ATE512959T1 - 2-substituierte benzimidazolpiperidinanaloga als selektive antagonisten des auf das melanin- konzentrierende hormon wirkenden rezeptors zur behandlung von obesitas und verwandten erkrankungen - Google Patents
2-substituierte benzimidazolpiperidinanaloga als selektive antagonisten des auf das melanin- konzentrierende hormon wirkenden rezeptors zur behandlung von obesitas und verwandten erkrankungenInfo
- Publication number
- ATE512959T1 ATE512959T1 AT04782252T AT04782252T ATE512959T1 AT E512959 T1 ATE512959 T1 AT E512959T1 AT 04782252 T AT04782252 T AT 04782252T AT 04782252 T AT04782252 T AT 04782252T AT E512959 T1 ATE512959 T1 AT E512959T1
- Authority
- AT
- Austria
- Prior art keywords
- benzimidazolepiperidine
- obesity
- analogs
- substituted
- treatment
- Prior art date
Links
- 102000029828 Melanin-concentrating hormone receptor Human genes 0.000 title 1
- 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 title 1
- 208000008589 Obesity Diseases 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49887603P | 2003-08-29 | 2003-08-29 | |
| PCT/US2004/027734 WO2005023798A1 (en) | 2003-08-29 | 2004-08-26 | 2-substituted benzimidazole piperidines analogs as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE512959T1 true ATE512959T1 (de) | 2011-07-15 |
Family
ID=34272746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04782252T ATE512959T1 (de) | 2003-08-29 | 2004-08-26 | 2-substituierte benzimidazolpiperidinanaloga als selektive antagonisten des auf das melanin- konzentrierende hormon wirkenden rezeptors zur behandlung von obesitas und verwandten erkrankungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7511146B2 (enExample) |
| EP (1) | EP1664022B1 (enExample) |
| JP (1) | JP4672662B2 (enExample) |
| CN (1) | CN1845916A (enExample) |
| AR (1) | AR045496A1 (enExample) |
| AT (1) | ATE512959T1 (enExample) |
| CA (1) | CA2536929C (enExample) |
| MX (1) | MXPA06002372A (enExample) |
| TW (1) | TW200524902A (enExample) |
| WO (1) | WO2005023798A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070091038A (ko) * | 2004-12-24 | 2007-09-06 | 프로시디온 리미티드 | Ｇ-단백질 결합 수용체(ｇｐｒ116) 효능제 및 비만 및당뇨병을 치료하기 위한 이의 용도 |
| AU2006264649A1 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | GPCR agonists |
| CL2008000018A1 (es) * | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
| EP2114933B1 (en) * | 2007-01-04 | 2011-09-07 | Prosidion Ltd | Piperidine gpcr agonists |
| PE20081849A1 (es) * | 2007-01-04 | 2009-01-26 | Prosidion Ltd | Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr |
| WO2010065704A1 (en) * | 2008-12-04 | 2010-06-10 | Glaxo Group Limited | Method for preparing a spiroindoline and a precursor thereof |
| CN104860919B (zh) * | 2015-03-26 | 2017-11-10 | 天津药物研究院有限公司 | 含哌啶的苯并咪唑衍生物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908830A (en) | 1996-10-31 | 1999-06-01 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes and obesity |
| US20020169166A1 (en) * | 2001-03-09 | 2002-11-14 | Cowart Marlon D. | Benzimidazoles that are useful in treating sexual dysfunction |
| US6900329B2 (en) | 2001-03-21 | 2005-05-31 | Schering Corporation | MCH antagonists and their use in the treatment of obesity |
| JO2390B1 (en) * | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
| CA2443672C (en) * | 2001-04-12 | 2011-03-29 | Pharmacopeia, Inc. | Aryl and biaryl piperidines used as mch antagonists |
| US6664273B2 (en) * | 2001-11-26 | 2003-12-16 | Schering Corporation | Piperidine based MCH antagonists for treatment of obesity and CNS disorders |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
-
2004
- 2004-08-25 AR ARP040103055A patent/AR045496A1/es unknown
- 2004-08-26 US US10/926,557 patent/US7511146B2/en not_active Expired - Fee Related
- 2004-08-26 JP JP2006524846A patent/JP4672662B2/ja not_active Expired - Fee Related
- 2004-08-26 AT AT04782252T patent/ATE512959T1/de not_active IP Right Cessation
- 2004-08-26 TW TW093125667A patent/TW200524902A/zh unknown
- 2004-08-26 WO PCT/US2004/027734 patent/WO2005023798A1/en not_active Ceased
- 2004-08-26 CA CA2536929A patent/CA2536929C/en not_active Expired - Fee Related
- 2004-08-26 EP EP04782252A patent/EP1664022B1/en not_active Expired - Lifetime
- 2004-08-26 MX MXPA06002372A patent/MXPA06002372A/es active IP Right Grant
- 2004-08-26 CN CNA2004800249377A patent/CN1845916A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1845916A (zh) | 2006-10-11 |
| US7511146B2 (en) | 2009-03-31 |
| JP2007504146A (ja) | 2007-03-01 |
| AR045496A1 (es) | 2005-11-02 |
| EP1664022A1 (en) | 2006-06-07 |
| MXPA06002372A (es) | 2006-06-20 |
| EP1664022B1 (en) | 2011-06-15 |
| TW200524902A (en) | 2005-08-01 |
| JP4672662B2 (ja) | 2011-04-20 |
| CA2536929C (en) | 2010-09-28 |
| CA2536929A1 (en) | 2005-03-17 |
| WO2005023798A1 (en) | 2005-03-17 |
| US20050054628A1 (en) | 2005-03-10 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |