KR930009986A - 고수율의 n-벤질옥시카보닐-l-아스파트산의 제조방법 - Google Patents

고수율의 n-벤질옥시카보닐-l-아스파트산의 제조방법 Download PDF

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KR930009986A
KR930009986A KR1019910021640A KR910021640A KR930009986A KR 930009986 A KR930009986 A KR 930009986A KR 1019910021640 A KR1019910021640 A KR 1019910021640A KR 910021640 A KR910021640 A KR 910021640A KR 930009986 A KR930009986 A KR 930009986A
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South Korea
Prior art keywords
aspartic acid
benzyloxycarbonyl
toluene
high yield
preparing high
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KR1019910021640A
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English (en)
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KR940011148B1 (ko
Inventor
최경석
주대권
한민수
최홍규
Original Assignee
유영학
주식회사 미 원
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Priority to KR1019910021640A priority Critical patent/KR940011148B1/ko
Publication of KR930009986A publication Critical patent/KR930009986A/ko
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Publication of KR940011148B1 publication Critical patent/KR940011148B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 인공 감미료인 α-L-아스파틸-L-페닐알라닌 메틸 에스텔르의 원료 물질들중의 하나인 N-벤질옥시카보닐-L-아스파트산을 고수율로 제조하는 방법에 관한 것으로 구체적으로는 L-아스파트산을 증류수에 녹여 45% NaOH 로 pH를 11.0으로 유지하고 온도를 55℃이상으로 올린 다음, 톨루엔이 함유된 벤질옥시카보닐 클로라이드와 톨루엔을 첨가한 후 55℃이상의 온도에서 교반하에 반응시키는 것을 특징으로 하는데, 본 발명에 따르면 종래의 방법들보다 제조 수율이 향상된 98% 이상의 N-벤질옥시카보닐-L-아스파트산을 제조할 수 있게 된다.

Description

고수율의 N-벤질옥시카보닐-L-아스파트산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. L-아스파트산을 증류수에 녹여 45% NaOH로 pH룰 11.0으로 유지하고 온도를 55℃이상으로 올린 다음, 톨루엔이 함유된 벤질옥시카보닐 클로라이드와 톨루엔을 첨가한 후 55℃이상의 온도에서 교반하여 반응시키는 것을 특징으로 하는 N-벤질옥시카보닐-L-아스파트산을제조방법.
  2. 제1항에 있어서, 톨루엔이 50-90% 함유된 벤질옥시카보닐 클로라이드를 사용하고, 톨루엔을 L-아스파트산 중량 대비 1-3배 부피로 첨가하는 것을 특징으로 하는 N-벤질옥시카보닐-L-아스파트산의 제조방법.
  3. 제1항에 있어서, 반응 온도를 55℃~80℃로 하는 것을 특징으로 하는 N-벤질옥시카보닐-L-아스파트산의제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910021640A 1991-11-29 1991-11-29 고수율의 n-벤질옥시카보닐-l-아스파트산의 제조방법 KR940011148B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910021640A KR940011148B1 (ko) 1991-11-29 1991-11-29 고수율의 n-벤질옥시카보닐-l-아스파트산의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910021640A KR940011148B1 (ko) 1991-11-29 1991-11-29 고수율의 n-벤질옥시카보닐-l-아스파트산의 제조방법

Publications (2)

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KR930009986A true KR930009986A (ko) 1993-06-21
KR940011148B1 KR940011148B1 (ko) 1994-11-24

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KR1019910021640A KR940011148B1 (ko) 1991-11-29 1991-11-29 고수율의 n-벤질옥시카보닐-l-아스파트산의 제조방법

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9724739B2 (en) 2014-04-25 2017-08-08 Kepco Nuclear Fuel Co., Ltd. Gap control device for pilger die assembly of cold pilger mills

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9724739B2 (en) 2014-04-25 2017-08-08 Kepco Nuclear Fuel Co., Ltd. Gap control device for pilger die assembly of cold pilger mills

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Publication number Publication date
KR940011148B1 (ko) 1994-11-24

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