ATE528644T1 - Verwendung ionischer matrizen zur analyse von gewebeabschnitten durch maldi-massenspektrometrie - Google Patents
Verwendung ionischer matrizen zur analyse von gewebeabschnitten durch maldi-massenspektrometrieInfo
- Publication number
- ATE528644T1 ATE528644T1 AT06795327T AT06795327T ATE528644T1 AT E528644 T1 ATE528644 T1 AT E528644T1 AT 06795327 T AT06795327 T AT 06795327T AT 06795327 T AT06795327 T AT 06795327T AT E528644 T1 ATE528644 T1 AT E528644T1
- Authority
- AT
- Austria
- Prior art keywords
- mass spectrometry
- tissue sections
- maldi mass
- conjugate
- analyzing tissue
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/0059—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by a photon beam, photo-dissociation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Electron Tubes For Measurement (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68784805P | 2005-06-07 | 2005-06-07 | |
PCT/IB2006/002311 WO2007007192A1 (en) | 2005-06-07 | 2006-06-07 | Use of ionic matrices for maldi mass spectrometry analysis of tissue sections |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE528644T1 true ATE528644T1 (de) | 2011-10-15 |
Family
ID=37309311
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06795326T ATE520022T1 (de) | 2005-06-07 | 2006-06-07 | Verwendung von konjugaten mit mittels photodissoziation oder fragmentation spaltbaren bindern für die massenspektrometrieanalyse von gewebeschnitten |
AT06795327T ATE528644T1 (de) | 2005-06-07 | 2006-06-07 | Verwendung ionischer matrizen zur analyse von gewebeabschnitten durch maldi-massenspektrometrie |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06795326T ATE520022T1 (de) | 2005-06-07 | 2006-06-07 | Verwendung von konjugaten mit mittels photodissoziation oder fragmentation spaltbaren bindern für die massenspektrometrieanalyse von gewebeschnitten |
Country Status (7)
Country | Link |
---|---|
US (2) | US8221972B2 (de) |
EP (6) | EP2287602A1 (de) |
JP (2) | JP5220593B2 (de) |
AT (2) | ATE520022T1 (de) |
CA (2) | CA2611297A1 (de) |
ES (1) | ES2371203T3 (de) |
WO (2) | WO2007007192A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2004075208A2 (en) * | 2003-02-24 | 2004-09-02 | Simon Fraser University | Formation of closely packed microspots and irradiation of same |
DE102007024857B4 (de) * | 2007-05-29 | 2017-11-02 | Bruker Daltonik Gmbh | Bildgebende Massenspektrometrie für kleine Moleküle in flächigen Proben |
US20090286286A1 (en) * | 2007-11-06 | 2009-11-19 | Ambergen , Inc. | Methods for controlling amplification |
JP5072682B2 (ja) * | 2008-03-28 | 2012-11-14 | 富士フイルム株式会社 | 質量分析用デバイス、これを用いる質量分析装置および質量分析方法 |
JP5092861B2 (ja) * | 2008-04-14 | 2012-12-05 | 株式会社島津製作所 | 混合液体マトリックスを用いたmaldi質量分析法 |
CN101726360B (zh) * | 2008-10-06 | 2011-11-02 | 中央大学 | 高频谱扫描装置及其方法 |
JP2012529058A (ja) * | 2009-06-03 | 2012-11-15 | ウエイン・ステート・ユニバーシテイ | レーザースプレーイオン化を用いる質量分析 |
EP2488876B1 (de) | 2009-10-13 | 2017-03-01 | Nanostring Technologies, Inc | Proteinnachweis über nanoreporter |
WO2011073740A1 (en) * | 2009-12-15 | 2011-06-23 | Centre National De La Recherche Scientifique (Cnrs) | Matrices for mass spectrometry imaging |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
CA2794522C (en) | 2010-04-05 | 2019-11-26 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
US9523680B2 (en) * | 2010-06-30 | 2016-12-20 | Ambergen, Inc. | Global Proteomic screening of random bead arrays using mass spectrometry imaging |
EP2588144B1 (de) | 2010-07-02 | 2018-05-09 | Ventana Medical Systems, Inc. | Nachweis von zielmolekülen mit massenmarkierungen und massenspektrometrie |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
FR2976076B1 (fr) | 2011-05-31 | 2015-02-27 | Imabiotech | Procede de detection et de quantification d'une molecule cible dans un tissu |
AU2012290318B2 (en) * | 2011-07-29 | 2016-09-01 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
CN104244989A (zh) * | 2012-02-29 | 2014-12-24 | Ambrx公司 | 含有新颖前药的分子组合物和其用途 |
EP2767832A1 (de) | 2013-02-18 | 2014-08-20 | Imabiotech | Photo- oder chemolabile Konjugate zur Detektion von Molekülen |
CA2899994C (en) | 2013-02-25 | 2022-08-30 | Imabiotech | Method to evaluate the tissue targeting of a molecule of interest |
WO2014176435A2 (en) | 2013-04-25 | 2014-10-30 | Bergo Vladislav B | Microarray compositions and methods of their use |
EP3013984B1 (de) | 2013-06-25 | 2023-03-22 | Prognosys Biosciences, Inc. | Verfahren zur bestimmung der räumlichen muster biologischer ziele in einer probe |
EP3043891B1 (de) * | 2013-09-13 | 2019-01-16 | The Board of Trustees of The Leland Stanford Junior University | Multiplex-bildgebung von geweben unter verwendung von massenmarkierungen und sekundärionenmassenspektrometrie |
AU2015222268B2 (en) * | 2014-02-26 | 2017-06-29 | Ventana Medical Systems, Inc. | Photo-selective method for biological sample analysis field |
DE102015003440A1 (de) * | 2015-03-16 | 2016-09-22 | Friedrich-Schiller-Universität Jena | Verfahren zur MALDI-MSI Analytik von Objekten, insbesondere biologischen Gewebeproben, und Target zur Analytik sowie dessen Herstellung |
EP3901282B1 (de) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben |
CA2992480A1 (en) * | 2015-07-17 | 2017-01-26 | Nanostring Technologies, Inc. | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
SG10202107053QA (en) | 2015-07-17 | 2021-08-30 | Nanostring Technologies Inc | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
SG11201804086VA (en) | 2015-12-04 | 2018-06-28 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
WO2017151748A1 (en) * | 2016-03-01 | 2017-09-08 | Trustees Of Boston University | Light-stimulated release of cargo from oligonucleotides |
GR20160100143A (el) * | 2016-04-11 | 2017-11-30 | Αχιλλεας Αλεξανδρος Βαϊρης | Ελεγχος κατεργασιων συγκολλησης με τριβη |
EP3336546B1 (de) * | 2016-12-13 | 2020-07-01 | Miltenyi Biotec B.V. & Co. KG | Umkehrbare zellmarkierung mit konjugaten mit zwei lösbaren bindungsstellen |
JPWO2018143357A1 (ja) * | 2017-02-01 | 2019-11-21 | 国立大学法人浜松医科大学 | 標的物質と親和性の高い物質をスクリーニングする方法 |
CA3073832A1 (en) | 2017-09-07 | 2019-03-14 | Adeptrix Corp. | Multiplexed bead arrays for proteomics |
SG11202007501SA (en) | 2018-02-12 | 2020-09-29 | Nanostring Technologies Inc | Biomolecular probes and methods of detecting gene and protein expression |
CN109917058A (zh) * | 2019-03-14 | 2019-06-21 | 南京农业大学 | 细胞内四种游离脱氧核苷酸的高效液相测定方法 |
JP7384358B2 (ja) | 2020-04-27 | 2023-11-21 | 株式会社島津製作所 | 有機化合物の構造解析方法 |
US11789027B2 (en) * | 2020-10-29 | 2023-10-17 | Ambergen, Inc. | Photocleavable mass-tags for multiplexed mass spectrometric imaging of tissues using biomolecular probes |
CN113861074A (zh) * | 2021-09-23 | 2021-12-31 | 中国检验检疫科学研究院 | 一种新型离子液体maldi基质的制备方法及应用 |
WO2024108178A1 (en) * | 2022-11-18 | 2024-05-23 | Genentech, Inc. | Signal amplification and multiplexing using mass tags for ia-lc-ms/ms based assays |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US4625014A (en) * | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
ATE187501T1 (de) | 1996-01-23 | 1999-12-15 | Rapigene Inc | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit |
US5808300A (en) * | 1996-05-10 | 1998-09-15 | Board Of Regents, The University Of Texas System | Method and apparatus for imaging biological samples with MALDI MS |
CA2274587A1 (en) | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
GB9815166D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
WO2000068434A2 (en) | 1999-05-07 | 2000-11-16 | Yale University | Multiple tag analysis |
WO2002014867A2 (en) | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
AU2002240423B2 (en) * | 2001-02-14 | 2006-03-09 | Picoliter Inc. | Acoustic sample introduction for analysis and/or processing |
US7183116B2 (en) * | 2001-05-14 | 2007-02-27 | The Institute For Systems Biology | Methods for isolation and labeling of sample molecules |
US6756586B2 (en) * | 2001-10-15 | 2004-06-29 | Vanderbilt University | Methods and apparatus for analyzing biological samples by mass spectrometry |
DE10238069A1 (de) * | 2002-08-19 | 2004-03-04 | N.V. Nutricia | MALDI-Matrix |
GB0228429D0 (en) * | 2002-12-05 | 2003-01-08 | Novartis Ag | Organic compounds |
WO2005067648A2 (en) | 2004-01-08 | 2005-07-28 | Vanderbilt University | Multiplex spatial profiling of gene expression |
US7588906B2 (en) * | 2004-02-24 | 2009-09-15 | Wisconsin Alumni Research Foundation | Hydrogels for biomolecule analysis and corresponding method to analyze biomolecules |
EP1756307A1 (de) | 2004-05-20 | 2007-02-28 | Trillion Genomics Limited | Verwendung massenmarkierter sonden zum nachweis von zielnukleinsäuren mittels massenspektrometrie |
-
2006
- 2006-06-07 JP JP2008515317A patent/JP5220593B2/ja not_active Expired - Fee Related
- 2006-06-07 EP EP10180422A patent/EP2287602A1/de not_active Withdrawn
- 2006-06-07 EP EP06795326A patent/EP1889047B1/de not_active Not-in-force
- 2006-06-07 CA CA002611297A patent/CA2611297A1/en not_active Abandoned
- 2006-06-07 AT AT06795326T patent/ATE520022T1/de not_active IP Right Cessation
- 2006-06-07 JP JP2008515318A patent/JP2008542784A/ja active Pending
- 2006-06-07 US US11/921,678 patent/US8221972B2/en active Active
- 2006-06-07 EP EP10167401.8A patent/EP2322921B1/de not_active Not-in-force
- 2006-06-07 US US11/916,558 patent/US8148676B2/en not_active Expired - Fee Related
- 2006-06-07 CA CA2611266A patent/CA2611266C/en not_active Expired - Fee Related
- 2006-06-07 EP EP10167400.0A patent/EP2322920B1/de not_active Not-in-force
- 2006-06-07 WO PCT/IB2006/002311 patent/WO2007007192A1/en not_active Application Discontinuation
- 2006-06-07 AT AT06795327T patent/ATE528644T1/de not_active IP Right Cessation
- 2006-06-07 EP EP06795327A patent/EP1891426B1/de not_active Not-in-force
- 2006-06-07 ES ES06795326T patent/ES2371203T3/es active Active
- 2006-06-07 EP EP10167398.6A patent/EP2325631B1/de not_active Not-in-force
- 2006-06-07 WO PCT/IB2006/002309 patent/WO2007000669A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20110151451A1 (en) | 2011-06-23 |
WO2007000669A2 (en) | 2007-01-04 |
EP1889047A2 (de) | 2008-02-20 |
EP2322921A1 (de) | 2011-05-18 |
EP2325631A1 (de) | 2011-05-25 |
EP2322920B1 (de) | 2014-12-10 |
ATE520022T1 (de) | 2011-08-15 |
EP2287602A1 (de) | 2011-02-23 |
JP5220593B2 (ja) | 2013-06-26 |
EP1891426A1 (de) | 2008-02-27 |
ES2371203T3 (es) | 2011-12-28 |
EP2325631B1 (de) | 2015-01-28 |
JP2008542784A (ja) | 2008-11-27 |
CA2611297A1 (en) | 2007-01-18 |
CA2611266C (en) | 2015-11-24 |
US20080203289A1 (en) | 2008-08-28 |
US8148676B2 (en) | 2012-04-03 |
WO2007000669A3 (en) | 2007-12-06 |
EP2322920A1 (de) | 2011-05-18 |
EP1891426B1 (de) | 2011-10-12 |
WO2007007192A1 (en) | 2007-01-18 |
US8221972B2 (en) | 2012-07-17 |
CA2611266A1 (en) | 2007-01-04 |
EP2322921B1 (de) | 2014-08-06 |
EP1889047B1 (de) | 2011-08-10 |
WO2007007192A8 (en) | 2008-04-17 |
JP2008542783A (ja) | 2008-11-27 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |