ATE533358T1 - Verfahren zum kontrollieren von schädlingen mittels rnai - Google Patents

Verfahren zum kontrollieren von schädlingen mittels rnai

Info

Publication number
ATE533358T1
ATE533358T1 AT06849359T AT06849359T ATE533358T1 AT E533358 T1 ATE533358 T1 AT E533358T1 AT 06849359 T AT06849359 T AT 06849359T AT 06849359 T AT06849359 T AT 06849359T AT E533358 T1 ATE533358 T1 AT E533358T1
Authority
AT
Austria
Prior art keywords
rnai
controlling pests
double stranded
stranded rna
rna molecules
Prior art date
Application number
AT06849359T
Other languages
German (de)
English (en)
Inventor
Romaan Raemaekers
Pascale Feldmann
Geert Plaetinck
Irene Nooren
Els Bleu
Frederic Pecqueur
Laurent Kubler
Nicole Damme
Lies Degrave
Isabel Remory
Original Assignee
Devgen Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devgen Nv filed Critical Devgen Nv
Application granted granted Critical
Publication of ATE533358T1 publication Critical patent/ATE533358T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/60—Isolated nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Insects & Arthropods (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catching Or Destruction (AREA)
AT06849359T 2005-09-16 2006-09-18 Verfahren zum kontrollieren von schädlingen mittels rnai ATE533358T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US71803405P 2005-09-16 2005-09-16
US75819106P 2006-01-12 2006-01-12
US77116006P 2006-02-07 2006-02-07
US83791006P 2006-08-16 2006-08-16
IBPCT/IB2006/003446 2006-09-15
PCT/IB2006/004008 WO2007083193A2 (en) 2005-09-16 2006-09-18 Methods for controlling pests using rnai

Publications (1)

Publication Number Publication Date
ATE533358T1 true ATE533358T1 (de) 2011-12-15

Family

ID=38287985

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06849359T ATE533358T1 (de) 2005-09-16 2006-09-18 Verfahren zum kontrollieren von schädlingen mittels rnai

Country Status (14)

Country Link
US (2) US8933042B2 (pt-PT)
EP (5) EP2281876A3 (pt-PT)
JP (2) JP5530632B2 (pt-PT)
CN (1) CN104357447A (pt-PT)
AT (1) ATE533358T1 (pt-PT)
AU (1) AU2006335978B2 (pt-PT)
BR (1) BRPI0615792A2 (pt-PT)
CA (1) CA2622671C (pt-PT)
ES (2) ES2568933T3 (pt-PT)
HU (1) HUE027349T2 (pt-PT)
MX (2) MX348513B (pt-PT)
PL (2) PL2270181T3 (pt-PT)
PT (1) PT2270181E (pt-PT)
WO (1) WO2007083193A2 (pt-PT)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612194B2 (en) 2001-07-24 2009-11-03 Monsanto Technology Llc Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof
CA2693280C (en) 2004-04-09 2017-09-12 Monsanto Technology Llc Compositions and methods for control of insect infestations in plants
US8404927B2 (en) 2004-12-21 2013-03-26 Monsanto Technology Llc Double-stranded RNA stabilized in planta
CN101213301B (zh) * 2005-05-31 2013-02-27 德福根有限公司 用于防治昆虫和蜘蛛类动物的RNAi
PT2295584E (pt) * 2005-09-16 2015-09-22 Devgen Nv Métodos com base em plantas transgénicas para infestações em plantas utilizando arn de interferência
ATE548459T1 (de) 2005-09-16 2012-03-15 Monsanto Technology Llc Verfahren zur genetischen kontrolle von insektenbefall bei pflanzen und zusammensetzungen
WO2007080127A2 (en) * 2006-01-12 2007-07-19 Devgen N.V. Dsrna as insect control agent
US8906876B2 (en) 2006-01-12 2014-12-09 Devgen Nv Methods for controlling pests using RNAi
EP2377939A3 (en) 2006-01-12 2012-01-18 deVGen N.V. Transgenic plant-based methods for plant pests using RNAi
US20080317881A1 (en) 2007-05-09 2008-12-25 Devgen N.V. Method for sustainable transgene transcription
US8097712B2 (en) 2007-11-07 2012-01-17 Beelogics Inc. Compositions for conferring tolerance to viral disease in social insects, and the use thereof
JP2009263362A (ja) * 2008-04-04 2009-11-12 Univ Of Tokushima 二本鎖ｒｎａを用いた害虫駆除剤
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
HUE033056T2 (hu) 2010-03-08 2017-11-28 Monsanto Technology Llc Polinukleotid molekulák génszabályozáshoz növényekben
MX350595B (es) * 2010-04-23 2017-09-11 Novartis Ag * Composiciones organicas para tratar enfermedades relacionadas con beta-enac.
EP3587580A1 (en) * 2010-10-27 2020-01-01 Devgen NV Down-regulating gene expression in insect pests
CN102732554B (zh) 2011-03-31 2015-08-05 中国科学院上海生命科学研究院 一种提高植物抗虫能力的方法
EP2699686B1 (en) * 2011-04-20 2017-11-29 Devgen NV Plants resistant to insect pests
CA2848689A1 (en) 2011-09-13 2013-03-21 Monsanto Technology Llc Methods and compositions for weed control targeting pds
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
UY34822A (es) 2012-05-24 2013-12-31 Seeds Ltd Ab Composiciones y métodos para silenciar la expresión genética
US9688983B2 (en) 2012-12-20 2017-06-27 Dow Agrosciences Llc Nucleic acid molecules that confer resistance to coleopteran pests
EP2941488B1 (en) 2013-01-01 2023-03-22 Monsanto Technology LLC Methods of introducing dsrna to plant seeds for modulating gene expression
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
US10609930B2 (en) 2013-03-13 2020-04-07 Monsanto Technology Llc Methods and compositions for weed control
CN105263329B (zh) 2013-03-13 2020-09-18 孟山都技术公司 用于杂草控制的方法和组合物
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
EP3608412A3 (en) 2013-07-19 2020-04-08 Monsanto Technology LLC Compositions and methods for controlling leptinotarsa
CA2929533C (en) 2013-11-04 2023-06-06 Monsanto Technology Llc Compositions and methods for controlling arthropod parasite and pest infestations
UA119253C2 (uk) 2013-12-10 2019-05-27 Біолоджикс, Інк. Спосіб боротьби із вірусом у кліща varroa та у бджіл
CN105979770B (zh) 2014-01-15 2019-07-05 孟山都技术公司 用于使用epsps多核苷酸的杂草控制的方法和组合物
US11091770B2 (en) 2014-04-01 2021-08-17 Monsanto Technology Llc Compositions and methods for controlling insect pests
WO2015200223A1 (en) 2014-06-23 2015-12-30 Monsanto Technology Llc Compositions and methods for regulating gene expression via rna interference
US11807857B2 (en) 2014-06-25 2023-11-07 Monsanto Technology Llc Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
RU2754955C2 (ru) 2014-07-29 2021-09-08 Монсанто Текнолоджи Ллс Композиции и способы борьбы с насекомыми-вредителями
RU2017111817A (ru) * 2014-10-13 2018-11-15 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Молекулы нуклеиновой кислоты альфа-субъединицы коатомера copi, которые придают устойчивость к жесткокрылым и полужесткокрылым вредителям
MX2017009521A (es) 2015-01-22 2018-11-09 Monsanto Technology Llc Composiciones y métodos para controlar leptinotarsa.
EP3578543A1 (en) 2015-04-17 2019-12-11 Dow AgroSciences LLC Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
US10883103B2 (en) 2015-06-02 2021-01-05 Monsanto Technology Llc Compositions and methods for delivery of a polynucleotide into a plant
AU2016270913A1 (en) 2015-06-03 2018-01-04 Monsanto Technology Llc Methods and compositions for introducing nucleic acids into plants
CN108431207A (zh) 2015-10-12 2018-08-21 美国陶氏益农公司 赋予对鞘翅目和半翅目害虫的抗性的wupa核酸分子
AU2016371636A1 (en) 2015-12-18 2018-06-21 Dow Agrosciences Llc Ribosomal protein L40 (RPL40) nucleic acid molecules that confer resistance to coleopteran and hemipteran pests
US11252965B2 (en) 2016-07-13 2022-02-22 Indiana University Research And Technology Corporation RNAi insecticide materials and methods
WO2018046312A2 (en) * 2016-09-06 2018-03-15 Syngenta Participations Ag Improvements in or relating to gene silencing
WO2018053451A1 (en) 2016-09-16 2018-03-22 Pebble Labs Novel paratransgenic system for the biocontrol of disease-transmitting mosquitos
CN118044519A (zh) * 2016-10-12 2024-05-17 科迪华农业科技有限责任公司 具有杀虫效用的分子、以及与其相关的中间体、组合物和方法
US20200071713A1 (en) * 2016-12-06 2020-03-05 Pebble Labs Usa Inc. System and methods for the biocontrol of plant pathogens
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3342780A1 (en) 2016-12-30 2018-07-04 Dow AgroSciences LLC Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests
US10470468B2 (en) * 2017-04-11 2019-11-12 Mclaughlin Gormley King Company Mixtures of sabadilla oil and fungicides and uses thereof
AR113761A1 (es) 2017-10-18 2020-06-10 Syngenta Participations Ag Control de plagas de hemípteros utilizando moléculas de arn
MA52107B1 (fr) 2018-07-18 2022-11-30 Plantarcbio Ltd Compositions et procédés pour l'atténuation d'une infestation par le ravageur rhynchophorus ferrugineus
CN109370910B (zh) * 2018-08-03 2021-09-07 贵州省植物保护研究所 一种短帚霉及其用途
CN112770761A (zh) * 2018-09-13 2021-05-07 先正达农作物保护股份公司 使用rna分子控制植物有害生物
CN111849980B (zh) * 2020-06-30 2022-03-22 华南农业大学 一类抑制小菜蛾PPO激活的miRNAs及其应用
CN115786334B (zh) * 2022-07-27 2023-07-18 广东省农业科学院植物保护研究所 一种调控红火蚁生殖的小分子rna及其应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876197A (en) 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
JPS59205983A (ja) 1983-04-28 1984-11-21 ジエネツクス・コ−ポレイシヨン 異種遺伝子を原核微生物で発現させる方法
US4880734A (en) 1984-05-11 1989-11-14 Chiron Corporation Eukaryotic regulatable transcription
ATE103333T1 (de) 1987-03-23 1994-04-15 Zymogenetics Inc Hohe proteinsyntheserate in hefe.
EP0315447A3 (en) 1987-11-06 1990-07-18 Teijin Limited Method of immunological measurement of human protein s and reagent and kit therefor
US5614395A (en) 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
US5789214A (en) 1988-03-08 1998-08-04 Novartis Finance Corporation Method of inducing gene transcription in a plant
US5550318A (en) 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
CA2074355C (en) 1990-01-22 2008-10-28 Ronald C. Lundquist Method of producing fertile transgenic corn plants
US5639949A (en) 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5633435A (en) 1990-08-31 1997-05-27 Monsanto Company Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases
WO1992009696A1 (en) 1990-11-23 1992-06-11 Plant Genetic Systems, N.V. Process for transforming monocotyledonous plants
US5593874A (en) 1992-03-19 1997-01-14 Monsanto Company Enhanced expression in plants
JPH08501928A (ja) 1992-07-02 1996-03-05 ハイブライドン インコーポレイテッド 治療剤としての自己安定化オリゴヌクレオチド
US6118047A (en) 1993-08-25 2000-09-12 Dekalb Genetic Corporation Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
US7034009B2 (en) * 1995-10-26 2006-04-25 Sirna Therapeutics, Inc. Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
US5693512A (en) 1996-03-01 1997-12-02 The Ohio State Research Foundation Method for transforming plant tissue by sonication
DE19631919C2 (de) 1996-08-07 1998-07-16 Deutsches Krebsforsch Anti-Sinn-RNA mit Sekundärstruktur
GB9827152D0 (en) 1998-07-03 1999-02-03 Devgen Nv Characterisation of gene function using double stranded rna inhibition
US6703491B1 (en) * 1999-03-17 2004-03-09 Exelixis, Inc. Drosophila sequences
US6511824B1 (en) * 1999-03-17 2003-01-28 Exelixis, Inc. Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use
US6326193B1 (en) * 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
WO2001037654A2 (en) 1999-11-24 2001-05-31 Dna Plant Technology Corporation METHOD OF EXPRESSING dsRNA IN PLANTS TO INHIBIT INSECT PESTS
AU2001245945A1 (en) * 2000-03-23 2001-10-03 Pe Corporation (Ny) Detection kits, such as nucleic acid arrays, for detecting the expression of 10,000 or more drosophila genes and uses thereof
GB0012233D0 (en) 2000-05-19 2000-07-12 Devgen Nv Vector constructs
US7109393B2 (en) 2000-08-15 2006-09-19 Mendel Biotechnology, Inc. Methods of gene silencing using inverted repeat sequences
US20020048814A1 (en) 2000-08-15 2002-04-25 Dna Plant Technology Corporation Methods of gene silencing using poly-dT sequences
EP1210875A1 (en) * 2000-12-04 2002-06-05 Aventis CropScience GmbH Modulating gene expression in insects by using double-stranded RNA (dsRNA)
AUPR621501A0 (en) * 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna
WO2004002271A1 (en) 2002-06-03 2004-01-08 Harbor Steel & Supply Corporation Carrousel file
EP1516051A4 (en) 2002-06-21 2007-05-02 Monsanto Technology Llc INTRON DOUBLE-STRANDED RNA HYBRID GENES, AND USES THEREOF
US20040053289A1 (en) * 2002-09-09 2004-03-18 The Regents Of The University Of California Short interfering nucleic acid hybrids and methods thereof
EP1560931B1 (en) * 2002-11-14 2011-07-27 Dharmacon, Inc. Functional and hyperfunctional sirna
US7655785B1 (en) * 2002-11-14 2010-02-02 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
IL157538A0 (en) * 2003-08-21 2004-03-28 Bar Ilan Res & Dev Company Ltd Plant resistant to cytoplasm-feeding parasites
EP1682663A2 (en) * 2003-09-15 2006-07-26 Cenix Bioscience GmbH The use of eukaryotic genes affecting spindle formation or microtubule function during cell division for diagnosis and treatment of proliferative diseases
PL1687435T3 (pl) * 2003-11-17 2012-02-29 Bayer Cropscience Nv Odporność na owady z użyciem hamowania ekspresji genów
EP1716238B1 (fr) 2003-12-23 2017-12-06 Bayer S.A.S. Methode pour modifier l'expression genique d' un champignon phytopathogene
CA2693280C (en) 2004-04-09 2017-09-12 Monsanto Technology Llc Compositions and methods for control of insect infestations in plants
AU2005295796B2 (en) * 2004-10-13 2010-07-22 University Of Georgia Research Foundation, Inc. Nematode resistant transgenic plants
BRPI0516329A (pt) * 2004-10-25 2008-03-11 Devgen Nv moléculas de rna de multidomìnio que compreendem pelo menos um aptámero para a aplicação de rna de cordão duplo a organismos de pestes
PL1807520T3 (pl) 2004-10-25 2013-01-31 Devgen Nv Konstrukty do RNA
ATE548459T1 (de) * 2005-09-16 2012-03-15 Monsanto Technology Llc Verfahren zur genetischen kontrolle von insektenbefall bei pflanzen und zusammensetzungen
PT2295584E (pt) * 2005-09-16 2015-09-22 Devgen Nv Métodos com base em plantas transgénicas para infestações em plantas utilizando arn de interferência
EP1984511A2 (en) * 2006-02-13 2008-10-29 Monsanto Technology LLP Selecting and stabilizing dsrna constructs

Also Published As

Publication number Publication date
EP2281876A2 (en) 2011-02-09
ES2557513T3 (es) 2016-01-26
US9982258B2 (en) 2018-05-29
EP2270182B1 (en) 2016-02-10
EP2270181A3 (en) 2012-04-04
US8933042B2 (en) 2015-01-13
AU2006335978A1 (en) 2007-07-26
CA2622671C (en) 2020-12-22
EP2269444A3 (en) 2012-04-04
EP2269444A2 (en) 2011-01-05
PL2270181T3 (pl) 2016-04-29
WO2007083193A2 (en) 2007-07-26
PL2270182T3 (pl) 2016-07-29
EP2270181B1 (en) 2015-10-21
EP2281876A3 (en) 2012-04-11
ES2568933T3 (es) 2016-05-05
US20090306189A1 (en) 2009-12-10
US20150065557A1 (en) 2015-03-05
MX339645B (es) 2016-06-03
EP2270181A2 (en) 2011-01-05
US20180142237A9 (en) 2018-05-24
CA2622671A1 (en) 2007-07-26
PT2270181E (pt) 2016-01-26
EP2270182A3 (en) 2012-04-18
JP5530632B2 (ja) 2014-06-25
CN104357447A (zh) 2015-02-18
BRPI0615792A2 (pt) 2009-06-16
JP2014113156A (ja) 2014-06-26
WO2007083193A3 (en) 2008-01-24
AU2006335978B2 (en) 2014-02-20
EP2270182A2 (en) 2011-01-05
JP2009508482A (ja) 2009-03-05
EP1934357B1 (en) 2011-11-16
MX348513B (es) 2017-06-16
HUE027349T2 (en) 2016-09-28
EP1934357A2 (en) 2008-06-25

Similar Documents

Publication Publication Date Title
ATE533358T1 (de) Verfahren zum kontrollieren von schädlingen mittels rnai
EP2295584A3 (en) Transgenic plant-based methods for plant pests using RNAi
EP2348115A3 (en) Transgenic plant-based methods for plant pests using RNAi
UA111934C2 (uk) ТРАНСГЕННА РОСЛИНА, ЩО МІСТИТЬ ДНК, ЯКА КОДУЄ ІНСЕКТИЦИДНИЙ БІЛОК Vip3Ab, І ДНК, ЯКА КОДУЄ ІНСЕКТИЦИДНИЙ БІЛОК Cry1Fa, СТІЙКА ДО ЛУСКОКРИЛИХ ШКІДНИКІВ
IL185253A (en) Cytoquenols are preserved in spirocetal, a process for their preparation, preparations containing them and methods for their use in the control of pests
EA200800838A1 (ru) Модуляция иммуностимулирующих свойств короткой интерферирующей рибонуклеиновой кислоты (siphk) с помощью модификации нуклеотидов
EA201100981A1 (ru) Иминные соединения для борьбы с беспозвоночными вредителями
WO2006036916A3 (en) Rnai modulation of apob and uses thereof
WO2012143543A3 (en) Plants resistant to insect pests
HRP20130750T1 (hr) Postupak identifikacije molekula za vezanje koje mogu neutralizirati virus bjesnoä†e
ATE483032T1 (de) Verfahren zur herstellung von oligonukleotiden
BR122019001711B8 (pt) Composição e método para o controle de pragas de lepidópteros
EA200800448A1 (ru) Нуклеотидные последовательности, кодирующие инсектицидные белки
WO2005081714A3 (en) Use of interfering rna in the production of transgenic animals
EA200800869A1 (ru) Модуляция экспрессии рецептора глюкагона
DE602005025669D1 (de) Pflanzen mit veränderten wachstumseigenschaften und verfahren zu deren herstellung
EP2599872A3 (en) Plants having enhanced yield-related traits and a method for making the same
WO2007014075A3 (en) Rnai modulation of the rho-a gene in research models
WO2007048628A3 (en) Structures of active guide rna molecules and method of selection
DE602006009901D1 (de) Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin
ATE469974T1 (de) Pflanzen mit gesteigertem saatertrag und verfahren zu deren herstellung
FI20050649A0 (fi) Menetelmä puun tai puutuotteiden käsittelemiseksi
DE602008002140D1 (de) Verfahren zum Erhalten von natürlichem Astaxanthin aus Eiern und Gonaden aus Schnecken
ATE491797T1 (de) Pflanzen mit erhöhtem ertrag und verfahren zur herstellung davon
ATE538098T1 (de) Verfahren zum herstellen von 5-fluor-1,3-dialkyl- 1h-pyrazol-4-carbonsäurechloriden