WO2008126106A8 - Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts - Google Patents
Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts Download PDFInfo
- Publication number
- WO2008126106A8 WO2008126106A8 PCT/IN2008/000245 IN2008000245W WO2008126106A8 WO 2008126106 A8 WO2008126106 A8 WO 2008126106A8 IN 2008000245 W IN2008000245 W IN 2008000245W WO 2008126106 A8 WO2008126106 A8 WO 2008126106A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- darifenacin
- preparation
- pharmaceutically acceptable
- acceptable salts
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
The present invention relates to novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts. Darifenacin is chemically known as 3 -(S)-(-)-(l -carbamoyl- 1,1 -diphenylmethyl)-l- [2- (2,3-dihydro benzofuran-5-yl)ethyl]pyrrolidine and represented by formula (II). The invention also relates to the novel polymorphs of the pharmaceutically acceptable salts of darifenacin and the methods for their preparation.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN790CH2007 | 2007-04-16 | ||
IN790/CHE/2007 | 2007-04-16 | ||
IN2004CH2007 | 2007-09-06 | ||
IN2004/CHE/2007 | 2007-09-06 | ||
IN895CH2008 | 2008-04-10 | ||
IN895/CHE/2008 | 2008-04-10 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008126106A2 WO2008126106A2 (en) | 2008-10-23 |
WO2008126106A8 true WO2008126106A8 (en) | 2009-04-30 |
WO2008126106A3 WO2008126106A3 (en) | 2011-07-14 |
Family
ID=39864466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2008/000245 WO2008126106A2 (en) | 2007-04-16 | 2008-04-15 | Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008126106A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009007853A2 (en) * | 2007-06-08 | 2009-01-15 | Actavis Group Ptc Ehf | Novel polymorphs of darifenacin free base and its hydrobromide salt |
US20090018346A1 (en) * | 2007-07-13 | 2009-01-15 | Medichem, S.A. | Amorphous Form Of Darifenacin Hydrobromide And Processes For The Preparation Thereof |
JP2012041277A (en) * | 2010-08-13 | 2012-03-01 | Kaneka Corp | Improved method for producing 1, 3-disubstituted pyrrolidine compound or salt thereof |
CN101973971A (en) * | 2010-09-26 | 2011-02-16 | 山东邹平大展新材料有限公司 | Method for preparing 5-halogenated ethyl-2,3-dihydrobenzofuran |
FI126118B (en) | 2012-02-10 | 2016-06-30 | Upm Kymmene Corp | Cellulose pulp pretreatment method |
CN110922294A (en) * | 2019-12-11 | 2020-03-27 | 安徽至善新材料有限公司 | Method for preparing organic bromide from organic chloride |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL76583A (en) * | 1984-10-19 | 1988-08-31 | Robins Co Inc A H | 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them |
GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
US20070203221A1 (en) * | 2005-12-27 | 2007-08-30 | Valeriano Merli | Processes for preparing darifenacin hydrobromide |
AR062676A1 (en) * | 2006-09-07 | 2008-11-26 | Medichem Sa | IMPROVED PROCEDURE TO PREPARE 1,3-DISPOSED PIRROLIDINE COMPOUNDS |
EP2109601A2 (en) * | 2007-01-05 | 2009-10-21 | Dr. Reddy's Laboratories Ltd. | Preparation of darifenacin and its salts |
-
2008
- 2008-04-15 WO PCT/IN2008/000245 patent/WO2008126106A2/en active Search and Examination
Also Published As
Publication number | Publication date |
---|---|
WO2008126106A3 (en) | 2011-07-14 |
WO2008126106A2 (en) | 2008-10-23 |
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