ATE542901T1 - Glykosyliertes il-7, herstellung und anwendungen - Google Patents

Glykosyliertes il-7, herstellung und anwendungen

Info

Publication number
ATE542901T1
ATE542901T1 AT06795556T AT06795556T ATE542901T1 AT E542901 T1 ATE542901 T1 AT E542901T1 AT 06795556 T AT06795556 T AT 06795556T AT 06795556 T AT06795556 T AT 06795556T AT E542901 T1 ATE542901 T1 AT E542901T1
Authority
AT
Austria
Prior art keywords
polypeptides
well
relates
preparation
glycosylated
Prior art date
Application number
AT06795556T
Other languages
English (en)
Inventor
Michel Morre
Brigitte Assouline
Iann Rance
Anne Gregoire
Corinne Breque
Original Assignee
Cytheris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytheris filed Critical Cytheris
Application granted granted Critical
Publication of ATE542901T1 publication Critical patent/ATE542901T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT06795556T 2005-07-20 2006-07-19 Glykosyliertes il-7, herstellung und anwendungen ATE542901T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05291556A EP1746161A1 (de) 2005-07-20 2005-07-20 Glykosylierte IL-7, Verfahren zur Herstellung und Verwendung davon
PCT/IB2006/002663 WO2007010401A2 (en) 2005-07-20 2006-07-19 Glycosylated il-7, preparation and uses

Publications (1)

Publication Number Publication Date
ATE542901T1 true ATE542901T1 (de) 2012-02-15

Family

ID=35385570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06795556T ATE542901T1 (de) 2005-07-20 2006-07-19 Glykosyliertes il-7, herstellung und anwendungen

Country Status (20)

Country Link
US (3) US7708985B2 (de)
EP (2) EP1746161A1 (de)
JP (2) JP5685363B2 (de)
CN (2) CN105647939A (de)
AT (1) ATE542901T1 (de)
AU (1) AU2006271315B2 (de)
CA (2) CA2615562C (de)
CY (1) CY1112655T1 (de)
DK (1) DK1904635T3 (de)
EA (1) EA012802B1 (de)
ES (1) ES2379732T3 (de)
HK (1) HK1115154A1 (de)
IL (1) IL188480A0 (de)
NO (1) NO344802B1 (de)
NZ (1) NZ564907A (de)
PL (1) PL1904635T3 (de)
PT (1) PT1904635E (de)
SI (1) SI1904635T1 (de)
WO (1) WO2007010401A2 (de)
ZA (1) ZA200800533B (de)

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BRPI0719446A2 (pt) 2006-09-28 2013-12-10 Schering Corp Uso de il-10 peguilada para tratar câncer
CL2007003411A1 (es) * 2006-11-28 2008-07-04 Centelion Proteina fusion que consiste en una region fc de una inmunoglobulina con un fragmento o dominio soluble de un receptor para fgf; polinucleotido que la codifica y vector y celula que lo comprenden; composicion farmaceutica que comprende la proteina fu
CN101943688B (zh) * 2009-07-10 2013-01-02 复旦大学 一种利用质谱靶板富集糖基化肽段的方法
AU2011261161A1 (en) 2010-06-01 2013-01-10 Ludwig Institute For Cancer Research Limited Antibodies directed to the unprocessed receptor tyrosine kinase c-Met
EP2596010B1 (de) * 2010-07-19 2017-04-12 Otago Innovation Limited Signalbiomarker
JP6296536B2 (ja) 2010-11-05 2018-03-20 メドベット サイエンス ピーティーワイエルティーディーＭｅｄｖｅｔ Ｓｃｉｅｎｃｅ Ｐｔｙ Ｌｔｄ 内皮前駆細胞のマーカーおよびその使用
CA2820956C (en) * 2010-12-10 2016-05-03 University Of Central Florida Research Foundation, Inc. Methods and compositions comprising il-7 receptor ligands
EP2739301B1 (de) 2011-08-03 2016-01-20 Cytheris Hcv-immuntherapie
EP2986306A4 (de) 2013-04-18 2016-12-07 Armo Biosciences Inc Verfahren zur verwendung von interleukin-10 zur behandlung von erkrankungen und leiden
AU2014281828B2 (en) 2013-06-17 2019-05-09 Armo Biosciences, Inc. Method for assessing protein identity and stability
US11413332B2 (en) 2013-11-11 2022-08-16 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN104725484B (zh) * 2013-12-19 2018-03-13 中国科学院微生物研究所 一种糖基化多肽及其制备方法和其应用
EP3119412A1 (de) 2014-03-21 2017-01-25 Boreal Invest Endgültige nanofiltration von gelösten proteinzusammensetzungen zur entfernung von immunogenen aggregaten
WO2015187295A2 (en) 2014-06-02 2015-12-10 Armo Biosciences, Inc. Methods of lowering serum cholesterol
KR20170084033A (ko) 2014-10-22 2017-07-19 아르모 바이오사이언시스 인코포레이티드 질환 및 장애를 치료하기 위해 인터루킨-10을 사용하는 방법
CN104372021A (zh) * 2014-11-05 2015-02-25 太仓思源生物医药有限公司 人白细胞介素-2蛋白质的制备方法
US10618970B2 (en) 2015-02-03 2020-04-14 Armo Biosciences, Inc. Method of treating cancer with IL-10 and antibodies that induce ADCC
AU2016268403A1 (en) 2015-05-28 2017-12-07 Armo Biosciences, Inc. Pegylated interleukin-10 for use in treating cancer
CA2986388C (en) 2015-06-11 2024-02-27 Genexine, Inc. Modified interleukin-7 protein and uses thereof
CN108473549A (zh) * 2015-10-23 2018-08-31 阿珀吉科吉尼科斯股份公司 单链gitr受体激动剂蛋白
KR102386735B1 (ko) 2015-11-06 2022-04-14 주식회사 제넥신 변형된 인터루킨-7 융합 단백질의 제형
CN108697764A (zh) 2015-12-04 2018-10-23 格纳西尼有限公司 含有免疫球蛋白fc融合白细胞介素-7融合蛋白的用于预防或治疗流感病毒感染的药物组合物
WO2017095191A1 (ko) * 2015-12-04 2017-06-08 주식회사 제넥신 면역글로불린 fc가 융합된 인터루킨-7 융합 단백질을 포함하는 사람 파필로마바이러스 유래 질환의 예방 또는 치료용 약학적 조성물
CN106317226B (zh) * 2016-08-19 2017-09-05 安源医药科技（上海）有限公司 用于构建融合蛋白的连接肽
SG11202005036RA (en) 2018-01-25 2020-06-29 I Mab Biopharma Us Ltd Anti-pd-l1 antibody and il-7 fusions
JP2022507606A (ja) 2018-11-16 2022-01-18 ネオイミューンテック， インコーポレイテッド Ｉｌ－７タンパク質と免疫チェックポイント阻害剤の組み合わせで腫瘍を治療する方法
US20230071889A1 (en) 2018-12-21 2023-03-09 Ose Immunotherapeutics Bifunctional anti-pd-1/il-7 molecule
AU2020383176B2 (en) * 2019-11-15 2023-10-19 Genexine, Inc. Fusion protein including modified interleukin-7 and TGF beta receptor II and use thereof
KR20220150274A (ko) 2020-01-13 2022-11-10 네오이뮨텍, 인코퍼레이티드 Il-7 단백질과 이중특이적 항체의 조합물을 사용한 종양의 치료 방법
US20230210952A1 (en) 2020-02-05 2023-07-06 Washington University Method of treating a solid tumor with a combination of an il-7 protein and car-bearing immune cells
US20230398184A1 (en) 2020-10-26 2023-12-14 Neoimmunetech, Inc. Methods of inducing stem cell mobilization
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CN113817043B (zh) * 2021-09-22 2023-07-25 清华大学 制备活性铁调节激素的方法
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Also Published As

Publication number Publication date
ZA200800533B (en) 2008-12-31
JP5685363B2 (ja) 2015-03-18
CN101228275A (zh) 2008-07-23
EP1904635A2 (de) 2008-04-02
ES2379732T3 (es) 2012-05-03
AU2006271315A1 (en) 2007-01-25
CN101228275B (zh) 2016-02-24
AU2006271315B2 (en) 2011-08-11
NO344802B1 (no) 2020-05-04
JP2009501543A (ja) 2009-01-22
CN105647939A (zh) 2016-06-08
EP1746161A1 (de) 2007-01-24
NO20080045L (no) 2008-04-21
EA012802B1 (ru) 2009-12-30
NZ564907A (en) 2011-09-30
SI1904635T1 (sl) 2012-10-30
CY1112655T1 (el) 2016-02-10
EP1904635B1 (de) 2012-01-25
US20120016104A1 (en) 2012-01-19
EA200800368A1 (ru) 2008-06-30
CA2615562A1 (en) 2007-01-25
US20100196312A1 (en) 2010-08-05
PT1904635E (pt) 2012-03-06
US8034327B2 (en) 2011-10-11
PL1904635T3 (pl) 2012-07-31
CA2615562C (en) 2014-11-04
WO2007010401A2 (en) 2007-01-25
BRPI0613747A2 (pt) 2011-02-08
US7708985B2 (en) 2010-05-04
DK1904635T3 (da) 2012-02-27
IL188480A0 (en) 2008-04-13
US20080206190A1 (en) 2008-08-28
CA2859145C (en) 2018-11-27
HK1115154A1 (en) 2008-11-21
CA2859145A1 (en) 2007-01-25
WO2007010401A3 (en) 2007-04-19
US8153114B2 (en) 2012-04-10
JP2015057392A (ja) 2015-03-26

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