ATE523190T1 - Teroidlösung aerosolformulierung mit verbesserter chemischer stabilität - Google Patents
Teroidlösung aerosolformulierung mit verbesserter chemischer stabilitätInfo
- Publication number
- ATE523190T1 ATE523190T1 AT06005429T AT06005429T ATE523190T1 AT E523190 T1 ATE523190 T1 AT E523190T1 AT 06005429 T AT06005429 T AT 06005429T AT 06005429 T AT06005429 T AT 06005429T AT E523190 T1 ATE523190 T1 AT E523190T1
- Authority
- AT
- Austria
- Prior art keywords
- chemical stability
- teroid
- aerosol formulation
- improved chemical
- solution aerosol
- Prior art date
Links
- 239000000443 aerosol Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 3
- 238000002144 chemical decomposition reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052755 nonmetal Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/38—Details of the container body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13996199P | 1999-06-18 | 1999-06-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE523190T1 true ATE523190T1 (de) | 2011-09-15 |
Family
ID=22489103
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06005429T ATE523190T1 (de) | 1999-06-18 | 2000-06-15 | Teroidlösung aerosolformulierung mit verbesserter chemischer stabilität |
| AT00941435T ATE320794T1 (de) | 1999-06-18 | 2000-06-15 | Aerosolprodukte von steroidlösung mit verbesserter chemischer stabilität |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00941435T ATE320794T1 (de) | 1999-06-18 | 2000-06-15 | Aerosolprodukte von steroidlösung mit verbesserter chemischer stabilität |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6315985B1 (enExample) |
| EP (2) | EP1194121B1 (enExample) |
| JP (1) | JP4777560B2 (enExample) |
| AT (2) | ATE523190T1 (enExample) |
| AU (1) | AU777505B2 (enExample) |
| CA (1) | CA2371931A1 (enExample) |
| DE (1) | DE60026840T2 (enExample) |
| WO (1) | WO2000078286A1 (enExample) |
Families Citing this family (76)
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| US6315985B1 (en) | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
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| WO2001019342A2 (en) * | 1999-09-11 | 2001-03-22 | Glaxo Group Limited | Pharmaceutical formulation of fluticasone propionate |
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| IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
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| TW523409B (en) * | 2000-09-15 | 2003-03-11 | Baxter Int | Container for inhalation anesthetic |
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| US6126919A (en) * | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| US5891420A (en) * | 1997-04-21 | 1999-04-06 | Aeropharm Technology Limited | Environmentally safe triancinolone acetonide aerosol formulations for oral inhalation |
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| US6120752A (en) | 1997-05-21 | 2000-09-19 | 3M Innovative Properties Company | Medicinal aerosol products containing formulations of ciclesonide and related steroids |
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| US6045784A (en) * | 1998-05-07 | 2000-04-04 | The Procter & Gamble Company | Aerosol package compositions containing fluorinated hydrocarbon propellants |
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| US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| DE19847969A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Lagerfähig flüssige Formulierung mit Formoterol |
| DK1131059T3 (da) * | 1998-11-13 | 2003-06-30 | Jago Res Ag | Tørpulver til inhalation |
| DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| IT1303788B1 (it) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
| US6261539B1 (en) * | 1998-12-10 | 2001-07-17 | Akwete Adjei | Medicinal aerosol formulation |
| US6290930B1 (en) * | 1998-12-18 | 2001-09-18 | Baker Norton Pharmaceuticals, Inc. | Pharmaceutical solution aerosol formulations containing fluoroalkanes and budesonide |
| US6004537A (en) * | 1998-12-18 | 1999-12-21 | Baker Norton Pharmaceuticals, Inc. | Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol |
| US6315985B1 (en) | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| US6322053B1 (en) * | 2000-02-08 | 2001-11-27 | Valiant Machine & Tool Inc. | Balancing system with a force multiplying device |
| IT1317846B1 (it) * | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
| IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
| BR0015884A (pt) * | 2000-05-22 | 2003-07-08 | Chiesi Farma Spa | Formulações de soluções farmacêuticas estáveis para inaladores de dose medida pressurizados |
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| EP1415647A1 (en) * | 2002-10-23 | 2004-05-06 | CHIESI FARMACEUTICI S.p.A. | "Long-acting beta-2 agonists ultrafine formulations" |
| EP1340492A1 (en) * | 2002-03-01 | 2003-09-03 | CHIESI FARMACEUTICI S.p.A. | Aerosol formulations for pulmonary administration of medicaments having systemic effects |
| KR100947409B1 (ko) * | 2002-03-01 | 2010-03-12 | 키에시 파르마슈티시 엣스. 피. 에이. | 포모테롤 초미세 조성물 |
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-
2000
- 2000-06-13 US US09/592,885 patent/US6315985B1/en not_active Expired - Lifetime
- 2000-06-15 AU AU56142/00A patent/AU777505B2/en not_active Ceased
- 2000-06-15 AT AT06005429T patent/ATE523190T1/de not_active IP Right Cessation
- 2000-06-15 WO PCT/US2000/016462 patent/WO2000078286A1/en not_active Ceased
- 2000-06-15 EP EP00941435A patent/EP1194121B1/en not_active Expired - Lifetime
- 2000-06-15 AT AT00941435T patent/ATE320794T1/de not_active IP Right Cessation
- 2000-06-15 DE DE60026840T patent/DE60026840T2/de not_active Expired - Lifetime
- 2000-06-15 CA CA002371931A patent/CA2371931A1/en not_active Abandoned
- 2000-06-15 EP EP06005429A patent/EP1693053B1/en not_active Expired - Lifetime
- 2000-06-15 JP JP2001504351A patent/JP4777560B2/ja not_active Expired - Fee Related
-
2001
- 2001-10-04 US US09/970,746 patent/US6610273B2/en not_active Expired - Lifetime
-
2003
- 2003-07-30 US US10/630,414 patent/US20040033201A1/en not_active Abandoned
-
2005
- 2005-02-22 US US11/061,529 patent/US20050220717A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1693053A3 (en) | 2007-06-27 |
| CA2371931A1 (en) | 2000-12-28 |
| EP1693053A2 (en) | 2006-08-23 |
| AU5614200A (en) | 2001-01-09 |
| US20050220717A1 (en) | 2005-10-06 |
| US20040033201A1 (en) | 2004-02-19 |
| DE60026840D1 (de) | 2006-05-11 |
| EP1693053B1 (en) | 2011-09-07 |
| US20020071810A1 (en) | 2002-06-13 |
| US6315985B1 (en) | 2001-11-13 |
| JP4777560B2 (ja) | 2011-09-21 |
| WO2000078286A1 (en) | 2000-12-28 |
| ATE320794T1 (de) | 2006-04-15 |
| JP2003502357A (ja) | 2003-01-21 |
| DE60026840T2 (de) | 2006-10-12 |
| US6610273B2 (en) | 2003-08-26 |
| EP1194121B1 (en) | 2006-03-22 |
| AU777505B2 (en) | 2004-10-21 |
| EP1194121A1 (en) | 2002-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |