ATE417111T1 - Resorbierbare synthetische proteine zur verwendung in implantaten - Google Patents

Resorbierbare synthetische proteine zur verwendung in implantaten

Info

Publication number
ATE417111T1
ATE417111T1 AT95913976T AT95913976T ATE417111T1 AT E417111 T1 ATE417111 T1 AT E417111T1 AT 95913976 T AT95913976 T AT 95913976T AT 95913976 T AT95913976 T AT 95913976T AT E417111 T1 ATE417111 T1 AT E417111T1
Authority
AT
Austria
Prior art keywords
repeating units
compositions
active substance
biologically active
methods
Prior art date
Application number
AT95913976T
Other languages
English (en)
Inventor
Joseph Cappello
Original Assignee
Protein Polymer Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Polymer Tech Inc filed Critical Protein Polymer Tech Inc
Application granted granted Critical
Publication of ATE417111T1 publication Critical patent/ATE417111T1/de

Links

Classifications

    • DTEXTILES; PAPER
    • D01NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01FCHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • A61L17/10At least partially resorbable materials containing macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/043Proteins; Polypeptides; Degradation products thereof
    • A61L31/047Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18Manufacture of films or sheets
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/61Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00Characterised by the use of proteins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Textile Engineering (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
AT95913976T 1994-03-11 1995-03-10 Resorbierbare synthetische proteine zur verwendung in implantaten ATE417111T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/212,237 US5606019A (en) 1987-10-29 1994-03-11 Synthetic protein as implantables

Publications (1)

Publication Number Publication Date
ATE417111T1 true ATE417111T1 (de) 2008-12-15

Family

ID=22790163

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95913976T ATE417111T1 (de) 1994-03-11 1995-03-10 Resorbierbare synthetische proteine zur verwendung in implantaten

Country Status (7)

Country Link
US (3) US5606019A (de)
EP (1) EP0804595B1 (de)
JP (1) JP3378254B2 (de)
AT (1) ATE417111T1 (de)
CA (1) CA2183644A1 (de)
DE (1) DE69535895D1 (de)
WO (1) WO1995024478A1 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
US5969106A (en) * 1996-08-07 1999-10-19 The Hospital For Sick Children Self-aligning peptides modeled on human elastin and other fibrous proteins
US6489446B1 (en) 1996-08-07 2002-12-03 Hsc Research And Development Limited Partnership Self-aligning peptides modeled on human elastin and other fibrous proteins
US6127166A (en) * 1997-11-03 2000-10-03 Bayley; Hagan Molluscan ligament polypeptides and genes encoding them
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
WO1999030632A1 (en) * 1997-12-18 1999-06-24 Comfort Biomedical, Inc. Bone augmentation for prosthetic implants and the like
AU3867400A (en) * 1999-03-19 2000-10-09 Duke University Methods of using bioelastomers
IT1309453B1 (it) * 1999-10-01 2002-01-23 Consorzio Per Gli Studi Uni Substrato bioartificiale per la realizzazione di tessuti e organianimali, in particolare umani.
EP1328220B1 (de) * 2000-10-24 2011-01-05 CryoLife, Inc. Bioprothetischer füller und methoden, insbesondere für die bildung von bandscheibenbioprothesen in situ
US7226615B2 (en) * 2000-11-07 2007-06-05 Cryolife, Inc. Expandable foam-like biomaterials and methods
US6629988B2 (en) * 2001-08-28 2003-10-07 Ethicon, Inc. Composite staple for completing an anastomosis
EP1450846A4 (de) * 2001-10-02 2004-11-24 Tufts College Sich selbst anordnende polymeren, und daraus hergestellte materialien
AU2002350026A1 (en) * 2001-11-01 2003-05-12 Lawrence M. Boyd System and method for the pretreatment of the endplates of an intervertebral disc
EP1448089A4 (de) 2001-11-01 2008-06-04 Spine Wave Inc Vorrichtungen und vefahren zur wiederinstandsetzung einer rückgratscheibe
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US20110009960A1 (en) * 2001-11-16 2011-01-13 Allergan, Inc. Prosthetic fabric structure
CA2525994C (en) * 2002-06-24 2012-10-16 Tufts University Silk biomaterials and methods of use thereof
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
US7297678B2 (en) * 2003-03-12 2007-11-20 Genencor International, Inc. Use of repeat sequence protein polymers in personal care compositions
US20050142094A1 (en) * 2003-03-12 2005-06-30 Manoj Kumar Use of repeat sequence protein polymers in personal care compositions
EP1613796B1 (de) * 2003-04-10 2017-03-22 Tufts University Konzentrierte wässrige seidenfibroinlösung und deren verwendung
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
CN1910196A (zh) * 2004-01-13 2007-02-07 东丽株式会社 含有蜘蛛丝蛋白质的丝线以及产生该丝线的蚕
WO2006098744A2 (en) * 2004-06-16 2006-09-21 Affinergy, Inc. Ifbm’s to promote attachment of target analytes
US7740660B2 (en) 2004-06-29 2010-06-22 Spine Wave, Inc. Methods for treating defects and injuries of an intervertebral disc
US7825083B2 (en) * 2005-02-10 2010-11-02 Spine Wave, Inc. Synovial fluid barrier
US20070098702A1 (en) * 2005-02-17 2007-05-03 University Of Maryland, Baltimore Recombinant protein polymer vectors for systemic gene delivery
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US20060253068A1 (en) * 2005-04-20 2006-11-09 Van Bilsen Paul Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart
CA2619727C (en) * 2005-08-22 2014-11-18 Genencor International, Inc. Composites of repeat sequence proteins and their preparation
US20070102010A1 (en) * 2005-10-07 2007-05-10 Lemperle Stefan M Naso-pharyngeal tissue engineering
US8178495B2 (en) 2008-06-27 2012-05-15 Duke University Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
CN101384272B (zh) 2005-12-20 2013-05-01 杜克大学 用于递送具有增强的药理性质的活性剂的方法和组合物
US20130172274A1 (en) * 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US7709227B2 (en) * 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
US20070179618A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US20070179615A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
CA2669114C (en) * 2006-11-13 2014-12-16 The University Of Sydney Use of tropoelastin for repair or restoration of tissue
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8192760B2 (en) * 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
EP2129772B1 (de) 2007-02-27 2016-07-27 Trustees Of Tufts College Gewebegezüchtete seidenorgane
WO2008140703A2 (en) 2007-05-10 2008-11-20 Elastin Specialties, Inc. Synthetic peptide materials for joint reconstruction, repair and cushioning
JP2010529230A (ja) 2007-05-29 2010-08-26 トラスティーズ オブ タフツ カレッジ 音波処理を用いた絹フィブロインのゲル化のための方法
EP2249886A4 (de) * 2008-02-07 2013-05-22 Tufts College 3-dimensionale seiden-hydroxylapatit-zusammensetzungen
EP2296629B1 (de) 2008-05-09 2014-07-02 Evonik Corporation Biokompatible und biologisch abbaubare elastomere polymere
JP5727366B2 (ja) * 2008-05-15 2015-06-03 タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ 絹ポリマーに基づくアデノシン放出:てんかんに対する潜在的治療能力
US8501172B2 (en) * 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
CN105268020A (zh) 2008-10-09 2016-01-27 塔夫茨大学信托人 含有甘油的改性丝膜
US9204953B2 (en) 2008-12-15 2015-12-08 Allergan, Inc. Biocompatible surgical scaffold with varying stretch
US9308070B2 (en) * 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
US9326840B2 (en) 2008-12-15 2016-05-03 Allergan, Inc. Prosthetic device and method of manufacturing the same
US9204954B2 (en) * 2008-12-15 2015-12-08 Allergan, Inc. Knitted scaffold with diagonal yarn
EP2373252B1 (de) 2008-12-15 2015-10-14 Allergan, Inc. Prothetische vorrichtung und herstellungsverfahren dafür
WO2011008842A2 (en) 2009-07-14 2011-01-20 Trustees Of Tufts College Electrospun silk material systems for wound healing
PL3311828T3 (pl) * 2009-08-14 2021-11-22 Phasebio Pharmaceuticals, Inc. Zmodyfikowane wazoaktywne peptydy jelitowe
EP2475330A1 (de) * 2009-09-11 2012-07-18 Allergan, Inc. Prothesenvorrichtung und herstellungsverfahren dafür
EP2483460B1 (de) 2009-09-28 2015-09-02 Trustees Of Tufts College Verfahren zur herstellung gezogene seiden-egel-fasern
JP5730317B2 (ja) 2009-09-29 2015-06-10 タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法
US9132207B2 (en) 2009-10-27 2015-09-15 Spine Wave, Inc. Radiopaque injectable nucleus hydrogel compositions
US9603971B2 (en) 2010-03-05 2017-03-28 Trustees Of Tufts College Silk-based ionomeric compositions
WO2012031144A2 (en) 2010-09-01 2012-03-08 Trustees Of Tufts College Silk fibroin and polyethylene glycol-based biomaterials
BR112013009609A2 (pt) 2010-10-19 2016-07-12 Tufts College microagulhas à base de fibroína de seda e métodos para fazer os mesmos
US9745353B2 (en) 2010-11-29 2017-08-29 Bioo Scientific Corporation Production of anti-peptide antibodies
CN103370089A (zh) * 2011-02-18 2013-10-23 国立大学法人京都大学 组织再生用材料、含有该组织再生用材料的蛋白质水溶液和使该组织再生用材料凝胶化的方法
US9700425B1 (en) 2011-03-20 2017-07-11 Nuvasive, Inc. Vertebral body replacement and insertion methods
US10335519B2 (en) 2011-04-20 2019-07-02 Trustees Of Tufts College Dynamic silk coatings for implantable devices
CA2873553C (en) 2011-06-06 2020-01-28 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
JP6077316B2 (ja) * 2012-02-02 2017-02-08 三洋化成工業株式会社 組織再生用材料及び組織再生用タンパク質溶液
EP2811987B1 (de) 2012-02-06 2021-01-20 Children's Medical Center Corporation Mehrschichtiges biomaterial zur geweberegenerierung und wundheilung
EP2668962B1 (de) * 2012-05-29 2016-10-26 Albert-Ludwigs-Universität Freiburg Proteinassembler
WO2013192388A1 (en) 2012-06-20 2013-12-27 University Of Virginia Patent Foundation Compositions and methods for regulating glucose homeostasis and insulin action
JP6058367B2 (ja) * 2012-11-28 2017-01-11 三洋化成工業株式会社 インプラント用コーティング剤、インプラント及びインプラントの製造方法
US20140194370A1 (en) 2013-01-08 2014-07-10 University Of Utah Research Foundation Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer
JP6326326B2 (ja) * 2013-08-30 2018-05-16 三洋化成工業株式会社 創傷治癒剤
CA2947982C (en) 2014-05-08 2022-11-29 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
CA2976038A1 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
US20180055958A1 (en) * 2015-03-12 2018-03-01 Sanyo Chemical Industries, Ltd. Method for producing protein composition, and protein composition
KR101706296B1 (ko) * 2015-12-21 2017-02-13 주식회사 브레인온 기억력, 학습력, 인지력 향상용 조성물
KR101844481B1 (ko) * 2016-03-04 2018-04-02 주식회사 브레인온 기억력 향상 효과를 가지는 펩타이드
US20180201645A1 (en) 2015-12-21 2018-07-19 Brainon Inc. Composition for improving memory, learning ability, and cognitive ability
WO2018053111A1 (en) 2016-09-15 2018-03-22 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
EP3630115B1 (de) 2017-05-22 2025-12-10 University Of Virginia Patent Foundation Zusammensetzungen und verfahren zu ihrer herstellung und verwendung von mitochondrialen entkopplern
US10849914B2 (en) 2017-06-12 2020-12-01 University Of Utah Research Foundation Methods for producing chemoembolic agents for the delivery of anti-cancer agents
KR101844480B1 (ko) * 2017-07-24 2018-04-02 주식회사 브레인온 기억력 향상 효과를 가지는 펩타이드
CN112262141A (zh) 2018-04-20 2021-01-22 弗吉尼亚理工大学知识产权有限公司 可用作线粒体解偶联剂的咪唑吡啶
WO2020071208A1 (ja) 2018-10-05 2020-04-09 国立大学法人広島大学 半月板再生用材料
EP4071162A4 (de) * 2019-12-02 2023-12-27 Kyoto University Bronchiales embolisationsmaterial

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215200A (en) * 1978-10-02 1980-07-29 Cornell Research Foundation, Inc. Chemically and enzymatically modified collagen hemostatic agent
US4589882A (en) * 1983-09-19 1986-05-20 Urry Dan W Enzymatically crosslinked bioelastomers
US4783523A (en) * 1986-08-27 1988-11-08 Urry Dan W Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides
US5243038A (en) * 1986-11-04 1993-09-07 Protein Polymer Technologies, Inc. Construction of synthetic DNA and its use in large polypeptide synthesis
WO1988003533A1 (en) * 1986-11-04 1988-05-19 Syntro Corporation Construction of synthetic dna and its use in large polypeptide synthesis
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
EP0406357B1 (de) * 1988-11-09 1998-01-07 Protein Polymer Technologies, Inc. Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer
US5171505A (en) * 1990-11-28 1992-12-15 E. I. Du Pont De Nemours And Company Process for spinning polypeptide fibers
US5235041A (en) * 1990-12-28 1993-08-10 Protein Polymer Technologies, Inc. Purification of structurally ordered recombinant protein polymers
US5523291A (en) * 1993-09-07 1996-06-04 Datascope Investment Corp. Injectable compositions for soft tissue augmentation
US5773577A (en) * 1994-03-03 1998-06-30 Protein Polymer Technologies Products comprising substrates capable of enzymatic cross-linking

Also Published As

Publication number Publication date
DE69535895D1 (de) 2009-01-22
US6380154B1 (en) 2002-04-30
JP2001508754A (ja) 2001-07-03
EP0804595A4 (de) 1997-11-05
US5606019A (en) 1997-02-25
EP0804595A1 (de) 1997-11-05
WO1995024478A1 (en) 1995-09-14
US20020045567A1 (en) 2002-04-18
US20030176355A1 (en) 2003-09-18
JP3378254B2 (ja) 2003-02-17
EP0804595B1 (de) 2008-12-10
CA2183644A1 (en) 1995-09-14

Similar Documents

Publication Publication Date Title
ATE417111T1 (de) Resorbierbare synthetische proteine zur verwendung in implantaten
ES2346457T3 (es) Composiciones de un factor de crecimiento derivado de plaquetas y metodos para usarlas.
ES2647227T3 (es) Método para reticular ácido hialurónico; método para preparar un hidrogel inyectable; hidrogel obtenido; uso del gel obtenido
KR100260672B1 (ko) 방출 조절된 이식체로서 유용한 중합체성 조성물
ES2522575T3 (es) Composiciones de hidrogel bioactivo para la regeneración del tejido conjuntivo
Giavaresi et al. Blood vessel formation after soft-tissue implantation of hyaluronan-based hydrogel supplemented with copper ions
CN102231992B (zh) 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法
ES2219656T3 (es) Composicion de implante que promueve la osteointegracion, conjunto de implante y uso.
US5364839A (en) Osteoinductive pharmaceutical formulations
ES2287406T3 (es) Materiales de vendaje para heridas que comprenden colageno y celulosa oxidada.
DE60101339T2 (de) Stimulierung des knochenwachstums mit peptidderivaten von thrombin
KR100629380B1 (ko) 뼈 성장 촉진 화합물의 방출 제어형 중합체성 조성물
CN104853742B (zh) 用于治疗用途的基于交联透明质酸和羟基磷灰石的可注射无菌水性制剂
US20100317587A1 (en) Injectable bone regeneration gel containing bone formation enhancing peptide
FI20001696A7 (fi) Biologisesti aktiivinen materiaali
DE69738398D1 (de) Biokeramische zusammensetzung
KR101401944B1 (ko) 콜라겐과 피브린이 혼합된 조직 실란트 및 그 제조방법
ATE238049T1 (de) Verwendung von kreatinsubstanzen zur behandlung von knochen- und knorpelzellen und geweben
JP2021184903A (ja) 骨間隙を充填するための材料および方法
AU5939800A (en) Bone sialoprotein-based compositions for enhamcing connective tissue repair
DE60313982T2 (de) Dimere von thrombinpeptidderivaten
US20070275032A1 (en) Use Of A Mixture For The Production Of An Agent For Treating Defective Or Degenerated Cartilage In The Production Of Natural Cartilage Replacement In Vitro
ES2150902T3 (es) Procedimientos para potenciar la cicatrizacion de heridas y la reparacion de tejidos.
JP2001131086A (ja) エンドセリンを含む結合組織修復促進組成物および該組成物の調製におけるエンドセリンの使用
AU650673B2 (en) Bone growth stimulator

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties