ATE522516T1 - Inhibitoren der ikk-beta-serin-threonin- proteinkinase - Google Patents
Inhibitoren der ikk-beta-serin-threonin- proteinkinaseInfo
- Publication number
- ATE522516T1 ATE522516T1 AT07824358T AT07824358T ATE522516T1 AT E522516 T1 ATE522516 T1 AT E522516T1 AT 07824358 T AT07824358 T AT 07824358T AT 07824358 T AT07824358 T AT 07824358T AT E522516 T1 ATE522516 T1 AT E522516T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- ikk
- inhibitors
- optionally substituted
- serine
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000001253 Protein Kinase Human genes 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0621720A GB0621720D0 (en) | 2006-11-01 | 2006-11-01 | Inhibitors of ikk- serine-threonine protein kinase |
| GB0715470A GB0715470D0 (en) | 2007-08-09 | 2007-08-09 | IKK- serine-threonine protein kinase inhibitors |
| PCT/GB2007/004114 WO2008053182A1 (en) | 2006-11-01 | 2007-10-29 | IKK-β SERINE-THREONINE PROTEIN KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE522516T1 true ATE522516T1 (de) | 2011-09-15 |
Family
ID=39015937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07824358T ATE522516T1 (de) | 2006-11-01 | 2007-10-29 | Inhibitoren der ikk-beta-serin-threonin- proteinkinase |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8003695B2 (enExample) |
| EP (1) | EP2078007B1 (enExample) |
| JP (1) | JP2010508336A (enExample) |
| KR (1) | KR20090077975A (enExample) |
| AT (1) | ATE522516T1 (enExample) |
| AU (1) | AU2007315943A1 (enExample) |
| BR (1) | BRPI0718056A2 (enExample) |
| CA (1) | CA2668338A1 (enExample) |
| DK (1) | DK2078007T3 (enExample) |
| EA (1) | EA200900616A1 (enExample) |
| ES (1) | ES2372707T3 (enExample) |
| IL (1) | IL198267A0 (enExample) |
| MX (1) | MX2009004442A (enExample) |
| NZ (1) | NZ576705A (enExample) |
| WO (1) | WO2008053182A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| GB0803747D0 (en) | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
| MX2010011501A (es) * | 2008-04-23 | 2010-11-30 | Chroma Therapeutics Ltd | Inhibidores de proteina cinasa de serina-treonina ikk-beta. |
| BRPI0911480A2 (pt) * | 2008-04-26 | 2018-04-03 | Chroma Therapeutics Ltd | inibidores de proteínas serina-treonina quinase ikk-beta |
| EP2361245A4 (en) * | 2008-11-26 | 2012-06-13 | Trt Pharma Inc | HYBRID-IONONE AND CURCUMINE MOLECULES AS ANTICREBIALS |
| GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
| GB0907120D0 (en) * | 2009-04-24 | 2009-06-03 | Chroma Therapeutics Ltd | Inhibitors of IKK-ß serine-threonine protein kinase |
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| HRP20171320T1 (hr) | 2012-10-17 | 2017-10-20 | Macrophage Pharma Limited | Terc-butil n-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alaninat ili njegova sol, hidrat ili solvat |
| US9809577B2 (en) * | 2013-12-11 | 2017-11-07 | Biogen Ma Inc. | Biaryl inhibitors of Bruton's tyrosine kinase |
| GB201713975D0 (en) | 2017-08-31 | 2017-10-18 | Macrophage Pharma Ltd | Medical use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| SE0300092D0 (sv) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
-
2007
- 2007-10-29 WO PCT/GB2007/004114 patent/WO2008053182A1/en not_active Ceased
- 2007-10-29 AT AT07824358T patent/ATE522516T1/de not_active IP Right Cessation
- 2007-10-29 AU AU2007315943A patent/AU2007315943A1/en not_active Abandoned
- 2007-10-29 JP JP2009535115A patent/JP2010508336A/ja not_active Withdrawn
- 2007-10-29 EA EA200900616A patent/EA200900616A1/ru unknown
- 2007-10-29 US US12/513,206 patent/US8003695B2/en not_active Expired - Fee Related
- 2007-10-29 CA CA002668338A patent/CA2668338A1/en not_active Abandoned
- 2007-10-29 DK DK07824358.1T patent/DK2078007T3/da active
- 2007-10-29 MX MX2009004442A patent/MX2009004442A/es active IP Right Grant
- 2007-10-29 BR BRPI0718056-0A patent/BRPI0718056A2/pt not_active IP Right Cessation
- 2007-10-29 ES ES07824358T patent/ES2372707T3/es active Active
- 2007-10-29 NZ NZ576705A patent/NZ576705A/en not_active IP Right Cessation
- 2007-10-29 KR KR1020097011261A patent/KR20090077975A/ko not_active Withdrawn
- 2007-10-29 EP EP07824358A patent/EP2078007B1/en not_active Not-in-force
-
2009
- 2009-04-21 IL IL198267A patent/IL198267A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ576705A (en) | 2011-12-22 |
| EP2078007A1 (en) | 2009-07-15 |
| DK2078007T3 (da) | 2011-12-12 |
| ES2372707T3 (es) | 2012-01-25 |
| US8003695B2 (en) | 2011-08-23 |
| WO2008053182A1 (en) | 2008-05-08 |
| IL198267A0 (en) | 2009-12-24 |
| EA200900616A1 (ru) | 2010-04-30 |
| BRPI0718056A2 (pt) | 2013-11-05 |
| JP2010508336A (ja) | 2010-03-18 |
| EP2078007B1 (en) | 2011-08-31 |
| MX2009004442A (es) | 2009-05-22 |
| CA2668338A1 (en) | 2008-05-08 |
| KR20090077975A (ko) | 2009-07-16 |
| AU2007315943A1 (en) | 2008-05-08 |
| US20100087515A1 (en) | 2010-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |