ATE413176T1 - Verwendung von 1-azabicyclo(2.2.2)octan-3-on- derivaten zur behandlung von krebstumoren - Google Patents
Verwendung von 1-azabicyclo(2.2.2)octan-3-on- derivaten zur behandlung von krebstumorenInfo
- Publication number
- ATE413176T1 ATE413176T1 AT01970421T AT01970421T ATE413176T1 AT E413176 T1 ATE413176 T1 AT E413176T1 AT 01970421 T AT01970421 T AT 01970421T AT 01970421 T AT01970421 T AT 01970421T AT E413176 T1 ATE413176 T1 AT E413176T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- azabicyclo
- octane
- derivatives
- cancer tumors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23416400P | 2000-09-20 | 2000-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE413176T1 true ATE413176T1 (de) | 2008-11-15 |
Family
ID=22880210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01970421T ATE413176T1 (de) | 2000-09-20 | 2001-09-19 | Verwendung von 1-azabicyclo(2.2.2)octan-3-on- derivaten zur behandlung von krebstumoren |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6921765B2 (de) |
| EP (1) | EP1319000B1 (de) |
| JP (1) | JP4865982B2 (de) |
| AT (1) | ATE413176T1 (de) |
| AU (2) | AU2001290422B2 (de) |
| CA (1) | CA2423192C (de) |
| DE (1) | DE60136473D1 (de) |
| DK (1) | DK1319000T3 (de) |
| ES (1) | ES2316473T3 (de) |
| WO (1) | WO2002024692A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69912808T2 (de) | 1999-12-08 | 2004-09-30 | Centre National De La Recherche Scientifique (C.N.R.S.) | Verwendung von Hymenialdisin und dessen Derivaten zur Herstellung therapeutischer Mittel |
| AU2001286561B2 (en) * | 2000-08-21 | 2007-02-08 | Georgetown University | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
| DK1319000T3 (da) * | 2000-09-20 | 2009-02-16 | Aprea Ab | Anvendelse af 1-azabicyclo(2,2,2)oktan-3-on-derivater til behandling af cancertumorer |
| ATE333280T1 (de) | 2002-02-21 | 2006-08-15 | Aprea Ab | Verwendung von niedermolekularen verbindungen zur herstellung eines medikaments zur behandlung von durch mutation p53-vermittelten erkrankungen |
| JP2005528392A (ja) * | 2002-04-12 | 2005-09-22 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
| DE60321330D1 (de) | 2002-04-12 | 2008-07-10 | Merck & Co Inc | Tyrosinkinase-hemmer |
| WO2003086315A2 (en) | 2002-04-12 | 2003-10-23 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| SE0300812D0 (sv) * | 2003-03-24 | 2003-03-24 | Karolinska Innovations Ab | Use of chemical compounds for preparing pharmaceutical compositions, and method of testing substances for medical effect |
| JP2006521375A (ja) * | 2003-03-24 | 2006-09-21 | アプレア アクチボラゲット | １−アザビシクロ［２．２．２］オクタンの薬剤としての使用及び不活性野生型ｐ５３を活性化する能力に関する化合物の試験方法 |
| SE0400708D0 (sv) | 2004-03-22 | 2004-03-22 | Aprea Ab | New compounds and use thereof |
| US7790474B1 (en) | 2005-07-15 | 2010-09-07 | Schering Corporation | p53 modulators |
| GB0813873D0 (en) * | 2008-07-30 | 2008-09-03 | Univ Dundee | Compounds |
| US9186365B2 (en) | 2009-07-31 | 2015-11-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antiangiogenic small molecules and methods of use |
| IN2012DN05192A (de) | 2010-01-21 | 2015-10-23 | Aprea Ab | |
| CN104860994A (zh) * | 2014-02-20 | 2015-08-26 | 中国药科大学 | 3-奎宁环酮类含磷化合物的制备及其医药用途 |
| WO2017159877A1 (en) * | 2016-03-18 | 2017-09-21 | Eisai R&D Management Co., Ltd. | Use of eribulin and 3-quinuclidinone derivatives in the treatment of cancer |
| CN109280054A (zh) * | 2017-07-21 | 2019-01-29 | 上海时莱生物技术有限公司 | 氘代3-奎宁环酮类化合物、制备方法及用途 |
| CN109280056A (zh) * | 2017-07-21 | 2019-01-29 | 上海时莱生物技术有限公司 | 手性3-奎宁环酮类化合物、制备方法及用途 |
| WO2019173806A1 (en) * | 2018-03-09 | 2019-09-12 | Texas Tech University System | Compositions and methods for the diagnosis and treatment of alt cancer |
| EP3806850A2 (de) * | 2018-06-15 | 2021-04-21 | Ideaya Biosciences, Inc. | Verfahren zur hemmung proliferativer zellen |
| BR112021005171A2 (pt) | 2018-09-20 | 2021-06-15 | Aprea Therapeutics Ab | derivados de quinuclidina-3-ona e seu uso em tratamento de câncer |
| US20220339141A1 (en) | 2019-09-18 | 2022-10-27 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein |
| WO2021170772A1 (en) | 2020-02-26 | 2021-09-02 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of cd47 mediated signaling |
| WO2021180338A1 (en) | 2020-03-09 | 2021-09-16 | Aprea Therapeutics Ab | Combination treatment with a p53 reactivator and an inhibitor of dna methyltransferase post stem cell transplant |
| WO2022175402A1 (en) | 2021-02-18 | 2022-08-25 | Aprea Therapeutics Ab | Quinuclidine-3-one derivatives |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3384641A (en) * | 1967-09-19 | 1968-05-21 | Aldrich Chem Co Inc | 2-methylene-3-quinuclidones |
| US3726877A (en) * | 1970-10-28 | 1973-04-10 | Univ Temple | Amine substituted methylene quinuclidone anti-bacterial agents |
| US4448906A (en) * | 1982-06-16 | 1984-05-15 | Nuodex Inc. | Surface-coating compositions |
| JPS6028961A (ja) * | 1983-07-25 | 1985-02-14 | 高取 吉太郎 | Ν−１−アダマンチルマレイミド及び其の製法 |
| US4599344A (en) * | 1984-10-31 | 1986-07-08 | Schering A.G. | Quinuclidines and quinuclidinium salts as antiarrhythmic agents |
| JPS6225137A (ja) * | 1985-07-26 | 1987-02-03 | Bridgestone Corp | ゴム組成物 |
| JPH072740B2 (ja) | 1990-06-01 | 1995-01-18 | フアイザー・インコーポレイテツド | ３―アミノ―２―アリールキヌクリジン |
| CA2093778A1 (en) * | 1992-04-10 | 1993-10-11 | George R. Brown | Heterocyclic compounds |
| PT785198E (pt) * | 1996-01-19 | 2000-11-30 | Lonza Ag | Processo para a producao de 3-quinuclidinol opticamente activo. |
| US6034150A (en) | 1996-08-23 | 2000-03-07 | University Of Southern Mississippi | Polymerization processes using aliphatic maleimides |
| US6432975B1 (en) * | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| DK1319000T3 (da) * | 2000-09-20 | 2009-02-16 | Aprea Ab | Anvendelse af 1-azabicyclo(2,2,2)oktan-3-on-derivater til behandling af cancertumorer |
-
2001
- 2001-09-19 DK DK01970421T patent/DK1319000T3/da active
- 2001-09-19 DE DE60136473T patent/DE60136473D1/de not_active Expired - Lifetime
- 2001-09-19 AT AT01970421T patent/ATE413176T1/de active
- 2001-09-19 AU AU2001290422A patent/AU2001290422B2/en not_active Expired
- 2001-09-19 CA CA2423192A patent/CA2423192C/en not_active Expired - Lifetime
- 2001-09-19 EP EP01970421A patent/EP1319000B1/de not_active Expired - Lifetime
- 2001-09-19 ES ES01970421T patent/ES2316473T3/es not_active Expired - Lifetime
- 2001-09-19 AU AU9042201A patent/AU9042201A/xx active Pending
- 2001-09-19 WO PCT/SE2001/002008 patent/WO2002024692A1/en active Application Filing
- 2001-09-19 US US10/381,011 patent/US6921765B2/en not_active Expired - Lifetime
- 2001-09-19 JP JP2002529102A patent/JP4865982B2/ja not_active Expired - Lifetime
-
2004
- 2004-12-14 US US11/010,430 patent/US7348330B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4865982B2 (ja) | 2012-02-01 |
| US7348330B2 (en) | 2008-03-25 |
| ES2316473T3 (es) | 2009-04-16 |
| US20030166674A1 (en) | 2003-09-04 |
| US6921765B2 (en) | 2005-07-26 |
| JP2004509890A (ja) | 2004-04-02 |
| DE60136473D1 (de) | 2008-12-18 |
| AU2001290422B2 (en) | 2006-06-15 |
| EP1319000B1 (de) | 2008-11-05 |
| DK1319000T3 (da) | 2009-02-16 |
| CA2423192A1 (en) | 2002-03-28 |
| CA2423192C (en) | 2010-11-23 |
| US20050090540A1 (en) | 2005-04-28 |
| AU9042201A (en) | 2002-04-02 |
| EP1319000A1 (de) | 2003-06-18 |
| WO2002024692A1 (en) | 2002-03-28 |
| WO2002024692A8 (en) | 2002-09-26 |
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| UEP | Publication of translation of european patent specification |
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