ATE471324T1 - Triazolophthalazine - Google Patents
TriazolophthalazineInfo
- Publication number
- ATE471324T1 ATE471324T1 AT05784647T AT05784647T ATE471324T1 AT E471324 T1 ATE471324 T1 AT E471324T1 AT 05784647 T AT05784647 T AT 05784647T AT 05784647 T AT05784647 T AT 05784647T AT E471324 T1 ATE471324 T1 AT E471324T1
- Authority
- AT
- Austria
- Prior art keywords
- triazolophthalazines
- meanings
- compounds
- formula
- given
- Prior art date
Links
- 229940121828 Phosphodiesterase 2 inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104221 | 2004-09-02 | ||
| PCT/EP2005/054266 WO2006024640A2 (en) | 2004-09-02 | 2005-08-31 | Triazolophthalazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE471324T1 true ATE471324T1 (de) | 2010-07-15 |
Family
ID=34929521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05784647T ATE471324T1 (de) | 2004-09-02 | 2005-08-31 | Triazolophthalazine |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7851472B2 (enExample) |
| EP (1) | EP1791543B1 (enExample) |
| JP (1) | JP5140427B2 (enExample) |
| KR (1) | KR101368093B1 (enExample) |
| CN (1) | CN101133057B (enExample) |
| AT (1) | ATE471324T1 (enExample) |
| AU (1) | AU2005279221C9 (enExample) |
| BR (1) | BRPI0514586A (enExample) |
| CA (1) | CA2578368C (enExample) |
| DE (1) | DE602005021894D1 (enExample) |
| EA (1) | EA014324B1 (enExample) |
| ES (1) | ES2347337T3 (enExample) |
| IL (1) | IL181271A (enExample) |
| NO (1) | NO20071127L (enExample) |
| NZ (1) | NZ553160A (enExample) |
| WO (1) | WO2006024640A2 (enExample) |
| ZA (1) | ZA200701137B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA012505B1 (ru) * | 2005-01-05 | 2009-10-30 | Никомед Гмбх | Триазолофталазины в качестве ингибиторов pde-2 |
| JP5130053B2 (ja) * | 2005-01-05 | 2013-01-30 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリアゾロフタラジン |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
| US20140045856A1 (en) | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| EP3087060B1 (en) | 2013-12-23 | 2020-05-13 | Merck Sharp & Dohme Corp. | Pyrimidone carboxamide compounds as pde2 inhibitors |
| EP3091983B1 (en) | 2014-01-08 | 2019-10-02 | Intra-Cellular Therapies, Inc. | Pharmaceutical compositions comprising a pde-1 inhibitor and a pde-2 inhibitor |
| HRP20212035T1 (hr) | 2014-04-23 | 2022-04-01 | Dart Neuroscience Llc | Pripravci koji sadrže supstituirane [1,2,4]triazolo[1,5-a]pirimidin-7-il spojeve kao inhibitore pde2 |
| TWI568737B (zh) | 2014-11-05 | 2017-02-01 | 達特神經科學（開曼）有限責任公司 | 作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物 |
| AU2015357498B2 (en) | 2014-12-06 | 2019-09-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| MX371158B (es) | 2014-12-06 | 2020-01-20 | Intra Cellular Therapies Inc | Compuestos inhibidores de pde2. |
| WO2016145614A1 (en) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Triazolyl pyrimidinone compounds as pde2 inhibitors |
| US10287269B2 (en) | 2015-03-26 | 2019-05-14 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as PDE2 inhibitors |
| WO2016179059A1 (en) | 2015-05-05 | 2016-11-10 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as pde2 inhibitors |
| WO2016183741A1 (en) | 2015-05-15 | 2016-11-24 | Merck Sharp & Dohme Corp. | Pyrimidinone amide compounds as pde2 inhibitors |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016209749A1 (en) | 2015-06-25 | 2016-12-29 | Merck Sharp & Dohme Corp. | Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors |
| WO2017000277A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
| WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| EP3156405A1 (en) | 2015-10-13 | 2017-04-19 | Boehringer Ingelheim International GmbH | Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| JP2021504466A (ja) | 2017-11-23 | 2021-02-15 | オスロ ウニヴェルシティ ホスピタル ホーエフ | 頻脈の治療 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI81350C (fi) * | 1982-01-18 | 1990-10-10 | Lepetit Spa | Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat. |
| RU2128175C1 (ru) * | 1994-08-09 | 1999-03-27 | Эйсай Ко., Лтд. | Конденсированный пиридазин или его фармакологически приемлемая соль, средство, проявляющее ингибирующую активность в отношении циклической гмф- фосфодиэстеразы |
| DE69521209T2 (de) * | 1994-09-16 | 2002-03-07 | Takeda Chemical Industries, Ltd. | Triazolopyridazine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel |
| US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| IL127911A0 (en) | 1996-07-25 | 1999-11-30 | Merck Sharp & Dohme | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
| DE69807074T2 (de) | 1997-05-08 | 2003-04-03 | Merck Sharp & Dohme Ltd., Hoddesdon | Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden |
| US6235741B1 (en) * | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
| GB9715977D0 (en) * | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801208D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
| GB0028583D0 (en) * | 2000-11-23 | 2001-01-10 | Merck Sharp & Dohme | Therapeutic compounds |
| GB0108475D0 (en) * | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| US6958334B2 (en) | 2001-04-10 | 2005-10-25 | Merck & Co., Inc. | Inhibitors of Akt activity |
| EA012505B1 (ru) * | 2005-01-05 | 2009-10-30 | Никомед Гмбх | Триазолофталазины в качестве ингибиторов pde-2 |
| JP5130053B2 (ja) * | 2005-01-05 | 2013-01-30 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリアゾロフタラジン |
-
2005
- 2005-08-31 DE DE602005021894T patent/DE602005021894D1/de not_active Expired - Lifetime
- 2005-08-31 BR BRPI0514586-4A patent/BRPI0514586A/pt not_active IP Right Cessation
- 2005-08-31 US US11/660,748 patent/US7851472B2/en not_active Expired - Fee Related
- 2005-08-31 KR KR1020077006869A patent/KR101368093B1/ko not_active Expired - Fee Related
- 2005-08-31 ES ES05784647T patent/ES2347337T3/es not_active Expired - Lifetime
- 2005-08-31 JP JP2007528875A patent/JP5140427B2/ja not_active Expired - Fee Related
- 2005-08-31 EA EA200700537A patent/EA014324B1/ru not_active IP Right Cessation
- 2005-08-31 CA CA2578368A patent/CA2578368C/en not_active Expired - Fee Related
- 2005-08-31 CN CN200580038057XA patent/CN101133057B/zh not_active Expired - Fee Related
- 2005-08-31 WO PCT/EP2005/054266 patent/WO2006024640A2/en not_active Ceased
- 2005-08-31 AU AU2005279221A patent/AU2005279221C9/en not_active Ceased
- 2005-08-31 AT AT05784647T patent/ATE471324T1/de not_active IP Right Cessation
- 2005-08-31 NZ NZ553160A patent/NZ553160A/en not_active IP Right Cessation
- 2005-08-31 EP EP05784647A patent/EP1791543B1/en not_active Expired - Lifetime
-
2007
- 2007-02-08 ZA ZA200701137A patent/ZA200701137B/xx unknown
- 2007-02-11 IL IL181271A patent/IL181271A/en not_active IP Right Cessation
- 2007-02-28 NO NO20071127A patent/NO20071127L/no not_active Application Discontinuation
-
2010
- 2010-04-23 US US12/766,478 patent/US20100286140A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL181271A0 (en) | 2007-07-04 |
| NZ553160A (en) | 2010-08-27 |
| CN101133057A (zh) | 2008-02-27 |
| AU2005279221C9 (en) | 2012-08-23 |
| KR101368093B1 (ko) | 2014-03-14 |
| WO2006024640A2 (en) | 2006-03-09 |
| US20090005372A1 (en) | 2009-01-01 |
| EA014324B1 (ru) | 2010-10-29 |
| EA200700537A1 (ru) | 2007-10-26 |
| DE602005021894D1 (de) | 2010-07-29 |
| AU2005279221C1 (en) | 2012-05-24 |
| IL181271A (en) | 2013-11-28 |
| ES2347337T3 (es) | 2010-10-28 |
| ZA200701137B (en) | 2008-11-26 |
| AU2005279221A1 (en) | 2006-03-09 |
| US20100286140A1 (en) | 2010-11-11 |
| US7851472B2 (en) | 2010-12-14 |
| BRPI0514586A (pt) | 2008-06-17 |
| CA2578368A1 (en) | 2006-03-09 |
| CA2578368C (en) | 2013-07-02 |
| EP1791543A2 (en) | 2007-06-06 |
| WO2006024640A3 (en) | 2007-06-07 |
| HK1115590A1 (en) | 2008-12-05 |
| JP2008511586A (ja) | 2008-04-17 |
| AU2005279221B2 (en) | 2011-10-13 |
| KR20070047834A (ko) | 2007-05-07 |
| JP5140427B2 (ja) | 2013-02-06 |
| NO20071127L (no) | 2007-02-28 |
| CN101133057B (zh) | 2011-03-09 |
| EP1791543B1 (en) | 2010-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |