ATE501121T1 - 4-ä(3- fluorphenoxy)phenylmethylüpiperidinmethandsulfo atverwendungen, syntheseverfahren und pharmazeutische zusammensetzungen - Google Patents
4-ä(3- fluorphenoxy)phenylmethylüpiperidinmethandsulfo atverwendungen, syntheseverfahren und pharmazeutische zusammensetzungenInfo
- Publication number
- ATE501121T1 ATE501121T1 AT07728049T AT07728049T ATE501121T1 AT E501121 T1 ATE501121 T1 AT E501121T1 AT 07728049 T AT07728049 T AT 07728049T AT 07728049 T AT07728049 T AT 07728049T AT E501121 T1 ATE501121 T1 AT E501121T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical compositions
- phenylmethylüpiperidine
- methanesulfoate
- fluorphenoxy
- synthetic methods
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 3- FLUORPHENOXY Chemical class 0.000 title 1
- 238000010189 synthetic method Methods 0.000 title 1
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- ZEFXAHXKTLEBQA-UHFFFAOYSA-N 4-[(3-fluorophenoxy)-phenylmethyl]piperidine;methanesulfonic acid Chemical compound CS(O)(=O)=O.FC1=CC=CC(OC(C2CCNCC2)C=2C=CC=CC=2)=C1 ZEFXAHXKTLEBQA-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06380112A EP1854785A1 (de) | 2006-05-12 | 2006-05-12 | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulponat: Anwendungen, Verfahren zur Synthese und pharmazeutische Zusammensetzungen |
| US11/486,350 US20070265306A1 (en) | 2006-05-12 | 2006-07-13 | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions |
| PCT/EP2007/053582 WO2007131846A1 (en) | 2006-05-12 | 2007-04-12 | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501121T1 true ATE501121T1 (de) | 2011-03-15 |
Family
ID=37061190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07728049T ATE501121T1 (de) | 2006-05-12 | 2007-04-12 | 4-ä(3- fluorphenoxy)phenylmethylüpiperidinmethandsulfo atverwendungen, syntheseverfahren und pharmazeutische zusammensetzungen |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20070265306A1 (de) |
| EP (2) | EP1854785A1 (de) |
| JP (1) | JP2009536962A (de) |
| KR (1) | KR20090009971A (de) |
| CN (1) | CN101443312B (de) |
| AT (1) | ATE501121T1 (de) |
| AU (1) | AU2007251663B2 (de) |
| BR (1) | BRPI0710856A2 (de) |
| CA (1) | CA2651933A1 (de) |
| CY (1) | CY1111460T1 (de) |
| DE (1) | DE602007013040D1 (de) |
| DK (1) | DK2032534T3 (de) |
| ES (1) | ES2362683T3 (de) |
| HR (1) | HRP20110333T1 (de) |
| MX (1) | MX2008014439A (de) |
| MY (1) | MY148406A (de) |
| NO (1) | NO20085052L (de) |
| NZ (1) | NZ572714A (de) |
| PL (1) | PL2032534T3 (de) |
| RS (1) | RS51858B (de) |
| RU (1) | RU2412169C2 (de) |
| SI (1) | SI2032534T1 (de) |
| WO (1) | WO2007131846A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1854785A1 (de) * | 2006-05-12 | 2007-11-14 | Faes Farma, S.A. | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulponat: Anwendungen, Verfahren zur Synthese und pharmazeutische Zusammensetzungen |
| ES2434250T3 (es) | 2008-07-24 | 2013-12-16 | Theravance, Inc. | Compuestos de 3-(fenoxifenilmetil)pirrolidina |
| WO2010120910A1 (en) * | 2009-04-15 | 2010-10-21 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| US7994209B2 (en) * | 2009-07-13 | 2011-08-09 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
| JP5714580B2 (ja) | 2009-07-21 | 2015-05-07 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ３−フェノキシメチルピロリジン化合物 |
| ES2533434T3 (es) | 2010-10-11 | 2015-04-10 | Theravance Biopharma R&D Ip, Llc | Inhibidores de la captación de la serotonina |
| WO2012075239A1 (en) | 2010-12-03 | 2012-06-07 | Theravance, Inc. | Serotonin reuptake inhibitors |
| US9002322B2 (en) * | 2011-09-29 | 2015-04-07 | Apple Inc. | Authentication with secondary approver |
| CN104887675B (zh) * | 2014-03-05 | 2018-08-07 | 江苏恩华药业股份有限公司 | [(芳氧基)(杂芳基)]甲基哌啶衍生物在制备治疗抑郁症的药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203149A (en) * | 1968-06-10 | 1970-08-26 | Ici Ltd | Piperidine derivatives |
| US6518284B2 (en) * | 1998-11-18 | 2003-02-11 | Faes, Fabrica Espanola De Productos Quimicos Y Farmaceuticos S.A. | 4-substituted piperidines |
| ES2157148B1 (es) * | 1998-11-18 | 2002-03-01 | Faes Fabrica Espanola De Produ | Nuevas piperidinas 4-sustituidas. |
| AP2006003771A0 (en) * | 2004-04-30 | 2006-10-31 | Warner Lambert Co | Substituted morpholine compounds for the treatmentof central nervous system disorders |
| EP1854785A1 (de) * | 2006-05-12 | 2007-11-14 | Faes Farma, S.A. | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulponat: Anwendungen, Verfahren zur Synthese und pharmazeutische Zusammensetzungen |
-
2006
- 2006-05-12 EP EP06380112A patent/EP1854785A1/de not_active Withdrawn
- 2006-07-13 US US11/486,350 patent/US20070265306A1/en not_active Abandoned
-
2007
- 2007-04-12 CN CN2007800172665A patent/CN101443312B/zh not_active Expired - Fee Related
- 2007-04-12 RS RS20110154A patent/RS51858B/sr unknown
- 2007-04-12 PL PL07728049T patent/PL2032534T3/pl unknown
- 2007-04-12 MY MYPI20084507A patent/MY148406A/en unknown
- 2007-04-12 WO PCT/EP2007/053582 patent/WO2007131846A1/en not_active Ceased
- 2007-04-12 EP EP07728049A patent/EP2032534B1/de active Active
- 2007-04-12 JP JP2009510383A patent/JP2009536962A/ja not_active Ceased
- 2007-04-12 RU RU2008148941/04A patent/RU2412169C2/ru not_active IP Right Cessation
- 2007-04-12 US US12/299,907 patent/US20100004283A1/en not_active Abandoned
- 2007-04-12 ES ES07728049T patent/ES2362683T3/es active Active
- 2007-04-12 SI SI200730543T patent/SI2032534T1/sl unknown
- 2007-04-12 DK DK07728049.3T patent/DK2032534T3/da active
- 2007-04-12 KR KR1020087030170A patent/KR20090009971A/ko not_active Ceased
- 2007-04-12 AT AT07728049T patent/ATE501121T1/de active
- 2007-04-12 CA CA002651933A patent/CA2651933A1/en not_active Abandoned
- 2007-04-12 MX MX2008014439A patent/MX2008014439A/es active IP Right Grant
- 2007-04-12 BR BRPI0710856-7A patent/BRPI0710856A2/pt not_active IP Right Cessation
- 2007-04-12 AU AU2007251663A patent/AU2007251663B2/en not_active Ceased
- 2007-04-12 HR HR20110333T patent/HRP20110333T1/hr unknown
- 2007-04-12 NZ NZ572714A patent/NZ572714A/en not_active IP Right Cessation
- 2007-04-12 DE DE602007013040T patent/DE602007013040D1/de active Active
-
2008
- 2008-12-04 NO NO20085052A patent/NO20085052L/no not_active Application Discontinuation
-
2011
- 2011-05-17 CY CY20111100477T patent/CY1111460T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007131846A1 (en) | 2007-11-22 |
| RS51858B (sr) | 2012-02-29 |
| SI2032534T1 (sl) | 2011-06-30 |
| EP2032534B1 (de) | 2011-03-09 |
| RU2412169C2 (ru) | 2011-02-20 |
| DE602007013040D1 (de) | 2011-04-21 |
| CN101443312A (zh) | 2009-05-27 |
| JP2009536962A (ja) | 2009-10-22 |
| MY148406A (en) | 2013-04-30 |
| KR20090009971A (ko) | 2009-01-23 |
| AU2007251663B2 (en) | 2012-04-05 |
| ES2362683T3 (es) | 2011-07-11 |
| HK1130053A1 (en) | 2009-12-18 |
| AU2007251663A1 (en) | 2007-11-22 |
| US20070265306A1 (en) | 2007-11-15 |
| NO20085052L (no) | 2008-12-04 |
| CN101443312B (zh) | 2011-07-06 |
| RU2008148941A (ru) | 2010-06-20 |
| CY1111460T1 (el) | 2015-08-05 |
| US20100004283A1 (en) | 2010-01-07 |
| CA2651933A1 (en) | 2007-11-22 |
| DK2032534T3 (da) | 2011-04-26 |
| EP2032534A1 (de) | 2009-03-11 |
| EP1854785A1 (de) | 2007-11-14 |
| PL2032534T3 (pl) | 2011-08-31 |
| BRPI0710856A2 (pt) | 2011-05-17 |
| MX2008014439A (es) | 2009-01-21 |
| HRP20110333T1 (hr) | 2011-06-30 |
| NZ572714A (en) | 2010-08-27 |
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| UEP | Publication of translation of european patent specification |
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