ATE520688T1 - Verfahren zur herstellung von darifenacin- wasserstoff-bromid - Google Patents

Verfahren zur herstellung von darifenacin- wasserstoff-bromid

Info

Publication number
ATE520688T1
ATE520688T1 AT09705800T AT09705800T ATE520688T1 AT E520688 T1 ATE520688 T1 AT E520688T1 AT 09705800 T AT09705800 T AT 09705800T AT 09705800 T AT09705800 T AT 09705800T AT E520688 T1 ATE520688 T1 AT E520688T1
Authority
AT
Austria
Prior art keywords
hydrogen bromide
darifenacin
producing
pyrrolidine
base
Prior art date
Application number
AT09705800T
Other languages
English (en)
Inventor
Ludmila Hejtmankova
Josef Jirman
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Application granted granted Critical
Publication of ATE520688T1 publication Critical patent/ATE520688T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT09705800T 2008-01-28 2009-01-14 Verfahren zur herstellung von darifenacin- wasserstoff-bromid ATE520688T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20080045A CZ300895B6 (cs) 2008-01-28 2008-01-28 Zpusob prípravy Darifenacinu
PCT/CZ2009/000003 WO2009094957A1 (en) 2008-01-28 2009-01-14 A method for the preparation of darifenacin hydrogen bromide

Publications (1)

Publication Number Publication Date
ATE520688T1 true ATE520688T1 (de) 2011-09-15

Family

ID=40512484

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09705800T ATE520688T1 (de) 2008-01-28 2009-01-14 Verfahren zur herstellung von darifenacin- wasserstoff-bromid

Country Status (8)

Country Link
US (1) US20100317871A1 (de)
EP (1) EP2238129B1 (de)
AT (1) ATE520688T1 (de)
CZ (1) CZ300895B6 (de)
EA (1) EA017928B1 (de)
PL (1) PL2238129T3 (de)
UA (1) UA99640C2 (de)
WO (1) WO2009094957A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011070419A1 (en) * 2009-12-10 2011-06-16 Aurobindo Pharma Limited An improved process for the preparation of darifenacin hydrobromide
CN107721955B (zh) * 2016-11-30 2019-10-11 内蒙古京东药业有限公司 达非那新中间体2，3-二氢-5-苯并呋喃乙酸的制备新方法
CN107721954B (zh) * 2016-11-30 2020-02-14 内蒙古京东药业有限公司 达非那新中间体2，3-二氢-5-苯并呋喃乙酸的制备新方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
GB9518953D0 (en) * 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
GB0129962D0 (en) * 2001-12-14 2002-02-06 Pfizer Ltd Method of treatment
GB0207104D0 (en) * 2002-03-26 2002-05-08 Pfizer Ltd Stable hydrate of a muscarinic receptor antagonist
US20070197630A1 (en) * 2005-12-27 2007-08-23 Valeriano Merli Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof

Also Published As

Publication number Publication date
PL2238129T3 (pl) 2011-12-30
US20100317871A1 (en) 2010-12-16
EP2238129B1 (de) 2011-08-17
EA201001191A1 (ru) 2010-12-30
CZ200845A3 (cs) 2009-09-02
EP2238129A1 (de) 2010-10-13
UA99640C2 (ru) 2012-09-10
EA017928B1 (ru) 2013-04-30
WO2009094957A1 (en) 2009-08-06
CZ300895B6 (cs) 2009-09-02

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Legal Events

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