada | Compounds as inhibitors of DNA methyltransferases |
| CN105294648B (zh) * | 2015-11-30 | 2017-11-28 | 山东罗欣药业集团股份有限公司 | 一种西他沙星的制备方法 |
| WO2022037631A1 (zh) * | 2020-08-21 | 2022-02-24 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3204126A1 (de) | 1982-02-06 | 1983-08-11 | Bayer Ag, 5090 Leverkusen | Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4814450A (en) | 1984-07-09 | 1989-03-21 | Ciba-Geigy Corporation | Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives |
| JPS61112075A (ja) * | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
| EP0214092A1 (en) | 1985-08-08 | 1987-03-11 | Ciba-Geigy Ag | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
| US5334595A (en) | 1992-10-23 | 1994-08-02 | Sterling Winthrop Inc. | Pyrazoloquinolones as anticancer agents |
| GB9716347D0 (en) | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| TWI271406B (en) | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
| GB0108475D0 (en) * | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| JP3896309B2 (ja) | 2001-07-09 | 2007-03-22 | ファイザー株式会社 | プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体 |
| US7674906B2 (en) | 2002-12-16 | 2010-03-09 | Active Biotech Ab | Tetracyclic immunomodulatory compounds |
| US20050245563A1 (en) | 2003-05-29 | 2005-11-03 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| CA2621560A1 (en) | 2005-09-07 | 2007-03-15 | Braincells, Inc. | Modulation of neurogenesis by hdac inhibition |
| JP2008047893A (ja) * | 2006-08-11 | 2008-02-28 | Samsung Electronics Co Ltd | 薄膜トランジスタ表示板及びその製造方法 |
| ATE544344T1 (de) * | 2007-06-08 | 2012-02-15 | Helicon Therapeutics Inc | Therapeutische pyrazolochinolinderivate |
-
2008
- 2008-06-06 AT AT08770402T patent/ATE544344T1/de active
- 2008-06-06 KR KR1020107000330A patent/KR20100039331A/ko not_active Withdrawn
- 2008-06-06 MX MX2009013202A patent/MX2009013202A/es active IP Right Grant
- 2008-06-06 CA CA002688395A patent/CA2688395A1/en not_active Abandoned
- 2008-06-06 BR BRPI0812366A patent/BRPI0812366A2/pt not_active IP Right Cessation
- 2008-06-06 US US12/135,036 patent/US7872002B2/en not_active Expired - Fee Related
- 2008-06-06 JP JP2010511387A patent/JP2010529143A/ja active Pending
- 2008-06-06 AU AU2008261884A patent/AU2008261884A1/en not_active Abandoned
- 2008-06-06 ES ES08770402T patent/ES2386168T3/es active Active
- 2008-06-06 EP EP08770402A patent/EP2166852B1/en not_active Not-in-force
- 2008-06-06 CN CN200880024823A patent/CN101742908A/zh active Pending
- 2008-06-06 WO PCT/US2008/066201 patent/WO2008154438A1/en not_active Ceased
-
2009
- 2009-11-22 IL IL202270A patent/IL202270A0/en unknown
-
2010
- 2010-11-18 US US12/949,655 patent/US8598159B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2166852B1 (en) | 2012-02-08 |
| CA2688395A1 (en) | 2008-12-18 |
| MX2009013202A (es) | 2010-04-09 |
| AU2008261884A1 (en) | 2008-12-18 |
| EP2166852A1 (en) | 2010-03-31 |
| US8598159B2 (en) | 2013-12-03 |
| US7872002B2 (en) | 2011-01-18 |
| IL202270A0 (en) | 2010-06-16 |
| BRPI0812366A2 (pt) | 2016-08-02 |
| US20110065693A1 (en) | 2011-03-17 |
| EP2166852A4 (en) | 2010-07-07 |
| KR20100039331A (ko) | 2010-04-15 |
| HK1142775A1 (en) | 2010-12-17 |
| CN101742908A (zh) | 2010-06-16 |
| WO2008154438A1 (en) | 2008-12-18 |
| ES2386168T3 (es) | 2012-08-10 |
| JP2010529143A (ja) | 2010-08-26 |
| US20080306049A1 (en) | 2008-12-11 |
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