ATE295894T1 - Verfahren zur herstellung von polyhydroxybutyrat und verwandten polyhydroxyalkanoaten in den plastiden hoeherer pflanzen - Google Patents

Verfahren zur herstellung von polyhydroxybutyrat und verwandten polyhydroxyalkanoaten in den plastiden hoeherer pflanzen

Info

Publication number
ATE295894T1
ATE295894T1 AT94926515T AT94926515T ATE295894T1 AT E295894 T1 ATE295894 T1 AT E295894T1 AT 94926515 T AT94926515 T AT 94926515T AT 94926515 T AT94926515 T AT 94926515T AT E295894 T1 ATE295894 T1 AT E295894T1
Authority
AT
Austria
Prior art keywords
plastids
phb
higher plants
polyhydroxyalkanoates
plants
Prior art date
Application number
AT94926515T
Other languages
English (en)
Inventor
Christopher Roland Somerville
Christiane Nawrath
Yves Poirier
Original Assignee
Univ Michigan State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan State filed Critical Univ Michigan State
Application granted granted Critical
Publication of ATE295894T1 publication Critical patent/ATE295894T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT94926515T 1993-08-17 1994-08-17 Verfahren zur herstellung von polyhydroxybutyrat und verwandten polyhydroxyalkanoaten in den plastiden hoeherer pflanzen ATE295894T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10819393A 1993-08-17 1993-08-17
US08/254,357 US5610041A (en) 1991-07-19 1994-06-06 Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
PCT/US1994/009265 WO1995005472A2 (en) 1993-08-17 1994-08-17 Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants

Publications (1)

Publication Number Publication Date
ATE295894T1 true ATE295894T1 (de) 2005-06-15

Family

ID=26805624

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94926515T ATE295894T1 (de) 1993-08-17 1994-08-17 Verfahren zur herstellung von polyhydroxybutyrat und verwandten polyhydroxyalkanoaten in den plastiden hoeherer pflanzen

Country Status (9)

Country Link
US (1) US5610041A (de)
EP (1) EP0719342B1 (de)
JP (1) JPH09501832A (de)
AT (1) ATE295894T1 (de)
AU (1) AU7633094A (de)
DE (1) DE69434377T2 (de)
ES (1) ES2240965T3 (de)
HK (1) HK1013110A1 (de)
WO (1) WO1995005472A2 (de)

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US6083729A (en) 1995-10-26 2000-07-04 Metabolix, Inc. Methods for isolating polyhydroxyalkanoates from plants
GB9522896D0 (en) * 1995-11-08 1996-01-10 Zeneca Ltd Polyester production
US5849894A (en) * 1995-11-29 1998-12-15 Monsanto Company Rhodospirillum rubrum poly-β-hydroxyalkanoate synthase
WO1997022711A1 (en) 1995-12-19 1997-06-26 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
US6946588B2 (en) 1996-03-13 2005-09-20 Monsanto Technology Llc Nucleic acid encoding a modified threonine deaminase and methods of use
US5959179A (en) * 1996-03-13 1999-09-28 Monsanto Company Method for transforming soybeans
US5958745A (en) * 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
GB9606187D0 (en) * 1996-03-23 1996-05-29 Inst Of Food Research Production of vanillin
US5750848A (en) * 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
JP3062459B2 (ja) * 1996-08-14 2000-07-10 理化学研究所 ポリエステル重合酵素遺伝子及びポリエステルの製造方法
WO1998036078A1 (en) * 1997-02-13 1998-08-20 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
WO1999000505A1 (en) * 1997-06-30 1999-01-07 The Curators Of The University Of Missouri Use of dna encoding plastid pyruvate dehydrogenase and branched chain oxoacid dehydrogenase components to enhance polyhydroxyalkanoate biosynthesis in plants
EP1015565B1 (de) * 1997-09-19 2006-04-12 Metabolix, Inc. Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten
EP1044278A1 (de) * 1998-01-05 2000-10-18 Monsanto Company Biosynthese mittelkettiger polyhydroyalkanoaten
WO1999034687A1 (en) 1998-01-07 1999-07-15 Metabolix, Inc. Animal nutrition compositions
US6649382B1 (en) * 1998-01-19 2003-11-18 Lg Chemical Ltd. Methods of making polyhydroxyalkanoate using biosynthesis genes from alcaligenes latus
US6586658B1 (en) 1998-03-06 2003-07-01 Metabolix, Inc. Modification of fatty acid metabolism in plants
CA2322729C (en) * 1998-03-06 2010-06-15 Metabolix, Inc. Modification of fatty acid metabolism in plants
US6103956A (en) * 1998-03-31 2000-08-15 Regents Of The University Of Minnesota Polyhydroxyalkanoate synthesis in plants
US6143952A (en) * 1998-03-31 2000-11-07 Regents Of The University Of Minnesota Modified pseudomonas oleovorans phaC1 nucleic acids encoding bispecific polyhydroxyalkanoate polymerase
WO1999051760A1 (en) 1998-04-08 1999-10-14 Metabolix, Inc. Methods for separation and purification of biopolymers
MXPA00011401A (es) * 1998-05-22 2003-04-22 Metabolix Inc Composiciones de biopolimero de polimero de polihidroxialcanoato.
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
AU768244B2 (en) * 1998-07-30 2003-12-04 Metabolix, Inc. Enzymes for biopolymer production
ES2302386T3 (es) 1998-08-04 2008-07-01 Metabolix, Inc. Produccion de polihidroxialcanoatos a partir de polioles.
US6160199A (en) * 1998-12-21 2000-12-12 The Procter & Gamble Company Absorbent articles comprising biodegradable PHA copolymers
US6174990B1 (en) 1998-12-21 2001-01-16 The Procter & Gamble Company Films comprising biodegradable PHA copolymers
US6077931A (en) * 1998-12-21 2000-06-20 The Procter & Gamble Company Biodegradable PHA copolymers
AU3516100A (en) 1999-03-05 2000-09-21 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
CA2365276C (en) 1999-03-15 2009-08-25 Universite Laval Method for producing polyhydroxyalkanoates in recombinant organisms
AU750835B2 (en) * 1999-05-12 2002-08-01 Metabolix, Inc. Methods for purifying polyhydroxyalkanoates
WO2000078985A1 (en) * 1999-06-24 2000-12-28 Metabolix, Inc. Plant multi-gene expression constructs
US6451564B1 (en) 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
DE60040125D1 (de) * 1999-08-09 2008-10-16 Riken Wako Verfahren zur Transformierung von Pflanzen, transformierte Pflanzen und Verfahren zur Herstellung von Polyestern
AU2001284997A1 (en) * 2000-08-24 2002-03-04 Maxygen, Inc. Constructs and their use in metabolic pathway engineering
US20030194784A1 (en) * 2001-04-17 2003-10-16 Sherman David H. DNA encoding methymycin and pikromycin
EP2216405A1 (de) 2002-05-03 2010-08-11 Monsanto Technology LLC Saatspezifische USP-Promotoren zur Expression von Genen in Pflanzen
US20030213013A1 (en) * 2002-05-07 2003-11-13 Caimi Perry G. Fructose polymer synthesis in monocot plastids
DE10240035A1 (de) * 2002-08-30 2004-03-11 Rehm, Bernd H.A., PD Dr.rer.nat. Biogene Polyester-Partikel definierter Größe mit funktionalisierten Oberflächen:Herstellungsverfahren und pharmazeutische Zubereitungen, in denen diese enthalten sind
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TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
BRPI0918483A2 (pt) 2008-09-10 2020-07-14 Genomatica, Inc organismo microbiano que não ocorre naturalmente, e, método para produzir um composto
JP5964747B2 (ja) 2009-06-04 2016-08-03 ゲノマチカ， インク． １，４−ブタンジオールの生成のための微生物体及び関連する方法
VN29235A1 (de) * 2009-06-04 2012-03-26
CA2777459A1 (en) * 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
RU2012132908A (ru) 2010-02-11 2014-03-20 Метаболикс, Инк. Способ получения производных химических соединений
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
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BR112014030202A2 (pt) 2012-06-04 2017-09-12 Genomatica Inc microorganismos e métodos para a produção de 4-hidroxibutirato 1,4-butanodiol e compostos relacionados
PT3692155T (pt) 2017-10-04 2022-11-03 Lanzatech Inc Produção de poli-hidroxibutirato em micro-organismos de wood-ljungdahl

Family Cites Families (9)

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US5229279A (en) * 1987-06-29 1993-07-20 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5245023A (en) * 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) * 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
EP0482077B1 (de) * 1989-07-10 1998-10-21 Massachusetts Institute Of Technology Verfahren zur Herstellung von Polyester-Biopolymeren
GB9108756D0 (en) * 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
GB9115245D0 (en) * 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
ATE295891T1 (de) * 1991-07-19 2005-06-15 Univ Michigan State Transgene pflanzen die polyhydroxyalkanoate produzieren
GB9223332D0 (en) * 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
GB9306490D0 (en) * 1993-03-29 1993-05-19 Zeneca Ltd Plant gene specifying acetyl,coenzyme a carboxylase and transformed plants containing same

Also Published As

Publication number Publication date
DE69434377D1 (de) 2005-06-23
EP0719342A1 (de) 1996-07-03
WO1995005472A2 (en) 1995-02-23
DE69434377T2 (de) 2006-02-02
ES2240965T3 (es) 2005-10-16
AU7633094A (en) 1995-03-14
US5610041A (en) 1997-03-11
JPH09501832A (ja) 1997-02-25
WO1995005472A3 (en) 1995-03-30
EP0719342B1 (de) 2005-05-18
HK1013110A1 (en) 1999-08-13

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