ATE473271T1 - Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen - Google Patents

Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen

Info

Publication number
ATE473271T1
ATE473271T1 AT04751538T AT04751538T ATE473271T1 AT E473271 T1 ATE473271 T1 AT E473271T1 AT 04751538 T AT04751538 T AT 04751538T AT 04751538 T AT04751538 T AT 04751538T AT E473271 T1 ATE473271 T1 AT E473271T1
Authority
AT
Austria
Prior art keywords
vectors
cells
producing
transgenic plants
compositions obtained
Prior art date
Application number
AT04751538T
Other languages
English (en)
Inventor
Guy Cardineau
Hugh Mason
Joyce Vaneck
Dwayne Kirk
Amanda Walmsley
Original Assignee
Thompson Boyce Plant Res
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thompson Boyce Plant Res, Dow Agrosciences Llc filed Critical Thompson Boyce Plant Res
Application granted granted Critical
Publication of ATE473271T1 publication Critical patent/ATE473271T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • C12N15/68Stabilisation of the vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04751538T 2003-05-05 2004-05-04 Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen ATE473271T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46799803P 2003-05-05 2003-05-05
PCT/US2004/014182 WO2004098533A2 (en) 2003-05-05 2004-05-04 Vectors and cells for preparing immunoprotective compositions derived from transgenic plants

Publications (1)

Publication Number Publication Date
ATE473271T1 true ATE473271T1 (de) 2010-07-15

Family

ID=33435152

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04751538T ATE473271T1 (de) 2003-05-05 2004-05-04 Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen

Country Status (13)

Country Link
US (3) US7132291B2 (de)
EP (1) EP1620550B1 (de)
KR (1) KR20060035596A (de)
CN (1) CN100393870C (de)
AR (1) AR044246A1 (de)
AT (1) ATE473271T1 (de)
AU (1) AU2004235813B2 (de)
BR (1) BRPI0410340A (de)
CA (1) CA2524293A1 (de)
DE (1) DE602004028004D1 (de)
NZ (1) NZ543348A (de)
WO (1) WO2004098533A2 (de)
ZA (1) ZA200508930B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026375A2 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
CN1326998C (zh) * 2004-11-25 2007-07-18 中国农业科学院哈尔滨兽医研究所 编码h5亚型禽流感病毒血凝素蛋白的基因及其应用
CN101378781B (zh) 2005-08-03 2013-08-07 美国弗劳恩霍夫股份有限公司 制造免疫球蛋白的组合物和方法
NZ568562A (en) 2005-11-04 2011-03-31 Dow Agroscience Llc Preparation of vaccine master cell lines using recombinant plant suspension cultures
WO2008060669A2 (en) * 2006-04-21 2008-05-22 Dow Agrosciences Llc Vaccine for avian influenza and methods of use
EP1984388B1 (de) * 2006-02-13 2016-07-06 iBio, Inc. Hpv-antigene, impfstoffzusammensetzungen und zugehörige verfahren
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
KR20080106433A (ko) * 2006-02-13 2008-12-05 프라운호퍼 유에스에이, 인코포레이티드 인플루엔자 항원, 백신 조성물 및 관련 방법
KR100766775B1 (ko) * 2006-04-24 2007-11-01 대한민국 장출혈성대장균(ehec) 감염증 예방용 톡소이드 백신
CN100487119C (zh) * 2006-05-09 2009-05-13 中国农业科学院哈尔滨兽医研究所 表达禽流感病毒H5亚型HA蛋白的重组新城疫LaSota弱毒疫苗株
WO2007149715A2 (en) * 2006-06-16 2007-12-27 Dow Agrosciences Llc Novel dna sequences, vectors and proteins of avian influenza hemagglutinin
US20080241188A1 (en) * 2007-03-30 2008-10-02 Zeon Corporation Turkey herpesvirus vectored recombinant containing avian influenza genes
BRPI0810865A2 (pt) * 2007-04-28 2017-05-09 Fraunhofer Usa Inc antígenos de tripanossoma, composições vacinais, e métodos relacionados
HUE031698T2 (en) * 2007-06-15 2017-07-28 Medicago Inc Modification of glycoprotein production in plants
KR100964462B1 (ko) * 2007-07-10 2010-06-16 성균관대학교산학협력단 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법
WO2009009759A2 (en) * 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
AU2009202819B2 (en) * 2007-07-13 2014-08-28 Aramis Biotechnologies Inc. Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
CA2615372A1 (en) * 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CN101820903A (zh) * 2007-08-20 2010-09-01 美国弗劳恩霍夫股份有限公司 预防性和治疗性流感疫苗、抗原、组合物和方法
EA034733B1 (ru) 2008-01-21 2020-03-13 Медикаго Инк. Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение
PT2294202E (pt) * 2008-07-08 2015-10-09 Medicago Inc Antigénios gripais recombinantes solúveis
MX2011000657A (es) 2008-07-18 2011-03-21 Medicago Inc Epitopo de inmunizacion de nuevo virus de la influenza.
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US9233148B2 (en) * 2009-01-09 2016-01-12 Samuel Bogoch Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza
WO2010117786A1 (en) 2009-03-30 2010-10-14 Mount Sinai School Of Medicine Of New York University Influenza virus vaccines and uses thereof
JP5871796B2 (ja) * 2009-06-24 2016-03-01 メディカゴ インコーポレイテッド ヘマグルチニンを含むキメラインフルエンザウイルス様粒子
CA2772964C (en) * 2009-09-22 2020-10-27 Medicago Inc. Method of preparing plant-derived proteins
EP2483307A1 (de) 2009-09-29 2012-08-08 Fraunhofer USA, Inc. Influenza-hämagglutinin-antikörper, zusammensetzungen daraus und zugehörige verfahren
JP5838473B2 (ja) 2009-12-28 2016-01-06 サノフィ ワクチン テクノロジーズ エス.エー.エス. 微細藻類におけるヘマグルチニン−ノイラミニダーゼタンパク質の産生方法
EP3213766A1 (de) * 2009-12-28 2017-09-06 Merial Ltd. Rekombinantes ndv-antigen und verwendungen davon
WO2011103453A2 (en) 2010-02-18 2011-08-25 Mount Sinai School Of Medicine Vaccines for use in the prophylaxis and treatment of influenza virus disease
KR20130075732A (ko) 2010-03-30 2013-07-05 마운트 시나이 스쿨 오브 메디슨 인플루엔자 바이러스 백신 및 이의 용도
RU2606609C2 (ru) 2010-10-27 2017-01-10 Филип Моррис Продактс С.А. Способ (варианты) захвата представляющих интерес частиц из смеси
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
IN2014CN02114A (de) 2011-09-20 2015-05-29 Sinai School Medicine
PL2760882T3 (pl) * 2011-09-30 2023-09-11 Medicago Inc. Zwiększenie wydajności cząsteczek wirusowopodobnych w roślinach
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
BR112015014482A2 (pt) 2012-12-18 2017-11-21 Icahn School Med Mount Sinai vacinas para vírus influenza e seus usos
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
IL295155A (en) 2013-03-28 2022-09-01 Medicago Inc Production of influenza virus-like particles in plants
TWI714522B (zh) 2014-01-10 2021-01-01 加拿大商苜蓿股份有限公司 Cpmv強化子元件
CA2974699A1 (en) 2015-01-23 2016-07-28 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
CN109641041A (zh) 2016-06-15 2019-04-16 西奈山伊坎医学院 流感病毒血细胞凝集素蛋白及其用途
EP3606555A4 (de) 2017-04-07 2021-08-04 Icahn School of Medicine at Mount Sinai Neuraminidase-antikörper gegen influenza-b-virus und verwendungen davon
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
EP3959216A4 (de) 2019-04-24 2023-01-11 Icahn School of Medicine at Mount Sinai Neuraminidase-antikörper gegen influenza-b-virus und verwendungen davon
EP4392565A4 (de) * 2021-08-24 2025-02-12 Futuragene Israel Ltd. Sequenzen und promotoren zur verwendung in pflanzenzellen und verfahren zur herstellung und verwendung solcher sequenzen
WO2023237726A1 (en) * 2022-06-10 2023-12-14 Pantarhei Oncology B.V. An intracellular tumor-specific variant of human zona pellucida glycoprotein 3 and nucleic acids coding therefor for use in the treatment of cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE218797T1 (de) 1988-09-06 2002-06-15 Univ Washington Orale-immunisierung durch verwendung von transgenen pflanzen
US20010053367A1 (en) 1991-08-26 2001-12-20 Prodigene, Inc. Vaccines expressed in plants
US5612487A (en) 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
US6034298A (en) 1991-08-26 2000-03-07 Prodigene, Inc. Vaccines expressed in plants
US5426108A (en) 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
DE69533964T2 (de) 1994-10-24 2006-03-30 The Texas A & M University System, College Station Orale immunisierung durch verwendung von transgenen pflanzen
US5733556A (en) 1995-10-18 1998-03-31 Akzo Nobel N.V. Newcastle disease virus combination vaccine
US6395964B1 (en) 1995-10-24 2002-05-28 The Texas A&M University System Oral immunization with transgenic plants
EP0974660A1 (de) * 1998-06-19 2000-01-26 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Newcastle-Krankheitsvirus Infektiöser Klone, Impfstoffe und Diagnosetest
WO2002000169A2 (en) * 2000-06-26 2002-01-03 The United States Of America, As Represented By The Secretary Of Agriculture Production of vaccines using transgenic plants
BR0208880A (pt) * 2001-04-13 2004-12-07 Thompson Boyce Plant Res Métodos para produzir um homogeneizado seco estável de uma planta transgênica que expressa uma proteìna heteróloga, para prevenir uma doença patogênica em um animal, para liberar uma proteìna transgênica a um animal, de contracepção e para induzir uma resposta imune mucosal, homogeneizado seco estável, composição farmacêutica, planta transgênica, célula de planta, vetor plasmìdico para transformar uma célula de planta, composição de alimento, e, alimento

Also Published As

Publication number Publication date
EP1620550A2 (de) 2006-02-01
US7407802B2 (en) 2008-08-05
DE602004028004D1 (de) 2010-08-19
BRPI0410340A (pt) 2006-05-30
CA2524293A1 (en) 2004-11-18
ZA200508930B (en) 2007-03-28
AR044246A1 (es) 2005-09-07
EP1620550B1 (de) 2010-07-07
US20050048074A1 (en) 2005-03-03
AU2004235813B2 (en) 2010-07-29
US7132291B2 (en) 2006-11-07
AU2004235813A1 (en) 2004-11-18
WO2004098533A3 (en) 2005-08-04
CN1788077A (zh) 2006-06-14
US20080076177A1 (en) 2008-03-27
EP1620550A4 (de) 2006-06-14
US20090017065A1 (en) 2009-01-15
NZ543348A (en) 2008-08-29
CN100393870C (zh) 2008-06-11
KR20060035596A (ko) 2006-04-26
WO2004098533A2 (en) 2004-11-18

Similar Documents

Publication Publication Date Title
ATE473271T1 (de) Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen
ATE505548T1 (de) Insektizidzusammensetzungen und verfahren zur herstellung von insektenbeständigen transgenen pflanzen
EP1635772A4 (de) Stabile immunoprophylaktische und therapeutische zusammensetzungen aus transgenen pflanzenzellen und herstellungsverfahren
DE602006012283D1 (de) Integrierte schaltung und verfahren zu ihrer herstellung
EP1968124A4 (de) Halbleiter-leuchtelement und prozess zu seiner herstellung
ATE548459T1 (de) Verfahren zur genetischen kontrolle von insektenbefall bei pflanzen und zusammensetzungen
DE502004008318D1 (de) Speicher-schaltungsanordnung und verfahren zur herstellung
DE112005002138A5 (de) Verfahren und Vorrichtung zur Herstellung von Formkörpern aus Cellulose
ATE434388T1 (de) Fermentierte produkte aus sojafaserstoffpartikel und verfahren ihrer herstellung
EP1838846A4 (de) Verfahren und zusammensetzungen zur verkapselung von zellen
DE60134888D1 (de) Verfahren und vektoren zur herstellung von transgenen pflanzen
DE602004021001D1 (de) Fettsäuredesaturasen aus primula
DE60327066D1 (de) Saure protein- und ballaststoffhaltige zusammensetzungen und verfahren zu ihrer herstellung
DE602004003071D1 (de) Verfahren zur herstellung von ammoniak aus wasser und stickstoff am einsatzort
DE602006012972D1 (de) Mikronisierte tanaproget zusammensetzungen und verfahren zu ihrer herstellung
DE602004009011D1 (de) Kristallinisches Material IM-12 und Verfahren zu seiner Herstellung
EP1909315A4 (de) Siliziumwafer und prozess zu seiner herstellung
DE60333840D1 (de) Geformte absorbierende auflagen und verfahren zur dessen herstellung
ATE457126T1 (de) Pflanzenwachstumsregulierende zusammensetzungen
ATE418270T1 (de) Verfahren zur herstellung von polyphenol angereicherten zusammensetzungen aus kakaoschale
DE602005026176D1 (de) Rollenlose spule und verfahren zu ihrer herstellung
DE502006009351D1 (de) Feinteiliges azopigment und verfahren zu seiner herstellung
DE60323456D1 (de) Herstellung von Nanopartikeln
DE602006014866D1 (de) Elastisches polyurethangarn und verfahren zu seiner herstellung
DE60321659D1 (de) Zusammensetzungen zur haarentfernung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties