CN101865928B - Super-hydrophobic surface micro-droplet operation and control method based on electric field effect - Google Patents
Super-hydrophobic surface micro-droplet operation and control method based on electric field effect Download PDFInfo
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- CN101865928B CN101865928B CN2010101645462A CN201010164546A CN101865928B CN 101865928 B CN101865928 B CN 101865928B CN 2010101645462 A CN2010101645462 A CN 2010101645462A CN 201010164546 A CN201010164546 A CN 201010164546A CN 101865928 B CN101865928 B CN 101865928B
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Abstract
The invention discloses a super-hydrophobic surface micro-droplet operation and control method based on the electric field effect, which belongs to the technical field of micro fluid operation control. The invention is characterized in that a conductive micro post type object or a high-absorption-power super-hydrophobic horizontal plane with a conductive layer is used as a micro-droplet operation tool, the conductive micro post type object or the high-absorption-power super-hydrophobic horizontal plane with the conductive layer is placed on a multi-coordinate microchecker and is connected to any electrode of a power supply, the other electrode of the power supply is connected with a sample platform electrode, the conductive micro post type object or the high-absorption-power super-hydrophobic horizontal plane with the conductive layer is used for absorbing micro-droplet samples on a sample table, the droplets automatically fall down after the conductive micro post type object or the high-absorption-power super-hydrophobic horizontal plane with the conductive layer is moved to a proper position and is electrified, and the conveyance operation on the micro-droplets is completed. The micro-droplets do not need any treatment, the defects of the existing micro-droplet operation and control technology are overcome, and the application range of the micro-droplet operation control technology is widened.
Description
Technical field
The invention belongs to microfluidic procedures control technology field, relate to the little liquid drop control method of a kind of super hydrophobic surface based on electric field action.
Background technology
The technology that controls of little drop all has application in a lot of fields, and such as microchemical analysis, biomacromolecule is analyzed, clinical diagnosis etc.For this Study on Technology, two kinds of methods appear mainly: based on the polyphasic flow method and the surperficial sessile drop method of microchannel.Technology based on the little drop of operational processes of microchannel has developed decades; Need two phase or the participations of heterogeneous fluid; Loss of easy generation micro-example and microchannel are stopped up, and turbulent flow appears in corner easily in the microchannel, cause micro-example to lose efficacy with transmitting mixing mutually mutually.In recent years; Based on the moistening chip lab of electricity, light-operated, electromagnetic field control; The little drop control technology of two-dimensional surface set of mechanical vibration control and sound field excitation control etc.; Overcome part shortcoming based on the fluid channel technology, but because the part technical characterstic of itself, the transmission path and the direction of microfluid drop sample also receive very big restriction.Little drop is carried out direct control a lot of benefits are arranged; The transmission direction of little drop sample that change that can be random will be operated even can cross a platform and carry out three-dimensional operation to another platform; This has all brought a lot of convenience to application, the problem of also having avoided a lot of adhesions and two that the wall fluid in microchannel, occurs to merge mutually simultaneously.
At present carrying out the relevant patent report of direct control for little drop sample does not almost have, on the super hydrophobic surface that especially has wide application prospects in the microfluidic control field arbitrarily operation transport little drop.River thunder academician seminar has reported a kind of still very high nano-tube array super hydrophobic surface of its absorption affinity of high contact angle that has; Being used as " little drop mechanical arm " directly operates little drop on the super hydrophobic surface; Its benefit is that little drop sample is carried out break-even transporting; But can only be put into the drop absorption affinity than the water-wetted surface that transports surface adsorption Li Genggao, and can not be placed on the lower super hydrophobic surface of surface itself or absorption affinity, range of application is very limited.For can be on the arbitrary surfaces reciprocal little drop of operation; Jiang Lei and Zhao have reported the transport process of utilizing the little drop of magnetic field control magnetic; For some little drops good effect is arranged with magnetic; But be not that all samples can both be processed into and have magnetic, also to a certain degree limit application.
Summary of the invention
The present invention proposes a kind of method of directly controlling little drop, and the operator only need carry out simple sample position and add the voltage-operated process that transports that can accomplish little drop sample of unloading.The present invention can realize transporting of little drop on any super hydrophobic surface, need not little drop is carried out any processing, has overcome the deficiency that existing little drop controls technology, widens little drop and controls the The Application of Technology scope.
The super-hydrophobic plane of high absorption affinity that the present invention utilizes the little column of conduction or has conductive layer perhaps has the high absorption affinity super hydrophobic surface of conductive layer and the relative position between the appearance platform electrode as little drop operator with the little column of multi-coordinate micropositioner control conduction.Two poles is received the little column of conduction respectively perhaps to be had on the high absorption affinity super hydrophobic surface and conducting sample platform of conductive layer; The super-hydrophobic plane of high absorption affinity that perhaps has conductive layer with the little column of conduction is adsorbed on the little drop sample on the sample stage; Move to suitable position; Add voltage, drop falls automatically, has promptly accomplished the operation that transports of little drop.Concrete technical scheme may further comprise the steps:
Step 1: the installation of operating means: the high absorption affinity super hydrophobic surface installation that little column that will conduct electricity perhaps has conductive layer is placed on the multi-coordinate micropositioner, and is connected to any utmost point of power supply, and another utmost point of power supply is received the electrode of kind platform; On the same surface level of sample stage, digital camera is installed, this digital camera links to each other with computing machine.Power supply can be direct supply or AC power.
Step 2: little drop placement surface is installed: connect horizontal positioned on the appearance platform of electrode in step 1 and desire the surface of operating little drop sample above that, one is the super hydrophobic surface of low absorption affinity.
Step 3: little drop transport process: put little drop sample that desire will be operated on the surface that in step 2, places; The little column of mounted conduction in the step 1 or high absorption affinity super hydrophobic surface with conductive layer are moved to the top of little drop sample that desire will operate, and decline contacts with little drop sample, drop is mentioned in rising; Move to the position that desire will be placed; Add voltage, and increase voltage gradually, directly cause drop and fall; The powered-down switch has promptly been accomplished transporting of a little drop.
Effect of the present invention and benefit are:
1) a kind of new direct control provided by the invention is controlled the method for little drop.
2) can on the super hydrophobic surface of arbitrarily low absorption affinity, place little drop sample.
3) instrument used in the present invention all is the general industry product of buying easily, to application market a bigger range of choice is provided.
4) the multi-coordinate device that transports of the present invention can be manually, also can be automatic, bring convenience to operation.
Description of drawings
Fig. 1 is the auxiliary little drop operating control device synoptic diagram of electric field.
Fig. 2 is little drop operation transport process synoptic diagram.
Among the figure: 1 computing machine; The little rod of 2 conductions; 3 digital cameras; 4 multi-coordinate micropositioners; 5 power supplys; 6 kinds of platforms; 7 super hydrophobic surfaces; 8 drops.
Embodiment
Be described in detail specific embodiment of the present invention below in conjunction with technical scheme and accompanying drawing.
Embodiment 1
Be example with the little rod of stainless steel among the embodiment, using diameter is that little rod of 140 μ m is as little drop operator.The multi-coordinate micropositioner is manual operator's console.
Step 1: the installation of operating means: with diameter is that little excellent 2 of 140 μ m install and to be placed on the multi-coordinate micropositioner 4, and is connected to any utmost point of power supply 5, and another utmost point of power supply 5 is received kind platform 6 electrodes.Power supply 5 is direct supplys.
Step 2: little drop placement surface is installed: connect horizontal positioned tetradecylic acid copper super hydrophobic surface 7 on the appearance platform 4 of electrode in step 1.
Step 3: little drop transport process: put little drop sample 8 that desire will be operated on the surface 7 that in step 2, places, with mounted little excellent 2 being XY to adjustment in the step 1, moving to the radius that desire will operate is little drop sample 8 tops of 0.56mm; And decline contacts with little drop sample 8, rises when mentioning drop 8 to little drop 8 distances from bottom surface 7 0.214mm, and adjustment micropositioner 4XY direction is to position that desire will be placed; Opening power 5 switches; And increasing voltage gradually, during to voltage 836V, drop falls; Powered-down 5 switches have promptly been accomplished transporting of little drop 8.
Claims (1)
1. the little liquid drop control method of the super hydrophobic surface based on electric field action is characterized in that comprising the steps:
Step 1: the installation of operating means: the high absorption affinity super hydrophobic surface that the little column (2) that will conduct electricity perhaps has conductive layer is arranged on the multi-coordinate micropositioner (4), and is connected to any utmost point of power supply (5), and another utmost point of power supply is received the electrode of sample stage (6); On the same surface level of sample stage (6), digital camera (3) is installed, this digital camera links to each other with computing machine (1);
Step 2: the laying of little drop placement surface: the sample stage (6) that connects electrode in step 1 goes up the super hydrophobic surface (7) that the level laying desires to operate little drop above that;
Step 3: little drop transport process: the super hydrophobic surface (7) in that step 2 obtains is gone up little drop (8) that the placement desire will be operated; Little column of conduction (2) that step 1 is obtained or the high absorption affinity super hydrophobic surface with conductive layer move to the top of little drop (8) that desire will operate, and decline contacts with little drop (8), and little drop (8) is mentioned in rising; Move to the position that desire will be placed; Add voltage, and increase voltage gradually, directly cause little drop and fall; Powered-down (5) switch has promptly been accomplished transporting of little drop (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101645462A CN101865928B (en) | 2010-05-06 | 2010-05-06 | Super-hydrophobic surface micro-droplet operation and control method based on electric field effect |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101645462A CN101865928B (en) | 2010-05-06 | 2010-05-06 | Super-hydrophobic surface micro-droplet operation and control method based on electric field effect |
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| Publication Number | Publication Date |
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| CN101865928A CN101865928A (en) | 2010-10-20 |
| CN101865928B true CN101865928B (en) | 2012-07-18 |
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| CN2010101645462A Expired - Fee Related CN101865928B (en) | 2010-05-06 | 2010-05-06 | Super-hydrophobic surface micro-droplet operation and control method based on electric field effect |
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Families Citing this family (9)
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| CN104991460B (en) * | 2015-07-02 | 2017-06-16 | 大连海事大学 | A kind of surface wettability controllable device and regulation and control method |
| CN105289766B (en) * | 2015-10-02 | 2017-08-01 | 大连理工大学 | A kind of lossless operation device of organic drop nonpolar under water |
| CN106237949B (en) * | 2016-07-29 | 2017-11-10 | 大连理工大学 | A kind of method by controlling super-hydrophobic metallic matrix temperature to realize the lossless transfer of drop |
| JP6830406B2 (en) * | 2017-06-01 | 2021-02-17 | 株式会社日立製作所 | Dispenser |
| CN108406739B (en) * | 2018-03-23 | 2020-10-02 | 哈尔滨工业大学 | Liquid surface micro-component transmission method and device based on magnetically driven micro-robot |
| CN110064447B (en) * | 2019-04-25 | 2020-04-21 | 电子科技大学 | Digital micro-fluidic control device adopting electric field control and control method |
| CN110270271A (en) * | 2019-07-05 | 2019-09-24 | 金华职业技术学院 | A kind of preparation facilities of spherical liquid particle |
| CN110721647B (en) * | 2019-10-21 | 2021-12-07 | 河北工业大学 | Method and device for ultrasonic atomization airflow real-time liquefaction |
| CN112007583B (en) * | 2020-08-26 | 2021-09-28 | 电子科技大学 | Preparation and control method of micro-droplets |
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| WO2006003293A2 (en) * | 2004-06-04 | 2006-01-12 | Universite Des Sciences Et Technologies De Lille | Device for handling drops for biochemical analysis, method for producing said device and a system for microfludic analysis |
| CN101679078A (en) * | 2007-05-24 | 2010-03-24 | 数字化生物系统 | Electrowetting based digital microfluidics |
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| WO2006003293A2 (en) * | 2004-06-04 | 2006-01-12 | Universite Des Sciences Et Technologies De Lille | Device for handling drops for biochemical analysis, method for producing said device and a system for microfludic analysis |
| CN101679078A (en) * | 2007-05-24 | 2010-03-24 | 数字化生物系统 | Electrowetting based digital microfluidics |
| CN101699329A (en) * | 2009-10-19 | 2010-04-28 | 无锡职业技术学院 | Electrowetting technology-based light fluid filter |
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Inventor after: Wu Chengwei Inventor after: Shi Litao Inventor after: Jiang Chenggang Inventor after: Zhou Ping Inventor after: Ma Guojun Inventor before: Wu Chengwei Inventor before: Shi Litao Inventor before: Zhou Ping Inventor before: Jiang Chenggang Inventor before: Ma Guojun |
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Free format text: CORRECT: INVENTOR; FROM: WU CHENGWEI SHI LITAO ZHOU PING JIANG CHENGGANG MA GUOJUN TO: WU CHENGWEI SHI LITAO JIANG CHENGGANG ZHOU PING MA GUOJUN |
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