WO2006003293A3 - Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique - Google Patents

Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique Download PDF

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Publication number
WO2006003293A3
WO2006003293A3 PCT/FR2005/001385 FR2005001385W WO2006003293A3 WO 2006003293 A3 WO2006003293 A3 WO 2006003293A3 FR 2005001385 W FR2005001385 W FR 2005001385W WO 2006003293 A3 WO2006003293 A3 WO 2006003293A3
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WO
WIPO (PCT)
Prior art keywords
analysis
producing
mask
relates
microfludic
Prior art date
Application number
PCT/FR2005/001385
Other languages
English (en)
Other versions
WO2006003293A2 (fr
Inventor
Jean-Christophe Fourrier
Francois Caron
Pierre Tabourier
Christian Druon
Original Assignee
Univ Lille Sciences Tech
Centre Nat Rech Scient
Jean-Christophe Fourrier
Francois Caron
Pierre Tabourier
Christian Druon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Lille Sciences Tech, Centre Nat Rech Scient, Jean-Christophe Fourrier, Francois Caron, Pierre Tabourier, Christian Druon filed Critical Univ Lille Sciences Tech
Priority to KR1020067025513A priority Critical patent/KR101179411B1/ko
Priority to AT05775767T priority patent/ATE540756T1/de
Priority to CA2568805A priority patent/CA2568805C/fr
Priority to US11/628,416 priority patent/US20080110753A1/en
Priority to EP05775767A priority patent/EP1781409B1/fr
Priority to JP2007514033A priority patent/JP4763690B2/ja
Priority to CN2005800240790A priority patent/CN101031362B/zh
Publication of WO2006003293A2 publication Critical patent/WO2006003293A2/fr
Publication of WO2006003293A3 publication Critical patent/WO2006003293A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
    • F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
    • F05C2225/00—Synthetic polymers, e.g. plastics; Rubber
    • F05C2225/04—PTFE [PolyTetraFluorEthylene]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)

Abstract

L'invention a pour premier objet un dispositif de manipulation de gouttes sur un plan de déplacement par électromouillage, comprenant au moins une piste de déplacement. La piste comprend un substrat électriquement isolant à la surface duquel reposent deux ou plusieurs électrodes conductrices interdigitées. Ces électrodes sont recouvertes d'une couche diélectrique isolante, elles-mêmes recouvertes d'une couche partiellement mouillante. L'invention se rapporte également à un procédé de fabrication du dispositif précité dans lequel la création de la couche partiellement mouillante comprend la création d'un masque en matériau photosensible par dépôt de ce matériau sur un substrat, une étape photolithographique, la révélation du matériau photosensible, le dépôt d'un matériau non mouillant sur le masque, au moins un recuit en dissolution, dissolution du masque, et au moins un recuit après dissolution. L'invention se rapporte enfin à un système d'analyse microfluidique d'un échantillon de liquide, qui comprend au moins un moyen de préparation de l'échantillon de liquide couplé à au moins un dispositif de manipulation de gouttes selon l'invention, lui-même couplé à au moins un moyen d'analyse de l'échantillon.
PCT/FR2005/001385 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique WO2006003293A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020067025513A KR101179411B1 (ko) 2004-06-04 2005-06-06 생화학적 분석을 위한 점적 조작용 장치, 상기 장치의 제조방법 및 마이크로 흐름 분석용 시스템
AT05775767T ATE540756T1 (de) 2004-06-04 2005-06-06 Vorrichtung zur handhabung von tropfen zur biochemischen analyse, verfahren zur herstellung einer derartigen vorrichtung und system zur mikrofluidischen analyse
CA2568805A CA2568805C (fr) 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique
US11/628,416 US20080110753A1 (en) 2004-06-04 2005-06-06 Device For Handling Drops For Biochemical Analysis, Method For Producing Said Device And A System For Microfluidic Analysis
EP05775767A EP1781409B1 (fr) 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique
JP2007514033A JP4763690B2 (ja) 2004-06-04 2005-06-06 生化学的分析のために液滴を扱う装置、前記装置を製造する方法及びマイクロ流体分析
CN2005800240790A CN101031362B (zh) 2004-06-04 2005-06-06 用于生物化学分析的液滴操纵装置，制造所述装置的方法与微流体分析系统

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0406080A FR2871150B1 (fr) 2004-06-04 2004-06-04 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique
FR0406080 2004-06-04

Publications (2)

Publication Number Publication Date
WO2006003293A2 WO2006003293A2 (fr) 2006-01-12
WO2006003293A3 true WO2006003293A3 (fr) 2006-09-21

Family

ID=34946857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/001385 WO2006003293A2 (fr) 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique

Country Status (9)

Country Link
US (1) US20080110753A1 (fr)
EP (1) EP1781409B1 (fr)
JP (1) JP4763690B2 (fr)
KR (1) KR101179411B1 (fr)
CN (1) CN101031362B (fr)
AT (1) ATE540756T1 (fr)
CA (1) CA2568805C (fr)
FR (1) FR2871150B1 (fr)
WO (1) WO2006003293A2 (fr)

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JP4763690B2 (ja) 2011-08-31
US20080110753A1 (en) 2008-05-15
FR2871150B1 (fr) 2006-09-22
JP2008502882A (ja) 2008-01-31
KR20070053165A (ko) 2007-05-23
CN101031362A (zh) 2007-09-05
CA2568805A1 (fr) 2006-01-12
EP1781409B1 (fr) 2012-01-11
CN101031362B (zh) 2012-01-11
EP1781409A2 (fr) 2007-05-09
CA2568805C (fr) 2012-08-28
WO2006003293A2 (fr) 2006-01-12
ATE540756T1 (de) 2012-01-15
KR101179411B1 (ko) 2012-09-07
FR2871150A1 (fr) 2005-12-09

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