ATE520396T1 - Isoflavon-nanoteilchen und ihre verwendung - Google Patents
Isoflavon-nanoteilchen und ihre verwendungInfo
- Publication number
- ATE520396T1 ATE520396T1 AT06706520T AT06706520T ATE520396T1 AT E520396 T1 ATE520396 T1 AT E520396T1 AT 06706520 T AT06706520 T AT 06706520T AT 06706520 T AT06706520 T AT 06706520T AT E520396 T1 ATE520396 T1 AT E520396T1
- Authority
- AT
- Austria
- Prior art keywords
- isoflavone
- compositions
- nanoparticles
- nanoparticle compositions
- isoflavone nanoparticles
- Prior art date
Links
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 title abstract 6
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 title abstract 6
- 235000008696 isoflavones Nutrition 0.000 title abstract 6
- 239000002105 nanoparticle Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- 239000003674 animal food additive Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000002778 food additive Substances 0.000 abstract 1
- -1 foodstuff Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/20—Ingredients acting on or related to the structure
- A23V2200/25—Nanoparticles, nanostructures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Polymers & Plastics (AREA)
- Birds (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Dispersion Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05014096 | 2005-06-29 | ||
PCT/EP2006/000827 WO2007000193A1 (en) | 2005-06-29 | 2006-01-31 | Isoflavone nanoparticles and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE520396T1 true ATE520396T1 (de) | 2011-09-15 |
Family
ID=36013328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06706520T ATE520396T1 (de) | 2005-06-29 | 2006-01-31 | Isoflavon-nanoteilchen und ihre verwendung |
Country Status (9)
Country | Link |
---|---|
US (1) | US8951560B2 (de) |
EP (1) | EP1904053B1 (de) |
JP (1) | JP5134535B2 (de) |
KR (1) | KR101242851B1 (de) |
CN (1) | CN101212964A (de) |
AT (1) | ATE520396T1 (de) |
BR (1) | BRPI0612848B8 (de) |
ES (1) | ES2369928T3 (de) |
WO (1) | WO2007000193A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0612705A2 (pt) * | 2005-06-29 | 2010-11-30 | Dsm Ip Assets Bv | composições tópicas compreendendo nanopartìculas de uma isoflavona |
CA2669392C (en) | 2006-11-17 | 2016-05-10 | Abbott Gmbh & Co. Kg | Nanocrystals for use in topical cosmetic formulations and method of production thereof |
WO2008137831A1 (en) * | 2007-05-07 | 2008-11-13 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Water-soluble nanoparticles containing water-insoluble compounds |
JP2011503232A (ja) | 2007-11-20 | 2011-01-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 免疫応答の調節 |
FR2932488B1 (fr) * | 2008-06-13 | 2012-10-26 | Roquette Freres | Compositions thermoplastiques ou elastomeriques a base d'amidon et procede de preparation de telles compositions. |
IT1394148B1 (it) | 2008-09-12 | 2012-05-25 | Visottica Ind S P A Con Unico Socio | Cerniera elastica a doppio scatto per occhiali |
KR101849059B1 (ko) * | 2008-12-11 | 2018-04-13 | 악센투아 파마슈투칼스 아베 | 제니스테인의 결정성 형태 |
US20100215700A1 (en) * | 2009-02-25 | 2010-08-26 | Conopco, Inc., D/B/A Unilever | Shear Gels and Compositions Comprising Shear Gels |
US9889098B2 (en) * | 2009-10-22 | 2018-02-13 | Vizuri Health Sciences Llc | Methods of making and using compositions comprising flavonoids |
US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
US8900635B2 (en) * | 2010-11-15 | 2014-12-02 | Humanetics Corporation | Nanoparticle isoflavone compositions and methods of making and using the same |
BRPI1101820A2 (pt) * | 2011-04-29 | 2013-06-18 | Hebron Farmaceutica Pesq Des E Inovacao Tec Ltda | composiÇÕes farmacÊuticas e seus usos para tratamento e/ou prevenÇço de doenÇas decorrentes do hipoestrogenismo no trato genital inferior feminino |
US9623003B1 (en) | 2013-04-04 | 2017-04-18 | Humanetics Corporation | Method of mitigating long and short term detrimental effects of exposure to medical imaging ionizing radiation by administration of genistein |
US9623004B2 (en) | 2013-08-02 | 2017-04-18 | Humanetics Corporation | Administration of a therapeutic amount of genistein to mitigate erectile dysfunction resulting from radiation therapy for prostate cancer only throughout a defined administration period commencing shortly before and concluding after radiation therapy |
US9084726B2 (en) | 2013-11-26 | 2015-07-21 | Humanetics Corporation | Suspension compositions of physiologically active phenolic compounds and methods of making and using the same |
WO2015087329A1 (en) | 2013-12-12 | 2015-06-18 | Technion Research & Development Foundation Limited | Pectin based nanoparticles |
FI126755B (en) * | 2014-04-28 | 2017-05-15 | Kemira Oyj | A process for preparing a suspension from microfibrillated cellulose, microfibrillated cellulose and its use |
FR3023474B1 (fr) * | 2014-07-09 | 2016-07-22 | Oreal | Huile anhydre a base de particules a liberation d'agent benefique |
CN114306275B (zh) * | 2021-12-24 | 2023-05-26 | 齐鲁工业大学 | 一种豌豆肽负载大豆异黄酮复合纳米粒子及其制备方法和应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
US5824702A (en) * | 1996-06-07 | 1998-10-20 | Mount Sinai School Of Medicine Of The City University Of New York | Genistein as a preventive against ultraviolet induced skin photodamage and cancer |
WO1999038509A1 (en) | 1998-01-28 | 1999-08-05 | Dusan Miljkovic | Isoflavanoid formulations for oral administration |
DE19825856A1 (de) | 1998-06-10 | 1999-12-16 | Labtec Gmbh | Topische Arzneimittelzubereitung |
MX220923B (es) * | 1999-01-25 | 2004-06-11 | Ato Bv | Nanoparticulas biopolimericas. |
JP4006133B2 (ja) * | 1999-05-17 | 2007-11-14 | 松谷化学工業株式会社 | 可溶性イソフラボン組成物及びその製造方法 |
FR2817478A1 (fr) | 2000-12-04 | 2002-06-07 | Oreal | Suspensions aqueuses de nanospheres de principes actifs lipophiles |
US20040256749A1 (en) | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
FR2820320B1 (fr) * | 2001-02-02 | 2003-04-04 | Oreal | Suspension de nanospheres de principe actif lipophile stabilisee par des polymeres hydrodispersibles |
DE10114305A1 (de) | 2001-03-23 | 2002-09-26 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen mit einem Gehalt an Isoflavonen und Verwendung von Isoflavonen zur Herstellung kosmetischer und dermatologischer Zubereitungen zur Reduktion des Sebumgehaltes der Haut |
EP1269994A3 (de) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten |
JP4013034B2 (ja) * | 2001-10-24 | 2007-11-28 | 横浜油脂工業株式会社 | 可溶化性イソフラボン組成物、その製造法及びイソフラボン含有水性飲料の製造方法 |
WO2003049689A2 (en) * | 2001-12-06 | 2003-06-19 | Nutraceutix, Inc. | Isoflavone composition for oral delivery |
DE60320380T2 (de) * | 2002-02-14 | 2009-05-20 | Dsm Ip Assets B.V. | Coenzym q10 formulierungen |
BRPI0612705A2 (pt) * | 2005-06-29 | 2010-11-30 | Dsm Ip Assets Bv | composições tópicas compreendendo nanopartìculas de uma isoflavona |
-
2006
- 2006-01-31 BR BRPI0612848A patent/BRPI0612848B8/pt not_active IP Right Cessation
- 2006-01-31 EP EP06706520A patent/EP1904053B1/de not_active Not-in-force
- 2006-01-31 JP JP2008518646A patent/JP5134535B2/ja not_active Expired - Fee Related
- 2006-01-31 ES ES06706520T patent/ES2369928T3/es active Active
- 2006-01-31 US US11/994,216 patent/US8951560B2/en active Active
- 2006-01-31 CN CNA2006800237970A patent/CN101212964A/zh active Pending
- 2006-01-31 WO PCT/EP2006/000827 patent/WO2007000193A1/en active Application Filing
- 2006-01-31 KR KR1020077030532A patent/KR101242851B1/ko active IP Right Grant
- 2006-01-31 AT AT06706520T patent/ATE520396T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2007000193A1 (en) | 2007-01-04 |
ES2369928T3 (es) | 2011-12-09 |
EP1904053A1 (de) | 2008-04-02 |
US8951560B2 (en) | 2015-02-10 |
JP2008544963A (ja) | 2008-12-11 |
US20090035336A1 (en) | 2009-02-05 |
BRPI0612848A2 (pt) | 2010-11-30 |
WO2007000193A9 (en) | 2007-12-13 |
BRPI0612848B8 (pt) | 2021-05-25 |
EP1904053B1 (de) | 2011-08-17 |
KR101242851B1 (ko) | 2013-03-12 |
KR20080020643A (ko) | 2008-03-05 |
BRPI0612848B1 (pt) | 2020-03-31 |
BRPI0612848A8 (pt) | 2017-12-26 |
CN101212964A (zh) | 2008-07-02 |
JP5134535B2 (ja) | 2013-01-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |