KR880005114A - 광학적활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논 및 그 제조방법 - Google Patents
광학적활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논 및 그 제조방법 Download PDFInfo
- Publication number
- KR880005114A KR880005114A KR870011210A KR870011210A KR880005114A KR 880005114 A KR880005114 A KR 880005114A KR 870011210 A KR870011210 A KR 870011210A KR 870011210 A KR870011210 A KR 870011210A KR 880005114 A KR880005114 A KR 880005114A
- Authority
- KR
- South Korea
- Prior art keywords
- optically active
- pyrrolidino
- trifluoromethylphenyl
- methyl
- isomer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 광학적 활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논 및 약제학적으로 허용되는 그 염.
- 제1항에 있어서, 광학적 활성 화합물이 ℓ-이성체인 프로파논 및 그 염.
- dℓ-2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논을 광학적 활성 아세틸페닐 글리신 또는 광학적 활성 능금산과 반응시켜, 상응하는 두종류의 디아스테레오머염을 생성하고, 이어서 광학적 분할(optical resolution) 처리로 석출된 결정을 디아스테레오머염으로 분해하고, 광학적 활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논을 분리시킴을 특징으로 하여 이를 제조하는 방법.
- 제3항에 있어서, 광학적 활성 아세틸페닐글리신이 L-이성체이고, 광학적 활성 능금산이 D-이성체이며, 목적하는 광학적 활성 생성물이 ℓ-이성체인 방법.
- 제3항에 있어서, 광학적 분할에 사용되는 용매가 케톤, 알을 및 알킬지방족 카르복실레이트로 이루어진 그룹으로 부터 선택한 하나 이상의 것인 방법.
- 제3항에 있어서, 광학적 분할에 사용되는 용매가 에틸아세테이트인 방법.
- 제3항에 있어서, 광학적 분할의 결정 석출시간을 약 1 내지 약 150시간 처리하고 결정 석출 온도를 약 0℃ 내지 70℃에서 실시하는 방법.
- 제3항에 있어서, 석출된 결정 디아스테레오머염의 분해를 알칼리 존재하 0℃ 내지 50℃의 수중에서 실시하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23911686 | 1986-10-09 | ||
JP239116 | 1986-10-09 | ||
JP86-239116 | 1986-10-09 | ||
JP87-199086 | 1987-08-11 | ||
JP199086 | 1987-08-11 | ||
JP19908687 | 1987-08-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880005114A true KR880005114A (ko) | 1988-06-28 |
KR940003292B1 KR940003292B1 (ko) | 1994-04-20 |
Family
ID=26511334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870011210A KR940003292B1 (ko) | 1986-10-09 | 1987-10-06 | 광학적 활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논 및 그 제조방법 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0266577B1 (ko) |
KR (1) | KR940003292B1 (ko) |
CN (1) | CN1013441B (ko) |
CZ (1) | CZ279005B6 (ko) |
DE (1) | DE3773331D1 (ko) |
ES (1) | ES2025117B3 (ko) |
HU (1) | HU197319B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5338857A (en) * | 1989-08-04 | 1994-08-16 | Mitsui Toatsu Chemicals Incorporated | Aminoketone derivatives of 1,2-oxazole and use thereof |
JP3164631B2 (ja) * | 1991-02-26 | 2001-05-08 | 三井化学株式会社 | 光学活性アミノケトン誘導体及びその製造法 |
US5843478A (en) * | 1995-10-06 | 1998-12-01 | Nippon Kayaku Kabushiki Kaisha | Lanperisone formulation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3203962A (en) * | 1962-10-11 | 1965-08-31 | Ciba Geigy Corp | Alpha-phenyl-beta pyrrolidino-propiophenones |
AU4261285A (en) * | 1984-06-01 | 1985-12-05 | Tokyo Tanabe Company Limited | 1-propanone derivatives |
KR930010702B1 (ko) * | 1985-04-11 | 1993-11-08 | 닛뽕 가야꾸 가부시기가이샤 | 아미노케톤 유도체의 제조방법 |
-
1987
- 1987-10-06 KR KR1019870011210A patent/KR940003292B1/ko not_active IP Right Cessation
- 1987-10-08 ES ES87114722T patent/ES2025117B3/es not_active Expired - Lifetime
- 1987-10-08 EP EP87114722A patent/EP0266577B1/en not_active Expired - Lifetime
- 1987-10-08 DE DE8787114722T patent/DE3773331D1/de not_active Expired - Lifetime
- 1987-10-09 HU HU874575A patent/HU197319B/hu not_active IP Right Cessation
- 1987-10-09 CZ CS877325A patent/CZ279005B6/cs not_active IP Right Cessation
- 1987-10-09 CN CN87106871A patent/CN1013441B/zh not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3773331D1 (de) | 1991-10-31 |
CN87106871A (zh) | 1988-06-08 |
EP0266577B1 (en) | 1991-09-25 |
EP0266577A1 (en) | 1988-05-11 |
ES2025117B3 (es) | 1992-03-16 |
CZ732587A3 (en) | 1994-02-16 |
CN1013441B (zh) | 1991-08-07 |
CZ279005B6 (en) | 1994-11-16 |
KR940003292B1 (ko) | 1994-04-20 |
HUT45490A (en) | 1988-07-28 |
HU197319B (en) | 1989-03-28 |
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