CN110026675B - Method for realizing surface tension micro-operation of liquid surface micro object by utilizing multiple beams of laser - Google Patents
Method for realizing surface tension micro-operation of liquid surface micro object by utilizing multiple beams of laser Download PDFInfo
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- CN110026675B CN110026675B CN201910324496.0A CN201910324496A CN110026675B CN 110026675 B CN110026675 B CN 110026675B CN 201910324496 A CN201910324496 A CN 201910324496A CN 110026675 B CN110026675 B CN 110026675B
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- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
Abstract
A surface tension micro-operation method for realizing liquid surface micro objects by utilizing multiple beams of laser relates to the micro-operation of the liquid surface micro objects. The invention solves the problems of high cost, low operation efficiency, and poor liquid level driving universality and operation precision of an external electric field or magnetic field of the existing optical tweezers. The method comprises the following steps that firstly, a plurality of laser beams are adopted to irradiate and heat tiny objects floating on a liquid surface, the positions of light spots of the laser beams on the liquid surface are adjusted, so that the centers of the light spots are all positioned outside the edges of target objects, and the target objects are bound between the laser beams under the action of surface tension of the liquid surface; secondly, moving the laser beam through manual or automatic control to perform liquid level micro-moving operation on the tiny objects floating on the liquid level; and step three, adjusting the energy, wavelength, pulse frequency, spot size and spacing parameters of the laser beam, and carrying out micro-operation on the tiny objects floating on the liquid surface. The invention is used in the fields of micro-assembly, drug screening and separation, physical and chemical experiments and biological engineering.
Description
Technical Field
The invention relates to the technical field of micro-nano technology, in particular to a method for realizing surface tension micro-operation of a liquid surface micro object by utilizing multiple beams of laser.
Background
The liquid level has the characteristics of small resistance, low abrasion, friendly biological cells (tissues), easy operation and the like, the non-contact macro-micro operation taking the liquid level as a carrier can effectively reduce the adhesion phenomenon, can be used for realizing the functions of two-dimensional operation, assembly or reconstruction and the like, and has wide application prospect in the fields of micro-assembly, drug screening and separation, physicochemical experiments, bioengineering and the like. At present, the technology can be used for liquid level micromanipulation of micro objects, most commonly optical tweezers, optical traps generated by photon impact are used for realizing the capture operation of particles, because the momentum of photons is small, the operation based on the optical tweezers technology mainly faces to objects below a micron level, a corresponding optical system is complex, the cost is high, the operation efficiency is low, and the technology is similar to the technology of magnetic tweezers and acoustic tweezers; in addition, the liquid level driving method based on an applied electric field (electrophoresis, dielectrophoresis) or a magnetic field has many disadvantages in terms of versatility, operation accuracy, single-target operation, and the like. At present, the micro-nano technology is developed at a high speed, a universal, efficient, trans-scale and high-precision liquid level nondestructive micro-operation method and technology are developed, and the method and the technology have important significance for promoting the application of the micro-nano technology.
In summary, the existing optical tweezers have high cost, low operation efficiency, and poor liquid level driving universality and operation accuracy of the external electric field or magnetic field.
Disclosure of Invention
The invention provides a method for realizing surface tension micro-operation of a liquid surface micro object by utilizing multiple beams of laser, aiming at solving the problems of high cost, low operation efficiency, and poor liquid surface driving universality and operation precision of an external electric field or magnetic field in the existing optical tweezers technology.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the method for realizing the surface tension micro-operation of the liquid surface micro object by utilizing the multiple beams of laser is realized according to the following steps:
step one, capturing a target object:
irradiating and heating the tiny objects floating on the liquid surface by adopting a plurality of laser beams, enabling the centers of light spots to be positioned outside the edges of the target objects by adjusting the positions of the light spots of the laser beams on the liquid surface, and binding the target objects between the laser beams under the action of surface tension of the liquid surface;
step two, moving the laser beam:
the laser beam is controlled to move manually or automatically, and the liquid level micro-moving operation is carried out on the micro objects floating on the liquid level;
step three, adjusting laser beams:
and regulating the energy, wavelength, pulse frequency, spot size and interval parameters of the laser beam to perform micro operation on the micro object floating on the liquid surface.
In one embodiment, the surface tension micromanipulation method of the liquid surface micro object adopts a laser emitting device which comprises a z-direction moving platform 11, a y-direction moving platform 12, an x-direction moving platform 13, a base 14, a z-direction rotary table 20, a laser head seat 19 and a plurality of laser heads 18; the x-direction moving platform 13 is installed on the base 14, the y-direction moving platform 12 is installed on the x-direction moving platform 13, one end of the z-direction moving platform 11 is installed on the y-direction moving platform 12, the z-direction rotary table 20 is installed on the other end of the z-direction moving platform 11, the laser head seat 19 is installed on the lower end face of the z-direction rotary table 20, and the laser heads 18 are installed on the laser head seat 19.
In one embodiment, a plurality of laser heads 18 are mounted uniformly on a laser head mount 19.
In one embodiment, the size of the small objects floating on the liquid surface is between sub-millimeter and sub-centimeter.
In one embodiment, the liquid level in step one is a gas-liquid interface or two immiscible liquid interfaces.
In one embodiment, the liquid surface micro-movement operation in the second step is translation or rotation on the two-dimensional liquid surface.
Compared with the prior art, the invention has the following beneficial effects:
the method for realizing the surface tension micro-operation of the liquid surface micro-object by utilizing the multiple beams of laser realizes the capture of the target object by adopting the laser beam irradiation, has high positioning precision, can realize the selective operation of the target object, and has low cost by adopting the laser irradiation;
the method for realizing surface tension micro-operation of the liquid surface micro-objects by utilizing multiple beams of laser induces the surface tension by utilizing the photo-thermal effect, can operate target objects made of different materials, and has high universality;
according to the method for realizing surface tension micro-operation of the liquid surface micro-object by utilizing the multiple beams of laser, due to the scale effect, when the scale of the target object is reduced to a millimeter level or below, the surface tension effect gradually takes the dominant effect, micro-operation of the micro-object is realized by inducing the surface tension effect, and the operation efficiency is high;
the method for realizing surface tension micro-operation of the liquid surface micro-object by utilizing multiple beams of laser can operate the object from a sub-centimeter level to a sub-millimeter level by means of the surface tension effect, namely, cross-scale micro-operation;
the method for realizing surface tension micro-operation of the liquid surface micro-object by utilizing multiple beams of laser adopts a laser beam irradiation mode, is non-contact, and has small damage and pollution to a target object and a liquid environment by reasonably controlling laser beam parameters;
the invention can realize programmable and controllable high-precision liquid level micro-operation by controlling the movement of the laser beam, and is applied to the fields of micro-assembly, drug screening and separation, physical and chemical experiments and biological engineering.
Drawings
FIG. 1 is a schematic structural diagram of a laser emitting device according to a third embodiment of the present invention;
FIG. 2 is a schematic diagram of the laser induced surface tension effect of a first embodiment of the present invention;
FIG. 3 is a schematic diagram of the present invention employing multiple laser shots to effect a liquid level target object movement operation;
in the figure: the device comprises a base, a laser head seat, a laser turntable, a target object, a temperature field, a liquid level, a first laser beam, a second laser beam, a 11-position z-direction translation table, a y-direction translation table, a x-direction translation table, a base, a container, a liquid level, a third laser beam, a laser head seat and a z-direction turntable, wherein the base is 1, the liquid level is 2, the three-phase contact line is 3, the laser beam is 4, the three-phase contact line is 4, the left-side surface tension is 5, the target object is 6.
Detailed Description
The first embodiment is as follows: as shown in fig. 1, the method for performing surface tension micromanipulation of a liquid surface fine object by using a plurality of laser beams according to the present embodiment includes the steps of:
step one, capturing a target object:
irradiating and heating the tiny objects floating on the liquid surface by adopting a plurality of laser beams, enabling the centers of light spots to be positioned outside the edges of the target objects by adjusting the positions of the light spots of the laser beams on the liquid surface, and binding the target objects between the laser beams under the action of surface tension of the liquid surface;
step two, moving the laser beam:
the laser beam is controlled to move manually or automatically, and the liquid level micro-moving operation is carried out on the micro objects floating on the liquid level;
step three, adjusting laser beams:
and regulating the energy, wavelength, pulse frequency, spot size and interval parameters of the laser beam to perform micro operation on the micro object floating on the liquid surface.
As shown in fig. 3, in the present embodiment, the number of the plurality of laser beams is at least two, the laser beams are in a fence shape, and the spot centers of the laser beams on the liquid surface are all located outside the edge of the target object. So design, the laser beam rail encloses target object 6 at central authorities, and when many laser beams moved simultaneously, target object 6 and arbitrary laser beam take place the contact, all can produce the surface tension effect that pushes target object 6 to laser beam rail central authorities, through reasonable control laser beam parameter, moving speed, can tie target object 6 within the laser beam rail all the time, and then realize the liquid level micro-operation of target object 6 through the motion of control laser beam. Other components and connections are the same as those in the first embodiment.
The second embodiment is as follows: as shown in fig. 1, the laser emitter used in the method for micro-manipulation of surface tension of a liquid surface micro object according to the present embodiment includes a z-direction moving platform 11, a y-direction moving platform 12, an x-direction moving platform 13, a base 14, a z-direction turntable 20, a laser head seat 19, and a plurality of laser heads 18; the x-direction moving platform 13 is installed on the base 14, the y-direction moving platform 12 is installed on the x-direction moving platform 13, one end of the z-direction moving platform 11 is installed on the y-direction moving platform 12, the z-direction rotary table 20 is installed on the other end of the z-direction moving platform 11, the laser head seat 19 is installed on the lower end face of the z-direction rotary table 20, and the laser heads 18 are installed on the laser head seat 19. By the design, the shape and the size of the laser beam fence formed on the liquid level 16 can be adjusted by adjusting the installation angle of each laser head so as to adapt to target objects 6 with different shapes and sizes, and two-dimensional translation or rotation micro-operation of the target objects 6 on the liquid level 16 is realized by controlling the motion of the four-degree-of-freedom motion table. Other components and connections are the same as those in the first embodiment.
The third concrete implementation mode: as shown in fig. 1, a plurality of laser heads 18 of the present embodiment are mounted on a laser head base 19. By the design, the shape and the size of the laser beam fence formed on the liquid level 16 can be adjusted by adjusting the installation angle of each laser head so as to adapt to target objects 6 with different shapes and sizes. Other components and connection relationships are the same as those in the second embodiment.
The fourth concrete implementation mode: as shown in fig. 1, the size of the fine objects floating on the liquid surface in the present embodiment is in the range of submillimeter to submillimeter. By the design, the capture of the tiny objects can be realized by laser irradiation and the photo-thermal effect induced surface tension effect. Other components and connections are the same as those in the first embodiment.
The fifth concrete implementation mode: as shown in fig. 1 and 3, the liquid level in step one of the present embodiment is a gas-liquid interface or two immiscible liquid interfaces. By the design, the non-contact macro-micro operation with the liquid surface as a carrier can effectively reduce the sticking phenomenon, and has the characteristics of small resistance, low abrasion, friendly biological cells and easy operation. Other components and connections are the same as those in the first embodiment.
The sixth specific implementation mode: as shown in fig. 1 and 3, in step two of this embodiment, the liquid surface micro-movement operation is translation or rotation on the two-dimensional liquid surface. By the design, the two-dimensional operation of the target object can be realized by manually or automatically controlling the movement of the laser beam. Other components and connections are the same as those in the first embodiment.
Example (b):
as shown in fig. 3, the liquid level target object capturing and moving operation is realized by simultaneous irradiation of a plurality of laser beams: the target object 6 floats on the liquid level 8, a plurality of laser beams of the first laser beam 9 and the second laser beam 10 are adopted to be simultaneously projected to the periphery of the target object 6, the target object 6 is surrounded in the center by the laser beam enclosure, when the laser beams move simultaneously, the target object 6 is in contact with any laser beam, the surface tension effect of pushing the target object 6 to the center of the laser beam enclosure can be generated, the target object 6 can be always bound in the laser beam enclosure by reasonably controlling the parameters and the moving speed of the laser beams, and then the liquid level micro-operation of the target object 6 is realized by controlling the movement of the laser beams, and the embodiment is not limited to the first laser beam 9 and the second laser beam 10.
The above is only a preferred embodiment of the present invention, and it should be noted that: it will be apparent to those skilled in the art that various modifications and equivalents can be made without departing from the spirit of the invention, and it is intended that all such modifications and equivalents fall within the scope of the invention as defined in the claims.
The working principle is as follows:
based on photo-thermal effect, the invention uses two or more beams of laser to irradiate and heat the local part of the tiny object floating on the liquid surface, the object is bound between the laser beams all the time by means of surface tension, the liquid surface moving operation of the object is realized by moving the laser beams, and tiny objects with different sizes, different shapes and different materials can be operated by changing the attributes and the intervals of the laser beams.
Principle of laser induced surface tension:
as shown in fig. 2, the target object 6 floats on the liquid surface 8 by using the laser beam induced surface tension effect, the laser beam 3 spot is projected to a position near the right edge of the target object 6, and by means of the photothermal effect, a temperature field 7 is generated on the target object 6, so that the temperature at the right three-phase contact line 2 is increased, that is, higher than the temperature at the left three-phase contact line 4, and since the surface tension coefficient is inversely related to the temperature, the right surface tension 1 is reduced, and the left surface tension 5 is kept unchanged, a surface tension difference effect is generated in the horizontal direction on the left and right sides of the target object 6, and the target object 6 is driven to move.
Claims (6)
1. A micro-operation method for realizing surface tension of a liquid surface micro object by utilizing a plurality of laser beams is characterized by comprising the following steps:
step one, capturing a target object:
irradiating and heating the tiny objects floating on the liquid surface by adopting a plurality of laser beams, enabling the centers of light spots to be positioned outside the edges of the target objects by adjusting the positions of the light spots of the laser beams on the liquid surface, and binding the target objects between the laser beams under the action of surface tension of the liquid surface;
step two, moving the laser beam:
the laser beam is controlled to move manually or automatically, and the liquid level micro-moving operation is carried out on the micro objects floating on the liquid level;
step three, adjusting laser beams:
and regulating the energy, wavelength, pulse frequency, spot size and interval parameters of the laser beam to perform micro operation on the micro object floating on the liquid surface.
2. The method of claim 1, wherein the method comprises the steps of: the liquid surface micro object surface tension micro-operation method adopts a laser emitting device which comprises a z-direction moving platform (11), a y-direction moving platform (12), an x-direction moving platform (13), a base (14), a z-direction rotary table (20), a laser head seat (19) and a plurality of laser heads (18); the X-direction moving platform (13) is installed on the base (14), the Y-direction moving platform (12) is installed on the X-direction moving platform (13), one end of the Z-direction moving platform (11) is installed on the Y-direction moving platform (12), the Z-direction rotary table (20) is installed at the other end of the Z-direction moving platform (11), the laser head seat (19) is installed on the lower end face of the Z-direction rotary table (20), and the laser heads (18) are installed on the laser head seat (19).
3. The method of claim 2, wherein the method comprises the steps of: a plurality of laser heads (18) are uniformly arranged on the laser head seat (19).
4. The method of claim 1, wherein the method comprises the steps of: the size of the tiny objects floating on the liquid surface is between the submillimeter level and the submillimeter level.
5. The method as claimed in claim 1, wherein the liquid surface in step one is a gas-liquid interface or two immiscible liquid interfaces.
6. The method as claimed in claim 1, wherein the micro-movement of the liquid surface is a translation or rotation on a two-dimensional liquid surface.
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| WO2012167221A1 (en) * | 2011-06-03 | 2012-12-06 | Wayne State University | Optofluidic tweezers |
| GB2546748A (en) * | 2016-01-26 | 2017-08-02 | Sandon Global Engraving Tech Ltd | Liquid-bearing articles for transferring and applying liquids |
| CN106432767B (en) * | 2016-09-14 | 2018-12-21 | 北京航空航天大学 | A kind of preparation method of the photo-thermal self-lubricating oleogel remotely accurately driven for drop |
| CN206351047U (en) * | 2016-12-26 | 2017-07-25 | 华南师范大学 | Microfluid tweezers based on micro-nano fiber |
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