ATE488765T1 - Verfahren zum frühen nachweis einer nierenkrankheit und -verletzung - Google Patents

Verfahren zum frühen nachweis einer nierenkrankheit und -verletzung

Info

Publication number
ATE488765T1
ATE488765T1 AT05755309T AT05755309T ATE488765T1 AT E488765 T1 ATE488765 T1 AT E488765T1 AT 05755309 T AT05755309 T AT 05755309T AT 05755309 T AT05755309 T AT 05755309T AT E488765 T1 ATE488765 T1 AT E488765T1
Authority
AT
Austria
Prior art keywords
ngal
renal
injury
blood serum
early
Prior art date
Application number
AT05755309T
Other languages
German (de)
English (en)
Inventor
Prasad Devarajan
Jonathan Barasch
Original Assignee
Childrens Hosp Medical Center
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35449446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE488765(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Childrens Hosp Medical Center, Univ Columbia filed Critical Childrens Hosp Medical Center
Application granted granted Critical
Publication of ATE488765T1 publication Critical patent/ATE488765T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Transplanting Machines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT05755309T 2004-06-07 2005-06-07 Verfahren zum frühen nachweis einer nierenkrankheit und -verletzung ATE488765T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57766204P 2004-06-07 2004-06-07
US11/096,113 US20050272101A1 (en) 2004-06-07 2005-03-31 Method for the early detection of renal injury
PCT/US2005/019951 WO2005121788A2 (en) 2004-06-07 2005-06-07 Method for the early detection of renal disease and injury

Publications (1)

Publication Number Publication Date
ATE488765T1 true ATE488765T1 (de) 2010-12-15

Family

ID=35449446

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05755309T ATE488765T1 (de) 2004-06-07 2005-06-07 Verfahren zum frühen nachweis einer nierenkrankheit und -verletzung

Country Status (10)

Country Link
US (7) US20050272101A1 (cg-RX-API-DMAC7.html)
EP (2) EP2264459B1 (cg-RX-API-DMAC7.html)
JP (1) JP5054525B2 (cg-RX-API-DMAC7.html)
CN (1) CN101027556B (cg-RX-API-DMAC7.html)
AT (1) ATE488765T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005253142B2 (cg-RX-API-DMAC7.html)
CA (1) CA2569599C (cg-RX-API-DMAC7.html)
DE (1) DE602005024810D1 (cg-RX-API-DMAC7.html)
ES (1) ES2717900T3 (cg-RX-API-DMAC7.html)
WO (1) WO2005121788A2 (cg-RX-API-DMAC7.html)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2604285T3 (en) 2003-05-01 2014-12-01 Cornell Res Foundation Inc Method and carrier complex for delivering molecules to cells
WO2005107793A2 (en) * 2004-05-06 2005-11-17 The Trustees Of Columbia University Ngal for reduction and amelioration of ischemic and nephrotoxic injuries
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
SI1831699T1 (sl) * 2004-12-20 2010-03-31 Antibodyshop As Določanje nevtrofilnega lipokalina asociiranega z želatinazo ngal kot diagnostičnega markerja za ledvične bolezni
US20070037232A1 (en) 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
EP3725324A1 (en) * 2005-09-16 2020-10-21 Cornell Research Foundation, Inc. Aromatic-cationic peptide for use in a method for reducing cd36 expression
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
US10716749B2 (en) * 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
US7662578B2 (en) 2006-04-21 2010-02-16 Children's Hospital Medical Center Method and kit for the early detection of impaired renal status
US20080090765A1 (en) * 2006-05-25 2008-04-17 The Trustees Of Columbia University In The City Of New York Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage
WO2007137584A1 (en) 2006-05-30 2007-12-06 Antibodyshop A/S Methods and devices for rapid assessment of severity of injury
US20100210031A2 (en) * 2006-08-07 2010-08-19 Antibodyshop A/S Diagnostic Test to Exclude Significant Renal Injury
WO2008061149A2 (en) * 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for diagnosis and prognosis of renal artery stenosis
EP2095107B1 (en) 2006-11-14 2014-07-02 Alere San Diego, Inc. Methods for risk assignment
EP2137538B1 (en) * 2007-03-21 2014-04-09 Bioporto Diagnostics A/s Diagnostic test for renal injury
US8846036B2 (en) * 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
JP5746861B2 (ja) * 2007-10-19 2015-07-08 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 哺乳動物のｎｇａｌに結合する抗体及びその使用
US20090124022A1 (en) * 2007-10-19 2009-05-14 Abbott Laboratories Antibodies that bind to mammalian ngal and uses thereof
US20090123946A1 (en) * 2007-10-19 2009-05-14 Abbott Laboratories Immunoassays and kits for the detection of ngal
WO2009059259A2 (en) * 2007-10-31 2009-05-07 Children's Hospital Medical Center Detection of worsening renal disease in subjects with systemic lupus erythematosus
ES2475990T5 (es) * 2007-11-15 2017-07-06 Bioporto Diagnostics A/S Uso diagnóstico de formas moleculares individuales de un biomarcador
DK2252312T3 (da) 2008-02-07 2014-06-16 Univ Cornell Fremgangsmåder til forebyggelse eller behandling af insulinresistens
CN101951936A (zh) 2008-02-26 2011-01-19 康奈尔大学 用于防止和治疗急性肾损伤的方法
US8592170B2 (en) * 2008-03-12 2013-11-26 The Trustees Of Columbia University In The City Of New York High molecular weight Ngal as a biomarker for chronic kidney disease
GB0807214D0 (en) * 2008-04-21 2008-05-28 Belfast Health And Social Care Biomarkers
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions
US20100122355A1 (en) * 2008-07-16 2010-05-13 Neal Paragas Transgenic Reporter Mouse and Method for Use
AU2009285550B2 (en) * 2008-08-28 2015-06-18 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2010025434A1 (en) * 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2836218T3 (es) 2008-10-21 2021-06-24 Astute Medical Inc Procedimientos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US20110207161A1 (en) * 2008-10-21 2011-08-25 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20100105150A1 (en) * 2008-10-24 2010-04-29 Abbott Laboratories Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal
US8394606B2 (en) * 2008-11-05 2013-03-12 Abbott Laboratories Neutrophil gelatinase-associated lipocalin (NGAL) protein isoforms enriched from urine and recombinant chinese hamster ovary (CHO) cells and related compositions, antibodies, and methods of enrichment, analysis and use
KR20110084286A (ko) 2008-11-10 2011-07-21 아스튜트 메디컬 인코포레이티드 신손상 및 신부전의 진단 및 예후 예측을 위한 방법 및 조성물
US20100124829A1 (en) * 2008-11-17 2010-05-20 Hon Hai Precision Industry Co., Ltd. Electrical connector with a printed circuit board mounted thereon
KR20190006614A (ko) 2008-11-21 2019-01-18 퓨처 메디칼 다이아그노스틱스 코 엘티디 급성 신장 손상의 발견 또는 감시 방법, 장치 및 키트
KR20110097850A (ko) * 2008-11-22 2011-08-31 아스튜트 메디컬 인코포레이티드 신손상 및 신부전의 진단 및 예후 예측을 위한 방법 및 조성물
AU2010210537B2 (en) * 2009-02-06 2015-06-18 Astute Medical, Inc. Diagnosis and prognosis of renal injury and renal failure
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20100233740A1 (en) * 2009-02-12 2010-09-16 Jonathan Barasch Use of urinary ngal to distinguish kidney disease and predict mortality in subjects with cirrhosis
US20100233739A1 (en) * 2009-02-12 2010-09-16 Jonathan Barasch Use of urinary ngal to diagnose unilateral and bilateral urinary obstruction
CN102573881A (zh) 2009-03-20 2012-07-11 通用医疗公司以马萨诸塞州通用医疗公司名义经营 预防和治疗烧伤损伤和继发性并发症的方法
EP2435826B1 (en) * 2009-05-26 2014-05-21 Universidad De Salamanca Urinary gm2 activator protein as a marker of acute renal failure or the risk of developing acute renal failure
CA2770393A1 (en) 2009-08-07 2011-02-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP5909182B2 (ja) * 2009-08-12 2016-04-26 コーネル ユニヴァーシティー 代謝性症候群を予防し又は治療するための方法
EP3338788A1 (en) 2009-08-24 2018-06-27 Stealth Peptides International, Inc. Methods and copositions for preventing or treating opthalmic conditions
EP2470905B1 (en) * 2009-08-28 2015-01-07 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102711785A (zh) * 2009-10-05 2012-10-03 康奈尔大学 预防或治疗心力衰竭的方法
WO2011053832A1 (en) * 2009-10-29 2011-05-05 The Trustees Of Columbia University In The City Of New York Use of urinary ngal to diagnose sepsis in very low birth weight infants
JP2013510322A (ja) 2009-11-07 2013-03-21 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
NZ625423A (en) 2009-12-20 2015-02-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
MX341191B (es) 2010-02-05 2016-08-10 Astute Medical Inc Metodos y composiciones para diagnostico y prognosis de lesion renal y falla renal.
NZ602056A (en) * 2010-02-26 2014-11-28 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011269847A1 (en) 2010-02-26 2013-01-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
GB2478520A (en) * 2010-03-02 2011-09-14 Binding Site Group Ltd Kidney prognostic assay
US20110229921A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
CN102072960A (zh) * 2010-03-29 2011-05-25 武汉生之源生物科技有限公司 一种样本中中性粒细胞明胶酶相关脂质运载蛋白的检测方法
CA2798713A1 (en) * 2010-05-10 2011-11-17 Intrinsic Lifesciences Llc Markers for acute kidney injury
WO2011149962A1 (en) 2010-05-24 2011-12-01 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
EP2397559A1 (en) * 2010-06-17 2011-12-21 Max-Delbrück-Centrum Für Molekulare Medizin Stage-specific biomarkers for the diagnosis of acute kidney injury
CA2804297A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2415461B1 (en) * 2010-07-24 2012-10-31 Roche Diagnostics GmbH Stabilization of interleukin 6 in serum based solutions
US20130316370A1 (en) * 2010-10-07 2013-11-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102253217B (zh) * 2011-04-07 2013-08-07 武汉生之源生物科技有限公司 一种胶乳颗粒增强型中性粒细胞明胶酶相关脂质运载蛋白检测试剂盒
CN102243241A (zh) * 2011-04-07 2011-11-16 武汉生之源生物科技有限公司 一种匀相溶胶颗粒型中性粒细胞明胶酶相关脂质运载蛋白测定试剂盒及其制备方法
NL2007112C2 (en) 2011-07-14 2013-01-15 Brainlabs B V Novel diagnostic method for diagnosing depression and monitoring therapy effectiveness.
EP3489690A1 (en) * 2011-08-26 2019-05-29 Astute Medical, Inc. Methods and compositions for evaluation of the renal status
US20130062516A1 (en) * 2011-09-09 2013-03-14 Hsien-Shou Kuo Diganosis of a renal disease by oxygen and hydrogen isotopes in a biological sample
CN106018783A (zh) * 2011-09-14 2016-10-12 巴斯夫欧洲公司 用于评估肾毒性的手段和方法
EP2758774A4 (en) * 2011-09-22 2015-04-29 Univ Los Andes METHOD FOR MONITORING, DIAGNOSIS AND / OR FORECASTING ACUTE CHILDIER INJURY IN AN EARLY STAGE
EP2788759B1 (en) 2011-12-08 2019-02-20 Astute Medical, Inc. Methods and uses for diagnosis of renal injury and renal failure
JP5988199B2 (ja) * 2012-05-29 2016-09-07 学校法人順天堂 ＩｇＡ腎症診断法
GB201210587D0 (en) * 2012-06-14 2012-08-01 Belfast Health And Social Care Trust Predictive biomarker
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
PT2946211T (pt) 2013-01-17 2018-06-04 Astute Medical Inc Processos e composições para o diagnóstico e o prognóstico de lesões renais e insuficiência renal
US9791440B2 (en) 2013-07-15 2017-10-17 President And Fellows Of Harvard College Assays for antimicrobial activity and applications thereof
CN104198732B (zh) * 2014-08-28 2015-08-19 宁波瑞源生物科技有限公司 一种中性粒细胞明胶酶相关脂质运载蛋白含量检测试剂盒
CN104849469A (zh) * 2015-04-16 2015-08-19 广州市达瑞生物技术股份有限公司 一种检测ngal含量的试剂盒及其制备方法
CL2015003047A1 (es) 2015-10-15 2016-06-17 Univ Chile Método ex vivo para detectar precozmente injuria renal aguda en pacientes críticos, que comprende la mediciom en una muestra de tres proteinas como biomarcadores, factor de crecimiento fibroblástico 23, klotho y eritropoyetina
CA3026502A1 (en) 2016-06-06 2017-12-14 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
US11346846B2 (en) 2017-02-06 2022-05-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN110229214B (zh) * 2018-03-05 2022-03-18 四川大学华西医院 一种外泌体缓释多肽水凝胶及其制备方法和用途
JPWO2020080491A1 (ja) * 2018-10-17 2021-09-09 Kagami株式会社 血液中のクレアチニン量に基づく腎機能検査結果の妥当性を検定する方法
US11350887B2 (en) 2019-08-07 2022-06-07 Fresenius Medical Care Holdings, Inc. Systems and methods for detection of potential health issues

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US3635091A (en) * 1970-08-31 1972-01-18 Frederick D Linzer Midstream urine specimen and fractional fluid collectors
IT1074038B (it) * 1976-08-05 1985-04-17 Simes Esteri della epinina
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4357343A (en) * 1981-06-26 1982-11-02 Baxter Travenol Laboratories, Inc. Nutritional composition for management of renal failure
US4376100A (en) * 1981-11-23 1983-03-08 The Dow Chemical Company Lithium halide brine purification
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4640909A (en) * 1985-05-07 1987-02-03 J. T. Baker Chemical Company Bonded phase of silica and carboalkoxyalkyl silanes for solid phase extraction
US4870007A (en) * 1987-12-18 1989-09-26 Eastman Kodak Company Immobilized biotinylated receptor in test device, kit and method for determining a ligand
US5939272A (en) * 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5273743A (en) * 1990-03-09 1993-12-28 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
JP2912413B2 (ja) * 1990-03-28 1999-06-28 東亜医用電子株式会社 粒度分布作成方法
US5405832A (en) * 1991-11-27 1995-04-11 Immtech International Inc. Method of treating non-streptococcal bacterial infections
US5273961A (en) * 1992-09-22 1993-12-28 Genentech, Inc. Method of prophylaxis of acute renal failure
SE9401351D0 (sv) * 1994-04-21 1994-04-21 Venge A method for diagnosis
US5552313A (en) * 1994-11-21 1996-09-03 Kansas University DNA encoding mouse phosphotriesterase-related protein
AU7252896A (en) * 1995-10-02 1997-04-28 Trustees Of Columbia University In The City Of New York, The Biochemical markers of ischemia
US5750345A (en) * 1995-10-31 1998-05-12 Evanston Hospital Corporation Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
US5627034A (en) * 1995-12-05 1997-05-06 Wisconsin Alumni Research Foundation Assay for carcinoma proliferative status by measuring NGAL expression level
CN1147584C (zh) * 1996-05-24 2004-04-28 拜奥根有限公司 组织再生调节物
US5945294A (en) * 1996-11-26 1999-08-31 Heska Corporation Method to detect IgE
JP3334558B2 (ja) * 1997-04-23 2002-10-15 富士レビオ株式会社 酵素免疫測定方法及び試験片
JP3654912B2 (ja) * 1997-04-30 2005-06-02 マルハ株式会社 虚血性疾患の検出または予知方法
WO1999007740A2 (en) * 1997-08-06 1999-02-18 Zymogenetics, Inc. Lipocalin homologs
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6500627B1 (en) * 1998-02-03 2002-12-31 The Trustees Of Columbia University In The City Of New York Methods for predicting pregnancy outcome in a subject by HCG assay
US6309888B1 (en) * 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
AUPP784398A0 (en) * 1998-12-21 1999-01-21 Monash University Kidney disease detection and treatment
US6114123A (en) * 1999-06-14 2000-09-05 Incyte Pharmaceuticals, Inc. Lipocalin family protein
AU5330200A (en) * 1999-06-18 2001-01-09 Michigan State University Method and apparatus for the detection of volatile products in a sample
US6762032B1 (en) * 1999-08-23 2004-07-13 Biocrystal, Ltd. Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response
US20020160495A1 (en) * 2000-09-20 2002-10-31 University Of Medicine And Dentistry Soluble ischemia activated protein
JP2004510981A (ja) * 2000-10-03 2004-04-08 ロウェット、リサーチ、インスティテュート ピロール含有生体化合物の測定方法およびピロール含有生体化合物
AU1169702A (en) * 2000-10-13 2002-04-22 Childrens Medical Center Non-invasive enzyme screen for tissue remodelling-associated conditions
FI20010019A7 (fi) * 2001-01-05 2002-07-06 Biohit Oyj Menetelmä atrofisen gastriitin diagnostisoimiseksi
WO2002079781A1 (en) * 2001-03-28 2002-10-10 Heska Corporation Methods of detecting early renal disease in animals
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
ATE458199T1 (de) * 2001-05-04 2010-03-15 Biosite Inc Diagnostische marker der akuten koronaren syndrome und ihre verwendungen
US6767733B1 (en) * 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
US6986995B2 (en) * 2002-02-28 2006-01-17 Prometheus Laboratories, Inc. Methods of diagnosing liver fibrosis
US6847451B2 (en) * 2002-05-01 2005-01-25 Lifescan, Inc. Apparatuses and methods for analyte concentration determination
GB0215509D0 (en) 2002-07-04 2002-08-14 Novartis Ag Marker genes
EP1531834A1 (en) * 2002-07-17 2005-05-25 Index Pharmaceuticals AB Antisense compounds, methods and compositions for treating ngal-related inflammatory disorders
CN1417583A (zh) * 2002-11-27 2003-05-14 复旦大学 一种检测辐射肾性骨矿物盐损伤方法
EP2083270B1 (en) * 2003-03-27 2019-06-12 Children's Hospital Medical Center A method and kit for detecting the early onset of renal tubular cell injury
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
WO2005107793A2 (en) 2004-05-06 2005-11-17 The Trustees Of Columbia University Ngal for reduction and amelioration of ischemic and nephrotoxic injuries
SI1831699T1 (sl) 2004-12-20 2010-03-31 Antibodyshop As Določanje nevtrofilnega lipokalina asociiranega z želatinazo ngal kot diagnostičnega markerja za ledvične bolezni
WO2007137584A1 (en) * 2006-05-30 2007-12-06 Antibodyshop A/S Methods and devices for rapid assessment of severity of injury
EP2137538B1 (en) * 2007-03-21 2014-04-09 Bioporto Diagnostics A/s Diagnostic test for renal injury
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases

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US20100047837A1 (en) 2010-02-25
US20110143456A1 (en) 2011-06-16
AU2005253142A1 (en) 2005-12-22
EP2264459B1 (en) 2019-01-02
US20100028919A1 (en) 2010-02-04
EP1766395B2 (en) 2018-09-19
US20080014604A1 (en) 2008-01-17
JP2008501979A (ja) 2008-01-24
CA2569599A1 (en) 2005-12-22
DE602005024810D1 (de) 2010-12-30
US20090142774A1 (en) 2009-06-04
CN101027556B (zh) 2013-03-13
US20050272101A1 (en) 2005-12-08
WO2005121788A2 (en) 2005-12-22
EP2264459A3 (en) 2011-02-16
WO2005121788A3 (en) 2006-05-11
JP5054525B2 (ja) 2012-10-24
EP2264459A2 (en) 2010-12-22
AU2005253142B2 (en) 2011-09-29
US20110244489A1 (en) 2011-10-06
CA2569599C (en) 2018-10-23
EP1766395B1 (en) 2010-11-17
EP1766395A2 (en) 2007-03-28
CN101027556A (zh) 2007-08-29

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