ATE424379T1 - Verfahren zur herstellung von gesamt- salvianolsäure - Google Patents
Verfahren zur herstellung von gesamt- salvianolsäureInfo
- Publication number
- ATE424379T1 ATE424379T1 AT03732181T AT03732181T ATE424379T1 AT E424379 T1 ATE424379 T1 AT E424379T1 AT 03732181 T AT03732181 T AT 03732181T AT 03732181 T AT03732181 T AT 03732181T AT E424379 T1 ATE424379 T1 AT E424379T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- tanshintotalphenolic
- salvianolic acid
- producing total
- total salvianolic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Otolaryngology (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021179239A CN1202103C (zh) | 2002-05-23 | 2002-05-23 | 丹参总酚酸的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE424379T1 true ATE424379T1 (de) | 2009-03-15 |
Family
ID=29426731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03732181T ATE424379T1 (de) | 2002-05-23 | 2003-05-21 | Verfahren zur herstellung von gesamt- salvianolsäure |
Country Status (13)
Country | Link |
---|---|
US (1) | US7641922B2 (de) |
EP (1) | EP1506951B9 (de) |
JP (1) | JP4570461B2 (de) |
KR (1) | KR101004660B1 (de) |
CN (1) | CN1202103C (de) |
AT (1) | ATE424379T1 (de) |
AU (1) | AU2003242135B8 (de) |
CA (1) | CA2486378C (de) |
DE (1) | DE60326450D1 (de) |
DK (1) | DK1506951T3 (de) |
ES (1) | ES2326165T3 (de) |
RU (1) | RU2317973C2 (de) |
WO (1) | WO2003099759A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100339085C (zh) | 2003-09-23 | 2007-09-26 | 天津天士力制药股份有限公司 | 治疗心脑血管疾病的中药组合物 |
CN102579460B (zh) * | 2003-12-30 | 2015-04-29 | 麦仁斯有限公司 | 用增强代谢活性的丹参衍生物治疗肥胖和代谢综合症 |
CN100372525C (zh) * | 2004-06-01 | 2008-03-05 | 广东天之骄生命科技有限公司 | 一种复方丹参冻干粉针剂及其制备方法 |
JP2010180250A (ja) * | 2004-07-30 | 2010-08-19 | Iskra Ind Co Ltd | 最終糖化産物生成抑制剤 |
JP4633572B2 (ja) * | 2004-07-30 | 2011-02-16 | イスクラ産業株式会社 | 糖尿病改善剤 |
JP4868199B2 (ja) * | 2004-09-10 | 2012-02-01 | 学校法人鈴鹿医療科学大学 | サルビアノール酸bを有効成分とする神経幹細胞増殖剤 |
JP2006232698A (ja) * | 2005-02-23 | 2006-09-07 | Suzuka Univ Of Medical Science | サルビアノール酸b等を主成分とする脳卒中又は脳卒中後遺症の予防用又は治療用薬剤 |
WO2006115321A1 (en) * | 2005-04-25 | 2006-11-02 | Industry Academic Cooperation Foundation, Yeungnam University | Composition comprising the extract of salvia miltiorrhiza bge showing enhancing activity for the prevention or treatment of blood circulatory disease. |
CN1919251B (zh) * | 2005-08-24 | 2010-11-03 | 天津天士力制药股份有限公司 | 治疗心血管疾病的中药组合物 |
CN1919240B (zh) * | 2005-08-24 | 2011-02-16 | 天津天士力制药股份有限公司 | 治疗心脑血管疾病的中药 |
KR100725839B1 (ko) * | 2005-10-06 | 2007-12-11 | 일성신약주식회사 | 단삼으로부터 분리된 탄시논류의 화합물을 함유하는인지기능 장애의 예방 및 치료용 조성물 |
KR20070040209A (ko) * | 2005-10-11 | 2007-04-16 | 일성신약주식회사 | 단삼 분획물을 함유하는 인지기능 장애의 예방 및 치료용 조성물 |
CN101210002B (zh) * | 2006-12-27 | 2011-04-20 | 中国科学院大连化学物理研究所 | 一种丹酚酸b化学对照品的分离制备方法 |
CN101721468B (zh) * | 2008-10-21 | 2013-02-13 | 天津天士力之骄药业有限公司 | 一种丹参总酚酸制备方法 |
CN101401843B (zh) * | 2008-11-18 | 2011-10-05 | 阳国平 | 一种中药丹参有效成分的提取方法 |
US20120041062A1 (en) * | 2009-03-30 | 2012-02-16 | Tianjin Tasly Pharmaceutical Co., Ltd. | Compound of salvianolic acid l, preparation method and use thereof |
CA2807283C (en) * | 2010-08-06 | 2019-05-14 | Xijun Yan | Use of salvia miltiorrhiza composition in preparing drugs for secondary prevention of coronary heart disease |
CN104418744B (zh) * | 2013-08-29 | 2017-03-01 | 天士力制药集团股份有限公司 | 一种新的丹酚酸化合物t、其制备方法和用途 |
CN107951981A (zh) * | 2017-12-30 | 2018-04-24 | 黄旭东 | 一种筋骨伤涂剂及其制备方法 |
CN112315997B (zh) * | 2020-11-30 | 2022-03-25 | 四川省中医药科学院 | 一种丹参和葛根提取物的固体分散体及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000069296A (ko) * | 1996-12-05 | 2000-11-25 | 윌리암 제이.하트만 | 항바이러스 활성을 갖는 살비아 종의 추출물 |
US6043276A (en) * | 1998-06-25 | 2000-03-28 | Georgetown University School Of Medicine | Compounds obtained from salvia species having antiviral activity |
CN1129572C (zh) * | 1998-09-11 | 2003-12-03 | 中国科学院上海药物研究所 | 丹参多酚酸盐混合物及其制备方法和用途 |
US6299910B1 (en) * | 1999-04-07 | 2001-10-09 | Techical Sourcing International, Inc. | Methods for identification, purification, and manufacturing of the active constituent in Salvia-miltiorrhiza (dansheng) and the application of this product in enhancing cardiovascular functions |
CN1163227C (zh) | 1999-04-19 | 2004-08-25 | 上海中医药大学 | 丹酚酸b镁盐在制备治疗慢性肝病药剂中的应用 |
CN1229324C (zh) | 2001-09-26 | 2005-11-30 | 中国医学科学院药物研究所 | 丹参总酚酸的提取方法及其制剂的制法与用途 |
CN1161317C (zh) | 2001-09-27 | 2004-08-11 | 华东理工大学 | 从植物丹参中提取纯化丹参素的方法 |
-
2002
- 2002-05-23 CN CNB021179239A patent/CN1202103C/zh not_active Expired - Lifetime
-
2003
- 2003-05-21 CA CA2486378A patent/CA2486378C/en not_active Expired - Lifetime
- 2003-05-21 ES ES03732181T patent/ES2326165T3/es not_active Expired - Lifetime
- 2003-05-21 RU RU2004136577/04A patent/RU2317973C2/ru active
- 2003-05-21 US US10/515,963 patent/US7641922B2/en active Active
- 2003-05-21 DK DK03732181T patent/DK1506951T3/da active
- 2003-05-21 JP JP2004507417A patent/JP4570461B2/ja not_active Expired - Lifetime
- 2003-05-21 EP EP03732181A patent/EP1506951B9/de not_active Expired - Lifetime
- 2003-05-21 DE DE60326450T patent/DE60326450D1/de not_active Expired - Lifetime
- 2003-05-21 AU AU2003242135A patent/AU2003242135B8/en not_active Expired
- 2003-05-21 AT AT03732181T patent/ATE424379T1/de active
- 2003-05-21 KR KR1020047018929A patent/KR101004660B1/ko active IP Right Grant
- 2003-05-21 WO PCT/CN2003/000375 patent/WO2003099759A1/zh active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2326165T3 (es) | 2009-10-02 |
WO2003099759A8 (fr) | 2004-03-11 |
AU2003242135B8 (en) | 2009-12-03 |
CA2486378A1 (en) | 2003-12-04 |
AU2003242135B2 (en) | 2009-08-27 |
CN1459448A (zh) | 2003-12-03 |
WO2003099759A1 (fr) | 2003-12-04 |
KR20050024281A (ko) | 2005-03-10 |
CA2486378C (en) | 2011-02-22 |
DE60326450D1 (de) | 2009-04-16 |
US20050159491A1 (en) | 2005-07-21 |
AU2003242135A1 (en) | 2003-12-12 |
DK1506951T3 (da) | 2009-05-25 |
CN1202103C (zh) | 2005-05-18 |
RU2317973C2 (ru) | 2008-02-27 |
RU2004136577A (ru) | 2005-06-27 |
EP1506951B1 (de) | 2009-03-04 |
EP1506951A1 (de) | 2005-02-16 |
JP4570461B2 (ja) | 2010-10-27 |
JP2005538055A (ja) | 2005-12-15 |
US7641922B2 (en) | 2010-01-05 |
KR101004660B1 (ko) | 2011-01-03 |
EP1506951B9 (de) | 2009-08-26 |
EP1506951A4 (de) | 2005-08-03 |
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