JP2010508336A - ＩＫＫ−βセリン−スレオニンプロテインキナーゼ阻害剤 - Google Patents

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Publication number

JP2010508336A

JP2010508336A JP2009535115A JP2009535115A JP2010508336A JP 2010508336 A JP2010508336 A JP 2010508336A JP 2009535115 A JP2009535115 A JP 2009535115A JP 2009535115 A JP2009535115 A JP 2009535115A JP 2010508336 A JP2010508336 A JP 2010508336A

Authority

JP

Japan

Prior art keywords

cyclopentyl

alkyl

carbamoyl

optionally substituted

mmol

Prior art date

2006-11-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• 102000001284 I-kappa-B kinase Human genes 0.000 title description 13
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• 229940043355 kinase inhibitor Drugs 0.000 title description 5
• 239000003909 protein kinase inhibitor Substances 0.000 title 1
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• 239000001257 hydrogen Substances 0.000 claims abstract description 40
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 38
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 29
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• 125000003107 substituted aryl group Chemical group 0.000 claims abstract 2
• -1 chloro, methyl Chemical group 0.000 claims description 94
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• 239000000203 mixture Substances 0.000 claims description 56
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 45
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 29
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 24
• 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 24
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• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 18
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• 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 3
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 2
• 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 claims description 2
• 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims description 2
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• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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• 125000006203 morpholinoethyl group Chemical group [H]C([H])(*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims description 2
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• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
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