ATE412668T1 - Antimikrobielle kationische peptide und methoden zu ihrer identifizierung - Google Patents

Antimikrobielle kationische peptide und methoden zu ihrer identifizierung

Info

Publication number
ATE412668T1
ATE412668T1 AT96930303T AT96930303T ATE412668T1 AT E412668 T1 ATE412668 T1 AT E412668T1 AT 96930303 T AT96930303 T AT 96930303T AT 96930303 T AT96930303 T AT 96930303T AT E412668 T1 ATE412668 T1 AT E412668T1
Authority
AT
Austria
Prior art keywords
sub
entry
row
seq
tryptophan
Prior art date
Application number
AT96930303T
Other languages
German (de)
English (en)
Inventor
Timothy Falla
Robert Hancock
Monisha Gough
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of ATE412668T1 publication Critical patent/ATE412668T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT96930303T 1995-08-23 1996-08-23 Antimikrobielle kationische peptide und methoden zu ihrer identifizierung ATE412668T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US268795P 1995-08-23 1995-08-23

Publications (1)

Publication Number Publication Date
ATE412668T1 true ATE412668T1 (de) 2008-11-15

Family

ID=21701983

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96930303T ATE412668T1 (de) 1995-08-23 1996-08-23 Antimikrobielle kationische peptide und methoden zu ihrer identifizierung

Country Status (9)

Country Link
US (2) US6191254B1 (enExample)
EP (1) EP0846128B1 (enExample)
JP (1) JP3860838B2 (enExample)
AT (1) ATE412668T1 (enExample)
AU (1) AU6940796A (enExample)
CA (1) CA2230160A1 (enExample)
DE (1) DE69637731D1 (enExample)
ES (1) ES2316154T3 (enExample)
WO (1) WO1997008199A2 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
EP1174439B1 (en) * 1996-08-21 2008-10-08 Migenix Inc. Compositions and methods for treating infections using analogues of indolicidin
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6303575B1 (en) 1998-05-12 2001-10-16 The Regents Of The University Of California Indolicidin analogs and methods of using same
US6444645B1 (en) 1998-06-18 2002-09-03 The Regents Of The University Of California Crosslink-stabilized indolicidin analogs
US6288212B1 (en) * 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
WO2000026344A1 (en) * 1998-10-30 2000-05-11 Interlink Biotechnologies Llc Peptides with enhanced stability to protease degradation
US6946261B1 (en) 1998-11-20 2005-09-20 Migenix Inc. Efficient methods for producing anti-microbial cationic peptides in host cells
US6335318B1 (en) 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
US6497676B1 (en) 2000-02-10 2002-12-24 Baxter International Method and apparatus for monitoring and controlling peritoneal dialysis therapy
US6337317B1 (en) * 2000-06-27 2002-01-08 The University Of British Columbia Antimicrobial peptides and methods of use thereof
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
JP4511173B2 (ja) 2001-08-24 2010-07-28 マイジェニックス インコーポレイテッド 抗菌性および抗炎症性ペプチド
KR100438416B1 (ko) * 2001-09-19 2004-07-02 학교법인조선대학교 Ｃａ－ｍａ 펩타이드의 아미노산 중 하나 또는 그 이상을치환하여 ＋ 전극과 소수성 영역이 증가된 신규한펩타이드 및 그를 포함하는 약학적 조성물
US7507787B2 (en) * 2001-12-03 2009-03-24 The University Of British Columbia Effectors of innate immunity
US20030125662A1 (en) * 2002-01-03 2003-07-03 Tuan Bui Method and apparatus for providing medical treatment therapy based on calculated demand
US20030219854A1 (en) * 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
DE60335101D1 (de) * 2002-04-25 2011-01-05 Toagosei Co Ltd Antimikrobielles polypeptid und nutzung davon
US7119070B2 (en) 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
US7033769B2 (en) * 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US7238164B2 (en) 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
WO2005019241A2 (en) * 2003-08-18 2005-03-03 E.I. Dupont De Nemours And Company Cationic antimicrobial peptides and compositions thereof
JP4524671B2 (ja) * 2003-10-29 2010-08-18 東亞合成株式会社 抗菌ペプチド及びその利用
US20050209563A1 (en) * 2004-03-19 2005-09-22 Peter Hopping Cassette-based dialysis medical fluid therapy systems, apparatuses and methods
JP4507080B2 (ja) * 2004-07-30 2010-07-21 東亞合成株式会社 抗菌ペプチド及びその利用
JP4730584B2 (ja) 2004-12-06 2011-07-20 東亞合成株式会社 抗菌ペプチド及びその利用
EP1838331A4 (en) 2004-12-15 2012-12-26 Univ Colorado ANTIMICROBIAL PEPTIDES AND METHOD OF USE
WO2006088010A1 (ja) * 2005-02-15 2006-08-24 Toagosei Co., Ltd. 抗菌ペプチド及びその利用
US8870812B2 (en) 2007-02-15 2014-10-28 Baxter International Inc. Dialysis system having video display with ambient light adjustment
US8558964B2 (en) 2007-02-15 2013-10-15 Baxter International Inc. Dialysis system having display with electromagnetic compliance (“EMC”) seal
US7998115B2 (en) * 2007-02-15 2011-08-16 Baxter International Inc. Dialysis system having optical flowrate detection
US7731689B2 (en) 2007-02-15 2010-06-08 Baxter International Inc. Dialysis system having inductive heating
US8361023B2 (en) * 2007-02-15 2013-01-29 Baxter International Inc. Dialysis system with efficient battery back-up
PL2178549T3 (pl) * 2007-07-26 2017-03-31 Revance Therapeutics, Inc. Peptyd przeciwdrobnoustrojowy i jego kompozycje
US20100099614A1 (en) * 2008-10-06 2010-04-22 Hodges Robert S Antimicrobial Peptides and Methods of Use
GB0821616D0 (en) * 2008-11-26 2008-12-31 Lytix Biopharma As Compounds
EP2437770A4 (en) * 2009-06-05 2013-11-06 Univ Colorado Regents ANTIMICROBIAL PEPTIDES
US9134323B2 (en) 2009-12-01 2015-09-15 The Rockefeller University Antibody that specifically binds to an epitope in the tureet region of a human Kir channel
EP2558577B1 (en) 2010-04-16 2018-12-12 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
EP2755693A4 (en) 2011-09-12 2015-05-20 Moderna Therapeutics Inc MANIPULATED NUCLEIC ACIDS AND METHOD OF APPLICATION THEREFOR
AU2013243954A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
AU2013243949A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US20150072922A1 (en) * 2012-04-17 2015-03-12 The Research Institute At Nationwide Children's Hospital Rnase 7 antimicrobial peptides
MY151307A (en) * 2012-06-18 2014-05-05 Univ Malaya Peptides having antimicrobial activity
GB201401877D0 (en) 2014-02-04 2014-03-19 Univ Tromsoe Peptides
EP3067608A1 (en) * 2015-03-10 2016-09-14 Abu Dhabi Polymers Co. Ltd (Borouge) LLC. Eccentric polyolefin pipe
ES2981535T3 (es) 2015-11-10 2024-10-09 Visterra Inc Conjugados de molécula de anticuerpo-fármaco que se unen específicamente al lipopolisacárido y usos de los mismos
CN110431150A (zh) 2017-01-18 2019-11-08 威特拉公司 抗体分子-药物偶联物及其用途
WO2018160791A1 (en) 2017-03-03 2018-09-07 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
US10934943B2 (en) 2017-04-27 2021-03-02 General Electric Company Compressor apparatus with bleed slot and supplemental flange
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
CA3178465A1 (en) 2020-04-03 2021-10-07 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
CU24750B1 (es) * 2020-11-19 2025-06-11 Centro De Investig Y Desarrollo De Medicamentos Cidem Entidades peptídicas con actividad antimicrobiana frente a patógenos multi-drogoresistentes

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028530A (en) 1985-01-28 1991-07-02 Xoma Corporation AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques
US5166321A (en) 1985-01-28 1992-11-24 International Genetic Engineering, Inc. Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria
US5206154A (en) 1985-01-28 1993-04-27 Xoma Corporation Method of producing cecropins by microbiological techniques
US4810777A (en) 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
US4822608A (en) 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
WO1989011290A1 (en) 1988-05-27 1989-11-30 Magainin Sciences, Inc. Amphiphilic peptides and use thereof
SE8802939D0 (sv) 1988-08-19 1988-08-19 Kabigen Ab A method for the production and isolation of a fusion protein in eukaryotic cells
US5217956A (en) 1988-10-21 1993-06-08 The Children's Hospital Of Philadelphia Composition and treatment with biologically active peptides and certain anions
DE68916261T2 (de) 1988-10-21 1994-09-22 Philadelphia Children Hospital Zusammensetzung und behandelung mittels biologisch aktiven peptiden und bestimmten anionen.
JPH04502901A (ja) 1988-10-21 1992-05-28 マゲイニン　サイエンセス　インコーポレーテッド シーピーエフペプチド組成物およびその用途
CA2007913A1 (en) 1989-01-30 1990-07-30 Michael Zasloff Composition and treatment with peptide combinations
US5254535A (en) 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
FR2646777B1 (fr) 1989-05-12 1993-09-03 Bio Serae Lab Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications
US5073542A (en) 1989-06-07 1991-12-17 Magainin Sciences Inc. CPF peptide compositions and their use in inhibiting growth of target cells or a virus
US5045531A (en) 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins
EP0514464A4 (en) 1990-02-08 1993-04-28 Magainin Sciences, Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
US5227469A (en) 1990-02-14 1993-07-13 Genentech, Inc. Platelet aggregation inhibitors from the leech
WO1991016066A1 (en) 1990-04-23 1991-10-31 Magainin Sciences Inc. Composition and treatment with biologically active peptides and toxic cations
JPH05507077A (ja) 1990-04-27 1993-10-14 マゲイニン　サイエンセズ　インコーポレーテッド 生物活性ペプチドおよび駆虫剤もしくは抗真菌剤を使う組成物および治療法
EP0533795A4 (en) 1990-05-14 1993-10-20 Magainin Sciences, Inc. Composition of and treatment with biologically active peptides having d-amino acid residues
US5208220A (en) 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
US5202420A (en) 1990-10-25 1993-04-13 The Children's Hospital Of Philadelphia Tracheal antimicrobial peptides, dna sequences and methods for the production and use thereof
US5235038A (en) 1991-01-22 1993-08-10 Torry Pines Institute For Molecular Studies Deletion and substitution analogues of melittin peptide
AU654714B2 (en) 1991-04-08 1994-11-17 Magainin Pharmaceuticals, Inc. Novel peptide compositions and uses therefor
EP0590044A4 (en) 1991-06-12 1996-06-12 Magainin Pharma Composition and treatment with biologically active peptides having c-terminal substitutions
AU667479B2 (en) 1991-06-12 1996-03-28 Magainin Pharmaceuticals, Inc. Treating the oral cavity with ion-channel forming peptides
US5547939A (en) 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
JPH07501519A (ja) 1991-09-13 1995-02-16 マゲイニン　ファーマスーティカルズ，インコーポレーテッド 生物活性両親媒性ペプチド組成物およびその用途
JPH07501820A (ja) 1991-12-09 1995-02-23 マゲイニン　ファーマス−ティカルズ　インコーポレーテッド 生物活性ペプチドおよびキレート剤による組成物および治療法
CA2137087A1 (en) 1992-06-01 1993-12-09 U. Prasad Kari Biologically active peptides having n-terminal substitutions
EP0656952B1 (en) * 1992-08-21 2003-03-05 The University Of British Columbia Cationic peptides and method for production
CA2106720C (en) 1992-09-23 1997-12-16 Charles L. Deschenes Needle for use as part of a plastic fastener dispensing tool
US5635594A (en) * 1994-03-11 1997-06-03 University Of California, Los Angeles Gallinacins - antibiotic peptides
US5877274A (en) * 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides

Also Published As

Publication number Publication date
US7390873B2 (en) 2008-06-24
EP0846128B1 (en) 2008-10-29
US6191254B1 (en) 2001-02-20
EP0846128A2 (en) 1998-06-10
US20040019181A1 (en) 2004-01-29
JP3860838B2 (ja) 2006-12-20
WO1997008199A2 (en) 1997-03-06
AU6940796A (en) 1997-03-19
WO1997008199A3 (en) 1997-09-12
ES2316154T3 (es) 2009-04-01
CA2230160A1 (en) 1997-03-06
DE69637731D1 (de) 2008-12-11
JPH11511971A (ja) 1999-10-19
HK1011867A1 (en) 1999-07-23

Similar Documents

Publication Publication Date Title
DE69637731D1 (de) Antimikrobielle kationische peptide und methoden zu ihrer identifizierung
TW281675B (enExample)
DE69713112D1 (de) Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin-analogen
LV10107A (lv) Peptida atvasinajums ta iegusanas metode to satuross farmaceitisks sastavs un glaukomas arstesanas metode
ATE176241T1 (de) 3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten
AU5249898A (en) N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
ES2192620T3 (es) Polipeptido receptor de il-13.
AU1383297A (en) Novel n-(arylsulphonyl)amino acid derivatives having bradykinin receptor affinity
PT866691E (pt) Administracao sublingual e bucal de selegilina
RU94046091A (ru) Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения
KR950702577A (ko) 아젤레높시스 아페르타(agelenopsis aperta)로 부터의 칼슘 채널 차단 폴리펩티드(calcium channel blocking polypeptide from agelenopsis aperta)
DK0785950T3 (da) Keratinocyt vækstfaktoranaloger
BR9609847A (pt) Derivados de N-(4-Benzila-substituída)-2-aminolactam
AU579593B2 (en) Novel peptides which are active on the central nervous system and have an action on the cholinergic system
IL122606A0 (en) (S)-hydroxy-nitrile-lyase
PT635025E (pt) Processo para preparar proteinas modificadas
BR9609337A (pt) Preparação de derivado de biciclohexano
CA2136103A1 (en) Antibiotic cryptdin peptides and methods of their use
DE69633234D1 (de) Reinigung von dalbeheptide-antibiotika mittels isoelektrofokussierung
PT842193E (pt) Peptidos ciclicos analogos de somatostatina com actividade inibidora sobre a hormona do crescimento
GR3021408T3 (en) Cloning of a new member of the fibroblast growth factor (fgf) receptor family
NO952748D0 (no) Polypeptid som spesifikt inhiberer Cathepsin L.
FR2654430B1 (fr) Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
RU95102777A (ru) Способ лечения реперфузного повреждения и "оглушения" миокарда
TW197410B (enExample)

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties