ATE540756T1 - DEVICE FOR HANDLING DROPS FOR BIOCHEMICAL ANALYSIS, METHOD FOR PRODUCING SUCH DEVICE AND SYSTEM FOR MICROFLUIDIC ANALYSIS - Google Patents
DEVICE FOR HANDLING DROPS FOR BIOCHEMICAL ANALYSIS, METHOD FOR PRODUCING SUCH DEVICE AND SYSTEM FOR MICROFLUIDIC ANALYSISInfo
- Publication number
- ATE540756T1 ATE540756T1 AT05775767T AT05775767T ATE540756T1 AT E540756 T1 ATE540756 T1 AT E540756T1 AT 05775767 T AT05775767 T AT 05775767T AT 05775767 T AT05775767 T AT 05775767T AT E540756 T1 ATE540756 T1 AT E540756T1
- Authority
- AT
- Austria
- Prior art keywords
- mask
- analysis
- dissolution
- producing
- creation
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/088—Passive control of flow resistance by specific surface properties
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
- F05C2225/00—Synthetic polymers, e.g. plastics; Rubber
- F05C2225/04—PTFE [PolyTetraFluorEthylene]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
Abstract
A device for handling drops on a displacement by electrowetting plane, including at least one displacement track. The track includes an electrically insulating substrate on the surface of which rest two or more interdigitated conducting electrodes. These electrodes are covered by a dielectric insulating layer, itself covered by a partially-wetting layer. Also, a method for the manufacture of the aforementioned device, in which the creation of the partially-wetting layer includes the creation of a mask in a photosensitive material by the deposition of this material onto a substrate, then a photolithographic stage, followed by development of the photosensitive material, the deposition of a non-wetting material onto the mask, at least one annealing process before dissolution, dissolution of the mask, and at least one annealing process after dissolution. Also, a system for the microfluidic analysis of a liquid sample.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0406080A FR2871150B1 (en) | 2004-06-04 | 2004-06-04 | DROP HANDLING DEVICE FOR BIOCHEMICAL ANALYSIS, DEVICE MANUFACTURING METHOD, AND MICROFLUIDIC ANALYSIS SYSTEM |
PCT/FR2005/001385 WO2006003293A2 (en) | 2004-06-04 | 2005-06-06 | Device for handling drops for biochemical analysis, method for producing said device and a system for microfludic analysis |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE540756T1 true ATE540756T1 (en) | 2012-01-15 |
Family
ID=34946857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05775767T ATE540756T1 (en) | 2004-06-04 | 2005-06-06 | DEVICE FOR HANDLING DROPS FOR BIOCHEMICAL ANALYSIS, METHOD FOR PRODUCING SUCH DEVICE AND SYSTEM FOR MICROFLUIDIC ANALYSIS |
Country Status (9)
Country | Link |
---|---|
US (1) | US20080110753A1 (en) |
EP (1) | EP1781409B1 (en) |
JP (1) | JP4763690B2 (en) |
KR (1) | KR101179411B1 (en) |
CN (1) | CN101031362B (en) |
AT (1) | ATE540756T1 (en) |
CA (1) | CA2568805C (en) |
FR (1) | FR2871150B1 (en) |
WO (1) | WO2006003293A2 (en) |
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FR2871076A1 (en) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | DEVICE FOR LASER RADIATION DESORPTION INCORPORATING HANDLING OF THE LIQUID SAMPLE IN THE FORM OF INDIVIDUAL DROPS ENABLING THEIR CHEMICAL AND BIOCHEMICAL TREATMENT |
JP4632300B2 (en) * | 2005-02-14 | 2011-02-16 | 国立大学法人 筑波大学 | Liquid feeding device |
JP4893197B2 (en) * | 2006-09-28 | 2012-03-07 | ブラザー工業株式会社 | Liquid transfer device |
US8702938B2 (en) * | 2007-09-04 | 2014-04-22 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
BR122020017678B1 (en) | 2007-10-02 | 2021-08-03 | Labrador Diagnostics Llc | SYSTEM FOR AUTOMATIC DETECTION OF AN ANALYTE IN A BODY FLUID SAMPLE |
JP5383138B2 (en) * | 2008-10-01 | 2014-01-08 | シャープ株式会社 | Liquid feeding structure with electrowetting valve, microanalysis chip and analyzer using the same |
US8877512B2 (en) * | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
US8734628B2 (en) * | 2010-03-10 | 2014-05-27 | Empire Technology Development, Llc | Microfluidic channel device with array of drive electrodes |
CA2798123C (en) | 2010-05-05 | 2020-06-23 | The Governing Council Of The University Of Toronto | Method of processing dried samples using digital microfluidic device |
CN101865928B (en) * | 2010-05-06 | 2012-07-18 | 大连理工大学 | Super-hydrophobic surface micro-droplet operation and control method based on electric field effect |
JP4949506B2 (en) * | 2010-07-16 | 2012-06-13 | シャープ株式会社 | Channel structure, method for manufacturing the same, analysis chip, and analysis apparatus |
WO2012040861A1 (en) * | 2010-10-01 | 2012-04-05 | The Governing Council Of The University Of Toronto | Digital microfluidic devices and methods incorporating a solid phase |
JP2012150098A (en) * | 2010-12-28 | 2012-08-09 | Sharp Corp | Chip for detecting specimen, sensor using the same, and method for detecting specimen |
EP2666008B1 (en) | 2011-01-21 | 2021-08-11 | Labrador Diagnostics LLC | Systems and methods for sample use maximization |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
EP3865875A1 (en) * | 2011-09-25 | 2021-08-18 | Labrador Diagnostics LLC | Systems and methods for multi-analysis |
US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
CN102824933B (en) * | 2012-09-20 | 2014-09-03 | 复旦大学 | Digital micro-current chip electrode configuration for single drop transportation |
US9366647B2 (en) * | 2013-03-14 | 2016-06-14 | Taiwan Semiconductor Manufacturing Company, Ltd. | Optical detection for bio-entities |
US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
TWI507690B (en) * | 2014-09-02 | 2015-11-11 | Silicon Optronics Inc | Biochip package |
US20200390811A1 (en) * | 2015-04-23 | 2020-12-17 | The Trustees Of The University Of Pennsylvania | Compositions to disrupt protein kinase a anchoring and uses thereof |
EP3303548A4 (en) | 2015-06-05 | 2019-01-02 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
CN108026494A (en) | 2015-06-05 | 2018-05-11 | 米罗库鲁斯公司 | Limitation evaporation and the digital microcurrent-controlled apparatus and method of air matrix of surface scale |
EP3344388B1 (en) * | 2015-09-02 | 2020-11-11 | Tecan Trading AG | Magnetic conduits in microfluidics |
CN109715781A (en) | 2016-08-22 | 2019-05-03 | 米罗库鲁斯公司 | Feedback system for the parallel drop control in digital microcurrent-controlled equipment |
CN110383061A (en) | 2016-12-28 | 2019-10-25 | 米罗库鲁斯公司 | Digital microcurrent-controlled device and method |
US11623219B2 (en) | 2017-04-04 | 2023-04-11 | Miroculus Inc. | Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets |
CN110892258A (en) | 2017-07-24 | 2020-03-17 | 米罗库鲁斯公司 | Digital microfluidic system and method with integrated plasma collection device |
CN111587149B (en) | 2017-09-01 | 2022-11-11 | 米罗库鲁斯公司 | Digital microfluidic device and method of use thereof |
CA3096855A1 (en) | 2018-05-23 | 2019-11-28 | Miroculus Inc. | Control of evaporation in digital microfluidics |
WO2020175083A1 (en) * | 2019-02-25 | 2020-09-03 | 国立研究開発法人産業技術総合研究所 | Open space type liquid manipulating device |
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CN111804354B (en) | 2020-04-07 | 2021-09-21 | 苏州大学 | Liquid drop nondestructive transfer device and method, and liquid drop micro-reaction method |
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US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
JP2003294733A (en) * | 2002-03-29 | 2003-10-15 | Sumitomo Bakelite Co Ltd | Identifying method of protein quantity in cell, and substrate |
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KR100455293B1 (en) * | 2002-05-15 | 2004-11-06 | 삼성전자주식회사 | A process for producing array plate for a biomolecule comprising a hydrophilic region and a hydrophobic region |
JPWO2004008132A1 (en) * | 2002-07-11 | 2005-11-10 | 三菱電機株式会社 | Biomolecule separation cell, method for producing the same, and DNA sorting apparatus |
JP2004061229A (en) * | 2002-07-26 | 2004-02-26 | Hitachi Ltd | Infectious disease inspecting apparatus, inspection method, and micro fabrication for inspecting infection |
US7329545B2 (en) * | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
US6911132B2 (en) * | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
US6989234B2 (en) * | 2002-09-24 | 2006-01-24 | Duke University | Method and apparatus for non-contact electrostatic actuation of droplets |
JP4590542B2 (en) * | 2003-06-10 | 2010-12-01 | 国立大学法人九州工業大学 | Micro droplet transport device |
JP4385124B2 (en) * | 2004-03-12 | 2009-12-16 | 国立大学法人九州工業大学 | Electrically controllable microdroplet transport device |
FR2871076A1 (en) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | DEVICE FOR LASER RADIATION DESORPTION INCORPORATING HANDLING OF THE LIQUID SAMPLE IN THE FORM OF INDIVIDUAL DROPS ENABLING THEIR CHEMICAL AND BIOCHEMICAL TREATMENT |
US20060266700A1 (en) * | 2005-05-31 | 2006-11-30 | General Electric Company | Porous structures with engineered wettability properties and methods of making them |
-
2004
- 2004-06-04 FR FR0406080A patent/FR2871150B1/en not_active Expired - Fee Related
-
2005
- 2005-06-06 AT AT05775767T patent/ATE540756T1/en active
- 2005-06-06 KR KR1020067025513A patent/KR101179411B1/en not_active IP Right Cessation
- 2005-06-06 JP JP2007514033A patent/JP4763690B2/en not_active Expired - Fee Related
- 2005-06-06 US US11/628,416 patent/US20080110753A1/en not_active Abandoned
- 2005-06-06 EP EP05775767A patent/EP1781409B1/en not_active Not-in-force
- 2005-06-06 CN CN2005800240790A patent/CN101031362B/en not_active Expired - Fee Related
- 2005-06-06 WO PCT/FR2005/001385 patent/WO2006003293A2/en active Application Filing
- 2005-06-06 CA CA2568805A patent/CA2568805C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2008502882A (en) | 2008-01-31 |
WO2006003293A2 (en) | 2006-01-12 |
CN101031362B (en) | 2012-01-11 |
CA2568805A1 (en) | 2006-01-12 |
JP4763690B2 (en) | 2011-08-31 |
WO2006003293A3 (en) | 2006-09-21 |
EP1781409B1 (en) | 2012-01-11 |
FR2871150A1 (en) | 2005-12-09 |
CN101031362A (en) | 2007-09-05 |
KR101179411B1 (en) | 2012-09-07 |
FR2871150B1 (en) | 2006-09-22 |
CA2568805C (en) | 2012-08-28 |
KR20070053165A (en) | 2007-05-23 |
EP1781409A2 (en) | 2007-05-09 |
US20080110753A1 (en) | 2008-05-15 |
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