ATE529448T1 - Verringerung von endotoxin in polysialinsäuren - Google Patents

Verringerung von endotoxin in polysialinsäuren

Info

Publication number
ATE529448T1
ATE529448T1 AT08709658T AT08709658T ATE529448T1 AT E529448 T1 ATE529448 T1 AT E529448T1 AT 08709658 T AT08709658 T AT 08709658T AT 08709658 T AT08709658 T AT 08709658T AT E529448 T1 ATE529448 T1 AT E529448T1
Authority
AT
Austria
Prior art keywords
endotoxin
polysaccharide
reduction
psa
gel
Prior art date
Application number
AT08709658T
Other languages
English (en)
Inventor
Sanjay Jain
Peter Laing
Gregory Gregoriadis
Original Assignee
Lipoxen Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipoxen Technologies Ltd filed Critical Lipoxen Technologies Ltd
Application granted granted Critical
Publication of ATE529448T1 publication Critical patent/ATE529448T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT08709658T 2007-02-28 2008-02-28 Verringerung von endotoxin in polysialinsäuren ATE529448T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07103275 2007-02-28
PCT/GB2008/050138 WO2008104811A1 (en) 2007-02-28 2008-02-28 Reduction of endotoxin in polysialic acids

Publications (1)

Publication Number Publication Date
ATE529448T1 true ATE529448T1 (de) 2011-11-15

Family

ID=38255362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08709658T ATE529448T1 (de) 2007-02-28 2008-02-28 Verringerung von endotoxin in polysialinsäuren

Country Status (12)

Country Link
US (3) US20110159130A1 (de)
EP (3) EP2409995A3 (de)
JP (2) JP2010520320A (de)
KR (1) KR101523111B1 (de)
CN (1) CN101646693B (de)
AT (1) ATE529448T1 (de)
DK (1) DK2115010T3 (de)
ES (1) ES2375314T3 (de)
PL (1) PL2115010T3 (de)
PT (1) PT2115010E (de)
RU (1) RU2473567C2 (de)
WO (1) WO2008104811A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103361283B (zh) * 2012-04-01 2015-06-03 中国科学院微生物研究所 微生物发酵法生产多聚n-乙酰神经氨酸及其提纯方法
ES2824554T3 (es) * 2015-12-16 2021-05-12 Tcer Ab Plataforma de reactividad de células T
DE102016106271B4 (de) 2016-04-06 2018-03-29 Axagarius Gmbh & Co. Kg Aufreinigung von Nukleinsäure aus einer Nukleinsäure und Endotoxin enthaltenden Probe
WO2019171173A1 (en) * 2018-03-08 2019-09-12 Catalent U.K. Swindon Zydis Limited Process to reduce endotoxin in gelatin
TW202348297A (zh) * 2018-05-02 2023-12-16 美商里珍納龍藥品有限公司 用於評估生化過濾器的適合性的方法
CN109182423B (zh) * 2018-09-26 2020-07-07 武汉中科光谷绿色生物技术有限公司 促进大肠杆菌发酵生产聚唾液酸的方法
CN110423290B (zh) * 2019-08-23 2020-06-09 河北常山凯络尼特生物技术有限公司 一种去除寡聚透明质酸钠中内毒素的方法
CN113005161B (zh) * 2021-02-19 2023-04-28 中国科学院合肥物质科学研究院 一种聚唾液酸的制备方法及聚唾液酸制品
CN116253809A (zh) * 2023-04-19 2023-06-13 广州润虹医药科技股份有限公司 一种去除壳聚糖中内毒素的方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740503A (en) * 1980-08-22 1982-03-06 Seikagaku Kogyo Co Ltd Separation of saccharides
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
JPS6245786A (ja) 1985-08-23 1987-02-27 日本フツカ−株式会社 繊維品の防水処理法
GB2192633A (en) 1986-06-13 1988-01-20 Royal Postgrad Med School Endotoxin removal
US5589591A (en) 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
US5039610A (en) 1989-06-12 1991-08-13 Merck & Co., Inc. Process for removing bacterial endotoxin from gram-negative polysaccharides
US5169535A (en) * 1989-09-22 1992-12-08 Kurita Water Industries Ltd. Method of removing endotoxin
US5846951A (en) * 1991-06-06 1998-12-08 The School Of Pharmacy, University Of London Pharmaceutical compositions
GB9112212D0 (en) 1991-06-06 1991-07-24 Gregoriadis Gregory Pharmaceutical compositions
WO1993004183A1 (en) * 1991-08-16 1993-03-04 Merck & Co., Inc. Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
JPH06245786A (ja) * 1993-02-23 1994-09-06 Ngk Insulators Ltd コロミン酸の精製方法
CA2182397C (en) * 1994-02-07 2004-04-13 Metin Colpan Endotoxin reduction or removal process
AUPM388494A0 (en) 1994-02-16 1994-03-10 Csl Limited Process for removing endotoxins
WO1996037205A1 (fr) * 1995-05-25 1996-11-28 Ngk Insulators, Ltd. Remede contre l'endotoxinemie et des defaillances d'organes multiples induites par celle-ci
US5811403A (en) * 1996-09-30 1998-09-22 Vanderbilt University Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity
CA2278626C (en) * 1997-01-24 2010-04-27 Schweiz. Serum- & Impfinstitut Bern Novel method for the isolation of polysaccharides
KR100757630B1 (ko) * 1997-12-23 2007-09-10 박스터 헬쓰케어 에스.에이. 신규한 추출 및 단리 방법으로 수득되는 세균성 캡슐형 다당류
GB9907553D0 (en) * 1999-04-01 1999-05-26 Cantab Pharma Res Purification of biological preparations
US6774102B1 (en) 1999-09-29 2004-08-10 Gambro Dialysatoren Gmbh & Co. Kg Extracorporeal endotoxin removal method
DE10010342A1 (de) * 2000-03-06 2001-09-20 Merck Patent Gmbh Verfahren zur Abreicherung von Endotoxinen
US6962972B2 (en) 2000-05-16 2005-11-08 Lipoxen Technologies Limited Derivatization of proteins
KR100356738B1 (ko) * 2000-09-07 2002-10-18 주식회사 삼양제넥스 염기성 단백질로부터 엔도톡신을 제거하는 방법
JP4996791B2 (ja) 2001-03-14 2012-08-08 Ｊｎｃ株式会社 エンドトキシン吸着体、及びそれを用いたエンドトキシンの除去方法
AU2002258734A1 (en) 2001-04-13 2002-10-28 Wyeth Holdings Corporation Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography
CN1158295C (zh) * 2002-04-16 2004-07-21 广州市力拓发展有限公司 一种制备单唾液酸四己糖神经节苷脂制剂的方法
AU2002309259A1 (en) * 2002-05-09 2003-11-11 Massimo Porro Improved polysaccharide and glycoconjugate vaccines_____________
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
WO2005003152A1 (en) * 2003-06-24 2005-01-13 Akzo Nobel N.V. Removal of lipopolysacchrarides from protein- lipopolysaccharide complexes by nonflammable solvents
JP2005036036A (ja) * 2003-07-16 2005-02-10 Tanabe Seiyaku Co Ltd エンドトキシン除去方法
WO2005016974A1 (en) * 2003-08-12 2005-02-24 Lipoxen Technologies Limited Sialic acid derivatives for protein derivatisation and conjugation
WO2005026331A2 (en) * 2003-09-17 2005-03-24 Centelion Method of preparation of pharmaceutically grade plasmid dna
ES2640767T3 (es) 2004-08-12 2017-11-06 Lipoxen Technologies Limited Fraccionamientodepolisacáridos cargados
JP5100980B2 (ja) * 2005-05-18 2012-12-19 株式会社クラレ 化学物質の精製方法
CN100567500C (zh) * 2006-06-22 2009-12-09 江南大学 一种从产聚唾液酸大肠杆菌发酵液中提取聚唾液酸的方法
DK2049692T3 (en) 2006-07-13 2016-04-04 Serum Inst India Ltd Process for producing very high purity polysialic acid
JP5096466B2 (ja) 2006-07-25 2012-12-12 リポクセン テクノロジーズ リミテッド Ｎ末端ポリシアリル化
CN100383153C (zh) * 2006-09-01 2008-04-23 江南大学 一种聚唾液酸水解液的脱色方法

Also Published As

Publication number Publication date
WO2008104811A1 (en) 2008-09-04
EP2115010B1 (de) 2011-10-19
US20130172537A1 (en) 2013-07-04
EP2409995A3 (de) 2012-08-15
CN101646693B (zh) 2013-03-27
PL2115010T3 (pl) 2012-07-31
EP2409994A2 (de) 2012-01-25
EP2409994A3 (de) 2012-08-15
US9212232B2 (en) 2015-12-15
US20160096905A1 (en) 2016-04-07
US10301396B2 (en) 2019-05-28
RU2473567C2 (ru) 2013-01-27
CN101646693A (zh) 2010-02-10
EP2409995A2 (de) 2012-01-25
US20110159130A1 (en) 2011-06-30
JP2010520320A (ja) 2010-06-10
KR20090125783A (ko) 2009-12-07
EP2115010A1 (de) 2009-11-11
KR101523111B1 (ko) 2015-06-25
DK2115010T3 (da) 2012-02-06
JP2013216900A (ja) 2013-10-24
ES2375314T3 (es) 2012-02-28
RU2009134940A (ru) 2011-04-10
PT2115010E (pt) 2012-03-09
JP5677512B2 (ja) 2015-02-25

Similar Documents

Publication Publication Date Title
ATE529448T1 (de) Verringerung von endotoxin in polysialinsäuren
BR112012030530A2 (pt) Aparelho e processo para purificação de proteínas
BR112013012169B8 (pt) composição de líquido de lavagem para absorção de comtaminates ácidos de fluidos em um processo industrial e processo de redução de contaminantes ácidos em um fluxo de fluidos industrial
BR112012014736A2 (pt) purificação de isopreno a partir de recursos renováveis
BRPI0810744A2 (pt) Moléculas absorventes de oxigênio, objetos que as contêm, e métodos de sua utilização
WO2007005644A3 (en) Novel aryloxypropanamines
DE602006016859D1 (de) Neues verfahren für die bisulfitbehandlung
ATE554168T1 (de) Integriertes mikrofluidisches bauteil zum aufreinigen von analytmolekülen sowie verfahren zum aufreinigen
BR112012024956A2 (pt) processo para a purificação de uma proteína de fator de crescimento
DK1982734T3 (da) Fremgangsmåde og apparat til væskerensning
BR112012024550A2 (pt) processo para purificação de proteínas dependentes de vitamina k tal como o fator de coagulação ix
NO20093199L (no) Absorbenter for separering av sure gasser
BR112016015718A2 (pt) Processo de purificação de aminoácidos aromáticos
DK2134820T3 (da) Fremgangsmåde til tørring og rensning af en partikelformet blanding af cellulose/plastaffald
ATE509989T1 (de) Adsorber mit anthrachinonfarbstoffliganden zur trennung von biologischen stoffen
DK1951395T3 (da) Fremgangsmåde til kvantitativ bestemmelse af poloxamerer
WO2008087218A3 (en) Stabilizing and separation media for electrophoresis applications
MX360515B (es) Proceso para la reduccion y/o remocion del factor de coagulacion xi y factor de coagulacion xi activado de soluciones que contienen tales factores de coagulacion.
ATE423147T1 (de) Poly- und copoly(n-vinylamide) und deren verwendung in der kapillarelektrophorese
JP2005241299A5 (de)
GR1007341B (el) Διαγνωστικος προσδιορισμος
CY1118533T1 (el) Μεθοδος χρωματογραφιας συναφειας αντιδρομβινης iii
WO2012015219A3 (en) Real-time monitoring of depletion of high-abundance blood proteins or recovery of low-abundance blood proteins by uv spectrometry
ATE468343T1 (de) Verfahren zur reinigung von tacrolimus
JP2021067524A5 (de)