ATE540316T1 - Verfahren und vorrichtung zur abbildung von zielkomponenten in einer biologischen probe unter verwendung von permanentmagneten - Google Patents

Verfahren und vorrichtung zur abbildung von zielkomponenten in einer biologischen probe unter verwendung von permanentmagneten

Info

Publication number
ATE540316T1
ATE540316T1 AT09250366T AT09250366T ATE540316T1 AT E540316 T1 ATE540316 T1 AT E540316T1 AT 09250366 T AT09250366 T AT 09250366T AT 09250366 T AT09250366 T AT 09250366T AT E540316 T1 ATE540316 T1 AT E540316T1
Authority
AT
Austria
Prior art keywords
cells
target
sample
target cells
permanent magnet
Prior art date
Application number
AT09250366T
Other languages
English (en)
Inventor
Arjan G J Tibbe
Leon W M M Terstappen
Original Assignee
Veridex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Veridex Llc filed Critical Veridex Llc
Application granted granted Critical
Publication of ATE540316T1 publication Critical patent/ATE540316T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AT09250366T 2008-02-15 2009-02-13 Verfahren und vorrichtung zur abbildung von zielkomponenten in einer biologischen probe unter verwendung von permanentmagneten ATE540316T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/031,807 US7828968B2 (en) 2007-08-30 2008-02-15 Method and apparatus for imaging target components in a biological sample using permanent magnets

Publications (1)

Publication Number Publication Date
ATE540316T1 true ATE540316T1 (de) 2012-01-15

Family

ID=40506419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09250366T ATE540316T1 (de) 2008-02-15 2009-02-13 Verfahren und vorrichtung zur abbildung von zielkomponenten in einer biologischen probe unter verwendung von permanentmagneten

Country Status (7)

Country Link
US (2) US7828968B2 (de)
EP (1) EP2090889B1 (de)
JP (1) JP5507092B2 (de)
CN (1) CN101533012B (de)
AT (1) ATE540316T1 (de)
ES (1) ES2377178T3 (de)
HK (1) HK1137810A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2474509C (en) * 2002-02-14 2012-01-31 Immunivest Corporation Methods and algorithms for cell enumeration in a low-cost cytometer
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
US7828968B2 (en) * 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US8110101B2 (en) * 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
EP2359164A4 (de) 2008-12-10 2012-05-30 Abqmr Inc Kernmagnetresonanzgerät, verfahren und zugehörige technologie
US8790916B2 (en) 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
ES2690784T3 (es) * 2011-04-27 2018-11-22 Becton Dickinson And Company Dispositivos y métodos para separar fragmentos etiquetados magnéticamente en una muestra
EP2701851B1 (de) * 2011-04-29 2024-04-24 Becton Dickinson and Company Sammelsystem zur immobilisierung fluidischer inline-teilchen sowie verfahren dafür
EP2911791A4 (de) 2012-10-29 2016-11-02 Mbio Diagnostics Inc Biopartikelidentifikationssystem, kartusche und zugehörige verfahren
JPWO2014097991A1 (ja) * 2012-12-18 2017-01-12 コニカミノルタ株式会社 希少細胞検出装置、希少細胞検出方法、希少細胞観察システム、および細胞展開用デバイス
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
DE102013200927A1 (de) * 2013-01-22 2014-07-24 Siemens Aktiengesellschaft Verfahren zum Anreichern und Vereinzeln von Zellen mit Konzentrationen über mehrere logarithmische Stufen
US20150233932A1 (en) * 2013-02-19 2015-08-20 Ching-Ping Tseng Methods, Systems, and Compositions for Enrichment of Rare Cells
WO2015058103A1 (en) * 2013-10-18 2015-04-23 The Regents Of The University Of California Method and device for detecting molecules or particles using fractionalized volumes
US10564100B1 (en) * 2018-10-12 2020-02-18 SageMedic Corporation Analysis of viable and nonviable cells
CN111795919B (zh) * 2020-05-25 2024-03-26 中国人民解放军陆军军医大学第二附属医院 一种骨髓细胞形态学自动检测系统及其工作方法
EP3922991A1 (de) * 2020-06-10 2021-12-15 PreOmics GmbH Dispersion mit einem beweglichen magneten
CN114002195A (zh) * 2021-10-22 2022-02-01 中国科学院广州生物医药与健康研究院 一种辅助悬浮细胞成像的系统及其使用方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166768A (en) * 1977-11-14 1979-09-04 Monsanto Company Continuous cell culture system
US4498785A (en) * 1982-06-09 1985-02-12 Techne Corporation Floating magnetic stirrer for culture medium
US4465377A (en) * 1983-06-07 1984-08-14 Techne Corporation Magnetic stirrer apparatus with guided, floating stirrer
US5374531A (en) * 1993-03-22 1994-12-20 Zynaxis, Inc. Immunoassay for determination of cells
IL123210A0 (en) * 1998-02-06 1998-09-24 Gombinsky Moshe A device and system for the collection of magnetic particles
BR9907852A (pt) 1998-02-12 2000-10-24 Immunivest Corp Processos para detectar e enumerar células raras e cancerosas em uma população celular mista, para diagnosticar câncer de estágio precoce em um paciente de teste, para determinar a probabilidade de recorrência de câncer em um paciente humano anteriormente tratado de câncer, para distinguir um carcinoma confinado ao órgão de um carcinoma com propriedades metastáticas, para acompanhar a situação de remissão em um paciente humano com câncer que passa pelo tratamento de terapia contra o câncer e para aumentar quantidades de células epiteliais circulantes em uma amostra de sangue, partìcula magnética revestida, composição, conjuntos de teste para avaliar uma amostra de paciente quanto a presença de células raras circulantes, quanto a presença de células de tumor circulantes, quanto a presença de células de câncer de mama circulantes, quanto a presença de células de câncer de próstata circulantes, quanto a presença de células de câncer de cólon circulantes, quanto a presença de células de câncer de bexiga circulantes e para monitorar um paciente quanto a recorrência de câncer, e, fração de sangue periférico enriquecido quanto a células neoplásticas circulantes
US20010018192A1 (en) 1998-02-12 2001-08-30 Terstappen Leon W.M.M. Labeled cells for use as an internal functional control in rare cell detection assays
DE69939005D1 (de) * 1998-10-13 2008-08-14 Gambro Lundia Ab Biokompatibler polymerfilm
US6551843B1 (en) 1999-01-29 2003-04-22 Immunivest Corporation Methods for enhancing binding interactions between members of specific binding pairs
US6623982B1 (en) 1999-07-12 2003-09-23 Immunivest Corporation Increased separation efficiency via controlled aggregation of magnetic nanoparticles
CA2708573C (en) 2001-02-12 2012-05-01 Richard L. Columbus Cartridge for containing a specimen sample for optical analysis
EP1360496A4 (de) 2001-02-16 2005-03-09 Immunivest Corp Verfahren und reagenzien zur schnellen und effizienten isolierung zirkulierender krebszellen
JP2005501236A (ja) 2001-08-23 2005-01-13 イムニベスト・コーポレイション 分析用の細胞および生物学的検体の安定化
CA2474509C (en) 2002-02-14 2012-01-31 Immunivest Corporation Methods and algorithms for cell enumeration in a low-cost cytometer
US7011794B2 (en) 2002-11-25 2006-03-14 Immunivest Corporation Upon a cartridge for containing a specimen sample for optical analysis
WO2006102233A2 (en) 2005-03-18 2006-09-28 Immunivest Corporation Method and apparatus for imaging target components in a biological sample using permanent magnets
US7777885B2 (en) * 2005-08-17 2010-08-17 Veridex, Llc Diagnostic imaging device for the analysis of circulating rare cells
CN200945454Y (zh) * 2006-06-16 2007-09-12 复旦大学 一种便携式磁性分离笔
US7828968B2 (en) * 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets

Also Published As

Publication number Publication date
CN101533012B (zh) 2013-12-25
EP2090889B1 (de) 2012-01-04
HK1137810A1 (en) 2010-08-06
JP5507092B2 (ja) 2014-05-28
JP2009192539A (ja) 2009-08-27
ES2377178T3 (es) 2012-03-23
CN101533012A (zh) 2009-09-16
US20110014686A1 (en) 2011-01-20
US20090061477A1 (en) 2009-03-05
EP2090889A1 (de) 2009-08-19
US7828968B2 (en) 2010-11-09

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