ATE456376T1 - Immortalisierte hepatozyten - Google Patents
Immortalisierte hepatozytenInfo
- Publication number
- ATE456376T1 ATE456376T1 AT04794437T AT04794437T ATE456376T1 AT E456376 T1 ATE456376 T1 AT E456376T1 AT 04794437 T AT04794437 T AT 04794437T AT 04794437 T AT04794437 T AT 04794437T AT E456376 T1 ATE456376 T1 AT E456376T1
- Authority
- AT
- Austria
- Prior art keywords
- cell lines
- immortalized hepatocytes
- immortalized
- nontumorigenic
- virally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51050903P | 2003-10-10 | 2003-10-10 | |
PCT/US2004/033091 WO2006041488A1 (en) | 2003-10-10 | 2004-10-07 | Immortalized hepatocytes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE456376T1 true ATE456376T1 (de) | 2010-02-15 |
Family
ID=34435100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04794437T ATE456376T1 (de) | 2003-10-10 | 2004-10-07 | Immortalisierte hepatozyten |
Country Status (9)
Country | Link |
---|---|
US (2) | US7566567B2 (de) |
EP (2) | EP1685252A4 (de) |
JP (2) | JP2007518426A (de) |
AT (1) | ATE456376T1 (de) |
AU (1) | AU2004280238A1 (de) |
CA (2) | CA2541380A1 (de) |
DE (1) | DE602004025380D1 (de) |
IL (1) | IL174787A0 (de) |
WO (2) | WO2005034876A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007080990A1 (ja) * | 2006-01-12 | 2007-07-19 | Kazuo Ohashi | 肝組織細胞機能の長期維持方法 |
JP5737821B2 (ja) * | 2006-08-17 | 2015-06-17 | 一夫 大橋 | 血友病b治療剤及びその製造方法 |
US8099298B2 (en) * | 2007-02-14 | 2012-01-17 | Genelex, Inc | Genetic data analysis and database tools |
WO2009142767A1 (en) * | 2008-05-22 | 2009-11-26 | Lentigen Corporation | Lentivector-based protein production |
DE112009001245T5 (de) * | 2008-05-28 | 2012-03-15 | Basf Se | Mittel und Verfahren für die Beurteilung der Leberenzyminduktion |
CN101967499A (zh) * | 2009-12-09 | 2011-02-09 | 河南东都生物科技有限公司 | 一种还原型辅酶q10的生产方法 |
US10210312B2 (en) | 2013-02-03 | 2019-02-19 | Youscript Inc. | Systems and methods for quantification and presentation of medical risk arising from unknown factors |
CN103981147B (zh) * | 2013-02-08 | 2017-11-10 | 中国科学院上海生命科学研究院 | 一种新的制备肝实质细胞的方法 |
JP2015008686A (ja) * | 2013-06-28 | 2015-01-19 | 三菱レイヨン株式会社 | 肝臓細胞又はその前駆細胞に由来する細胞の状態を評価する方法、並びに、その方法に用いるプローブ又はプローブセット及びマイクロアレイ |
JP6418761B2 (ja) * | 2014-03-14 | 2018-11-07 | 国立大学法人東京工業大学 | 肝炎組織体、肝炎ウイルスの感染方法、肝炎組織体の製造方法、肝炎ウイルスの増殖方法、肝炎ワクチンの製造方法、スクリーニング方法、及びキット |
EP3746137A4 (de) * | 2018-01-30 | 2021-11-24 | Capricor, Inc. | Für die zelltherapie geeignete aktivierungsinduzierte gewebeeffektorzellen und daraus gewonnene abgeleitete extrazelluläre vesikel |
WO2023084648A1 (ja) * | 2021-11-10 | 2023-05-19 | 株式会社日立ハイテク | 薬剤相互作用解析方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS584728A (ja) * | 1981-05-01 | 1983-01-11 | メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン | α−1−抗トリプシンの精製 |
US5665589A (en) * | 1988-12-14 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Human liver epithelial cell lines |
US5652097A (en) * | 1994-12-14 | 1997-07-29 | Universite De Montreal | In vitro test to evaluate the inhibition potency of angiotensin II antagonists on angiotensinogen |
US5869243A (en) | 1996-03-05 | 1999-02-09 | Rhode Island Hospital | Immortalized hepatocytes |
BR9708021A (pt) * | 1996-03-11 | 1999-07-27 | Bayer Ag | Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína |
DE19711266C2 (de) | 1997-03-05 | 1999-06-17 | Hepavec Ag Fuer Gentherapie | Neue humane Leber-Zellinie |
EP1002132A4 (de) * | 1997-08-05 | 2005-04-27 | Human Genome Sciences Inc | Humane sekretierte proteine |
US6653105B2 (en) * | 1998-02-11 | 2003-11-25 | Vitagen, Inc. | Clonal cells and cell lines derived from C3A cells and methods of making and using them |
WO1999055853A1 (fr) | 1998-04-28 | 1999-11-04 | Takeda Chemical Industries, Ltd. | Lignee cellulaire hepatique immortalisee d'origine humaine |
AU6162199A (en) | 1998-09-25 | 2000-04-17 | Harvard-Mit Division Of Health Science And Technology | Reversibly immortalized hepatocytes and methods of use |
US6517830B1 (en) * | 1999-08-05 | 2003-02-11 | Emory University | Compositions and methods for the expression of factor VIII polypeptides and uses therefor |
WO2001098493A1 (fr) * | 2000-06-15 | 2001-12-27 | Kyowa Hakko Kogyo Co., Ltd | Proteine de liaison de facteur de croissance insulinoide |
WO2002026942A2 (en) | 2000-09-25 | 2002-04-04 | Walter Reed Army Institute Of Research | Human liver cell line |
CA2447116A1 (en) * | 2001-05-17 | 2002-11-21 | Board Of Trustees Of The University Of Illinois | Methods for treating liver disease and liver damage with growth hormone and foxm1b |
-
2004
- 2004-10-07 CA CA002541380A patent/CA2541380A1/en not_active Abandoned
- 2004-10-07 AT AT04794437T patent/ATE456376T1/de not_active IP Right Cessation
- 2004-10-07 EP EP04794573A patent/EP1685252A4/de not_active Withdrawn
- 2004-10-07 EP EP04794437A patent/EP1704227B1/de active Active
- 2004-10-07 US US10/574,163 patent/US7566567B2/en active Active
- 2004-10-07 JP JP2007506132A patent/JP2007518426A/ja active Pending
- 2004-10-07 US US10/574,167 patent/US20070104696A1/en not_active Abandoned
- 2004-10-07 WO PCT/US2004/033260 patent/WO2005034876A2/en active Search and Examination
- 2004-10-07 AU AU2004280238A patent/AU2004280238A1/en not_active Abandoned
- 2004-10-07 CA CA002550452A patent/CA2550452A1/en not_active Abandoned
- 2004-10-07 JP JP2006534388A patent/JP2007508019A/ja active Pending
- 2004-10-07 WO PCT/US2004/033091 patent/WO2006041488A1/en active Search and Examination
- 2004-10-07 DE DE602004025380T patent/DE602004025380D1/de active Active
-
2006
- 2006-04-04 IL IL174787A patent/IL174787A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE602004025380D1 (de) | 2010-03-18 |
AU2004280238A1 (en) | 2005-04-21 |
AU2004280238A2 (en) | 2005-04-21 |
JP2007508019A (ja) | 2007-04-05 |
EP1685252A2 (de) | 2006-08-02 |
EP1704227A4 (de) | 2007-01-17 |
WO2006041488A1 (en) | 2006-04-20 |
US7566567B2 (en) | 2009-07-28 |
EP1704227B1 (de) | 2010-01-27 |
JP2007518426A (ja) | 2007-07-12 |
CA2541380A1 (en) | 2005-04-21 |
WO2006041488A8 (en) | 2006-09-08 |
CA2550452A1 (en) | 2006-04-20 |
WO2005034876A2 (en) | 2005-04-21 |
WO2005034876A3 (en) | 2005-10-06 |
IL174787A0 (en) | 2006-08-20 |
EP1704227A1 (de) | 2006-09-27 |
EP1685252A4 (de) | 2006-11-29 |
US20070004039A1 (en) | 2007-01-04 |
US20070104696A1 (en) | 2007-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |