ATE46696T1 - 1- und 1,1-disubstituierte, 6-substituierte, 2carbamimidoyl-1-carbadethiapen-2-em-3carbons|uren, verfahren zur herstellung und diese enthaltende antibiotische zusammensetzung. - Google Patents
1- und 1,1-disubstituierte, 6-substituierte, 2carbamimidoyl-1-carbadethiapen-2-em-3carbons|uren, verfahren zur herstellung und diese enthaltende antibiotische zusammensetzung.Info
- Publication number
- ATE46696T1 ATE46696T1 AT82106901T AT82106901T ATE46696T1 AT E46696 T1 ATE46696 T1 AT E46696T1 AT 82106901 T AT82106901 T AT 82106901T AT 82106901 T AT82106901 T AT 82106901T AT E46696 T1 ATE46696 T1 AT E46696T1
- Authority
- AT
- Austria
- Prior art keywords
- carbamimidoyl
- aryl
- alkyl
- hydrogen
- inter alia
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
- C07C17/275—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of hydrocarbons and halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28959981A | 1981-08-03 | 1981-08-03 | |
| US28934581A | 1981-08-03 | 1981-08-03 | |
| US28960081A | 1981-08-03 | 1981-08-03 | |
| EP82106901A EP0071908B1 (en) | 1981-08-03 | 1982-07-30 | 1-, and 1,1-disubstituted-6-substituted-2-carbamimidoyl-1-carbadethiapen-2-em-3-carboxylic acids, a process for preparing and an antibiotic composition containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE46696T1 true ATE46696T1 (de) | 1989-10-15 |
Family
ID=27403880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82106901T ATE46696T1 (de) | 1981-08-03 | 1982-07-30 | 1- und 1,1-disubstituierte, 6-substituierte, 2carbamimidoyl-1-carbadethiapen-2-em-3carbons|uren, verfahren zur herstellung und diese enthaltende antibiotische zusammensetzung. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0071908B1 (en:Method) |
| JP (1) | JPS5826887A (en:Method) |
| AT (1) | ATE46696T1 (en:Method) |
| CA (1) | CA1198427A (en:Method) |
| DE (1) | DE3279960D1 (en:Method) |
| DK (1) | DK344882A (en:Method) |
| ES (1) | ES514240A0 (en:Method) |
| GR (1) | GR76873B (en:Method) |
| IE (1) | IE55401B1 (en:Method) |
| PT (1) | PT75357B (en:Method) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683301A (en) * | 1982-04-08 | 1987-07-28 | Bristol-Myers Company | Carbapenem antibiotics |
| FI832619A7 (fi) * | 1982-07-26 | 1984-01-27 | Sandoz Ag | Fluoralkylerade karbapenemderivat |
| US4732977A (en) * | 1982-09-28 | 1988-03-22 | Bristol Myers Company | Carbapenem antibiotics |
| ZA836966B (en) * | 1982-09-28 | 1984-04-25 | Bristol Myers Co | Carbapenem antibiotics |
| US4746736A (en) * | 1982-09-28 | 1988-05-24 | Bristol-Myers Company | Carbapenem antibiotics |
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| CH660736A5 (de) * | 1983-10-03 | 1987-06-15 | Sanraku Inc | Carbapenemderivate. |
| US4748238A (en) * | 1984-03-14 | 1988-05-31 | Merck & Co., Inc. | Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid |
| JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | １―置換カルバペネム―３―カルボン酸誘導体 |
| US4696923A (en) * | 1984-04-23 | 1987-09-29 | Merck & Co., Inc. | 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids |
| DE3581481D1 (de) * | 1984-10-31 | 1991-02-28 | Sumitomo Pharma | Beta-lactame und ihre herstellung. |
| CA1281720C (en) * | 1984-11-08 | 1991-03-19 | Makoto Sunagawa | Carbapenem compounds and production thereof |
| US5310897A (en) * | 1984-12-27 | 1994-05-10 | Sumitomo Pharmaceuticals Co., Ltd. | Beta-lactams and their production |
| US5104984A (en) * | 1985-03-29 | 1992-04-14 | Merck & Co., Inc. | Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates |
| ATE107278T1 (de) * | 1985-03-29 | 1994-07-15 | Merck & Co Inc | Enantioselektives verfahren zur herstellung von 1-beta-methylcarbapenem- antibiotikumzwischenprodukten. |
| DK189686A (da) * | 1985-04-27 | 1986-10-28 | Sankyo Co | Carbapenemforbindelser og fremgangsmaade til fremstilling deraf samt middel indeholdende forbindelserne |
| JPS62103063A (ja) * | 1985-10-29 | 1987-05-13 | Sagami Chem Res Center | アゼチジノン誘導体の製造方法 |
| ES2061439T3 (es) * | 1985-12-28 | 1994-12-16 | Sumitomo Pharma | Compuesto beta-lactama y su produccion. |
| JPH0759581B2 (ja) * | 1986-09-05 | 1995-06-28 | 日本レダリ−株式会社 | （１ｒ）−１−メチルカルバペネム−３−カルボン酸誘導体 |
| JPS6363680A (ja) * | 1986-09-05 | 1988-03-22 | Nippon Redarii Kk | （１ｒ）−１−メチルカルバペネム−３−カルボン酸誘導体 |
| JPH0713058B2 (ja) * | 1986-12-29 | 1995-02-15 | 日本レダリ−株式会社 | ４―置換アゼチジノン誘導体の製造方法 |
| DE68916908T2 (de) * | 1988-11-08 | 1994-12-01 | Daiichi Seiyaku Co | Carbapenemderivate. |
| US5672701A (en) * | 1990-01-16 | 1997-09-30 | Bristol-Myers Squibb Company | 4-substituted alkyl carbapenem antibiotics |
| EP0546742B1 (en) * | 1991-12-09 | 2001-06-20 | Takasago International Corporation | 4-(1,1-Dialkoxycarbonyl-alkyl)azetidin-2-one derivatives and synthesis of 4-(1-carboxy-alkyl)azetidin-2-one derivatives therefrom |
| US5750686A (en) * | 1993-06-16 | 1998-05-12 | Sumitomo Pharmaceuticals Company, Limited | Carbapenem compounds and process for producing the same |
| US5496816A (en) * | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| JPH1077285A (ja) | 1996-09-04 | 1998-03-24 | Sumitomo Pharmaceut Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| US20020049315A1 (en) * | 2000-09-06 | 2002-04-25 | Williams John M. | Crystalline forms of carbapenem intermediates |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260627A (en) * | 1978-10-24 | 1981-04-07 | Merck & Co., Inc. | 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids |
| DK446179A (da) * | 1978-10-24 | 1980-05-29 | Merck & Co Inc | Fremgangsmaade til fremstilling af substituerede 1-carbadethiapen-2-em-3-carboxylsyrer |
| EP0017992A1 (en) * | 1979-04-19 | 1980-10-29 | Merck & Co. Inc. | 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates |
| GR72296B (en:Method) * | 1979-12-03 | 1983-10-18 | Merck & Co Inc | |
| EP0038869A1 (en) * | 1980-04-30 | 1981-11-04 | Merck & Co. Inc. | Process for the preparation of 1-carbapenems, and intermediates for their preparation |
| PT73791B (en) * | 1980-10-17 | 1983-10-14 | Merck & Co Inc | Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids |
| EP0060077A1 (en) * | 1981-03-04 | 1982-09-15 | Beecham Group Plc | Beta-lactam antibiotics, their preparation and use |
-
1982
- 1982-07-22 ES ES514240A patent/ES514240A0/es active Granted
- 1982-07-27 GR GR68884A patent/GR76873B/el unknown
- 1982-07-30 DE DE8282106901T patent/DE3279960D1/de not_active Expired
- 1982-07-30 EP EP82106901A patent/EP0071908B1/en not_active Expired
- 1982-07-30 AT AT82106901T patent/ATE46696T1/de active
- 1982-07-30 IE IE1846/82A patent/IE55401B1/en not_active IP Right Cessation
- 1982-08-02 DK DK344882A patent/DK344882A/da not_active Application Discontinuation
- 1982-08-02 PT PT75357A patent/PT75357B/pt not_active IP Right Cessation
- 1982-08-02 CA CA000408575A patent/CA1198427A/en not_active Expired
- 1982-08-03 JP JP57134820A patent/JPS5826887A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CA1198427A (en) | 1985-12-24 |
| DK344882A (da) | 1983-02-04 |
| JPH0545596B2 (en:Method) | 1993-07-09 |
| EP0071908B1 (en) | 1989-09-27 |
| PT75357A (en) | 1982-09-01 |
| PT75357B (en) | 1985-11-20 |
| IE55401B1 (en) | 1990-09-12 |
| JPS5826887A (ja) | 1983-02-17 |
| GR76873B (en:Method) | 1984-09-04 |
| EP0071908A1 (en) | 1983-02-16 |
| ES8404184A1 (es) | 1984-04-16 |
| ES514240A0 (es) | 1984-04-16 |
| DE3279960D1 (en) | 1989-11-02 |
| IE821846L (en) | 1983-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3279960D1 (en) | 1-, and 1,1-disubstituted-6-substituted-2-carbamimidoyl-1-carbadethiapen-2-em-3-carboxylic acids, a process for preparing and an antibiotic composition containing the same | |
| JPS5569586A (en) | 11* 66 and 22substitutedd11carbaa22penenn 33carboxylic acid | |
| ATE27701T1 (de) | 2-carbamimidoyl-6-substituierte-1-carbadethiape - 2-em-3-carbonsaeure, verfahren zur herstellung und sie enthaltendes antibiotisches arzneipraeparat. | |
| NL930077I1 (nl) | Gesubstitueerde acylderivaten van 1,2,3,4-tetrahydroisochinoline-3-carbonzuren zouten ervan farmaceutische preparaten die de derivaten of zouten bevaaten en de bereiding daarvan | |
| NO177535C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive peptidforbindelser | |
| IE792027L (en) | Pyrroloazetidinones | |
| DE3775882D1 (de) | Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeuren ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen. | |
| HUT59417A (en) | Process for producing azasteroid compounds and pharmaceutical compositions comprising same as active ingredient | |
| ES474288A1 (es) | Un procedimiento para la preparacion de derivados del acido 7-oxo-1-aza-biciclo-(3,2,0)-hept-2-en-carboxilico 3 y 6-sus-tituidos | |
| EP0193148A3 (en) | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides | |
| ATE61340T1 (de) | Aminosaeurederivate und deren verfahren zur herstellung. | |
| ATE142641T1 (de) | Neue peptid-verbindungen und verfahren zur herstellung davon | |
| CA2036905A1 (en) | Condensed thiazole compounds, their production and use | |
| ATE141606T1 (de) | Cephemverbindungen und verfahren zu ihrer herstellung | |
| ATE19773T1 (de) | Nitroaliphatische verbindungen, verfahren zu deren herstellung und deren verwendung. | |
| ES8205224A1 (es) | Un procedimiento para la preparacion de acidos 1-carbadetiapen-2-em-3-carboxilios 6-1-y 2-sustituidos. | |
| DE69429753D1 (de) | Anitbiotisch wirksame Cephalosporine und Verfahren zu ihrer Herstellung | |
| WO1987004435A3 (en) | Xanthine compounds | |
| HUT57221A (en) | Process for producing pyrrolo(2,1-b)thiazol derivatives and pahrmaceutical compositions contiaining them as active components | |
| KR890701572A (ko) | 고리형 아미노산의 유도체,이들의 염, 이들을 함유하는 약제조성물 및 이들의 제조방법. |