CN206351047U - Microfluid tweezers based on micro-nano fiber - Google Patents
Microfluid tweezers based on micro-nano fiber Download PDFInfo
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- CN206351047U CN206351047U CN201621437168.XU CN201621437168U CN206351047U CN 206351047 U CN206351047 U CN 206351047U CN 201621437168 U CN201621437168 U CN 201621437168U CN 206351047 U CN206351047 U CN 206351047U
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Abstract
The utility model discloses a kind of microfluid tweezers based on micro-nano fiber, the tweezers include photo-thermal micro-nano fiber, microfluidic chambers, optical signal input mouth, miniflow pump, microfluid, photo-thermal micro-nano fiber is assembled by optical-thermal conversion material with micro-nano fiber, photo-thermal micro-nano fiber is immersed in microfluidic chambers bottom, and the optical signal that light source is sent is transmitted on photo-thermal micro-nano fiber；Miniflow pump is connected by pipeline with microfluidic chambers.Photo-thermal micro-nano fiber inspires heat by optical signal and then thermograde is produced in whole microfluid, and induction produces the Natural convection being characterized with vertical vortex flow and the thermocapillary convection being characterized with horizontal-type scroll stream.Fluid layer thickness can be changed by miniflow pump and then the flow pattern of microfluid is controlled.The heat of photo-thermal micro-nano fiber can be changed by the power of optical signal and then the flow strength of microfluid is controlled.This method is efficient and convenient, with low cost and efficient, can produce the flow of fluid of diversified forms.
Description
Technical field
The utility model belongs to optofluidic technical field, and in particular to a kind of microfluid tweezers based on micro-nano fiber.
Background technology
Micro-fluidic laboratory is also known as micro-fluidic chip, biology, chemistry, the sample preparation of medical analysis process, reaction, point
From, detection etc. basic operation unit be integrated on the chip of one piece several square centimeters (even more small), network is formed by microchannel,
Controlled fluid runs through whole system, can replace a kind of technology of standard biologic or chemical laboratory various functions.After 21 century,
Microflow control technique has obtained abundant development, and microflow control technique is used in multiple fields, develops into biology, chemistry, a thing
The brand-new research field of the multi-crossed disciplines such as reason, medical science, material, Micro Flow Control System.2004, U.S. Bus iness 2.0 were miscellaneous
Micro-fluidic chip is classified as one of seven kinds of technologies in " the change world " by will cover story.2006, Nature magazines released a phase
The special edition of " chip lab " is named as, research history, present situation and the application prospect of micro-fluidic chip are elaborated comprehensively.Due to micro-
Fluidic chip have the advantages that analysis efficiency high, sample and reagent consumption less, it is being easily integrated, small volume, fast and simple, in life
The fields such as thing chemistry, medical test, drug screening, environmental monitoring have been obtained for being widely applied.
Middle and later periods 21 century, the combination of booming microflow control technique and optical technology, both complement each other, and make
With regard to the generation of light-operated microfluidic technology.Traditional optical tweezer is realized pair by controlling intensity, polarization and the phase structure variable of laser
The capture and manipulation of object.However, it is desirable to which the excitation source of high-energy is used for the viscous force for overcoming surrounding liquid, with manipulation
The manipulation of micro Nano material is restricted in the small defect of sphere of action, micro-nano fluid and fluid.In addition, high performance tradition
Laser process is complicated, expensive；Collimation, focusing, conversion of polarization state of laser etc. are also required to the optical component of complexity
Realized with light path, therefore equipment bulky complex, the existing micro-fluid chip system integration is not easy to, its application is by the very day of one's doom
System.
Research shows, various speciality and variously-shaped material can be manipulated using the viscosity resistance of flow of fluid in itself,
With more preferable compatibility.Therefore, researching and developing a kind of big microfluid tweezers of cheap, simple to operate, fluid control range is
In the urgent need to.Heat energy is converted light energy into using optical-thermal conversion material, being then converted to the method for driving hydrodynamic energy is
The typical case of light-operated microfluidic technology.Light-operated miniflow had both met complicated pump valve device, surface chemistry and electrode mode or other linings
Bottom make demand, again allow it is large-sized it is micro-fluidic it is middle processing biochemical material when need not aid in any physics or
Mechanical pump device.
Utility model content
In order to overcome the shortcoming and deficiency of prior art, the purpose of this utility model is to provide a kind of based on micro-nano fiber
Microfluid tweezers, the tweezers are based on photo-thermal micro-nano fiber, using its tunable advantage, and it is vertical that induction microfluid is produced
Formula, horizontal, the vortex flow of vertical+horizontal, break through the current light-operated office that microfluidic technology form is single, function is single
Limit.
The purpose of this utility model is achieved through the following technical solutions：Microfluid tweezers based on micro-nano fiber, including tweezer
Subbase bottom, photo-thermal micro-nano fiber, microfluidic chambers, optical signal input mouth, miniflow pump, microfluid, the microfluidic chambers are arranged on tweezers
In substrate, the photo-thermal micro-nano fiber is assembled by optical-thermal conversion material with micro-nano fiber, and photo-thermal micro-nano fiber is immersed in micro-
Flow chamber bottom, photo-thermal micro-nano fiber one end is connected by optical signal input mouthful with external light source, and the optical signal that light source is sent exists
Transmitted on the photo-thermal micro-nano fiber；The microfluid is placed in microfluidic chambers, and miniflow pump is connected by pipeline with microfluidic chambers.
Described micro-nano fiber, can use any fiber optic materials well known in the art, such as quartz, silicon nitride or
Remaining fusing point is more than 100 degrees Celsius of polymer.It is preferably quartzy.
Described micro-nano fiber is preferred to use flame heating extension drawing single-mode quartz optical fibers and is made, and refractive index is
1.45, diameter is preferably 0.2~5 μm, with preferable surface flatness and length homogeneity, and excellent mechanical performance.
Described optical-thermal conversion material can use well known in the art with good photothermal deformation performance and heat conduction
The nano material of performance, is graphene, graphene oxide, nanogold colloid or nano silver colloid etc., preferably graphene oxide.
The optical-thermal conversion material can be coated on micro-nano fiber surface by modes such as coating, depositions.
Described photo-thermal micro-nano fiber is preferentially prepared using drop coating method, and preparation method is：By the second of graphene oxide
Alcoholic solution directly drops on micro-nano fiber formation ellipsoid structure, with the evaporation of alcohol, drop will gradually atrophy, finally in light
Fine surface gradually forms film.
The wave-length coverage of described optical signal may be selected in visible light wave range or near infrared band, but must avoid molten
The absorption bands of absorption bands and prioritizing selection optical-thermal conversion material in liquid, such as graphene oxide, 980nm with
And 1550nm has stronger absorption, for water, there is strong absorption in 1550nm wave bands and have in 980nm wave bands less
Absorption.Overall is preferably 980nm.
The luminous power of the optical signal is tunable, is preferentially chosen in the range of 20mW-100mW.
Described microfluidic chambers are used to hold microfluid.The microfluidic chambers of any shape well known in the art can be used.Can be with
Surrounded by the material well known in the art for microfluidic channel, material can use paraffin, dimethione (PDMS), gather
Methyl methacrylate (PMMA) or uv-curable glue etc..
Described miniflow pump is used to injecting or discharging microfluid, and is calculated by the volume injected with the microfluid of discharge
The thickness of microfluidic layer in microfluidic chambers, can use any kind of miniflow pump well known in the art or micro syringe
Deng.
Described microfluid can use any Newton type fluid as known in the art, preferably water, DMF, PBS buffering
Liquid etc..
The micro-nano granules for fluid trace are carried in described microfluid, can be used as known in the art any
The particle of material any shape, such as the polymer globules of regular spheroid, silica beads, or the bar-shaped metal micro-nano of rule
Rice noodles, semiconductor microactuator nano wire, polymer micro-nano rice noodles, or irregular shape carbon dust etc..
The mechanism of the described microfluid tweezers based on photo-thermal micro-nano fiber is：The utility model is based on optical-thermal conversion material
Limitation and absorption to the transmission light field on micro-nano fiber, produce the conversion of photo-thermal energy.Converted heat will be by miniflow
The photo-thermal micro-nano fiber of room central bottom starts to external diffusion, and then produces thermograde in whole microfluid.Thermograde
Generation cause the redistribution of the surface tension on microfluid internal density and microfluidic surface.The former generates buoyancy
Driving force, driving internal flow flows to high-order, formation Natural convection from low level.The latter generates surface shear stress, driving surface
Fluid flows to region of high surface tension from region of low surface tension, forms thermocapillary convection.By controlling the thickness of fluid layer, with regard to that can change
Become the Temperature Distribution of internal flow and surfactant fluid, so as to change the power of two kinds of convection current.Theoretical simulation shows that Natural convection is
The vortex flow of vertical, thermocapillary convection is the vortex flow of horizontal.With the increase of fluid layer thickness, thermocapillary convection
By dying down by force, Natural convection is changed from weak to strong, therefore the flow pattern of fluid can be controlled by controlling fluid layer thickness.Film
Fluid layer mainly produces the leading horizontal-type scroll flowing of thermocapillary convection, and the larger fluid layer of thickness ratio is mainly produced by buoyancy
The leading vertical vortex flow of convection current, for the fluid layer of suitable thickness, then occurs the whirlpool that horizontal is mixed with vertical
Eddy flow is moved.
The utility model compared with prior art, has the following advantages that and beneficial effect：
(1) from cost and feasibility, form is excited compared to conventional laser, the utility model is excited by optical coupling
Photo-thermal micro-nano fiber can more efficient, more be concentrated, more stably excite heat.Irradiated than producing laser beam with complicated optical system
It is more suitable.Photo-thermal micro-nano fiber can stably and firmly limit light in the material, enhance the interaction of laser and material,
Both the waste of luminous energy can be avoided, again can with it is more efficient, more concentrate, more stably excite heat.And these need only to one
Optical fiber laser, experimental facilities cost is relatively low, and energy loss is relatively low, adds efficiency of energy utilization.
(2) preparation method is efficient and convenient, with low cost and effective.Optical-thermal conversion material used in the utility model, not office
It is limited to graphene oxide, can be generalized to other optical-thermal conversion materials such as CNT, nanogold, Nano Silver etc..This practicality is new
Optical fiber used in type, is not limited to silica, can be generalized to other fiber optic materials such as silicon, polymer etc..
Brief description of the drawings
Fig. 1 is the structural representation of the present embodiment microfluid tweezers.
Fig. 2 a are that fluid layer is thicker, produce by the vertical vortex flow that Natural convection is dominated when, convection current in horizontal direction
Principle schematic.
Fig. 2 b are that fluid layer is thicker, produce by the vertical vortex flow that Natural convection is dominated when, convection current on vertical direction
Principle schematic.
Fig. 3 a are that fluid layer is relatively thin, when producing the horizontal-type scroll flowing that thermocapillary convection is dominated, convection current in horizontal direction
Principle schematic.
Fig. 3 b are that fluid layer is relatively thin, when producing the horizontal-type scroll flowing that thermocapillary convection is dominated, convection current on vertical direction
Principle schematic.
When Fig. 4 a are the vortex flows that generation horizontal is mixed with vertical, the principle schematic of convection current in horizontal direction.
When Fig. 4 b are the vortex flows that generation horizontal is mixed with vertical, the principle schematic of convection current on vertical direction.
Fig. 5 a, 5b are microphotos, and described microphoto shows to be based on photo-thermal micro-nano light under different optical input powers
The fine vertical vortex flow dominated by Natural convection.
Fig. 6 a, 6b are microphotos, and described microphoto shows to be based on photo-thermal micro-nano light under different optical input powers
The fine horizontal-type scroll dominated by thermocapillary convection flows.
Fig. 7 a, 7b are microphotos, and described microphoto shows to be based on photo-thermal micro-nano light under different optical input powers
The vortex flow that fine horizontal is mixed with vertical
Embodiment
The utility model is described in further detail with reference to embodiment and accompanying drawing, but implementation of the present utility model
Mode not limited to this.
The utility model controls the flow pattern of microfluid by controlling the heat distribution in microfluid.By exciting miniflow
Photo-thermal micro-nano fiber causes the redistribution of microfluid internal density and on microfluidic surface surface tension in body.Finally
Produce the Natural convection of vertical vortex flow and the thermocapillary convection of horizontal vortex flow.In the utility model, microfluid
Thickness is governing factor, and its change creates the Natural convection Long-term change trend opposite with thermocapillary convection, ultimately results in fluid stream
The change of dynamic model formula.Photo-thermal micro-nano fiber is excitaton source, and it changes identical Long-term change trend, ultimately results in flow of fluid intensity
Change.
Fig. 1 shows the structure for the microfluid tweezers that each following embodiment is based on.Microfluid tweezers include tweezers base
Bottom 1 and microfluidic chambers 2, microfluidic chambers 2 are arranged in tweezers substrate 1, and length is certain, and photo-thermal micro-nano fiber is placed in microfluidic chambers
Bottom center.Miniflow pump 3 is placed in a corner of microfluidic chambers, for introducing or discharging microfluid.As excitaton source, photo-thermal is micro-
Nano fiber is assembled by the optical-thermal conversion material 4 using graphene oxide as representative and micro-nano fiber 5.Graphene oxide have compared with
High refractive index, can be by most of original luminous energy limitation transmitted on optical fiber wherein.Simultaneous oxidation graphene has pole
Strong absorptivity, can excite higher temperature so as to realize by the light energy absorption limited under the optical input power of reduction.
Photo-thermal micro-nano fiber one end is connected by optical signal input mouthful 6 with external light source, and the optical signal that light source is sent is in the photo-thermal
Transmitted on micro-nano fiber.
Embodiment of the present utility model and physical mechanism are made respectively further in detail with reference to embodiment and accompanying drawing
Thin description.
Embodiment 1
The embodiment mainly produces the leading vertical vortex flow of Natural convection.In this embodiment, miniflow pump
The thicker fluid layer of the more liquid formation of injection, 30~100 μm of H thickness, now by exciting photo-thermal micro-nano light in microfluid
Fine heat spreads in microfluid, and the microfluid close to thermal source is due to the local expansion of temperature rise generation, density reduction.It is this
The redistribution of microfluid internal density generates buoyancy-driven power.This driving force direction is vertical direction, therefore drives fluid
A high position is flowed to from low level, and low level is flowed to from a high position, so circulation forms vertical vortex.The vertical direction of its convection current such as Fig. 2 b
It is shown.Simultaneously because the direction of thermal diffusion is using photo-thermal micro-nano fiber as axial symmetry, therefore, the horizontal direction of the convection current of generation also with
Photo-thermal micro-nano fiber is axial symmetry.Fig. 2 a show the direction of Natural convection observed in horizontal direction.And due to microfluid
Thickness is larger, and microfluidic surface temperature is more uniform, it is impossible to drive thermocapillary convection.
Embodiment 2
The embodiment mainly produces the leading horizontal-type scroll flowing of thermocapillary convection.In this embodiment, miniflow
Infusion enters less liquid and forms relatively thin fluid layer, 5~20 μm of H thickness, now by exciting photo-thermal micro-nano light in microfluid
Fine heat spreads in microfluid, in microfluidic surface, by paracentral microfluid because temperature elevation surface tension force diminishes.
The redistribution of this microfluidic surface tension force generates shear stress.Because this phenomenon is only present in microfluidic surface, this driving
Force direction is horizontal direction, therefore driving fluid region of low surface tension (high-temperature area) flows to region of high surface tension (low-temperature space
Domain), so circulation forms horizontal-type scroll.Its convection current direction is as shown in Figure 3 a.Because the direction of thermal diffusion is with microfluidic surface
For axial symmetry, therefore, the horizontal-type scroll of generation constitutes array by 4 vortexs, and adjacent vortex direction of rotation is opposite.Such as Fig. 3 b
Shown, because miniflow body thickness is smaller, temperature is more uniform on microfluid inner vertical direction, it is impossible to drive Natural convection.
Embodiment 3
It is main in the embodiment to produce the vortex flow that horizontal is mixed with vertical.Miniflow infusion enters appropriate liquid
So that the thickness H of microfluid is at 20~30 μm.Now by exciting photo-thermal micro-nano fiber in microfluid to cause inside microfluid
The redistribution of density and on microfluidic surface surface tension.The former forms Natural convection, referring to Fig. 4 b.The latter is formed
Thermocapillary convection, referring to Fig. 4 a, two kinds of convection current are overlapped.
The utility model embodiment and experimental implementation are made respectively further in detail with reference to embodiment and accompanying drawing
Description, but embodiment not limited to this of the present utility model.
Single-mode quartz optical fibers (SMF-28, Corning companies of the U.S.) are drawn using flame heating extension, diameter is drawn out
The micro-nano fiber for being 2mm for 1.0 μm, length.Photo-thermal micro-nano fiber is prepared using drop coating preparation method, method is：By oxygen
The ethanol solution of graphite alkene directly drops in formation ellipsoid structure on micro-nano fiber, and with the evaporation of alcohol, drop will gradually
Atrophy, finally gradually forms film in optical fiber surface.Graphene oxide layer length as shown in Figure 5 is 3 μm, and average thickness is
200nm.The photo-thermal micro-nano fiber being prepared from is placed on tweezers substrate.Surrounded using the olefin material of high temperature melting a length of
1mm, a width of 1mm, a height of 100 μm of microfluidic chambers.It is 20-100mW by tunable power, operation wavelength swashs for 980nm optical fiber
Light device is connected as light source with the optical signal input mouthful of photo-thermal micro-nano fiber.Optical signal from optical fiber laser is passed through into end
Mouth input, and transmitted on photo-thermal micro-nano fiber.By a diameter of 300nm polystyrene sphere colloidal solution with 1:100 ratio
Example is incorporated in water, and enters microfluidic chambers by miniflow infusion.Fluid flow pattern is judged by the motion track of polystyrene sphere.
Fig. 5-7 gives polystyrene sphere described in this example under the optical signal input of different miniflow body thicknesses and different capacity
The optical microscope image of movement locus.
As shown in Figure 5 a, 10 μ L shown microfluid is entered in microfluidic chambers by miniflow infusion, it is about 100 to form thickness
μm microfluid, in the case where power is the optical signal input that 40mW, wavelength are 980nm, polystyrene sphere produces vertical direction
Circulate, this represents to generate Natural convection on microfluid.As shown in Figure 5 b, input optical signal is continued and by optical signal power
80mW is promoted to, polystyrene sphere generation is larger range of to be circulated, and flowing velocity increases, this represents to produce on microfluid
Give birth to that intensity is bigger, the bigger Natural convection of scope.
As shown in Figure 6 a, 1 μ L shown microfluid is entered in microfluidic chambers by miniflow infusion, it is about 10 μm to form thickness
Microfluid, in the case where power is the optical signal input that 40mW, wavelength are 980nm, polystyrene sphere produces following for horizontal direction
Circulation is moved, from microscope view, and the track of polystyrene forms four vortex patterns.This represents to generate heat on microfluid
Capillary convection.As shown in Figure 6 b, continue input optical signal and optical signal power is promoted to 80mW, polystyrene sphere is produced more
Circulate on a large scale, and flowing velocity increases, this represents to generate that intensity is bigger on microfluid, the bigger hot capillary of scope
Convection current.
As shown in Figure 7a, 3 μ L shown microfluid is entered in microfluidic chambers by miniflow infusion, it is about 30 μm to form thickness
Microfluid, in the case where power is the optical signal input that 40mW, wavelength are 980nm, polystyrene sphere both generates vertical direction
Circulate, circulating for horizontal direction is generated again.This represents to generate Natural convection and hot hair simultaneously on microfluid
Thin convection current.As shown in Figure 7b, continue input optical signal and optical signal power is promoted to 80mW, polystyrene sphere produces bigger
Scope is circulated, and flowing velocity increases, and this represents to generate the intensity bigger hot capillary pair of big, scope on microfluid
Stream.
Above-described embodiment is the utility model preferably embodiment, but embodiment of the present utility model is not by above-mentioned
The limitation of embodiment, it is other it is any without departing from Spirit Essence of the present utility model with made under principle change, modify, replace
Generation, combination, simplification, should be equivalent substitute mode, are included within protection domain of the present utility model.
Claims (9)
1. the microfluid tweezers based on micro-nano fiber, it is characterised in that including tweezers substrate, photo-thermal micro-nano fiber, microfluidic chambers, light
Signal input port, miniflow pump, microfluid, the microfluidic chambers are arranged in tweezers substrate, and the photo-thermal micro-nano fiber is by photo-thermal
Transition material assembles with micro-nano fiber, and photo-thermal micro-nano fiber is immersed in microfluidic chambers bottom, and photo-thermal micro-nano fiber one end passes through
Optical signal input mouthful is connected with external light source, and the optical signal that light source is sent is transmitted on the photo-thermal micro-nano fiber；It is described micro-
Fluid is placed in microfluidic chambers, and miniflow pump is connected by pipeline with microfluidic chambers.
2. microfluid tweezers according to claim 1, it is characterised in that
The optical-thermal conversion material is coated on micro-nano fiber surface by coating or depositional mode；
The optical-thermal conversion material is graphene, graphene oxide, nanogold colloid or nano silver colloid.
3. microfluid tweezers according to claim 1, it is characterised in that
The material of micro-nano fiber is more than 100 degrees Celsius of polymer for quartz, silicon nitride or fusing point.
4. microfluid tweezers according to claim 1, it is characterised in that the photo-thermal micro-nano fiber is immersed in the miniflow
Room bottom center.
5. microfluid tweezers according to claim 1, it is characterised in that the wave-length coverage of the optical signal is in visible light wave
Section or near infrared band.
6. microfluid tweezers according to claim 5, it is characterised in that the luminous power tunable range of the optical signal exists
In the range of 20mW-100mW.
7. microfluid tweezers according to claim 1, it is characterised in that the material for preparing of microfluidic chambers is paraffin, poly- diformazan
Siloxanes, polymethyl methacrylate or uv-curable glue.
8. microfluid tweezers according to claim 1, it is characterised in that microfluid is times in water, DMF, PBS
Meaning is a kind of.
9. microfluid tweezers according to claim 1, it is characterised in that
The micro-nano granules for fluid trace are carried in the microfluid, micro-nano granules are that the polymer of regular spheroid is small
Ball, silica beads, the either bar-shaped metal micro-nano line of rule, semiconductor microactuator nano wire, polymer micro-nano rice noodles or not
Regular shape carbon dust.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106582903A (en) * | 2016-12-26 | 2017-04-26 | 华南师范大学 | Micro-fluidic chip based on photothermal waveguide and micro-fluidic method of micro-fluidic chip |
| CN109880744A (en) * | 2019-03-22 | 2019-06-14 | 华南师范大学 | Optofluidic cell sorting chip and its method for sorting cell |
| CN110026675A (en) * | 2019-04-22 | 2019-07-19 | 哈尔滨工业大学 | It is a kind of to realize liquid level small items surface tension microoperation method using multiple laser |
| CN112871750A (en) * | 2021-01-26 | 2021-06-01 | 华南师范大学 | Particle sorting chip based on cascade micro heat source and particle sorting method thereof |
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2016
- 2016-12-26 CN CN201621437168.XU patent/CN206351047U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106582903A (en) * | 2016-12-26 | 2017-04-26 | 华南师范大学 | Micro-fluidic chip based on photothermal waveguide and micro-fluidic method of micro-fluidic chip |
| CN106582903B (en) * | 2016-12-26 | 2018-12-07 | 华南师范大学 | Micro-fluidic chip and its microfluidic methods based on photo-thermal waveguide |
| CN109880744A (en) * | 2019-03-22 | 2019-06-14 | 华南师范大学 | Optofluidic cell sorting chip and its method for sorting cell |
| CN109880744B (en) * | 2019-03-22 | 2022-07-29 | 华南师范大学 | Photofluidic cell sorting chip and cell sorting method thereof |
| CN110026675A (en) * | 2019-04-22 | 2019-07-19 | 哈尔滨工业大学 | It is a kind of to realize liquid level small items surface tension microoperation method using multiple laser |
| CN112871750A (en) * | 2021-01-26 | 2021-06-01 | 华南师范大学 | Particle sorting chip based on cascade micro heat source and particle sorting method thereof |
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