ATE538110T1 - Herstellung von taxol und von docetaxel unter verwendung primärer amine - Google Patents

Herstellung von taxol und von docetaxel unter verwendung primärer amine

Info

Publication number
ATE538110T1
ATE538110T1 AT96907021T AT96907021T ATE538110T1 AT E538110 T1 ATE538110 T1 AT E538110T1 AT 96907021 T AT96907021 T AT 96907021T AT 96907021 T AT96907021 T AT 96907021T AT E538110 T1 ATE538110 T1 AT E538110T1
Authority
AT
Austria
Prior art keywords
taxol
primary amine
docetaxel
production
imine
Prior art date
Application number
AT96907021T
Other languages
English (en)
Inventor
Christopher K Murray
Quy Y Zheng
S Kent Peterson
Xiaoqin Cheng
Original Assignee
Natural Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natural Pharmaceuticals Inc filed Critical Natural Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE538110T1 publication Critical patent/ATE538110T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96907021T 1995-01-30 1996-01-30 Herstellung von taxol und von docetaxel unter verwendung primärer amine ATE538110T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/380,679 US5679807A (en) 1995-01-30 1995-01-30 Preparation of taxol and docetaxel through primary amines
PCT/US1996/001322 WO1996023780A1 (en) 1995-01-30 1996-01-30 Preparation of taxol and docetaxel through primary amines

Publications (1)

Publication Number Publication Date
ATE538110T1 true ATE538110T1 (de) 2012-01-15

Family

ID=23502073

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96907021T ATE538110T1 (de) 1995-01-30 1996-01-30 Herstellung von taxol und von docetaxel unter verwendung primärer amine

Country Status (7)

Country Link
US (2) US5679807A (de)
EP (1) EP0852581B1 (de)
JP (1) JPH11502516A (de)
AT (1) ATE538110T1 (de)
AU (1) AU694627B2 (de)
CA (1) CA2211799C (de)
WO (1) WO1996023780A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018186A1 (en) 1993-02-05 1994-08-18 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable a-ring side chains
US6002025A (en) * 1999-02-24 1999-12-14 Bcm Developement Inc. Method for the purification of taxanes
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US6656966B2 (en) 2000-06-22 2003-12-02 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
CA2441484A1 (en) * 2001-03-23 2002-10-03 Napro Biotherapeutics, Inc. Molecular conjugates for use in treatment of cancer
US6846937B2 (en) * 2001-10-05 2005-01-25 The University Of Toledo Method for the selective removal of acyl-functionality attached to the 2'-hydroxy-group of paclitaxel-related derivatives
ATE405556T1 (de) * 2002-04-05 2008-09-15 Natural Pharmaceuticals Inc Umwandlung von taxanmolekülen
WO2003094952A1 (en) * 2002-05-10 2003-11-20 Agennix Incorporated Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
ES2503265T3 (es) * 2002-08-04 2014-10-06 Phyton Holdings, Llc Métodos para convertir amidas de taxano en paclitaxel u otros taxanos
EP1599457A4 (de) * 2003-02-04 2008-05-07 Natural Pharmaceuticals Inc Verfahren und zusammensetzung für die zubereitung einer verbindung mit einem im wesentlichen ringchlorierungsfreien benzoylierenden wirkstoff
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
WO2005061474A1 (en) * 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
US20050192445A1 (en) * 2004-03-01 2005-09-01 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
US7585986B2 (en) * 2004-02-24 2009-09-08 Chatham Biotec, Limited Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
CA2563838C (en) * 2004-04-23 2012-06-19 Phytogen Life Sciences Inc. Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US7893283B2 (en) * 2004-06-04 2011-02-22 Chatham Biotec, Limited Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20050288520A1 (en) 2004-06-25 2005-12-29 Phytogen Life Sciences Inc. One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
US20050288521A1 (en) * 2004-06-29 2005-12-29 Phytogen Life Sciences Inc. Semi-synthetic conversion of paclitaxel to docetaxel
FR2882363B1 (fr) * 2005-02-24 2007-05-11 Seripharm Procede de preparation du docetaxel
CN100374429C (zh) * 2006-06-19 2008-03-12 昆明多希生物技术有限公司 以10-去乙酰紫杉醇为原料转化生产多烯紫杉醇的方法
CA2686915A1 (en) * 2008-12-04 2010-06-04 Queen's University At Kingston Schwartz reagents: methods of in situ generation and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5356928A (en) * 1992-11-06 1994-10-18 Hauser Chemical Research, Inc. Cytotoxic agents

Also Published As

Publication number Publication date
AU694627B2 (en) 1998-07-23
EP0852581A4 (de) 1998-07-15
AU5021096A (en) 1996-08-21
CA2211799A1 (en) 1996-08-08
WO1996023780A1 (en) 1996-08-08
JPH11502516A (ja) 1999-03-02
US5679807A (en) 1997-10-21
EP0852581A1 (de) 1998-07-15
EP0852581B1 (de) 2011-12-21
CA2211799C (en) 2010-04-27
US5808113A (en) 1998-09-15

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