ATE435295T1 - Herstellung von polyhydroxyalkanoate in pflanzen - Google Patents

Herstellung von polyhydroxyalkanoate in pflanzen

Info

Publication number
ATE435295T1
ATE435295T1 AT01203113T AT01203113T ATE435295T1 AT E435295 T1 ATE435295 T1 AT E435295T1 AT 01203113 T AT01203113 T AT 01203113T AT 01203113 T AT01203113 T AT 01203113T AT E435295 T1 ATE435295 T1 AT E435295T1
Authority
AT
Austria
Prior art keywords
plant
polyhydroxyalkanoates
plants
production
polyhydroxyalkanoate
Prior art date
Application number
AT01203113T
Other languages
English (en)
Inventor
Simon William Jonathan Bright
David Byrom
Philip Anthony Fentem
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Application granted granted Critical
Publication of ATE435295T1 publication Critical patent/ATE435295T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Biological Depolymerization Polymers (AREA)
AT01203113T 1991-04-24 1992-04-23 Herstellung von polyhydroxyalkanoate in pflanzen ATE435295T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919108756A GB9108756D0 (en) 1991-04-24 1991-04-24 Production of polyalkanoate in plants

Publications (1)

Publication Number Publication Date
ATE435295T1 true ATE435295T1 (de) 2009-07-15

Family

ID=10693835

Family Applications (2)

Application Number Title Priority Date Filing Date
AT92908920T ATE221126T1 (de) 1991-04-24 1992-04-23 Herstellung von polyhydroxyalkanoate in pflanzen
AT01203113T ATE435295T1 (de) 1991-04-24 1992-04-23 Herstellung von polyhydroxyalkanoate in pflanzen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT92908920T ATE221126T1 (de) 1991-04-24 1992-04-23 Herstellung von polyhydroxyalkanoate in pflanzen

Country Status (11)

Country Link
US (2) US5502273A (de)
EP (2) EP1176207B1 (de)
JP (1) JPH06510422A (de)
AT (2) ATE221126T1 (de)
AU (1) AU655816B2 (de)
CA (1) CA2109221C (de)
DE (2) DE69232694T2 (de)
DK (1) DK0589898T3 (de)
ES (2) ES2182819T3 (de)
GB (1) GB9108756D0 (de)
WO (1) WO1992019747A1 (de)

Families Citing this family (64)

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US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
ATE295891T1 (de) * 1991-07-19 2005-06-15 Univ Michigan State Transgene pflanzen die polyhydroxyalkanoate produzieren
US5610041A (en) * 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
WO1994012014A1 (en) * 1992-11-20 1994-06-09 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
DE69433502D1 (de) * 1993-11-09 2004-02-26 Du Pont Transgene fruktan - anreichernde nutzpflanzen und verfahren zu ihrer herstellung
RU2144047C1 (ru) * 1994-01-28 2000-01-10 Дзе Проктер Энд Гэмбл Компани Биоразлагаемые сополимеры, пластмассовые и впитывающие изделия, содержащие биоразлагаемые сополимеры
SG49096A1 (en) * 1994-01-28 1998-05-18 Procter & Gamble Biodegradable 3-polyhydtoxybuyrate/3- polyhydroxyhexanoate copolymer films
ZA95627B (en) * 1994-01-28 1995-10-05 Procter & Gamble Biodegradable copolymers and plastic articles comprising biodegradable copolymers
ID23491A (id) * 1994-01-28 1995-09-07 Procter & Gamble Kopolimer-kopolimer yang dapat dibiodegradasi dan baha-bahan plastik yang terdiri dari kopolimer-kopolimer yang dapat dibiodegradasi
CN1079835C (zh) * 1994-06-01 2002-02-27 普罗克特和甘保尔公司 利用空气分级作用回收聚羟基链烷酸酯的方法
CA2191713C (en) * 1994-06-01 2000-08-29 Isao Noda Process for recovering polyhydroxyalkanoates using centrifugal fractionation
GB9414506D0 (en) * 1994-07-18 1994-09-07 Zeneca Ltd Improved production of polyhydroxyalkanoate
GB9502456D0 (en) * 1995-02-08 1995-03-29 Univ Warwick Control of genes in transgenic plants
US6127606A (en) * 1995-02-08 2000-10-03 University Of Warwick Method of using transactivation proteins to control expression in transgenic plants
US6083729A (en) * 1995-10-26 2000-07-04 Metabolix, Inc. Methods for isolating polyhydroxyalkanoates from plants
US5849894A (en) * 1995-11-29 1998-12-15 Monsanto Company Rhodospirillum rubrum poly-β-hydroxyalkanoate synthase
EP0870053A4 (de) 1995-12-19 2002-09-11 Univ Minnesota Metabolisches verfahren zur herstellung von polyhydroxyalkanoat-monomer synthasen
US6143947A (en) * 1996-01-29 2000-11-07 The Procter & Gamble Company Fibers, nonwoven fabrics and absorbent articles comprising a biodegradable polyhydroxyalkanoate comprising 3-hydroxybutyrate and 3-hydroxyhexanoate
US6091002A (en) * 1996-03-13 2000-07-18 Monsanto Company Polyhydroxyalkanoates of narrow molecular weight distribution prepared in transgenic plants
US5958745A (en) * 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
US6946588B2 (en) 1996-03-13 2005-09-20 Monsanto Technology Llc Nucleic acid encoding a modified threonine deaminase and methods of use
US5959179A (en) * 1996-03-13 1999-09-28 Monsanto Company Method for transforming soybeans
US5750848A (en) * 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
AU8473198A (en) * 1997-06-30 1999-01-19 Curators Of The University Of Missouri, The Use of dna encoding plastid pyruvate dehydrogenase and branched chain oxoa cid dehydrogenase components to enhance polyhydroxyalkanoate biosynthesis in p lants
ATE328035T1 (de) * 1997-07-25 2006-06-15 Metabolix Inc Pha-zusammensetzungen und deren verwendung zur herstellung von pha-filmen
DE69838768T2 (de) 1997-09-19 2008-10-30 Metabolix, Inc., Cambridge Biologische Systeme zur Herstellung von Polyhydroxyalkanoat-Polymeren die 4-Hy droxysäure enthalten
AU5907198A (en) * 1998-01-05 1999-07-26 Monsanto Company Biosynthesis of medium chain length polyhydroxyalkanoates
US6207217B1 (en) 1998-01-07 2001-03-27 Pioneer Hi-Bred International, Inc. Animal nutrition compositions
JP3524495B2 (ja) * 1998-01-19 2004-05-10 エルジ ケミカル リミテッド アルカリゲネスラタス由来のポリヒドロキシアルカノエート生合成関連遺伝子
US6586658B1 (en) * 1998-03-06 2003-07-01 Metabolix, Inc. Modification of fatty acid metabolism in plants
ATE458822T1 (de) 1998-04-08 2010-03-15 Metabolix Inc Verfahren für die trennung und reinigung von biopolymeren
AU4199599A (en) 1998-05-22 1999-12-13 Metabolix, Inc. Polyhydroxyalkanoate biopolymer compositions
MXPA01001049A (es) * 1998-07-30 2002-08-20 Metabolix Inc Enzimas para produccion de biopolimeros.
ES2302386T3 (es) 1998-08-04 2008-07-01 Metabolix, Inc. Produccion de polihidroxialcanoatos a partir de polioles.
US6174990B1 (en) 1998-12-21 2001-01-16 The Procter & Gamble Company Films comprising biodegradable PHA copolymers
US6160199A (en) * 1998-12-21 2000-12-12 The Procter & Gamble Company Absorbent articles comprising biodegradable PHA copolymers
US6077931A (en) * 1998-12-21 2000-06-20 The Procter & Gamble Company Biodegradable PHA copolymers
WO2000040730A1 (en) * 1999-01-07 2000-07-13 University Of Massachusetts POLYHYDROXYALKANOATE BIOSYNTHESIS ASSOCIATED PROTEINS AND CODING REGION IN $i(BACILLUS MEGATERIUM)
US6835820B2 (en) 1999-01-07 2004-12-28 The University Of Massachusetts Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium
WO2000052183A1 (en) * 1999-03-05 2000-09-08 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
DK1161539T3 (da) 1999-03-15 2005-11-28 Univ Laval Fremgangsmåde til at fremstille polyhydroxyalkanoater i rekombinante organismer
US6451564B1 (en) 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
DE60040125D1 (de) 1999-08-09 2008-10-16 Riken Wako Verfahren zur Transformierung von Pflanzen, transformierte Pflanzen und Verfahren zur Herstellung von Polyestern
US7407778B2 (en) 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
ATE437884T1 (de) * 2003-05-29 2009-08-15 Jay W Pettegrew Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
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CN105936887A (zh) 2007-03-16 2016-09-14 基因组股份公司 用于1,4-丁二醇和其前体生物合成的组合物和方法
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
JP5912529B2 (ja) 2008-09-10 2016-04-27 ゲノマチカ， インク． １，４−ブタンジオールの生成のための微生物体
CN102498215A (zh) 2009-06-04 2012-06-13 基因组股份公司 生产1,4-丁二醇的微生物和相关方法
EP3199511B1 (de) * 2009-06-04 2020-01-29 Genomatica, Inc. Verfahren zur trennung von komponenten einer fermentierungsbrühe
JP2013507145A (ja) * 2009-10-13 2013-03-04 ゲノマチカ， インク． １，４−ブタンジオール、４−ヒドロキシブタナール、４−ヒドロキシブチリル−ＣｏＡ、プトレシン及び関連化合物の生成のための微生物体並びに関連する方法
US8530210B2 (en) * 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
EP2534141B1 (de) 2010-02-11 2016-04-20 Metabolix, Inc. Verfahren zur herstellung von gamma-butyrolacton
US8445244B2 (en) * 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
MX2013007958A (es) 2011-02-14 2013-08-01 Xyleco Inc Biomasa de procesamiento.
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EP3980546A4 (de) * 2019-06-10 2023-06-21 Yield10 Bioscience, Inc. Transgene landpflanzen, die einen polyhydroxyalkanoat-synthase-samen spezifisch mit zytosolischer lokalisierung exprimieren

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US4266855A (en) * 1979-09-24 1981-05-12 Quantor Corporation Quick change lens system
ATE93542T1 (de) * 1984-12-28 1993-09-15 Plant Genetic Systems Nv Rekombinante dna, die in pflanzliche zellen eingebracht werden kann.
US5245023A (en) * 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5229279A (en) 1987-06-29 1993-07-20 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
ATE227340T1 (de) * 1989-07-10 2002-11-15 Massachusetts Inst Technology Eine zur herstellung von polyhydroxybutyrat oder einem anderen polyhydroxyalkanoat geeignete pflanze oder pflanzliche zelle
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
GB9115245D0 (en) * 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
ATE295891T1 (de) * 1991-07-19 2005-06-15 Univ Michigan State Transgene pflanzen die polyhydroxyalkanoate produzieren
GB9223332D0 (en) 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants

Also Published As

Publication number Publication date
EP1176207B1 (de) 2009-07-01
ES2327897T3 (es) 2009-11-05
US6175061B1 (en) 2001-01-16
DK0589898T3 (da) 2002-11-18
AU1579792A (en) 1992-12-21
EP0589898B1 (de) 2002-07-24
US5502273A (en) 1996-03-26
EP0589898A1 (de) 1994-04-06
DE69232694D1 (de) 2002-08-29
EP1176207A2 (de) 2002-01-30
ES2182819T3 (es) 2003-03-16
AU655816B2 (en) 1995-01-12
CA2109221C (en) 2007-03-06
DE69232694T2 (de) 2003-03-06
EP1176207A3 (de) 2003-01-08
GB9108756D0 (en) 1991-06-12
JPH06510422A (ja) 1994-11-24
DE69233763D1 (de) 2009-08-13
ATE221126T1 (de) 2002-08-15
WO1992019747A1 (en) 1992-11-12
CA2109221A1 (en) 1992-10-25

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