ATE506354T1 - Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren - Google Patents
Substituierte arylcyclopropylacetamide als glucokinaseaktivatorenInfo
- Publication number
- ATE506354T1 ATE506354T1 AT03815189T AT03815189T ATE506354T1 AT E506354 T1 ATE506354 T1 AT E506354T1 AT 03815189 T AT03815189 T AT 03815189T AT 03815189 T AT03815189 T AT 03815189T AT E506354 T1 ATE506354 T1 AT E506354T1
- Authority
- AT
- Austria
- Prior art keywords
- arylcyclopropylacetamide
- substituted
- glucocinase
- activators
- glucocinase activators
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyrrole Compounds (AREA)
- Detergent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43853903P | 2003-01-06 | 2003-01-06 | |
| PCT/US2003/037088 WO2004063179A1 (en) | 2003-01-06 | 2003-12-16 | Substituted arylcyclopropylacetamides as glucokinase activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE506354T1 true ATE506354T1 (de) | 2011-05-15 |
Family
ID=32713343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03815189T ATE506354T1 (de) | 2003-01-06 | 2003-12-16 | Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7576108B2 (enExample) |
| EP (1) | EP1585739B1 (enExample) |
| JP (1) | JP4716734B2 (enExample) |
| AT (1) | ATE506354T1 (enExample) |
| AU (1) | AU2003297291A1 (enExample) |
| CA (1) | CA2509086C (enExample) |
| CY (1) | CY1111481T1 (enExample) |
| DE (1) | DE60336850D1 (enExample) |
| DK (1) | DK1585739T3 (enExample) |
| ES (1) | ES2362656T3 (enExample) |
| PT (1) | PT1585739E (enExample) |
| SI (1) | SI1585739T1 (enExample) |
| WO (1) | WO2004063179A1 (enExample) |
Families Citing this family (87)
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| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| PL375021A1 (en) | 2002-10-03 | 2005-11-14 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
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| US20080300243A1 (en) * | 2005-02-28 | 2008-12-04 | Kelly Michael G | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same |
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|---|---|---|---|---|
| BR0015671A (pt) * | 1999-11-18 | 2002-07-23 | Novartis Ag | Compostos de aminoheterociclamida pesticidal |
| EP1282612B1 (en) * | 2000-05-03 | 2004-12-29 | F. Hoffmann-La Roche Ag | Alkynyl phenyl heteroaromatic glucokinase activators |
| MXPA02010795A (es) * | 2000-05-08 | 2003-03-27 | Hoffmann La Roche | Activadores de glucocinasa de fenilamida sustituida por para-amino. |
| BR0110704A (pt) * | 2000-05-08 | 2003-01-28 | Hoffmann La Roche | Fenil - acetamidas substituìdas e seu uso como ativadores de glicocinase |
-
2003
- 2003-12-16 WO PCT/US2003/037088 patent/WO2004063179A1/en not_active Ceased
- 2003-12-16 AT AT03815189T patent/ATE506354T1/de active
- 2003-12-16 JP JP2004566494A patent/JP4716734B2/ja not_active Expired - Fee Related
- 2003-12-16 PT PT03815189T patent/PT1585739E/pt unknown
- 2003-12-16 DE DE60336850T patent/DE60336850D1/de not_active Expired - Lifetime
- 2003-12-16 US US10/541,047 patent/US7576108B2/en not_active Expired - Fee Related
- 2003-12-16 ES ES03815189T patent/ES2362656T3/es not_active Expired - Lifetime
- 2003-12-16 CA CA2509086A patent/CA2509086C/en not_active Expired - Fee Related
- 2003-12-16 SI SI200332000T patent/SI1585739T1/sl unknown
- 2003-12-16 AU AU2003297291A patent/AU2003297291A1/en not_active Abandoned
- 2003-12-16 EP EP03815189A patent/EP1585739B1/en not_active Expired - Lifetime
- 2003-12-16 DK DK03815189.0T patent/DK1585739T3/da active
-
2011
- 2011-05-20 CY CY20111100499T patent/CY1111481T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1585739E (pt) | 2011-05-13 |
| US20060111353A1 (en) | 2006-05-25 |
| EP1585739A1 (en) | 2005-10-19 |
| CA2509086A1 (en) | 2004-07-29 |
| ES2362656T3 (es) | 2011-07-11 |
| CY1111481T1 (el) | 2015-08-05 |
| WO2004063179A1 (en) | 2004-07-29 |
| JP4716734B2 (ja) | 2011-07-06 |
| AU2003297291A1 (en) | 2004-08-10 |
| SI1585739T1 (sl) | 2011-07-29 |
| EP1585739B1 (en) | 2011-04-20 |
| US7576108B2 (en) | 2009-08-18 |
| DK1585739T3 (da) | 2011-06-20 |
| CA2509086C (en) | 2012-08-21 |
| JP2006515858A (ja) | 2006-06-08 |
| DE60336850D1 (en) | 2011-06-01 |
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