ATE538380T1 - Nukleinsäure-programmierbare protein-arrays - Google Patents

Nukleinsäure-programmierbare protein-arrays

Info

Publication number
ATE538380T1
ATE538380T1 AT02707542T AT02707542T ATE538380T1 AT E538380 T1 ATE538380 T1 AT E538380T1 AT 02707542 T AT02707542 T AT 02707542T AT 02707542 T AT02707542 T AT 02707542T AT E538380 T1 ATE538380 T1 AT E538380T1
Authority
AT
Austria
Prior art keywords
nucleic acid
protein arrays
acid programmable
programmable protein
arrays
Prior art date
Application number
AT02707542T
Other languages
English (en)
Inventor
Joshua Labaer
Albert Lau
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE538380T1 publication Critical patent/ATE538380T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT02707542T 2001-01-23 2002-01-22 Nukleinsäure-programmierbare protein-arrays ATE538380T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26360701P 2001-01-23 2001-01-23
PCT/US2002/001882 WO2002059601A1 (en) 2001-01-23 2002-01-22 Nucleic-acid programmable protein arrays

Publications (1)

Publication Number Publication Date
ATE538380T1 true ATE538380T1 (de) 2012-01-15

Family

ID=23002490

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02707542T ATE538380T1 (de) 2001-01-23 2002-01-22 Nukleinsäure-programmierbare protein-arrays

Country Status (6)

Country Link
US (2) US6800453B2 (de)
EP (1) EP1360490B1 (de)
JP (3) JP4880188B2 (de)
AT (1) ATE538380T1 (de)
CA (1) CA2434139C (de)
WO (1) WO2002059601A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60120713T2 (de) 2000-08-15 2007-06-06 Discerna Ltd. Funktionelles protein array
JP4880188B2 (ja) * 2001-01-23 2012-02-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 核酸プログラム型タンパク質アレイ
EP1392342B1 (de) * 2001-05-11 2015-09-23 Yale University Globale analyse von proteinaktivitäten unter verwendung von proteom-chips
CA2458227A1 (en) * 2001-08-22 2003-03-06 Helix Biopharma Corporation Method and device for integrated protein expression, purification and detection
US20030162179A1 (en) * 2002-02-27 2003-08-28 General Electric Company Fabrication, performance testing, and screening of three dimensional arrays of materials
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
US20030235814A1 (en) * 2002-06-19 2003-12-25 Los Alamos National Laboratory Compositions and methods for selecting open reading frames
US20040043384A1 (en) * 2002-08-28 2004-03-04 Oleinikov Andrew V. In vitro protein translation microarray device
KR100523212B1 (ko) * 2003-01-04 2005-10-24 한국과학기술원 반응 단백질과 그의 기질 펩타이드간의 반응분석을 위한단백질 칩
US20040209243A1 (en) 2003-01-07 2004-10-21 Andrew Nixon Kunitz domain library
TW200412373A (en) * 2003-01-15 2004-07-16 Univ Nat Taiwan RCA combined nanoparticle-based optical detection technique for protein microarray
EP2455458B1 (de) 2003-01-31 2015-01-07 Promega Corporation Kovalentes Anbinden von Funktionsgruppen an Proteine
US7429472B2 (en) * 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
US7585815B2 (en) * 2003-07-24 2009-09-08 Lawrence Livermore National Security, Llc High throughput protein production screening
US7754497B2 (en) * 2003-08-29 2010-07-13 Reverse Proteomics Research Institute Co., Ltd. Method for immobilizing proteins
WO2005087932A2 (en) * 2003-10-03 2005-09-22 Promega Corporation Vectors for directional cloning
US8293503B2 (en) 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
US20050214890A1 (en) * 2003-11-26 2005-09-29 Zhiqun Tan Novel "Cleave-N-Read" system for protease activity assay and methods of use thereof
US20050260653A1 (en) * 2004-04-14 2005-11-24 Joshua Labaer Nucleic-acid programmable protein arrays
CN102453763A (zh) 2004-06-03 2012-05-16 阿什洛米克斯控股有限公司 诊断应激的药物和方法
US20090054255A1 (en) * 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
US7425436B2 (en) * 2004-07-30 2008-09-16 Promega Corporation Covalent tethering of functional groups to proteins and substrates therefor
US20070087400A1 (en) * 2004-07-30 2007-04-19 Aldis Darzins Covalent tethering of functional groups to proteins and substrates therefor
US7786261B2 (en) * 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains
JP4868731B2 (ja) * 2004-11-17 2012-02-01 独立行政法人理化学研究所 哺乳動物培養細胞由来の無細胞タンパク質合成システム
JP4686682B2 (ja) * 2004-12-02 2011-05-25 国立大学法人名古屋大学 リガンド親和性複合タンパク質の取得方法、抗体スクリーニング方法、抗体スクリーニング用キット、医療方法、抗体医薬、非免疫反応性抗体医薬、投薬方法
JPWO2006062200A1 (ja) * 2004-12-09 2008-06-12 ユニバーサル・バイオ・リサーチ株式会社 核酸ライブラリー及びタンパク質ライブラリー
US20060234265A1 (en) * 2005-03-21 2006-10-19 Jim Richey Microarrays having multi-functional, compartmentalized analysis areas and methods of use
WO2006105409A2 (en) * 2005-03-31 2006-10-05 Perkinelmer Las, Inc. Multiplex assay systems
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
JP2006337153A (ja) * 2005-06-01 2006-12-14 Toppan Printing Co Ltd Ｄｎａ合成判定装置、核酸タンク装置、ｄｎａチップ装置及びｄｎａ判定システム
GB0511717D0 (en) * 2005-06-09 2005-07-13 Babraham Inst Repeatable protein arrays
AU2006269820B2 (en) 2005-07-07 2012-01-19 Athlomics Pty Ltd Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
US7889347B2 (en) 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US20070224620A1 (en) * 2006-02-08 2007-09-27 Promega Corporation Compositions and methods for capturing and analyzing cross-linked biomolecules
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
MX2008016221A (es) 2006-07-05 2009-02-23 Catalyst Biosciences Inc Métodos de selección de proteasa y proteasas identificadas por este medio.
JP5680302B2 (ja) 2006-10-30 2015-03-04 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ キネティクス及び機能発現が高められた突然変異形ヒドロラーゼ・タンパク質
PT2147096E (pt) 2007-04-13 2015-07-21 Catalyst Biosciences Inc Polipéptidos do factor vii modificados e suas utilizações
WO2009058364A1 (en) * 2007-11-01 2009-05-07 The Arizona Board Of Regents On Behalf Of The University Of Arizona Cell-free methods for detecting protein-ligand interctions
US20090305899A1 (en) * 2007-11-16 2009-12-10 Invitrogen Incorporated Compositions and methods for determining immune status
CA2720472C (en) * 2008-04-05 2018-01-02 Single Cell Technology, Inc. Method of screening single cells for the production of biologically active agents
US20100081575A1 (en) * 2008-09-22 2010-04-01 Robert Anthony Williamson Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules
WO2010033229A2 (en) 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of molecules and displayed molecules and collections
DE102009012169B3 (de) * 2009-03-06 2010-11-04 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zum Herstellen eines Replikats oder eines Derivats aus einem Array von Molekülen und Anwendungen derselben
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
CA2763685A1 (en) * 2009-05-29 2010-12-02 The Board Of Regents Of The University Of Texas System Peptoid ligands for isolation and treatment of autoimmune t-cells
WO2010141421A1 (en) * 2009-06-02 2010-12-09 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
WO2011035205A2 (en) 2009-09-18 2011-03-24 Calmune Corporation Antibodies against candida, collections thereof and methods of use
US8759259B2 (en) * 2009-10-16 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
EP2556171B1 (de) 2010-04-05 2015-09-02 Prognosys Biosciences, Inc. Räumlich kodierte biologische assays
WO2011139806A2 (en) * 2010-04-27 2011-11-10 Diomics Corporation Integrated methods and systems for processing a molecular profile
DE102011010307A1 (de) 2011-02-03 2012-08-09 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zur Erzeugung von Protein-Mikroarrays
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
WO2013024821A1 (ja) * 2011-08-12 2013-02-21 国立大学法人筑波大学 並列反応用懸濁液、並列反応方法およびスクリーニング方法
DE102011054101A1 (de) 2011-09-30 2013-04-04 Albert-Ludwigs-Universität Freiburg Verfahren zur räumlichen Anordnung von Probenfragmenten zur Amplifikation und Immobilisierung für weitere Derivatisierungen
US8987174B2 (en) 2011-10-28 2015-03-24 Prognosys Biosciences, Inc. Methods for manufacturing molecular arrays
WO2013090364A1 (en) 2011-12-14 2013-06-20 Arizona Board Of Regents Method and apparatus for measuring phosphorylation kinetics on large arrays
WO2014143954A2 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents On Behalf Of Arizona State University Biosensor microarray compositions and methods
WO2014145458A1 (en) * 2013-03-15 2014-09-18 Arizona Board Of Regents On Behalf Of Arizona State University Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling
CA2907050C (en) 2013-03-15 2023-09-26 Prognosys Biosciences, Inc. Methods for detecting peptide/mhc/tcr binding
DK3013983T3 (da) 2013-06-25 2023-03-06 Prognosys Biosciences Inc Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
WO2015175755A1 (en) * 2014-05-15 2015-11-19 Arizona Board Of Regents On Behalf Of Arizona State University Nucleic acid-guided ordered protein assemblies and methods
US20160195546A1 (en) 2015-01-07 2016-07-07 Arizona Board Of Regents On Behalf Of Arizona State University Type 1 Diabetes Biomarkers
DK3901281T3 (da) 2015-04-10 2023-01-23 Spatial Transcriptomics Ab Rumligt adskilt, multipleks nukleinsyreanalyse af biologiske prøver
US11884978B2 (en) 2015-09-30 2024-01-30 Immunexpress Pty Ltd Pathogen biomarkers and uses therefor
EP3998345A1 (de) 2015-12-24 2022-05-18 ImmuneXpress Pty Ltd Triage-biomarker und verwendungen dafür
CN110199019A (zh) 2016-05-02 2019-09-03 Encodia有限公司 采用核酸编码的大分子分析
US10055620B2 (en) * 2017-01-13 2018-08-21 International Business Machines Corporation Baggage handling
US10648978B2 (en) 2017-02-09 2020-05-12 Mayo Foundation For Medical Education And Research Methods for detecting novel autoantibodies in Crohn's disease
WO2019079334A1 (en) * 2017-10-16 2019-04-25 Inanobio, Inc. DISEASE PROTEASE PROTEIN NETWORKS AND USES THEREOF
KR102556494B1 (ko) 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
EP3791188A1 (de) 2018-05-10 2021-03-17 The Methodist Hospital Verfahren zur prognose und behandlung einer krankheit
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP4025711A2 (de) 2019-11-08 2022-07-13 10X Genomics, Inc. Erhöhung der spezifität einer analytbindung
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
EP4219754B1 (de) 2019-12-23 2024-05-15 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von rna-template-ligation
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
EP4139485B1 (de) 2020-04-22 2023-09-06 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4158054A1 (de) 2020-06-02 2023-04-05 10X Genomics, Inc. Räumliche transkriptomik für antigenrezeptoren
WO2021247543A2 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Nucleic acid library methods
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4165207A1 (de) 2020-06-10 2023-04-19 10X Genomics, Inc. Verfahren zur bestimmung einer position eines analyten in einer biologischen probe
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
AU2022238446A1 (en) 2021-03-18 2023-09-07 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
EP4196605A1 (de) 2021-09-01 2023-06-21 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2028165A (en) * 1978-08-17 1980-03-05 Pilkington Brothers Ltd Treatment of flat glass
NL8102178A (nl) * 1981-05-02 1982-12-01 Stichting Centraal Lab Werkwijze voor het aantonen van tegen bepaalde antigenen gerichte antistoffen, alsmede inrichting en reagentia voor het uitvoeren van deze werkwijze.
SE8801070D0 (sv) * 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
US4868311A (en) * 1988-04-02 1989-09-19 The Trustees Of Columbia University In The City Of New York Biotinylated psoralens
AU649217B2 (en) * 1988-11-18 1994-05-19 Regents Of The University Of California, The Method for site-specifically incorporating unnatural amino acids into proteins
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6919211B1 (en) * 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5874564A (en) * 1990-03-21 1999-02-23 Isis Pharmaceuticals, Inc. Reagents and methods for modulating gene expression through RNA mimicry
US5283179A (en) 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method
US6399296B1 (en) * 1994-07-20 2002-06-04 The General Hospital Corporation Interaction trap systems for detecting protein interactions
PT937098E (pt) 1995-06-07 2002-12-31 Invitrogen Corp Clonagem recombinatoria in vitro utilizando locais de recombinacao modificados
US6143557A (en) 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
JPH1025299A (ja) 1996-07-12 1998-01-27 Nec Corp 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法
SE9604108D0 (sv) * 1996-11-08 1996-11-08 Maans Ehrenberg A method for the labelling of polypeptides and novel labelled polypeptides
EP1712623B1 (de) 1997-01-21 2011-10-19 The General Hospital Corporation Selektion von Proteinen unter Verwendung von RNA-Protein-Fusionen
EP1046036A4 (de) 1997-07-29 2003-08-27 James S Huston Verfahren zum erlangen von sonden mit peptidfunktion
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
ATE311443T1 (de) * 1997-09-03 2005-12-15 Biovation Ltd Methoden zur durchforstung (screenen) von proteinen
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6303323B1 (en) * 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6914137B2 (en) * 1997-12-06 2005-07-05 Dna Research Innovations Limited Isolation of nucleic acids
EP1068356B8 (de) * 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Adressierbare protein arrays
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
EP1018408B1 (de) * 1998-12-28 2002-10-02 Adolf Mohr Maschinenfabrik GmbH & Co. KG Planschneidmaschine zum Schneiden von gestapeltem, blattförmigem Gut
US6251601B1 (en) 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
CA2365431A1 (en) 1999-03-10 2000-09-14 Hui Ge Universal protein array system
US6225061B1 (en) * 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
GB9917027D0 (en) 1999-07-20 1999-09-22 Affibody Technology Sweeden Ab In vitro selection and optional identification of polypeptides using solid support carriers
GB9928787D0 (en) 1999-12-03 2000-02-02 Medical Res Council Direct screening method
AU2788101A (en) 2000-01-11 2001-07-24 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
WO2001057198A2 (en) 2000-01-31 2001-08-09 Sense Proteomic Limited Methods of generating protein expression arrays and the use thereof in rapid screening
US7816098B2 (en) * 2000-01-31 2010-10-19 Sense Proteomic Limited Methods of making and using a protein array
US20010041349A1 (en) * 2000-04-17 2001-11-15 Andrew Patron Protein expression system arrays and use in biological screening
US8399383B2 (en) 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
US20020049152A1 (en) 2000-06-19 2002-04-25 Zyomyx, Inc. Methods for immobilizing polypeptides
ES2292596T3 (es) 2000-06-23 2008-03-16 Domantis Limited Procedimiento de rastreo de matriz.
US6706474B1 (en) * 2000-06-27 2004-03-16 Board Of Trustees Of The University Of Illinois Nucleic acid enzyme biosensors for ions
CA2418105A1 (en) 2000-08-03 2002-02-14 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
DE60120713T2 (de) * 2000-08-15 2007-06-06 Discerna Ltd. Funktionelles protein array
WO2002018648A2 (en) 2000-08-25 2002-03-07 President And Fellows Of Harvard College Analysis of binding interactions
US6420150B1 (en) * 2000-11-27 2002-07-16 Pe Corporation (Ny) Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
WO2002064834A1 (en) * 2001-01-04 2002-08-22 Myriad Genetics, Inc. Novel two-hybrid system and use thereof
JP4880188B2 (ja) * 2001-01-23 2012-02-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 核酸プログラム型タンパク質アレイ
US20020168640A1 (en) * 2001-02-22 2002-11-14 Min Li Biochips comprising nucleic acid/protein conjugates
EP2423673B8 (de) * 2001-06-29 2020-10-28 Meso Scale Technologies, LLC. Vorrichtung zum Messen der Lumineszenz aus einer Multi-Well-Testplatte mit mehreren Wells, Verfahren zum Messen der Lumineszenz unter Verwendung der Vorrichtung und System welches die Vorrichtung umfasst
US6929944B2 (en) 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
WO2003031591A2 (en) 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
DE60309317T2 (de) * 2002-06-03 2007-05-31 Pamgene B.V. Biomolekulares kinetik-messverfahren mit hilfe von einem durchfluss-mikroarray
WO2004011031A1 (en) 2002-07-29 2004-02-05 Potomac, Pharma, Llc. Antipsychotic combination therapies and compositions of an alpha-2 adrenergic receptor antagonist and an atypical antipsychotic neuroleptic
EP1578428A4 (de) 2002-10-18 2008-11-26 Massachusetts Mental Health In Behandlung von alkohol- oderdrogenmissbrauch durch antagonisierung von alpha-a2 drenergen rezeptoren mitschwacher dopamin-blockierung
US20040076961A1 (en) * 2002-10-21 2004-04-22 Lewis Mark A. Biomolecule retaining material and methods for attaching biomolecules to a surface
US7276283B2 (en) * 2004-03-24 2007-10-02 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of carbon-containing substrates
US20050260653A1 (en) * 2004-04-14 2005-11-24 Joshua Labaer Nucleic-acid programmable protein arrays
WO2006020126A2 (en) * 2004-07-14 2006-02-23 Protometrix, Inc. Method for providing protein microarrays
US20060207467A1 (en) * 2005-03-19 2006-09-21 Bailey Samuel W Low voltage pyrotechnic igniter assembly
GB0511717D0 (en) * 2005-06-09 2005-07-13 Babraham Inst Repeatable protein arrays
US8178316B2 (en) * 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins

Also Published As

Publication number Publication date
US8609344B2 (en) 2013-12-17
JP4880188B2 (ja) 2012-02-22
JP2004536565A (ja) 2004-12-09
JP2010119392A (ja) 2010-06-03
WO2002059601A1 (en) 2002-08-01
US6800453B2 (en) 2004-10-05
EP1360490B1 (de) 2011-12-21
US20020192673A1 (en) 2002-12-19
CA2434139A1 (en) 2002-08-01
JP2009150897A (ja) 2009-07-09
CA2434139C (en) 2014-05-27
EP1360490A1 (de) 2003-11-12
EP1360490A4 (de) 2007-11-28
US20050048580A1 (en) 2005-03-03

Similar Documents

Publication Publication Date Title
ATE538380T1 (de) Nukleinsäure-programmierbare protein-arrays
DK1448595T3 (da) Antimikrobielle polypeptider
PT1398322E (pt) Polipeptidos hasilados, especialmente eritropoietina hasilada
NO20041098L (no) Ledende mikrotiterplate
BR0308735B1 (pt) escova de dente acionada.
NL1026264A1 (nl) Compacte precisiebundelmanipulatoren.
DK1436309T3 (da) BGL3-beta-glukosidase og nukleinsyrer kodende derfor
DK1214097T3 (da) Nukleinsyrer kodende for polyepitop-polypeptider
ATE454393T1 (de) Egvii-endoglucanase und dafür codierende nukleinsäuren
DK1752470T3 (da) GAG-bindende proteiner
DE10295504T1 (de) Protonen-selektive leitende Membranen
IL163686A0 (en) Artificial receptors, building blocks, and methods
NO20023132L (no) Asimut-propell
DK0981631T3 (da) Polypeptider, som har aminopeptidase-aktivitet, og nukleinsyrer, som koder for samme
NO20034452L (no) Sykdoms-assosiert protein
BR9916507A (pt) Proteìnas
DE60330489D1 (de) Schnell abgebaute reporter-fusionsproteine
NO20053511D0 (no) Nye fibrillin-liknende polypeptider
DE60207504D1 (de) Modulares Bass-Array
AU2003225685A1 (en) Method of preparing a protein array based on biochemical protein-protein interaction
DK1196607T3 (da) Antibakterielt chlamysin B-protein, gen kodende derfor samt ekspressionssystem
NO20053579D0 (no) Nye preadipocyttfaktor-1-liknende polypeptider.
NO20024029L (no) Nytt protein og gen som koder for proteinet
ITTO20020969A1 (it) Concentratore chimico per proteine.
AU2002259137A1 (en) Methods for determining secondary modifications of molecules using arrays