ATE540756T1 - Vorrichtung zur handhabung von tropfen zur biochemischen analyse, verfahren zur herstellung einer derartigen vorrichtung und system zur mikrofluidischen analyse - Google Patents
Vorrichtung zur handhabung von tropfen zur biochemischen analyse, verfahren zur herstellung einer derartigen vorrichtung und system zur mikrofluidischen analyseInfo
- Publication number
- ATE540756T1 ATE540756T1 AT05775767T AT05775767T ATE540756T1 AT E540756 T1 ATE540756 T1 AT E540756T1 AT 05775767 T AT05775767 T AT 05775767T AT 05775767 T AT05775767 T AT 05775767T AT E540756 T1 ATE540756 T1 AT E540756T1
- Authority
- AT
- Austria
- Prior art keywords
- mask
- analysis
- dissolution
- producing
- creation
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/088—Passive control of flow resistance by specific surface properties
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
- F05C2225/00—Synthetic polymers, e.g. plastics; Rubber
- F05C2225/04—PTFE [PolyTetraFluorEthylene]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0406080A FR2871150B1 (fr) | 2004-06-04 | 2004-06-04 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
PCT/FR2005/001385 WO2006003293A2 (fr) | 2004-06-04 | 2005-06-06 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE540756T1 true ATE540756T1 (de) | 2012-01-15 |
Family
ID=34946857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05775767T ATE540756T1 (de) | 2004-06-04 | 2005-06-06 | Vorrichtung zur handhabung von tropfen zur biochemischen analyse, verfahren zur herstellung einer derartigen vorrichtung und system zur mikrofluidischen analyse |
Country Status (9)
Country | Link |
---|---|
US (1) | US20080110753A1 (fr) |
EP (1) | EP1781409B1 (fr) |
JP (1) | JP4763690B2 (fr) |
KR (1) | KR101179411B1 (fr) |
CN (1) | CN101031362B (fr) |
AT (1) | ATE540756T1 (fr) |
CA (1) | CA2568805C (fr) |
FR (1) | FR2871150B1 (fr) |
WO (1) | WO2006003293A2 (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2871076A1 (fr) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
JP4632300B2 (ja) * | 2005-02-14 | 2011-02-16 | 国立大学法人 筑波大学 | 送液装置 |
JP4893197B2 (ja) * | 2006-09-28 | 2012-03-07 | ブラザー工業株式会社 | 液体移送装置 |
US8702938B2 (en) * | 2007-09-04 | 2014-04-22 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
EP3181228B1 (fr) | 2007-10-02 | 2020-07-29 | Labrador Diagnostics LLC | Dispositifs modulaires à utiliser sur place et leurs utilisations |
JP5383138B2 (ja) * | 2008-10-01 | 2014-01-08 | シャープ株式会社 | エレクトロウエッティングバルブ付き送液構造体、これを用いたマイクロ分析チップ及び分析装置 |
US8877512B2 (en) * | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
US8734628B2 (en) * | 2010-03-10 | 2014-05-27 | Empire Technology Development, Llc | Microfluidic channel device with array of drive electrodes |
EP2567213B1 (fr) | 2010-05-05 | 2018-01-24 | The Governing Council of the Universtiy of Toronto | Procédé de traitement d'échantillons séchés utilisant un dispositif microfluidique numérique |
CN101865928B (zh) * | 2010-05-06 | 2012-07-18 | 大连理工大学 | 一种基于电场作用的超疏水表面微液滴操控方法 |
JP4949506B2 (ja) * | 2010-07-16 | 2012-06-13 | シャープ株式会社 | 流路構造体及びその製造方法、並びに、分析チップ及び分析装置 |
WO2012040861A1 (fr) * | 2010-10-01 | 2012-04-05 | The Governing Council Of The University Of Toronto | Dispositifs microfluidiques numériques et procédés d'incorporation d'une phase solide |
JP2012150098A (ja) * | 2010-12-28 | 2012-08-09 | Sharp Corp | 検体検出用チップ、それを用いたセンサ、及び検体検出方法 |
RU2620922C2 (ru) | 2011-01-21 | 2017-05-30 | Теранос, Инк. | Системы и методы оптимизации использования образца |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
CN108490204A (zh) * | 2011-09-25 | 2018-09-04 | 赛拉诺斯知识产权有限责任公司 | 用于多重分析的系统和方法 |
US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
CN102824933B (zh) * | 2012-09-20 | 2014-09-03 | 复旦大学 | 一种单向液滴输运的数字微流芯片电极配置方法 |
US9366647B2 (en) * | 2013-03-14 | 2016-06-14 | Taiwan Semiconductor Manufacturing Company, Ltd. | Optical detection for bio-entities |
US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
TWI507690B (zh) * | 2014-09-02 | 2015-11-11 | Silicon Optronics Inc | 生物晶片構裝 |
US20200390811A1 (en) * | 2015-04-23 | 2020-12-17 | The Trustees Of The University Of Pennsylvania | Compositions to disrupt protein kinase a anchoring and uses thereof |
CN108026494A (zh) | 2015-06-05 | 2018-05-11 | 米罗库鲁斯公司 | 限制蒸发和表面结垢的空气基质数字微流控装置和方法 |
CN208562324U (zh) | 2015-06-05 | 2019-03-01 | 米罗库鲁斯公司 | 空气基质数字微流控(dmf)装置 |
CN109153016B (zh) * | 2015-09-02 | 2021-12-28 | 帝肯贸易股份公司 | 微流体中的磁导管 |
JP2020501107A (ja) | 2016-08-22 | 2020-01-16 | ミロキュラス インコーポレイテッド | デジタルマイクロ流体デバイスにおける並行小滴制御のためのフィードバックシステム |
WO2018126082A1 (fr) | 2016-12-28 | 2018-07-05 | Miroculis Inc. | Dispositifs microfluidiques numériques et procédés |
US11623219B2 (en) | 2017-04-04 | 2023-04-11 | Miroculus Inc. | Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets |
EP3658908A4 (fr) | 2017-07-24 | 2021-04-07 | Miroculus Inc. | Systèmes microfluidiques numériques et procédés à dispositif de collecte de plasma intégré |
EP3676009A4 (fr) | 2017-09-01 | 2021-06-16 | Miroculus Inc. | Dispositifs microfluidiques numériques et leurs procédés d'utilisation |
EP3796999A4 (fr) | 2018-05-23 | 2022-03-09 | Miroculus Inc. | Contrôle de l'évaporation dans la microfluidique numérique |
CN113474080B (zh) * | 2019-02-25 | 2023-04-11 | 国立研究开发法人产业技术综合研究所 | 开放空间型液体操作装置 |
WO2020210292A1 (fr) | 2019-04-08 | 2020-10-15 | Miroculus Inc. | Appareils microfluidiques numériques à cartouches multiples et procédés d'utilisation |
WO2021016614A1 (fr) | 2019-07-25 | 2021-01-28 | Miroculus Inc. | Dispositifs microfluidiques numériques et leurs procédés d'utilisation |
CN111804354B (zh) * | 2020-04-07 | 2021-09-21 | 苏州大学 | 液滴无损转移装置及方法、液滴微反应方法 |
US11772093B2 (en) | 2022-01-12 | 2023-10-03 | Miroculus Inc. | Methods of mechanical microfluidic manipulation |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1329729C (zh) * | 1996-06-28 | 2007-08-01 | 卡钳生命科学股份有限公司 | 微流体系统 |
JP3791999B2 (ja) * | 1997-03-24 | 2006-06-28 | 株式会社アドバンス | 液体微粒子ハンドリング装置 |
JP3829491B2 (ja) * | 1998-08-27 | 2006-10-04 | 株式会社日立製作所 | プローブチップ、プローブチップ作成方法、試料検出方法、及び試料検出装置 |
US6565727B1 (en) * | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
JP2002031638A (ja) * | 2000-07-17 | 2002-01-31 | Mitsubishi Chemicals Corp | 生体試料検出用チップ及び生体試料検出方法 |
JP2002027984A (ja) * | 2000-07-17 | 2002-01-29 | Mitsubishi Chemicals Corp | マイクロリアクタチップ,化学反応試験方法及びマイクロリアクタチップ用薄膜部材 |
US6773566B2 (en) * | 2000-08-31 | 2004-08-10 | Nanolytics, Inc. | Electrostatic actuators for microfluidics and methods for using same |
JP2003222611A (ja) * | 2001-11-20 | 2003-08-08 | Nec Corp | 分離装置、分離方法および分離装置の製造方法 |
US7163612B2 (en) * | 2001-11-26 | 2007-01-16 | Keck Graduate Institute | Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like |
JP2003230829A (ja) * | 2001-12-06 | 2003-08-19 | Hitachi Ltd | 平面マイクロファクトリー |
US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
JP2003294733A (ja) * | 2002-03-29 | 2003-10-15 | Sumitomo Bakelite Co Ltd | 細胞内蛋白量の同定方法及び基板 |
JP3914806B2 (ja) * | 2002-04-09 | 2007-05-16 | 三菱化学株式会社 | 分析用チップ |
KR100455293B1 (ko) * | 2002-05-15 | 2004-11-06 | 삼성전자주식회사 | 친수성 영역과 소수성 영역으로 구성되는 생물분자용어레이 판의 제조방법 |
JPWO2004008132A1 (ja) * | 2002-07-11 | 2005-11-10 | 三菱電機株式会社 | 生体分子分離セル及びその製造方法並びにdna分取装置 |
JP2004061229A (ja) * | 2002-07-26 | 2004-02-26 | Hitachi Ltd | 感染症検査装置、検査方法、及び感染検査用マイクロファブリケーション |
US7329545B2 (en) * | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
US6989234B2 (en) * | 2002-09-24 | 2006-01-24 | Duke University | Method and apparatus for non-contact electrostatic actuation of droplets |
US6911132B2 (en) * | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
JP4590542B2 (ja) * | 2003-06-10 | 2010-12-01 | 国立大学法人九州工業大学 | マイクロ液滴輸送デバイス |
JP4385124B2 (ja) * | 2004-03-12 | 2009-12-16 | 国立大学法人九州工業大学 | 電気的制御可能な微量液滴輸送デバイス |
FR2871076A1 (fr) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
US20060266700A1 (en) * | 2005-05-31 | 2006-11-30 | General Electric Company | Porous structures with engineered wettability properties and methods of making them |
-
2004
- 2004-06-04 FR FR0406080A patent/FR2871150B1/fr not_active Expired - Fee Related
-
2005
- 2005-06-06 KR KR1020067025513A patent/KR101179411B1/ko not_active IP Right Cessation
- 2005-06-06 CN CN2005800240790A patent/CN101031362B/zh not_active Expired - Fee Related
- 2005-06-06 CA CA2568805A patent/CA2568805C/fr not_active Expired - Fee Related
- 2005-06-06 AT AT05775767T patent/ATE540756T1/de active
- 2005-06-06 EP EP05775767A patent/EP1781409B1/fr not_active Not-in-force
- 2005-06-06 US US11/628,416 patent/US20080110753A1/en not_active Abandoned
- 2005-06-06 WO PCT/FR2005/001385 patent/WO2006003293A2/fr active Application Filing
- 2005-06-06 JP JP2007514033A patent/JP4763690B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4763690B2 (ja) | 2011-08-31 |
US20080110753A1 (en) | 2008-05-15 |
FR2871150B1 (fr) | 2006-09-22 |
JP2008502882A (ja) | 2008-01-31 |
KR20070053165A (ko) | 2007-05-23 |
CN101031362A (zh) | 2007-09-05 |
CA2568805A1 (fr) | 2006-01-12 |
EP1781409B1 (fr) | 2012-01-11 |
CN101031362B (zh) | 2012-01-11 |
EP1781409A2 (fr) | 2007-05-09 |
CA2568805C (fr) | 2012-08-28 |
WO2006003293A3 (fr) | 2006-09-21 |
WO2006003293A2 (fr) | 2006-01-12 |
KR101179411B1 (ko) | 2012-09-07 |
FR2871150A1 (fr) | 2005-12-09 |
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