ATE540679T1 - Verfahren zur verringerung der gastrointestinalen toxizität durch verabreichung von tegafur - Google Patents

Verfahren zur verringerung der gastrointestinalen toxizität durch verabreichung von tegafur

Info

Publication number
ATE540679T1
ATE540679T1 AT05738545T AT05738545T ATE540679T1 AT E540679 T1 ATE540679 T1 AT E540679T1 AT 05738545 T AT05738545 T AT 05738545T AT 05738545 T AT05738545 T AT 05738545T AT E540679 T1 ATE540679 T1 AT E540679T1
Authority
AT
Austria
Prior art keywords
tegafur
gastrointestinal toxicity
administration
reducing gastrointestinal
reducing
Prior art date
Application number
AT05738545T
Other languages
English (en)
Inventor
Takeshi Tahara
Hiroshi Ambe
Jun Kuritani
Naruo Nomura
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE540679T1 publication Critical patent/ATE540679T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05738545T 2004-04-29 2005-04-27 Verfahren zur verringerung der gastrointestinalen toxizität durch verabreichung von tegafur ATE540679T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56618004P 2004-04-29 2004-04-29
PCT/JP2005/008450 WO2005105086A1 (en) 2004-04-29 2005-04-27 Method for reducing gastrointestinal toxicity due to the administration of tegafur

Publications (1)

Publication Number Publication Date
ATE540679T1 true ATE540679T1 (de) 2012-01-15

Family

ID=35241420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05738545T ATE540679T1 (de) 2004-04-29 2005-04-27 Verfahren zur verringerung der gastrointestinalen toxizität durch verabreichung von tegafur

Country Status (16)

Country Link
US (1) US20080166427A1 (de)
EP (1) EP1750703B1 (de)
JP (1) JP5376758B2 (de)
AT (1) ATE540679T1 (de)
AU (1) AU2005237364B2 (de)
CY (2) CY1112451T1 (de)
DK (1) DK1750703T3 (de)
ES (1) ES2378072T3 (de)
HR (1) HRP20120293T1 (de)
ME (1) ME01335B (de)
PL (1) PL1750703T3 (de)
PT (1) PT1750703E (de)
RS (1) RS52217B (de)
RU (1) RU2348409C2 (de)
SI (1) SI1750703T1 (de)
WO (1) WO2005105086A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201039816A (en) * 2009-05-13 2010-11-16 Taiho Pharmaceutical Co Ltd Treatment of diffuse-type gastric cancers using S-1 and cisplatin
BR112012000873A2 (pt) * 2009-07-17 2019-11-05 Myriad Genetics Inc método de dosar 5-fluorouracil em uma amostra de um paciente tratado com f-fu ou um pró-fármaco deste, método de tratar um paciente com 5-fluorouracil ou um pró-fármaco deste, método de processamento de uma amostra de sangue de um paciente tratado com um regime compreendendo 5-fluorouracil ou um pró-fármaco deste para um teste de 5-fluorouracil, método de processamento de uma amostra de sangue de um paciente tratado com um regime compreendendo 5-fluorouracil ou um pró-fármaco deste, composição, kit, kit de teste, conjunto de seringa de transferência
WO2011022174A1 (en) * 2009-08-21 2011-02-24 Myriad Genetics, Inc. Method of processing blood samples containing 5-fu
EP2422784A1 (de) 2010-08-18 2012-02-29 Grindeks, a joint stock company Zusammensetzung aus TEGAFUR und Kaffeinsäurephenethyl-Ester (CAPE) und entweder Catechin, Kaempherol, Myrecetin oder Luteolin zur Potenzierung der Antitumor-Wirkung und zur Behandlung von Tumoren
EP2422815A1 (de) 2010-08-18 2012-02-29 Grindeks, a joint stock company Zusammensetzung enthaltend Tegafur und Catechin zur Potenzierung der Antitumor-Wirkung und zur Behandlung von Tumoren
EP2422848A1 (de) 2010-08-18 2012-02-29 Grindeks, a joint stock company Zusammensetzung aus tegafur und Indol-3-carbinol und entweder Catechin, Kaempherol, Myrecetin oder Luteolin zur Potenzierung der Antitumor-Wirkung und zur Behandlung von Tumoren
CN106456631A (zh) * 2014-03-06 2017-02-22 南加利福尼亚大学 利用短期饥饿方案结合激酶抑制剂来增强传统化学药物功效和可行性并逆转激酶在正常细胞和组织中的副作用
ES2926934T3 (es) 2014-03-28 2022-10-31 Univ Degli Studi Genova Inhibidores de tirosina quinasa para uso en un método de tratar cáncer en asociación con una ingesta calórica reducida
US20180110780A1 (en) * 2015-04-30 2018-04-26 Taiho Pharmaceutical Co., Ltd. Agent for alleviating side effect of antitumor drug
JP6439761B2 (ja) * 2016-08-09 2018-12-19 トヨタ自動車株式会社 ＮＯｘ吸蔵還元触媒の製造方法
CN106619689B (zh) * 2016-12-30 2018-05-01 陈晓华 一种用于治疗癌症的药物组合物、试剂盒及其应用
MX2022014094A (es) * 2020-05-19 2022-12-08 Cellix Bio Private Ltd Formulaciones farmaceuticas y sus preparaciones para el tratamiento del cancer.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635946A (en) * 1969-07-22 1972-01-18 Solomon Aronovich Giller N1-(2'-furanidyl)-derivatives of 5-substituted uracils
DE3585869D1 (de) * 1984-10-30 1992-05-21 Otsuka Pharma Co Ltd Zusammensetzung zur steigerung der antikrebsaktivitaet einer antikrebsverbindung.
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
DE69003670T2 (de) * 1989-01-05 1994-01-27 Otsuka Pharma Co Ltd Nicht einspritzbares karzinostatisches mittel zur vorbeugung der entzündung durch 5-fluoruracil und verfahren zur behandlung von krebs.
CA2087540C (en) * 1991-05-27 1999-01-19 Taiho Pharmaceutical Co., Ltd. Composition, method and kit for potentiating antitumor activity and for curing tumor
WO2000021956A1 (en) * 1998-10-12 2000-04-20 Leonidov Nikolai B New crystalline modification of 5-fluoro-1-(tetrahydro-2-furyl)-uracyl, and complex compounds based on this modification and having an antitumoral activity

Also Published As

Publication number Publication date
ME01335B (me) 2013-12-20
HRP20120293T1 (hr) 2012-04-30
DK1750703T3 (da) 2012-05-07
AU2005237364A1 (en) 2005-11-10
RU2006142101A (ru) 2008-06-20
CY2012014I1 (el) 2016-04-13
JP5376758B2 (ja) 2013-12-25
EP1750703A4 (de) 2008-02-27
CY2012014I2 (el) 2016-04-13
JP2007534634A (ja) 2007-11-29
PT1750703E (pt) 2012-02-23
RS52217B (sr) 2012-10-31
AU2005237364B2 (en) 2010-07-08
US20080166427A1 (en) 2008-07-10
CY1112451T1 (el) 2015-12-09
EP1750703B1 (de) 2012-01-11
PL1750703T3 (pl) 2012-05-31
WO2005105086A1 (en) 2005-11-10
EP1750703A1 (de) 2007-02-14
ES2378072T3 (es) 2012-04-04
SI1750703T1 (sl) 2012-02-29
RU2348409C2 (ru) 2009-03-10

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