CN201876373U - Liquid stratified sampling device, analysis testing device and blood type analysis meter - Google Patents

Liquid stratified sampling device, analysis testing device and blood type analysis meter Download PDF

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Publication number
CN201876373U
CN201876373U CN2010205235053U CN201020523505U CN201876373U CN 201876373 U CN201876373 U CN 201876373U CN 2010205235053 U CN2010205235053 U CN 2010205235053U CN 201020523505 U CN201020523505 U CN 201020523505U CN 201876373 U CN201876373 U CN 201876373U
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Prior art keywords
sampling needle
liquid
sampling
controller
sampling device
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CN2010205235053U
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马文美
饶觉陶
胡忠
卓灯亮
戴谭信
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GUANGZHOU IMPROVE MEDICAL CO Ltd
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GUANGZHOU IMPROVE MEDICAL CO Ltd
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Abstract

The utility model discloses a liquid stratified sampling device which comprises a sampling needle, a sampling needle moving mechanism and a controller, wherein the sampling needle moving mechanism is arranged in two different directions for moving the sampling needle; and the controller is used for controlling the sampling needle moving mechanism. The liquid stratified sampling device is accurate and rapid in sampling, avoids contaminating a specimen, is easy for realizing automation and informatization, and is capable of reducing the labor intensity of an inspector and improving the working efficiency.

Description

Liquid stratified sampling device, analytical test equipment and blood type analytical instrument
Technical field
The utility model relates to a kind of sampler, particularly relates to a kind of device that stratified liquid is taken a sample.
Background technology
When carrying out the such test of for example abo blood group analysis, need from the sample of layering, extract sample respectively.Specifically, with the abo blood group analysis is example, need measure with known anti-A and anti-Type B serum during positive definite form and have or not corresponding A antigen on the red blood cell or/and B antigen, need measure with known A cell and B cell during reverse type and have or not corresponding anti-A or anti-B in the serum.Like this, just there is problem how from whole blood, to extract blood plasma or serum.At present, adopt manual method to extract, promptly earlier centrifugal, and then the serum on upper strata poured out whole blood, lower floor be exactly blood plasma.Because serum is difficult to topple over totally,, be used for qualification test after also the blood plasma of lower floor will being cleaned by physiological saline in order to prepare the red cell suspension of accurate concentration.
Obviously, the mode that this employing is manually toppled over, not only operating speed slow, be easy to generate pollution, operator's working strength is big, and makes The whole analytical process can't realize robotization.
Therefore, need a kind of can be according to the instruction of controller, the device that stratified liquid is taken a sample automatically.
Summary of the invention
The purpose of this utility model is in order to overcome the defective that prior art exists, a kind of liquid stratified sampling device to be provided.In order to realize this purpose, technical solution adopted in the utility model is as follows.
According to the first aspect of the utility model embodiment, a kind of liquid stratified sampling device is provided, comprise sampling needle; In addition, also comprise: sampling needle travel mechanism is configured to move described sampling needle on two different directions; And controller, be configured to control described sampling needle travel mechanism.
In one embodiment, liquid stratified sampling device also comprises liquid driver, is communicated with described sampling needle, and is connected with described controller.
In one embodiment, liquid stratified sampling device also comprises level sensor, and end of probe is connected with described sampling needle, and output terminal is connected with described controller.
In one embodiment, the preset distance place under the described controller liquid level that is configured to described level sensor is detected is as the supernatant liquid sampled point.
In one embodiment, described supernatant liquid sampled point is the sampled point that floats.
In one embodiment, described controller is configured to preset distance place on the reference point as subnatant sampler body point; Wherein reference point is for placing the residing position, bottom of the container that stratified liquid is housed.
In one embodiment, described sampling needle travel mechanism further comprises: actuator is connected with described controller; Drive disk assembly connects with the output block of described actuator, and rotatable and move up and down under the drive of actuator; And cantilever, the described sampling needle of a termination, the described drive disk assembly of another termination.
In one embodiment, described sampling needle travel mechanism is configured to make described sampling needle to have at least one sample bits and at least one tells the sample position.
According to the second aspect of the utility model embodiment, a kind of analytical test equipment is provided, comprise liquid stratified sampling device according to the utility model embodiment first aspect.
According to the third aspect of the utility model embodiment, a kind of blood type analytical instrument is provided, comprise liquid stratified sampling device according to the utility model embodiment first aspect.
According to the liquid stratified sampling device of the utility model embodiment, sampling accurately reaches fast, has avoided the pollution to sample, and easily is automated and informationization, can reduce reviewer's working strength, increases work efficiency.
Below in conjunction with accompanying drawing and by specific embodiment the utility model is further specified, wherein same or analogous parts use the same reference numerals to represent in institute's drawings attached.In addition, for convenience of explanation, accompanying drawing is not drawn in proportion.
Description of drawings
Fig. 1 is the structured flowchart according to the liquid stratified sampling device of an embodiment of the utility model;
Fig. 2 is the structured flowchart according to the liquid stratified sampling device of another embodiment of the utility model;
Fig. 3 is the structured flowchart according to the liquid stratified sampling device of another embodiment of the utility model;
Fig. 4 is the condenser type level sensor synoptic diagram that is applicable to the liquid stratified sampling device of the utility model embodiment;
Fig. 5 a and 5b are the synoptic diagram according to explanation supernatant liquid sampled point, subnatant sampler body point and the reference point of an embodiment of the utility model;
Fig. 6 is the liquid stratified sampling schematic representation of apparatus according to an embodiment, wherein shows an example applicable to the sampling needle travel mechanism of this liquid stratified sampling device.
Embodiment
As shown in Figure 1, be according to the structured flowchart of the liquid stratified sampling device of an embodiment of the utility model, comprising: sampling needle 100, sampling needle travel mechanism 102 and controller 104.Wherein sampling needle travel mechanism 102 be configured to can be on two different directions, for example level and vertical direction move described sampling needle 100; Controller 104 is configured to control described sampling needle travel mechanism 102.In the present embodiment, can be according to the unified container that stratified liquid is housed of preassigned preparation (for example consistent test tube such as the capacity of stratified liquid, layer height), and controller 104 can be configured to make sampling needle travel mechanism 102 that sampling needle 100 is moved to predetermined different sampling spots according to predetermined instruction stratified liquid is taken a sample.In addition, in the present embodiment, can adopt mode such as mechanical or manual to carry out during sampling.
In another embodiment, liquid stratified sampling device also comprises liquid driver 106 alternatively.As shown in Figure 2, this liquid driver 106 is communicated with described sampling needle 100, for example is communicated with by the upper port of conduit with sampling needle 100; And this liquid driver 106 is connected with described controller 104, under the control of controller 104, drives described sampling needle 100 in when position sampling and draws samples, drives described sampling needle 100 sample that spues when telling the sample position.
In yet another embodiment, liquid stratified sampling device also comprises level sensor 108 alternatively.As shown in Figure 3, the end of probe of this level sensor 108 is connected with described sampling needle 100, and output terminal is connected with described controller 104.As shown in Figure 4, be that this level sensor is can buy on the market applicable to the condenser type level sensor example of the liquid stratified sampling device of the utility model embodiment.The end of probe of this level sensor i.e. " SHIELD " end is connected respectively to screen layer and sampling needle with " ELECTRODE " end, output terminal i.e. " OUTPUT " end is connected with described controller 104, perhaps also is connected with controller 104 by analog to digital converter alternatively as required.When sampling needle 100 touches the upper strata liquid level of stratified liquid (for example serum and blood plasma), end of probe is that the electric capacity between " SHIELD " end and " ELECTRODE " can change, thereby causes the i.e. output potential generation saltus step of " OUTPUT " end of output terminal.Controller 104 bases can determine from the variation of the electric potential signal of this level sensor whether sampling needle touches liquid level.Like this, preferably, the preset distance under the upper strata liquid level that described controller 104 can be configured to described level sensor is detected (for example including but not limited to about 2mm) is located as supernatant liquid sampled point 500, shown in Fig. 5 a.Under the control of controller 104, when sampling needle travel mechanism 102 moved to supernatant liquid sampled point 500 with sampling needle 100, controller 104 began to extract the supernatant liquid sample with regard to controlling liquid driver 106.In the present embodiment, further preferably described supernatant liquid sampled point 500 is the sampled points that float, just can control sampling needle travel mechanism 102 and move down sampling needle 100, make the supernatant liquid sampled point remain on preset distance place under the liquid level of upper strata all the time along with the extraction of supernatant liquid.
In addition, in other embodiments, described controller 104 can be configured to placement is equipped with the residing position, bottom of container of stratified liquid as reference point 502, shown in Fig. 5 b, and preset distance (for example including but not limited to about 4mm) on this reference point 502 located as subnatant sampler body point 504.Under the control of controller 104, when sampling needle travel mechanism 102 moved to subnatant sampler body point with sampling needle 100, controller 104 began to extract lower floor's sample with regard to controlling liquid driver 106.
As shown in Figure 6, be liquid stratified sampling schematic representation of apparatus, wherein than an example that shows in more detail applicable to the sampling needle travel mechanism 102 of this liquid stratified sampling device according to an embodiment.This sampling needle travel mechanism 102 comprises actuator 600, drive disk assembly 602, and cantilever 604.Wherein actuator 600 for example can be motor and the worm and gear that connects with motor etc., as long as can make drive disk assembly 602 rotate and move up and down, all applicable to present embodiment; In addition, this actuator 600 and described controller 104 (Fig. 5 a with 5b in not shown) are connected, by the work of controller 104 control actuators 600.Drive disk assembly 602 for example is a transmission shaft, connect with actuator 600 and under it drives, can rotate in the horizontal direction, but and in the vertical direction move down.One termination sampling needle 100 of cantilever 604, the described drive disk assembly 602 of another termination, preferably cantilever 604 is in horizontal direction and vertical with drive disk assembly 602, and sampling needle 100 is vertical with cantilever 604 again.
In this embodiment, liquid driver 106 is arranged near the sampling needle travel mechanism, and is communicated with sampling needle 100 by conduit 606; Level sensor 108 is arranged on cantilever 604 inside.Liquid driver 106 and level sensor 108 all are connected with controller 104 (Fig. 5 a with 5b in not shown).Sampling needle travel mechanism 102 is configured to make described sampling needle 100 to have at least one sample bits and at least one and tells the sample position, the lower position that the sampling needle of cantilever 604 belows of different angles as shown in Figure 6 100 is represented.The container 608 that stratified liquid is housed can be placed by sample bits place below sampling needle, and this residing position, container 608 bottoms is reference point 502; The sample position of telling below sampling needle is located, but placing response ware 610.Have a plurality of sample bits and a plurality of when telling the sample position, described controller 104 also can be configured to different sample bits to make the liquid that extracts from the container of predetermined sample bits be added to the predetermined reaction utensil of telling place, sample position with to tell the sample position corresponding one by one.
To the example that is sampled as of serum and blood plasma, the operating process according to the liquid stratified sampling device of the utility model embodiment is described when analyzing with blood group below.The principle of work of liquid stratified sampling is based on following condition of work: the sample specimen that (1) is equipped with two kinds of liquid must be (as serum and the blood plasma) that does not dissolve mutually; (2) when sampling, two kinds of liquid of this sample specimen must be in tangible stratification state is arranged, and promptly are not (states as whole blood after centrifugal, the upper strata is a blood plasma for serum lower floor) of mixing; (3) every kind of composition of this sample all must have certain height (for example about 10mm), and the blood sample sample of generally doing the blood group analysis is 2 to 3ml, and the height behind the heparin tube of packing into is about 30mm.More than 3 the blood sample sample in the blood group analysis all set up.Be the centrifugal whole blood sample of 30mm for being equipped with highly, draw serum and blood plasma respectively and carry out the positive reverse type of ABO when analyzing that concrete operations are as follows:
1. at first test tube is put into the sample sample placement position of liquid stratified sampling device, the test tube bottom is contacted with the reference point of this device;
2. determine to select to draw serum (it is anti-fixed to do) earlier, controller just starts the program of drawing supernatant liquid;
3. controller sends the instruction that moves down sampling needle and gives sampling needle travel mechanism;
4. sampling needle travel mechanism begins to move down sampling needle after receiving instruction, and when the lower port of sampling needle contacted with liquid level, the condenser type level sensor will be sent out a signal and give controller, tells it to arrive liquid level;
5. after controller was received the signal that arrives liquid level, will give instruction of sampling needle travel mechanism: the 2mm that descends again just stopped;
6. after sampling needle stopped, controller sends and instructs to the liquid driver: the start liquid driver was quantitatively inhaled sample (this uptake can preestablish), sucked complete back liquid driver and stopped;
7. controller sends and instructs to sampling needle travel mechanism: the up-samples pin rotates sampling needle to sampling needle and tells the sample position behind elemental height;
8. after sampling needle travel mechanism received instruction, the up-samples pin rotated sampling needle to sampling needle again and tells the sample position to elemental height;
9. controller sends instruction and gives the liquid driver: the serum in the sampling needle is told to reaction utensil.The serum sample procedure finishes, and enters the blood plasma program of drawing.
10. controller sends instruction: sampling needle is moved to sampling needle inhale the sample position, the sample position is inhaled by decline sampling needle to lower floor;
11. sampling needle travel mechanism receives the instruction back and rotates sampling needle to sampling needle suction sample position, the sample position is inhaled by decline sampling needle to lower floor;
Instruct to the liquid driver 12. controller sends: the start liquid driver is drawn quantitative blood plasma;
13. after the suction sample finished, controller sends instruction: the up-samples pin was to elemental height;
14. rotate sampling needle to telling the sample position;
15. change a new reaction utensil to telling the sample position;
16. controller sends instruction and gives the liquid driver: the serum in the sampling needle is told to reaction utensil.
Liquid stratified sampling device according to the utility model embodiment can be implemented in the various analytical test equipment, for example includes but not limited to blood type analytical instrument, and this is to realize easily to those skilled in the art, does not do detailed description at this.
More than by specific embodiment the utility model is illustrated, but the utility model is not limited to these specific embodiments.It will be understood by those skilled in the art that and to make various modifications to the utility model, be equal to replacement, change or the like.But these conversion all should be within protection domain of the present utility model as long as do not deviate from spirit of the present utility model.In addition, the more employed terms of present specification and claims, for example " level ", " vertically ", " on ", D score or the like, be not restriction, only be for convenience of description.In addition, the embodiment that above many places described " embodiment ", " another embodiment " or the like expression is different can certainly be with its all or part of realization in one embodiment.

Claims (7)

1. liquid stratified sampling device comprises:
Sampling needle;
It is characterized in that, also comprise:
Sampling needle travel mechanism is configured to move described sampling needle on two different directions; And
Controller is configured to control described sampling needle travel mechanism.
2. liquid stratified sampling device as claimed in claim 1 is characterized in that, also comprises:
Liquid driver is communicated with described sampling needle, and is connected with described controller.
3. liquid stratified sampling device as claimed in claim 1 is characterized in that, also comprises:
Level sensor, end of probe is connected with described sampling needle, and output terminal is connected with described controller.
4. as each described liquid stratified sampling device of claim 1 to 3, it is characterized in that described sampling needle travel mechanism further comprises:
Actuator is connected with described controller;
Drive disk assembly connects with the output block of described actuator, and rotatable and move up and down under the drive of actuator; And
Cantilever, the described sampling needle of a termination, the described drive disk assembly of another termination.
5. as each described liquid stratified sampling device of claim 1 to 3, it is characterized in that: described sampling needle travel mechanism is configured to make described sampling needle to have at least one sample bits and at least one tells the sample position.
6. an analytical test equipment is characterized in that: comprise each described liquid stratified sampling device of claim 1 to 5.
7. a blood type analytical instrument is characterized in that: comprise each described liquid stratified sampling device of claim 1 to 5.
CN2010205235053U 2010-08-30 2010-08-30 Liquid stratified sampling device, analysis testing device and blood type analysis meter Expired - Lifetime CN201876373U (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102661888A (en) * 2012-05-18 2012-09-12 济南美医林电子仪器有限公司 Uniformly mixing method and device for whole blood automatic layer absorbing sample suitable for hemorrheology detection
CN104155466A (en) * 2014-09-01 2014-11-19 江苏雷奥生物科技有限公司 Vertical movement mechanism for medical equipment
CN109374878A (en) * 2018-11-13 2019-02-22 武汉瀚海新酶生物科技有限公司 A kind of method of enzyme process detection platelet-activating factor acetylhydro-lase
CN109374358A (en) * 2018-12-21 2019-02-22 同方威视技术股份有限公司 Liquid sample system
CN112403304A (en) * 2020-11-20 2021-02-26 深圳市科曼医疗设备有限公司 Method for improving sucking, spitting and uniformly mixing efficiency

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102661888A (en) * 2012-05-18 2012-09-12 济南美医林电子仪器有限公司 Uniformly mixing method and device for whole blood automatic layer absorbing sample suitable for hemorrheology detection
CN102661888B (en) * 2012-05-18 2014-07-30 山东美医林电子仪器有限公司 Uniformly mixing method and device for whole blood automatic layer absorbing sample suitable for hemorrheology detection
CN104155466A (en) * 2014-09-01 2014-11-19 江苏雷奥生物科技有限公司 Vertical movement mechanism for medical equipment
CN109374878A (en) * 2018-11-13 2019-02-22 武汉瀚海新酶生物科技有限公司 A kind of method of enzyme process detection platelet-activating factor acetylhydro-lase
CN109374358A (en) * 2018-12-21 2019-02-22 同方威视技术股份有限公司 Liquid sample system
CN112403304A (en) * 2020-11-20 2021-02-26 深圳市科曼医疗设备有限公司 Method for improving sucking, spitting and uniformly mixing efficiency

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Granted publication date: 20110622