DE602004026903D1 - P-glycoprotein-inhibitor, verfahren zu dessen hersiesen enthält - Google Patents

P-glycoprotein-inhibitor, verfahren zu dessen hersiesen enthält

Info

Publication number
DE602004026903D1
DE602004026903D1 DE602004026903T DE602004026903T DE602004026903D1 DE 602004026903 D1 DE602004026903 D1 DE 602004026903D1 DE 602004026903 T DE602004026903 T DE 602004026903T DE 602004026903 T DE602004026903 T DE 602004026903T DE 602004026903 D1 DE602004026903 D1 DE 602004026903D1
Authority
DE
Germany
Prior art keywords
hersesis
glycoprotein inhibitor
anticancer agent
glycoprotein
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004026903T
Other languages
English (en)
Inventor
Keuk Chan Bang
Mi Young Cha
Young Gil Ahn
Young Jin Ham
Maeng Sup Kim
Gwan Sun Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Science Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Hanmi Pharmaceutical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd, Hanmi Pharmaceutical Industries Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Publication of DE602004026903D1 publication Critical patent/DE602004026903D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C04CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04BLIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632Organic additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
DE602004026903T 2003-10-07 2004-10-06 P-glycoprotein-inhibitor, verfahren zu dessen hersiesen enthält Active DE602004026903D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020030069582A KR100557093B1 (ko) 2003-10-07 2003-10-07 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법
PCT/KR2004/002550 WO2005033097A1 (en) 2003-10-07 2004-10-06 P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
DE602004026903D1 true DE602004026903D1 (de) 2010-06-10

Family

ID=36500896

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004026903T Active DE602004026903D1 (de) 2003-10-07 2004-10-06 P-glycoprotein-inhibitor, verfahren zu dessen hersiesen enthält

Country Status (23)

Country Link
US (1) US7625926B2 (de)
EP (1) EP1678162B1 (de)
JP (1) JP4481992B2 (de)
KR (1) KR100557093B1 (de)
CN (1) CN1863795B (de)
AT (1) ATE466008T1 (de)
AU (1) AU2004277475B2 (de)
BR (1) BRPI0415053B8 (de)
CA (1) CA2541301C (de)
DE (1) DE602004026903D1 (de)
DK (1) DK1678162T3 (de)
ES (1) ES2342290T3 (de)
HK (1) HK1096399A1 (de)
IL (1) IL174665A (de)
MX (1) MXPA06003803A (de)
NO (1) NO336127B1 (de)
NZ (1) NZ546257A (de)
PL (1) PL1678162T3 (de)
PT (1) PT1678162E (de)
RU (1) RU2317985C1 (de)
SI (1) SI1678162T1 (de)
WO (1) WO2005033097A1 (de)
ZA (1) ZA200603538B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0700773D0 (en) * 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
MX2009009304A (es) 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.
GB0706072D0 (en) * 2007-03-28 2007-05-09 Sterix Ltd Compound
CN103333157A (zh) 2008-09-02 2013-10-02 诺瓦提斯公司 作为激酶抑制剂的吡啶甲酰胺衍生物
KR101466245B1 (ko) * 2010-01-15 2014-12-01 한미사이언스 주식회사 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물
TW201408641A (zh) 2012-05-21 2014-03-01 Novartis Ag 可作爲激酶抑制劑之新穎環取代n-吡啶基醯胺
KR101986683B1 (ko) * 2012-12-13 2019-06-10 한미약품 주식회사 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
CN103804352B (zh) * 2014-01-23 2017-06-13 中国药科大学 三氮唑苯乙基四氢异喹啉类化合物及其制备方法和应用
KR20150135110A (ko) * 2014-05-23 2015-12-02 한미정밀화학주식회사 p-당단백질의 저해제 및 p-당단백질의 기질 약물을 포함하는 약제학적 조성물
CN104327046B (zh) * 2014-10-14 2017-11-17 中国药科大学 三氮唑‑n‑乙基四氢异喹啉类化合物及其制备方法和应用
JO3737B1 (ar) * 2015-07-21 2021-01-31 Athenex Therapeutics Ltd تركيبات علاجية من باكليتاكسيل تعطى عن طريق الفم ومثبط P-gp لعلاج السرطان
TWI715636B (zh) 2015-09-30 2021-01-11 香港商慧源香港創新有限公司 口服紫杉烷組合物及方法
CN112351779A (zh) * 2018-04-13 2021-02-09 慧源医疗有限公司 用于治疗血管肉瘤的口服给药紫杉醇和P-gp抑制剂的治疗组合
TW202038934A (zh) * 2018-12-14 2020-11-01 香港商慧源香港創新有限公司 用於治療癌症之口服投予多西紫杉醇(docetaxel)和P-gp抑制劑的醫療組合
US11752139B2 (en) * 2018-12-14 2023-09-12 Athenex HK Innovative Limited Therapeutic combinations of orally administered irinotecan and a p-gp inhibitor for the treatment of cancer
US20220135548A1 (en) 2019-02-14 2022-05-05 Teva Pharmaceuticals International Gmbh Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isoquinolinyl)ethyl]phenyl}-2h-tetrazol-5-yl)-4,5- dimethoxyphenyl]-4-oxo-4h-chromene-2-carboxamide and of its mesylate salt
WO2020230037A1 (en) * 2019-05-13 2020-11-19 Dr. Reddy's Laboratories Limited Alternate process for the preparation of encequidar
WO2021044350A1 (en) * 2019-09-04 2021-03-11 Dr. Reddy’S Laboratories Limited Solid forms of encequidar mesylate and processes thereof
EP4178679A1 (de) 2020-07-10 2023-05-17 Teva Czech Industries s.r.o. Feste formen von n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isochinolinyl)ethyl!phenyl}-2h-tetrazol-5-yl)4,5-dimethoxyphenyl)-4-oxo-4h-chromen-2-carboxamidmesylatsalz
JP2023544615A (ja) 2020-10-07 2023-10-24 アセネックス インコーポレイテッド アセトアミド-フェニルテトラゾール誘導体およびその使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69111077T2 (de) * 1990-11-06 1995-11-02 Pfizer Chinazolinderivate um die antitumorwirkung zu verbessern.
JP3223193B2 (ja) 1991-08-09 2001-10-29 株式会社日清製粉グループ本社 インドール誘導体およびそれらを有効成分とする抗癌剤耐性克服物質
JP2718830B2 (ja) 1992-07-10 1998-02-25 ラボラトワール、グラクソ、ソシエテ、アノニム アニリド誘導体
GB9717576D0 (en) 1997-08-19 1997-10-22 Xenova Ltd Pharmaceutical compounds
AU3408901A (en) * 2000-02-15 2001-08-27 Teijin Ltd Cancer remedy comprising anthranilic acid derivative as active ingredient
CN100349888C (zh) 2002-05-14 2007-11-21 埃克森诺瓦有限公司 药物化合物
KR100580743B1 (ko) 2003-10-08 2006-05-15 한미약품 주식회사 다약제 내성 저해 활성을 갖는 신규한 크로몬 유도체 또는이의 약제학적으로 허용가능한 염 및 이들의 제조 방법

Also Published As

Publication number Publication date
AU2004277475A1 (en) 2005-04-14
BRPI0415053A (pt) 2006-11-28
JP2007507493A (ja) 2007-03-29
SI1678162T1 (sl) 2010-07-30
MXPA06003803A (es) 2006-07-03
AU2004277475B2 (en) 2007-08-09
BRPI0415053B1 (pt) 2019-12-31
US7625926B2 (en) 2009-12-01
ES2342290T3 (es) 2010-07-05
NO20062019L (no) 2006-07-06
EP1678162A4 (de) 2008-07-02
NZ546257A (en) 2009-09-25
DK1678162T3 (da) 2010-08-02
CN1863795B (zh) 2011-05-18
RU2006114427A (ru) 2007-11-20
JP4481992B2 (ja) 2010-06-16
KR20050033734A (ko) 2005-04-13
NO336127B1 (no) 2015-05-18
BRPI0415053B8 (pt) 2021-05-25
US20070072900A1 (en) 2007-03-29
IL174665A (en) 2012-10-31
ZA200603538B (en) 2007-09-26
PL1678162T3 (pl) 2010-09-30
CN1863795A (zh) 2006-11-15
EP1678162A1 (de) 2006-07-12
HK1096399A1 (en) 2007-06-01
EP1678162B1 (de) 2010-04-28
RU2317985C1 (ru) 2008-02-27
WO2005033097A1 (en) 2005-04-14
KR100557093B1 (ko) 2006-03-03
PT1678162E (pt) 2010-05-19
IL174665A0 (en) 2006-08-20
ATE466008T1 (de) 2010-05-15
CA2541301C (en) 2010-02-02
CA2541301A1 (en) 2005-04-14

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