WO2007038571A3 - Prolyl hydroxylase antagonists - Google Patents
Prolyl hydroxylase antagonists Download PDFInfo
- Publication number
- WO2007038571A3 WO2007038571A3 PCT/US2006/037611 US2006037611W WO2007038571A3 WO 2007038571 A3 WO2007038571 A3 WO 2007038571A3 US 2006037611 W US2006037611 W US 2006037611W WO 2007038571 A3 WO2007038571 A3 WO 2007038571A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antagonists
- prolyl hydroxylase
- quinolin
- carbonyl
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Abstract
This invention relates to certain 2-[(quinolin-3-yl)carbonyl]aminoacetic acid derivatives of formula (I), where the various groups are defined herein, and which are useful in treating anemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72052005P | 2005-09-26 | 2005-09-26 | |
US60/720,520 | 2005-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007038571A2 WO2007038571A2 (en) | 2007-04-05 |
WO2007038571A3 true WO2007038571A3 (en) | 2007-10-11 |
Family
ID=37900404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/037611 WO2007038571A2 (en) | 2005-09-26 | 2006-09-26 | Prolyl hydroxylase antagonists |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007038571A2 (en) |
Cited By (1)
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---|---|---|---|---|
US8927591B2 (en) | 2008-11-14 | 2015-01-06 | Fibrogen, Inc. | Thiochromene derivatives as HIF hydroxylase inhibitors |
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EP1960363B1 (en) * | 2005-12-09 | 2014-01-22 | Amgen, Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions and uses thereof |
US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
LT3357911T (en) | 2006-06-26 | 2022-08-10 | Akebia Therapeutics Inc. | Prolyl hydroxylase inhibitors and methods of use |
JP5273587B2 (en) * | 2006-11-22 | 2013-08-28 | 味の素株式会社 | Process for producing phenylalanine derivative having quinazolinedione skeleton and production intermediate |
CA2672652C (en) | 2006-12-18 | 2012-04-17 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
EP2111399A2 (en) | 2006-12-18 | 2009-10-28 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
WO2008130508A1 (en) | 2007-04-18 | 2008-10-30 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
WO2008130527A1 (en) * | 2007-04-18 | 2008-10-30 | Merck & Co., Inc. | Novel 1,8-naphthyridine compounds |
US8048894B2 (en) | 2007-04-18 | 2011-11-01 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
WO2008137060A1 (en) | 2007-05-04 | 2008-11-13 | Amgen Inc. | Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity |
US8097620B2 (en) | 2007-05-04 | 2012-01-17 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
US20100222347A1 (en) | 2007-09-27 | 2010-09-02 | Kowa Company, Ltd. | Prophylactic and/or therapeutic agent for anemia, comprising tetrahydroquinoline compound as active ingredient |
WO2009073669A1 (en) | 2007-12-03 | 2009-06-11 | Fibrogen, Inc. | Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions |
EP2240178A4 (en) * | 2007-12-19 | 2011-10-26 | Glaxosmithkline Llc | Prolyl hydroxylase inhibitors |
US8952160B2 (en) | 2008-01-11 | 2015-02-10 | Fibrogen, Inc. | Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity |
WO2009100250A1 (en) * | 2008-02-05 | 2009-08-13 | Fibrogen, Inc. | Chromene derivatives and use thereof as hif hydroxylase activity inhibitors |
CN101951777A (en) * | 2008-02-25 | 2011-01-19 | 默沙东公司 | Tetrahydrofuropyridones |
WO2009134754A1 (en) | 2008-04-28 | 2009-11-05 | Janssen Pharmaceutica Nv | Benzoimidazole glycinamides as prolyl hydroxylase inhibitors |
US8217043B2 (en) | 2008-08-20 | 2012-07-10 | Fibrogen, Inc. | Compounds and methods for their use |
JP2012500802A (en) * | 2008-08-21 | 2012-01-12 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Prolyl hydroxylase inhibitor |
JP5572154B2 (en) * | 2009-03-31 | 2014-08-13 | 興和株式会社 | A prophylactic and / or therapeutic agent for anemia comprising a tetrahydroquinoline compound as an active ingredient |
JP2012532128A (en) | 2009-06-30 | 2012-12-13 | メルク・シャープ・エンド・ドーム・コーポレイション | Substituted 4-hydroxypyrimidine-5-carboxamide |
AU2010266558A1 (en) | 2009-06-30 | 2012-01-12 | Merck Sharp & Dohme Corp. | Substituted 4-hydroxypyrimidine-5-carboxamides |
AU2010273101B2 (en) * | 2009-07-15 | 2016-02-25 | Beijing Betta Pharmaceuticals Co., Ltd. | Compounds as hypoxia mimetics, and compositions, and uses thereof |
BR112012009452A2 (en) | 2009-10-21 | 2016-04-26 | Daiichi Sankyo Co Ltd | 5-hydroxypyrimidine-4-carboxamide derivative |
AU2010314982B2 (en) | 2009-11-06 | 2013-08-29 | Aerpio Therapeutics Inc. | Compositions and methods for treating colitis |
JP5676769B2 (en) | 2010-10-14 | 2015-02-25 | イムナール アクティエボラーグ | 1,2-Dihydro-4-hydroxy-2-oxo-quinoline-3-carboxyanilide as an AHR activator |
CN103608346B (en) | 2011-02-02 | 2016-06-15 | 菲布罗根有限公司 | As the 7-naphthyridine derivatives of hypoxia inducible factor (HIF) hydroxylase inhibitors |
GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
CN103717214A (en) | 2011-06-06 | 2014-04-09 | 阿克比治疗有限公司 | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
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WO2013043621A1 (en) | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
WO2013043624A1 (en) | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
US9273034B2 (en) | 2011-10-25 | 2016-03-01 | Janssen Pharmaceutica Nv | Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo[D]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid |
KR102018409B1 (en) | 2012-07-30 | 2019-09-04 | 다이쇼 세이야꾸 가부시끼가이샤 | Partially saturated nitrogen-containing heterocyclic compound |
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TWI598339B (en) | 2012-12-24 | 2017-09-11 | 卡地拉保健有限公司 | Novel quinolone derivatives |
LT3007695T (en) | 2013-06-13 | 2024-03-25 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
JP2016537365A (en) | 2013-11-15 | 2016-12-01 | アケビア セラピューティクス インコーポレイテッドAkebia Therapeutics Inc. | {[5- (3-Chlorophenyl) -3-hydroxypyridine-2-carbonyl] amino} acetic acid solid form, composition and use thereof |
US10065928B2 (en) * | 2014-09-02 | 2018-09-04 | Sunshine Lake Pharma Co., Ltd. | Quinolinone compound and use thereof |
WO2016045125A1 (en) * | 2014-09-28 | 2016-03-31 | Merck Sharp & Dohme Corp. | Inhibitors of hif prolyl hydroxylase |
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CR20170450A (en) | 2015-04-01 | 2018-04-03 | Akebia Therapeutics Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF THE ANEMIA |
CN105294648B (en) * | 2015-11-30 | 2017-11-28 | 山东罗欣药业集团股份有限公司 | A kind of preparation method of sitafloxacin |
CN108069952B (en) * | 2016-11-08 | 2022-09-27 | 广东东阳光药业有限公司 | Quinolinone compound and application thereof in medicines |
CA3097219A1 (en) | 2018-05-09 | 2019-11-14 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
EP4067346A4 (en) * | 2019-11-28 | 2023-11-08 | Sunshine Lake Pharma Co., Ltd. | Crystal form of quinolinone compound and use thereof |
CN111269177B (en) * | 2019-11-28 | 2023-05-09 | 广东东阳光药业有限公司 | Crystal forms of quinolinone compounds |
CN115010664A (en) * | 2021-03-05 | 2022-09-06 | 广东东阳光药业有限公司 | Crystal form of quinolinone compound and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4738971A (en) * | 1981-03-03 | 1988-04-19 | Aktiebolaset Leo | N-aryl-1,2-dihydro-4-substituted-1-alkyl-2-oxo-quinoline-3-carboxamides |
US20030153503A1 (en) * | 2001-12-06 | 2003-08-14 | Klaus Stephen J. | Methods of increasing endogenous erythropoietin (EPO) |
-
2006
- 2006-09-26 WO PCT/US2006/037611 patent/WO2007038571A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4738971A (en) * | 1981-03-03 | 1988-04-19 | Aktiebolaset Leo | N-aryl-1,2-dihydro-4-substituted-1-alkyl-2-oxo-quinoline-3-carboxamides |
US20030153503A1 (en) * | 2001-12-06 | 2003-08-14 | Klaus Stephen J. | Methods of increasing endogenous erythropoietin (EPO) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8927591B2 (en) | 2008-11-14 | 2015-01-06 | Fibrogen, Inc. | Thiochromene derivatives as HIF hydroxylase inhibitors |
US9149476B2 (en) | 2008-11-14 | 2015-10-06 | Fibrogen, Inc. | Thiochromene derivatives as HIF hydroxylase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2007038571A2 (en) | 2007-04-05 |
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