ATE490771T1 - Therapeutisches mittel für keratokonjunktive erkrankungen - Google Patents
Therapeutisches mittel für keratokonjunktive erkrankungenInfo
- Publication number
- ATE490771T1 ATE490771T1 AT04793171T AT04793171T ATE490771T1 AT E490771 T1 ATE490771 T1 AT E490771T1 AT 04793171 T AT04793171 T AT 04793171T AT 04793171 T AT04793171 T AT 04793171T AT E490771 T1 ATE490771 T1 AT E490771T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic agent
- ylmethoxy
- benzimidazol
- thiazolidine
- dione
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 3
- 206010013774 Dry eye Diseases 0.000 abstract 3
- 230000007547 defect Effects 0.000 abstract 2
- 206010023332 keratitis Diseases 0.000 abstract 2
- XMSXOLDPMGMWTH-UHFFFAOYSA-N rivoglitazone Chemical compound CN1C2=CC(OC)=CC=C2N=C1COC(C=C1)=CC=C1CC1SC(=O)NC1=O XMSXOLDPMGMWTH-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010010741 Conjunctivitis Diseases 0.000 abstract 1
- 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 abstract 1
- 206010037508 Punctate keratitis Diseases 0.000 abstract 1
- 206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000008996 filamentary keratitis Diseases 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 208000024205 superior limbic keratoconjunctivitis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003364864 | 2003-10-24 | ||
| PCT/JP2004/016063 WO2005039574A1 (ja) | 2003-10-24 | 2004-10-22 | 角結膜障害の治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490771T1 true ATE490771T1 (de) | 2010-12-15 |
Family
ID=34510137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04793171T ATE490771T1 (de) | 2003-10-24 | 2004-10-22 | Therapeutisches mittel für keratokonjunktive erkrankungen |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7358255B2 (de) |
| EP (1) | EP1679074B1 (de) |
| JP (1) | JP4217832B2 (de) |
| KR (1) | KR101154175B1 (de) |
| CN (1) | CN1870997B (de) |
| AT (1) | ATE490771T1 (de) |
| CA (1) | CA2543452C (de) |
| CY (1) | CY1111191T1 (de) |
| DE (1) | DE602004030470D1 (de) |
| DK (1) | DK1679074T3 (de) |
| ES (1) | ES2357801T3 (de) |
| PL (1) | PL1679074T3 (de) |
| PT (1) | PT1679074E (de) |
| SI (1) | SI1679074T1 (de) |
| TW (1) | TWI343256B (de) |
| WO (1) | WO2005039574A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060118520A (ko) * | 2003-10-29 | 2006-11-23 | 산텐 세이야꾸 가부시키가이샤 | 각결막장해 치료제 |
| WO2006064825A1 (ja) * | 2004-12-14 | 2006-06-22 | Santen Pharmaceutical Co., Ltd. | ドライアイ治療剤 |
| JP5186217B2 (ja) | 2005-11-28 | 2013-04-17 | 千寿製薬株式会社 | Ｐｐａｒアゴニスト含有医薬 |
| ATE525374T1 (de) | 2005-12-13 | 2011-10-15 | Incyte Corp | Heteroarylsubstituierte pyrroloä2,3-büpyridine und pyrroloä2,3-büpyrimidine als januskinaseinhibitoren |
| JP5247686B2 (ja) * | 2007-05-21 | 2013-07-24 | 千寿製薬株式会社 | ＰＰＡＲδアゴニスト含有医薬 |
| ES2467665T5 (es) | 2007-06-13 | 2022-11-03 | Incyte Holdings Corp | Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
| JP2009227668A (ja) * | 2008-02-25 | 2009-10-08 | Santen Pharmaceut Co Ltd | 角膜上皮バリア機能亢進剤 |
| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| WO2010135650A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
| JP6172939B2 (ja) * | 2009-05-22 | 2017-08-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｋ阻害薬としての３−［４−（７ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）−１ｈ−ピラゾール−１−イル］オクタン−またはヘプタン−ニトリル |
| TW201113285A (en) * | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PE20130038A1 (es) | 2010-03-10 | 2013-01-28 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de jak1 |
| KR102303885B1 (ko) | 2010-05-21 | 2021-09-24 | 인사이트 홀딩스 코포레이션 | Ｊａｋ 저해제에 대한 국소 제형 |
| WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| EA026201B1 (ru) | 2010-11-19 | 2017-03-31 | Инсайт Холдингс Корпорейшн | Циклобутилзамещенные производные пирролопиридина и пирролопиримидина как ингибиторы jak |
| CA2839767A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| RS62329B1 (sr) | 2012-11-15 | 2021-10-29 | Incyte Holdings Corp | Dozni oblici ruksolitiniba sa produženim vremenom oslobađanja |
| TR201820520T4 (tr) | 2013-03-06 | 2019-01-21 | Incyte Holdings Corp | Bir jak inhibitörü yapmaya yönelik prosesler ve ara ürünler. |
| DK3030227T3 (da) | 2013-08-07 | 2020-04-20 | Incyte Corp | Vedvarende frigivelses-doseringsformer for en jak1-inhibitor |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| WO2019152374A1 (en) | 2018-01-30 | 2019-08-08 | Incyte Corporation | Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
| CA3095487A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0264586B1 (de) * | 1986-08-28 | 1991-04-03 | Sanwa Kagaku Kenkyusho Co., Ltd. | Hydantoin-Derivate zur Behandlung von Komplikationen bei Diabetes |
| JP3072227B2 (ja) | 1994-08-01 | 2000-07-31 | 株式会社クボタ | 田植機の粉粒体供給装置 |
| JP3603129B2 (ja) | 1994-12-28 | 2004-12-22 | 株式会社三和化学研究所 | 糖尿病性角膜症の治療剤 |
| CZ293016B6 (cs) * | 1995-06-01 | 2004-01-14 | Sankyo Company Limited | Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem |
| US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) * | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| JP4339402B2 (ja) | 1996-12-31 | 2009-10-07 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物、並びに糖尿病及び関連疾患の治療におけるこれらの使用 |
| EP0909558A3 (de) * | 1997-08-29 | 1999-10-27 | Santen Pharmaceutical Co., Ltd. | Ophthalmische Lösung enthaltend ein Chromanderivat |
| JPH11130675A (ja) | 1997-08-29 | 1999-05-18 | Santen Pharmaceut Co Ltd | クロマン誘導体含有点眼液 |
| JP2001039976A (ja) | 1999-05-24 | 2001-02-13 | Sankyo Co Ltd | 縮合複素環化合物の塩酸塩 |
| TWI284533B (en) * | 1999-05-24 | 2007-08-01 | Sankyo Co | Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant |
| TW200514783A (en) | 1999-09-22 | 2005-05-01 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| JP2002220336A (ja) | 2000-11-22 | 2002-08-09 | Sankyo Co Ltd | 縮合複素環化合物の塩酸塩を含有する糖尿病の予防薬、治療薬 |
| JP4090013B2 (ja) | 2000-12-26 | 2008-05-28 | 第一三共株式会社 | 利尿剤及びインスリン抵抗性改善剤を含有する医薬組成物 |
| KR20060118520A (ko) * | 2003-10-29 | 2006-11-23 | 산텐 세이야꾸 가부시키가이샤 | 각결막장해 치료제 |
-
2004
- 2004-10-22 AT AT04793171T patent/ATE490771T1/de active
- 2004-10-22 JP JP2004307544A patent/JP4217832B2/ja not_active Expired - Fee Related
- 2004-10-22 DK DK04793171.2T patent/DK1679074T3/da active
- 2004-10-22 ES ES04793171T patent/ES2357801T3/es not_active Expired - Lifetime
- 2004-10-22 KR KR1020067009936A patent/KR101154175B1/ko not_active Expired - Fee Related
- 2004-10-22 CN CN2004800309819A patent/CN1870997B/zh not_active Expired - Fee Related
- 2004-10-22 EP EP04793171A patent/EP1679074B1/de not_active Expired - Lifetime
- 2004-10-22 DE DE602004030470T patent/DE602004030470D1/de not_active Expired - Lifetime
- 2004-10-22 WO PCT/JP2004/016063 patent/WO2005039574A1/ja not_active Ceased
- 2004-10-22 TW TW093132101A patent/TWI343256B/zh not_active IP Right Cessation
- 2004-10-22 PT PT04793171T patent/PT1679074E/pt unknown
- 2004-10-22 US US10/576,719 patent/US7358255B2/en not_active Expired - Fee Related
- 2004-10-22 CA CA2543452A patent/CA2543452C/en not_active Expired - Fee Related
- 2004-10-22 PL PL04793171T patent/PL1679074T3/pl unknown
- 2004-10-22 SI SI200431607T patent/SI1679074T1/sl unknown
-
2011
- 2011-02-18 CY CY20111100206T patent/CY1111191T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1111191T1 (el) | 2015-06-11 |
| CN1870997A (zh) | 2006-11-29 |
| PT1679074E (pt) | 2011-03-03 |
| KR101154175B1 (ko) | 2012-06-14 |
| KR20060100440A (ko) | 2006-09-20 |
| US7358255B2 (en) | 2008-04-15 |
| TW200518750A (en) | 2005-06-16 |
| JP2005145961A (ja) | 2005-06-09 |
| EP1679074A1 (de) | 2006-07-12 |
| EP1679074B1 (de) | 2010-12-08 |
| CA2543452A1 (en) | 2005-05-06 |
| ES2357801T3 (es) | 2011-04-29 |
| DE602004030470D1 (de) | 2011-01-20 |
| WO2005039574A1 (ja) | 2005-05-06 |
| EP1679074A4 (de) | 2009-03-25 |
| WO2005039574A8 (ja) | 2005-06-23 |
| CA2543452C (en) | 2012-03-13 |
| DK1679074T3 (da) | 2011-03-21 |
| TWI343256B (en) | 2011-06-11 |
| PL1679074T3 (pl) | 2011-05-31 |
| US20070060628A1 (en) | 2007-03-15 |
| CN1870997B (zh) | 2011-05-04 |
| JP4217832B2 (ja) | 2009-02-04 |
| SI1679074T1 (sl) | 2011-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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