ATE533857T1 - Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen - Google Patents

Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen

Info

Publication number
ATE533857T1
ATE533857T1 AT04702748T AT04702748T ATE533857T1 AT E533857 T1 ATE533857 T1 AT E533857T1 AT 04702748 T AT04702748 T AT 04702748T AT 04702748 T AT04702748 T AT 04702748T AT E533857 T1 ATE533857 T1 AT E533857T1
Authority
AT
Austria
Prior art keywords
mrna
pregnancy
amount
circulative
mrna species
Prior art date
Application number
AT04702748T
Other languages
English (en)
Inventor
Yuk-Ming Dennis Lo
Kai On Ng
Bo Yin Tsui
Wai Kwun Rossa Chiu
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Application granted granted Critical
Publication of ATE533857T1 publication Critical patent/ATE533857T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
AT04702748T 2003-01-17 2004-01-16 Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen ATE533857T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44090603P 2003-01-17 2003-01-17
PCT/GB2004/000145 WO2004065629A1 (en) 2003-01-17 2004-01-16 Circulating mrna as diagnostic markers for pregnancy-related disorders

Publications (1)

Publication Number Publication Date
ATE533857T1 true ATE533857T1 (de) 2011-12-15

Family

ID=32771876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04702748T ATE533857T1 (de) 2003-01-17 2004-01-16 Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen

Country Status (9)

Country Link
US (3) US7235359B2 (de)
EP (1) EP1583846B1 (de)
JP (1) JP4624977B2 (de)
CN (3) CN101245376A (de)
AT (1) ATE533857T1 (de)
AU (1) AU2004205774B2 (de)
CA (1) CA2513292C (de)
HK (2) HK1083227A1 (de)
WO (1) WO2004065629A1 (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767422B2 (en) * 1998-09-22 2010-08-03 Oncomedx, Inc. Detection of 5T4 RNA in plasma and serum
AU2001285157A1 (en) * 2000-08-28 2002-03-13 Oncomedx, Inc. 5t4 rna in plasma and serum as a marker for neoplastic disease
US20040009518A1 (en) * 2002-05-14 2004-01-15 The Chinese University Of Hong Kong Methods for evaluating a disease condition by nucleic acid detection and fractionation
AU2005337873A1 (en) * 2004-12-15 2007-05-10 Beth Israel Deaconess Medical Center Nucleic acids and polypeptides useful for diagnosing and treating complications of pregnancy
JP5219516B2 (ja) * 2005-03-18 2013-06-26 ザ チャイニーズ ユニバーシティー オブ ホンコン 染色体異数性の検出方法
EP2612928A3 (de) 2005-03-18 2013-09-11 The Chinese University Of Hong Kong Marker zur pränatalen Diagnose und Überwachung
WO2007044091A2 (en) * 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
EP1762575A1 (de) 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identifizierung Tumor-assoziierter Antigene für Diagnoseund Therapie
US7888017B2 (en) * 2006-02-02 2011-02-15 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive fetal genetic screening by digital analysis
US7790463B2 (en) * 2006-02-02 2010-09-07 Yale University Methods of determining whether a pregnant woman is at risk of developing preeclampsia
KR20080107464A (ko) * 2006-03-06 2008-12-10 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 혼합된 태아-모체 소스로부터 태아 dna 서열의 특이적 증폭
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
TWI335354B (en) 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
EP1970384A1 (de) 2007-03-14 2008-09-17 Ganymed Pharmaceuticals AG Monoklonale Antikörper zur Krebsbehandlung
JP5191041B2 (ja) * 2007-04-05 2013-04-24 エフ.ホフマン−ラ ロシュ アーゲー 急速ワンステップrt−pcr
JP5487555B2 (ja) * 2007-04-13 2014-05-07 国立大学法人 長崎大学 胎盤機能の網羅的かつ非侵襲的評価方法および検査用試薬
EP2147309A4 (de) * 2007-05-05 2010-08-04 Univ Western Ontario Verfahren für den nachweis von präeklampsie
PT2557517T (pt) 2007-07-23 2023-01-04 Univ Hong Kong Chinese Determinação de um desequilíbrio de sequências de ácido nucleico
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
US9404150B2 (en) 2007-08-29 2016-08-02 Sequenom, Inc. Methods and compositions for universal size-specific PCR
AU2009205956B2 (en) 2008-01-18 2015-07-02 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
EP2271772B1 (de) 2008-03-11 2014-07-16 Sequenom, Inc. Tests auf nukleinsäurebasis zur pränatalen geschlechtsbestimmung
US20090312411A1 (en) * 2008-03-27 2009-12-17 New York Society For The Raptured And Crippled Maintaining The Hospital For Special Surgery Preventing or reducing risk of miscarriages
EP2166021A1 (de) * 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Monoklonale Antikörper zur Krebsbehandlung
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
SI2334812T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
CN110187120B (zh) * 2008-10-31 2022-07-01 耶鲁大学 子痫前期检测和治疗的方法和组合物
GB0820999D0 (en) 2008-11-17 2008-12-24 Menon Johansson Anatole S Pregnancy testing
EP2199956A1 (de) * 2008-12-18 2010-06-23 Siemens Aktiengesellschaft Verfahren und System zum Verwalten von Ergebnissen eines Analyseverfahrens an Gegenständen, die entlang einer technischen Verfahrenslinie gehandhabt werden
US8404444B2 (en) * 2009-02-25 2013-03-26 Diacarta Llc Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid
CN101643785B (zh) * 2009-06-18 2011-12-21 中国人民解放军第二军医大学 用于妊娠高血压综合症检测的hsa-mir-210试剂盒及检测方法
EP2446267A1 (de) * 2009-06-24 2012-05-02 Health Corporation - Rambam Verfahren und kits zur isolation von plazentalen mikropartikeln und ihre verwendung zur diagnose von fetalen erkrankungen
CA2779750C (en) 2009-11-06 2019-03-19 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
WO2011087760A2 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
WO2011091046A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
EP2366031B1 (de) 2010-01-19 2015-01-21 Verinata Health, Inc Sequenzierungsverfahren in pränatale diagnosen
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
EP2371864A1 (de) 2010-03-23 2011-10-05 Ganymed Pharmaceuticals AG Monoklonale Antikörper zur Krebsbehandlung
KR20130123357A (ko) * 2010-06-07 2013-11-12 오스나트 에슈어-파비안 저산소증과 관련된 질환의 진단방법 및 키트
WO2011156763A1 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
CN103109192A (zh) * 2010-06-18 2013-05-15 塞尚公司 用于妊娠性高血压和先兆子痫的预后和风险评估的标志物
EP2596116A4 (de) 2010-07-23 2014-03-19 Harvard College Verfahren zur erkennung von autoimmun- oder autoimmunbezogenen erkrankungen oder leiden
US20120053073A1 (en) 2010-07-23 2012-03-01 President And Fellows Of Harvard College Methods for Detecting Signatures of Disease or Conditions in Bodily Fluids
WO2012012717A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
CN103124795A (zh) 2010-07-23 2013-05-29 哈佛大学校长及研究员协会 利用吞噬细胞检测疾病或病症的方法
GB201013151D0 (en) * 2010-08-04 2010-09-22 Isis Innovation Diagnostic method
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
JP5782704B2 (ja) * 2010-11-11 2015-09-24 東ソー株式会社 GAPDHmRNAの測定方法
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
EP3378954B1 (de) 2011-04-29 2021-02-17 Sequenom, Inc. Quantifizierung einer minderheitsvariante einer nukleinsäure
US9719129B2 (en) 2011-06-10 2017-08-01 Hitachi Chemical Co., Ltd. Methods for isolating vesicles from biological fluids
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
CA2863035C (en) 2012-01-27 2023-08-29 The Board Of Trustees Of The Leland Stanford Junior University Methods for profiling and quantitating cell-free rna
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US20130237442A1 (en) * 2012-03-07 2013-09-12 University Of Miami Methods and Compositions for Diagnosis of Non-Viable Early Pregnancy
EP2852682B1 (de) 2012-05-21 2017-10-04 Fluidigm Corporation Einzelpartikelanalyse von teilchenpopulationen
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CN104583421A (zh) 2012-07-19 2015-04-29 阿瑞奥萨诊断公司 遗传变体的基于多重的顺序连接的检测
KR101595439B1 (ko) * 2012-12-26 2016-02-19 웰스바이오 주식회사 산모 혈장의 mRNA 발현 차이를 이용한 태아의 염색체 이상 질환의 선별방법
SG11201506516TA (en) * 2013-02-28 2015-09-29 Univ Hong Kong Chinese Maternal plasma transcriptome analysis by massively parallel rna sequencing
GB201318465D0 (en) * 2013-10-18 2013-12-04 Oxford Nanopore Tech Ltd Method
US11585814B2 (en) 2013-03-09 2023-02-21 Immunis.Ai, Inc. Methods of detecting prostate cancer
NZ771629A (en) 2013-03-09 2022-12-23 Harry Stylli Methods of detecting cancer
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
ES2836127T3 (es) * 2013-03-15 2021-06-24 Sera Prognostics Inc Biomarcadores y métodos para predecir el parto prematuro
CN105189748B (zh) 2013-03-15 2021-06-08 血统生物科学公司 测序免疫组库的方法
DE212013000295U1 (de) 2013-05-06 2016-02-02 Hitachi Chemical Co. America, Ltd. Vorrichtungen zum Einfangen von Zielmolekülen
EP3495502B1 (de) * 2013-07-24 2021-09-08 The Chinese University Of Hong Kong Biomarker für frühgeburt
WO2015042708A1 (en) 2013-09-25 2015-04-02 Bio-Id Diagnostic Inc. Methods for detecting nucleic acid fragments
EP3117011B1 (de) 2014-03-13 2020-05-06 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
EP3693742B1 (de) 2014-09-11 2022-04-06 Harry Stylli Verfahren zum nachweis von prostatakrebs
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
US10370719B2 (en) 2014-11-12 2019-08-06 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
CN104593494B (zh) * 2015-01-12 2016-06-08 华中农业大学 猪初生重性状相关plac1基因分子标记的克隆及应用
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
CN105200150B (zh) * 2015-10-29 2019-03-01 北京泱深生物信息技术有限公司 作为骨关节炎诊治靶标的plac1基因
CA3032944A1 (en) * 2016-08-05 2018-02-08 Sera Prognostics, Inc. Biomarkers for predicting preterm birth in a pregnant female exposed to progestogens
EP3775260A4 (de) * 2018-03-28 2021-12-01 Certara USA, Inc. Verfahren und vorrichtung zur quantifizierung der proteinabundanz in gewebe durch zellfreie ribonukleinsäuren bei einer flüssigbiopsie
KR102605749B1 (ko) * 2018-05-25 2023-11-23 일루미나, 인코포레이티드 자간전증에 특이적인 순환 rna 시그니처
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
GB2597379B (en) 2019-02-14 2022-12-28 Mirvie Inc Methods and systems for determining a pregnancy-related state of a subject
CN110846400A (zh) * 2019-10-30 2020-02-28 吉林大学 人外周血循环FST mRNA检测试剂盒及其用途
CA3131748A1 (en) 2019-11-22 2021-05-27 Sarah E. SHULTZABERGER Circulating rna signatures specific to preeclampsia
CN110951863B (zh) * 2019-12-26 2023-06-02 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) 胎盘植入性疾病标志物
CN110938687B (zh) * 2019-12-26 2023-06-27 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) 胎盘植入性疾病标志物
KR20220102743A (ko) * 2021-01-14 2022-07-21 연세대학교 산학협력단 자간전증 또는 자간증의 예방 또는 치료용 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075212A (en) 1989-03-27 1991-12-24 University Of Patents, Inc. Methods of detecting picornaviruses in biological fluids and tissues
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
FR2745638A1 (fr) * 1996-03-04 1997-09-05 Roussy Inst Gustave Procede pour la detection de la transformation maligne de cellules humaines
JP2001524808A (ja) * 1996-12-10 2001-12-04 ジーントレイス・システムズ・インコーポレイテッド 放出可能な不揮発性の質量標識分子
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20020102530A1 (en) * 2000-07-07 2002-08-01 Keith James C. Methods and compositions for diagnosing and treating preeclampsia and gestational trophoblast disorders
US6664056B2 (en) * 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
RU2284035C2 (ru) 2001-06-19 2006-09-20 Айдахо Рисерч Фаундейшн Определение статуса беременности
US7112662B2 (en) * 2001-09-19 2006-09-26 Takeda Pharmaceutical Company Limited Anti-metasin antibodies and their methods of use
US20040009518A1 (en) * 2002-05-14 2004-01-15 The Chinese University Of Hong Kong Methods for evaluating a disease condition by nucleic acid detection and fractionation

Also Published As

Publication number Publication date
AU2004205774A1 (en) 2004-08-05
HK1122338A1 (en) 2009-05-15
US7829285B2 (en) 2010-11-09
US20040203037A1 (en) 2004-10-14
CN101245376A (zh) 2008-08-20
CA2513292A1 (en) 2004-08-05
EP1583846A1 (de) 2005-10-12
US20090162842A1 (en) 2009-06-25
JP4624977B2 (ja) 2011-02-02
US20080153090A1 (en) 2008-06-26
EP1583846B1 (de) 2011-11-16
HK1083227A1 (en) 2006-06-30
JP2006515517A (ja) 2006-06-01
CN101260429A (zh) 2008-09-10
US7235359B2 (en) 2007-06-26
CN1723289A (zh) 2006-01-18
CA2513292C (en) 2016-04-05
AU2004205774B2 (en) 2006-12-14
WO2004065629A1 (en) 2004-08-05
CN100379882C (zh) 2008-04-09
CN101260429B (zh) 2011-03-30

Similar Documents

Publication Publication Date Title
ATE533857T1 (de) Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen
Richter et al. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos
Pohler et al. Use of bovine pregnancy-associated glycoproteins to predict late embryonic mortality in postpartum Nelore beef cows
Spencer Screening for trisomy 21 in twin pregnancies in the first trimester using free β‐hCG and PAPP‐A, combined with fetal nuchal translucency thickness
Wald et al. Combining ultrasound and biochemistry in first‐trimester screening for Down's syndrome
TW200643175A (en) Markers for prenatal diagnosis and monitoring
Metzenbauer et al. First‐trimester placental volume as a marker for chromosomal anomalies: preliminary results from an unselected population
Kindahl et al. Endocrine changes in late bovine pregnancy with special emphasis on fetal well-being
Spencer et al. The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β‐hCG and PAPP‐A at 10–14 weeks of gestation
Ay et al. Screening for pre‐eclampsia by using maternal serum inhibin A, activin A, human chorionic gonadotropin, unconjugated estriol, and alpha‐fetoprotein levels and uterine artery Doppler in the second trimester of pregnancy
DE05739600T1 (de) Adam12, ein neuer marker für abnormale zellfunktion
Farag et al. Prediction of preeclampsia: can it be achieved?
Comstock et al. Is there a nuchal translucency millimeter measurement above which there is no added benefit from first trimester serum screening?
Engels et al. First‐trimester serum marker distribution in singleton pregnancies conceived with assisted reproduction
Matilainen et al. In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies
CA2576646A1 (en) System and method for assessing fetal abnormality based on landmarks
Simões et al. Assessment of luteal function by ultrasonographic appearance and measurement of corpora lutea in goats
Svirsky et al. First‐and second‐trimester maternal serum markers of pre‐eclampsia in twin pregnancy
CN106796241A (zh) 确定先兆子痫风险的方法
Hang Lam et al. Comparison and integration of first trimester fetal nuchal translucency and second trimester maternal serum screening for fetal Down syndrome
Christiansen et al. Human placental lactogen is a first‐trimester maternal serum marker of Down syndrome
Li et al. Maternal serum anti‐Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies
JPH09113508A (ja) 妊娠異常について妊娠期間中にスクリーニングするための方法および装置
Lam et al. The effect of fetal gender on nuchal translucency at 10–14 weeks of gestation
Prakash et al. Serum uric acid as marker for diagnosing preeclampsia