ATE430729T1 - Pyrrol- und pyrazolderivate als potentiatoren von glutamatrezeptoren - Google Patents

Pyrrol- und pyrazolderivate als potentiatoren von glutamatrezeptoren

Info

Publication number
ATE430729T1
ATE430729T1 AT04809674T AT04809674T ATE430729T1 AT E430729 T1 ATE430729 T1 AT E430729T1 AT 04809674 T AT04809674 T AT 04809674T AT 04809674 T AT04809674 T AT 04809674T AT E430729 T1 ATE430729 T1 AT E430729T1
Authority
AT
Austria
Prior art keywords
glutama
potentiators
pyrrole
receptors
pyrazole derivatives
Prior art date
Application number
AT04809674T
Other languages
English (en)
Inventor
Pamela Albaugh
Esteban Dominguez-Manzanares
Jian Hong
William Hornback
Delu Jiang
Paul Ornstein
Michelle Thompson
Eric Tromiczak
Zhipei Wu
Hamideh Zarrinmayeh
Dennis Zimmerman
Mansanet Ana Castano
Larry Huffman
William Miller
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE430729T1 publication Critical patent/ATE430729T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04809674T 2003-10-08 2004-09-27 Pyrrol- und pyrazolderivate als potentiatoren von glutamatrezeptoren ATE430729T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03380224 2003-10-08
US53779404P 2004-01-20 2004-01-20
PCT/US2004/028815 WO2005040110A1 (en) 2003-10-08 2004-09-27 Pyrrole and pyrazole derivatives as potentiators of glutamate receptors

Publications (1)

Publication Number Publication Date
ATE430729T1 true ATE430729T1 (de) 2009-05-15

Family

ID=34524773

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04809674T ATE430729T1 (de) 2003-10-08 2004-09-27 Pyrrol- und pyrazolderivate als potentiatoren von glutamatrezeptoren

Country Status (9)

Country Link
EP (1) EP1670757B1 (de)
AR (1) AR049417A1 (de)
AT (1) ATE430729T1 (de)
CA (1) CA2541458C (de)
DE (1) DE602004021011D1 (de)
ES (1) ES2324044T3 (de)
PE (1) PE20050476A1 (de)
TW (1) TW200526574A (de)
WO (1) WO2005040110A1 (de)

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BRPI0608642A2 (pt) * 2005-03-16 2010-01-19 Aventis Pharma Inc dipirazàis como agentes do sistema nervoso central
TW201431849A (zh) * 2005-06-06 2014-08-16 Lilly Co Eli Ａｍｐａ受體強化劑
TW200817385A (en) * 2006-07-04 2008-04-16 Organon Nv Heterocyclic derivatives
DE102007007605A1 (de) 2007-02-13 2008-08-14 J. Eberspächer GmbH & Co. KG Brennstoffzellensystem
JP2010143826A (ja) * 2007-04-12 2010-07-01 Mitsui Chemicals Inc ３−アミノチオフェン誘導体の製造方法
TW200922586A (en) * 2007-10-26 2009-06-01 Astrazeneca Ab Thiophene 1,2,4-triazole derivatives as modulators of mGluR5
WO2009054789A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,3-triazole pyrrolidine derivatives as modulators of mglur5
WO2009054792A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Aminopyridine derivatives as modulators of mglur5
WO2009054791A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mglur5
TW200934497A (en) 2007-11-13 2009-08-16 Organon Nv Heterocyclic derivatives
TW201012803A (en) 2008-06-06 2010-04-01 Organon Nv Heterocyclic derivatives
WO2010009029A2 (en) * 2008-07-15 2010-01-21 Wyeth Methods for the preparation of azole compounds
KR101724293B1 (ko) 2009-02-25 2017-04-07 다케다 야쿠힌 고교 가부시키가이샤 피롤 화합물의 제조 방법
US8633237B2 (en) 2009-04-09 2014-01-21 Merck Sharp & Dohme B.V. Indane derivatives
CA2773119C (en) 2009-09-29 2015-04-14 Albemarle Corporation Processes for producing 3-(methylthio) thiophene
WO2012020820A1 (ja) * 2010-08-11 2012-02-16 大正製薬株式会社 ヘテロアリール－ピラゾール誘導体
WO2012065947A1 (en) 2010-11-15 2012-05-24 Bayer Cropscience Ag 5-halogenopyrazolecarboxamides
JP2014062047A (ja) * 2011-01-21 2014-04-10 Taisho Pharmaceutical Co Ltd ピラゾール誘導体
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
SI2953942T1 (en) 2013-02-06 2018-03-30 Bayer Cropscience Ag Halogen-substituted pyrazole derivatives such as pesticides
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
CN105102448B (zh) 2013-02-28 2018-03-06 百时美施贵宝公司 作为rock1和rock2抑制剂的苯基吡唑衍生物
TWI688557B (zh) 2013-11-27 2020-03-21 德商拜耳動物保健有限公司 用於製備５-氟-１ｈ-吡唑之方法（一）
US9845312B2 (en) * 2013-11-27 2017-12-19 Bayer Cropscience Aktiengesellschaft Process for the preparation of 5-fluoro-1H-pyrazoles
US10273226B2 (en) 2014-01-03 2019-04-30 Bayer Animal Health Gmbh Pyrazolyl-heteroarylamides as pesticides
KR102540220B1 (ko) 2014-08-19 2023-06-02 바이엘 애니멀 헬스 게엠베하 헥사플루오로프로펜으로부터 5-플루오로-1h-피라졸의 제조 방법
EP3268353B1 (de) 2015-03-10 2020-09-09 Bayer Animal Health GmbH Pyrazolyl-derivate als schädlingsbekämpfungsmittel
WO2017169894A1 (ja) 2016-03-31 2017-10-05 住友化学株式会社 複素環化合物
WO2017175613A1 (ja) 2016-04-06 2017-10-12 住友化学株式会社 複素環化合物
CN111393348B (zh) * 2020-04-24 2023-03-28 黑龙江大学 一种氮位取代苯基吡咯类化合物及其在植物杀菌中的用途
CN113831280B (zh) * 2021-11-01 2023-08-15 上海埃农生物科技有限公司 一种啶酰菌胺的制备方法

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US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
PE20000942A1 (es) * 1998-07-31 2000-09-28 Lilly Co Eli Derivados de amida, carbamato y urea

Also Published As

Publication number Publication date
TW200526574A (en) 2005-08-16
PE20050476A1 (es) 2005-08-24
ES2324044T3 (es) 2009-07-29
CA2541458A1 (en) 2005-05-06
EP1670757A1 (de) 2006-06-21
DE602004021011D1 (de) 2009-06-18
EP1670757B1 (de) 2009-05-06
AR049417A1 (es) 2006-08-02
CA2541458C (en) 2011-09-20
WO2005040110A1 (en) 2005-05-06

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