ATE524454T1 - Inhibitoren von ikk-beta serinthreoninproteinkinase - Google Patents
Inhibitoren von ikk-beta serinthreoninproteinkinaseInfo
- Publication number
- ATE524454T1 ATE524454T1 AT07824361T AT07824361T ATE524454T1 AT E524454 T1 ATE524454 T1 AT E524454T1 AT 07824361 T AT07824361 T AT 07824361T AT 07824361 T AT07824361 T AT 07824361T AT E524454 T1 ATE524454 T1 AT E524454T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- alkyl
- formula
- hydrogen
- ikk
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0621720A GB0621720D0 (en) | 2006-11-01 | 2006-11-01 | Inhibitors of ikk- serine-threonine protein kinase |
GB0715469A GB0715469D0 (en) | 2007-08-09 | 2007-08-09 | Inhibitors of IKK serine-threonine protein kinase |
PCT/GB2007/004117 WO2008053185A1 (en) | 2006-11-01 | 2007-10-29 | INHIBITORS OF IKK-β SERINE-THREONINE PROTEIN KINASE |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE524454T1 true ATE524454T1 (de) | 2011-09-15 |
Family
ID=39012039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07824361T ATE524454T1 (de) | 2006-11-01 | 2007-10-29 | Inhibitoren von ikk-beta serinthreoninproteinkinase |
Country Status (5)
Country | Link |
---|---|
US (1) | US8106091B2 (de) |
EP (1) | EP2086956B1 (de) |
JP (1) | JP2010508337A (de) |
AT (1) | ATE524454T1 (de) |
WO (1) | WO2008053185A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0619753D0 (en) * | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
GB0803747D0 (en) | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
WO2009130434A1 (en) * | 2008-04-23 | 2009-10-29 | Chroma Therapeutics Ltd. | INHIBITORS OF IKK-β SERINE-THREONINE PROTEIN KINASE |
EA201001708A1 (ru) * | 2008-04-26 | 2011-06-30 | Хрома Терапьютикс Лтд. | Замещённые тиофенкарбоксамиды их применение в качестве ингибиторов ikk-бета серин-треонин протеинкиназ |
WO2010062829A1 (en) * | 2008-11-28 | 2010-06-03 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for treating osteoporosis |
GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
AR091858A1 (es) * | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) |
RS56184B1 (sr) | 2012-10-17 | 2017-11-30 | Macrophage Pharma Ltd | Terc-butil n-[2-{4-[6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1(2h)-il]-3,5-difluorofenil}etil]-l-alaninat ili njegova so, hidrat ili solvat |
CN107098924A (zh) * | 2017-05-19 | 2017-08-29 | 暨南大学 | 一种芳基硼酸酯修饰的氨基酸衍生物及其制备方法与应用 |
GB201713975D0 (en) | 2017-08-31 | 2017-10-18 | Macrophage Pharma Ltd | Medical use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0300092D0 (sv) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
-
2007
- 2007-10-29 US US12/447,271 patent/US8106091B2/en not_active Expired - Fee Related
- 2007-10-29 AT AT07824361T patent/ATE524454T1/de not_active IP Right Cessation
- 2007-10-29 WO PCT/GB2007/004117 patent/WO2008053185A1/en active Application Filing
- 2007-10-29 EP EP07824361A patent/EP2086956B1/de not_active Not-in-force
- 2007-10-29 JP JP2009535117A patent/JP2010508337A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US8106091B2 (en) | 2012-01-31 |
WO2008053185A1 (en) | 2008-05-08 |
US20100069473A1 (en) | 2010-03-18 |
EP2086956B1 (de) | 2011-09-14 |
EP2086956A1 (de) | 2009-08-12 |
JP2010508337A (ja) | 2010-03-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE524454T1 (de) | Inhibitoren von ikk-beta serinthreoninproteinkinase | |
DK2078007T3 (da) | Ikk-beta-serin-threonin-proteinkinasehæmmere | |
ATE523492T1 (de) | Chinolin- und chinoxalinderivate als inhibitoren der enzymatischen kinaseaktivität | |
GB0509225D0 (en) | Inhibitors of enzymatic activity | |
MY145603A (en) | 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | |
AR056327A1 (es) | Compuestos de nucleosidos para el tratamiento de infecciones virales | |
MX2010008637A (es) | Derivado de fenilpirrol novedoso. | |
MX2012002059A (es) | Compestos heterociclicos triciclicos como inhibidores de fosfoionositida 3-quinasa. | |
RS54311B1 (en) | KONDEZOVANI AMINODIHYDROTIAZINE DERIVATIVE | |
PE20120629A1 (es) | Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina | |
ATE554085T1 (de) | Neue inhibitoren von glutaminylcyclase | |
WO2005105732A8 (en) | Substituted methyl aryl or heteroaryl amide compounds | |
EA201171386A1 (ru) | ПРОИЗВОДНЫЕ ЦИКЛОПЕНТА[c]ПИРРОЛ-2-КАРБОКСИЛАТОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ | |
MX2019011762A (es) | Compuesto de 4-piridona o su sal, y composicion y formulacion farmaceutica que incluye el mismo. | |
TW200604175A (en) | Ortho substituted aryl or heteroaryl amide compounds | |
MX2012015023A (es) | Derivado novedoso de nicotinamida o sal del mismo. | |
MY152972A (en) | Azabicyclo compound and salt thereof | |
PE20150636A1 (es) | Dicianopiridinas alquilamino-sustituidas y sus profarmacos de ester de aminoacido | |
EA200870192A1 (ru) | Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ | |
TN2011000380A1 (en) | Triazolopyridine derivatives as p38 map kinase inhibitors | |
UA109638C2 (uk) | Сполуки та спосіб зниження рівня сечової кислоти | |
AR082696A1 (es) | Derivados heterociclicos nitrogenados de 1,2,4-oxadiazol, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades cardiovasculares e inflamatorias, entre otras | |
EA201070460A1 (ru) | 5,6-диарилпиридины, замещенные в положении 2 и 3, способ их получения и применение их в терапии | |
AR116022A1 (es) | Compuestos heteroaromáticos como inhibidores de vanina | |
GB0903480D0 (en) | Enzyme Inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |