AU6940796A - Antimicrobial cationic peptides and methods of screening for the same - Google Patents
Antimicrobial cationic peptides and methods of screening for the sameInfo
- Publication number
- AU6940796A AU6940796A AU69407/96A AU6940796A AU6940796A AU 6940796 A AU6940796 A AU 6940796A AU 69407/96 A AU69407/96 A AU 69407/96A AU 6940796 A AU6940796 A AU 6940796A AU 6940796 A AU6940796 A AU 6940796A
- Authority
- AU
- Australia
- Prior art keywords
- sub
- entry
- row
- seq
- tryptophan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US268795P | 1995-08-23 | 1995-08-23 | |
| US002687 | 1995-08-23 | ||
| PCT/IB1996/000996 WO1997008199A2 (en) | 1995-08-23 | 1996-08-23 | Antimicrobial cationic peptides and methods of screening for the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU6940796A true AU6940796A (en) | 1997-03-19 |
Family
ID=21701983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU69407/96A Abandoned AU6940796A (en) | 1995-08-23 | 1996-08-23 | Antimicrobial cationic peptides and methods of screening for the same |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6191254B1 (enExample) |
| EP (1) | EP0846128B1 (enExample) |
| JP (1) | JP3860838B2 (enExample) |
| AT (1) | ATE412668T1 (enExample) |
| AU (1) | AU6940796A (enExample) |
| CA (1) | CA2230160A1 (enExample) |
| DE (1) | DE69637731D1 (enExample) |
| ES (1) | ES2316154T3 (enExample) |
| WO (1) | WO1997008199A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| EP1174439B1 (en) * | 1996-08-21 | 2008-10-08 | Migenix Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| US6303575B1 (en) * | 1998-05-12 | 2001-10-16 | The Regents Of The University Of California | Indolicidin analogs and methods of using same |
| US6444645B1 (en) * | 1998-06-18 | 2002-09-03 | The Regents Of The University Of California | Crosslink-stabilized indolicidin analogs |
| US6288212B1 (en) * | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| WO2000026344A1 (en) * | 1998-10-30 | 2000-05-11 | Interlink Biotechnologies Llc | Peptides with enhanced stability to protease degradation |
| US6946261B1 (en) * | 1998-11-20 | 2005-09-20 | Migenix Inc. | Efficient methods for producing anti-microbial cationic peptides in host cells |
| US6335318B1 (en) | 1999-05-10 | 2002-01-01 | The Regents Of The University Of California | Antimicrobial theta defensins and methods of using same |
| US6497676B1 (en) | 2000-02-10 | 2002-12-24 | Baxter International | Method and apparatus for monitoring and controlling peritoneal dialysis therapy |
| US6337317B1 (en) * | 2000-06-27 | 2002-01-08 | The University Of British Columbia | Antimicrobial peptides and methods of use thereof |
| US6835536B2 (en) | 2001-08-21 | 2004-12-28 | Micrologix Biotech Inc. | Antimicrobial cationic peptides and formulations thereof |
| CA2457885A1 (en) * | 2001-08-24 | 2003-03-06 | Micrologix Biotech Inc. | Antimicrobial and anti-inflammatory peptides |
| KR100438416B1 (ko) * | 2001-09-19 | 2004-07-02 | 학교법인조선대학교 | Ca-ma 펩타이드의 아미노산 중 하나 또는 그 이상을치환하여 + 전극과 소수성 영역이 증가된 신규한펩타이드 및 그를 포함하는 약학적 조성물 |
| US7507787B2 (en) * | 2001-12-03 | 2009-03-24 | The University Of British Columbia | Effectors of innate immunity |
| US20030125662A1 (en) * | 2002-01-03 | 2003-07-03 | Tuan Bui | Method and apparatus for providing medical treatment therapy based on calculated demand |
| US20030219854A1 (en) * | 2002-03-21 | 2003-11-27 | Micrologix Biotech Inc. | Methods for producing modified anti-infective peptides |
| AU2003231471A1 (en) * | 2002-04-25 | 2003-11-10 | Toagosei Co., Ltd. | Antimicrobial polypeptide and utizliation thereof |
| US7119070B2 (en) | 2002-04-30 | 2006-10-10 | The Regents Of The University Of California | Antimicrobial theta defensins, analogs thereof, and methods of use |
| US7033769B2 (en) * | 2002-05-23 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | Method for discovering one or more peptides adapted for specific binding to a microorganism of interest |
| US7238164B2 (en) * | 2002-07-19 | 2007-07-03 | Baxter International Inc. | Systems, methods and apparatuses for pumping cassette-based therapies |
| US7550430B2 (en) * | 2003-08-18 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Cationic antimicrobial peptides and compositions |
| EP1688486B1 (en) * | 2003-10-29 | 2016-12-14 | Toagosei Co., Ltd. | Antibacterial peptide and utilization of the same |
| US20050209563A1 (en) * | 2004-03-19 | 2005-09-22 | Peter Hopping | Cassette-based dialysis medical fluid therapy systems, apparatuses and methods |
| JP4507080B2 (ja) * | 2004-07-30 | 2010-07-21 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| JP4730584B2 (ja) | 2004-12-06 | 2011-07-20 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| CN101111256B (zh) * | 2004-12-15 | 2012-04-25 | 科罗拉多大学 | 抗菌肽及其使用方法 |
| US20090030179A1 (en) * | 2005-02-15 | 2009-01-29 | Toagosei Co., Ltd | Antimicrobial peptide and use thereof |
| US7731689B2 (en) | 2007-02-15 | 2010-06-08 | Baxter International Inc. | Dialysis system having inductive heating |
| US7998115B2 (en) * | 2007-02-15 | 2011-08-16 | Baxter International Inc. | Dialysis system having optical flowrate detection |
| US8558964B2 (en) | 2007-02-15 | 2013-10-15 | Baxter International Inc. | Dialysis system having display with electromagnetic compliance (“EMC”) seal |
| US8361023B2 (en) * | 2007-02-15 | 2013-01-29 | Baxter International Inc. | Dialysis system with efficient battery back-up |
| US8870812B2 (en) * | 2007-02-15 | 2014-10-28 | Baxter International Inc. | Dialysis system having video display with ambient light adjustment |
| BRPI0813627B1 (pt) * | 2007-07-26 | 2021-09-14 | Revance Therapeutics, Inc | Composição farmacêutica ou cosmética compreendendo um peptídeo catiônico e kit para administração da mesma |
| EP2346521A4 (en) * | 2008-10-06 | 2012-06-20 | Univ Colorado Regents | PEPTIDES AND USE METHOD THEREFOR |
| GB0821616D0 (en) * | 2008-11-26 | 2008-12-31 | Lytix Biopharma As | Compounds |
| EP2437770A4 (en) * | 2009-06-05 | 2013-11-06 | Univ Colorado Regents | ANTIMICROBIAL PEPTIDES |
| US9134323B2 (en) | 2009-12-01 | 2015-09-15 | The Rockefeller University | Antibody that specifically binds to an epitope in the tureet region of a human Kir channel |
| US11225655B2 (en) | 2010-04-16 | 2022-01-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| EP3384938A1 (en) | 2011-09-12 | 2018-10-10 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| HK1206612A1 (en) | 2012-04-02 | 2016-01-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of secreted proteins |
| AU2013243952A1 (en) | 2012-04-02 | 2014-10-30 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US20150072922A1 (en) * | 2012-04-17 | 2015-03-12 | The Research Institute At Nationwide Children's Hospital | Rnase 7 antimicrobial peptides |
| MY151307A (en) * | 2012-06-18 | 2014-05-05 | Univ Malaya | Peptides having antimicrobial activity |
| GB201401877D0 (en) | 2014-02-04 | 2014-03-19 | Univ Tromsoe | Peptides |
| EP3067608A1 (en) * | 2015-03-10 | 2016-09-14 | Abu Dhabi Polymers Co. Ltd (Borouge) LLC. | Eccentric polyolefin pipe |
| ES2981535T3 (es) | 2015-11-10 | 2024-10-09 | Visterra Inc | Conjugados de molécula de anticuerpo-fármaco que se unen específicamente al lipopolisacárido y usos de los mismos |
| ES2994374T3 (en) | 2017-01-18 | 2025-01-23 | Visterra Inc | Antibody molecule-drug conjugates and uses thereof |
| WO2018160791A1 (en) | 2017-03-03 | 2018-09-07 | Massachusetts Institute Of Technology | Antimicrobial constructs and uses thereof |
| US10934943B2 (en) | 2017-04-27 | 2021-03-02 | General Electric Company | Compressor apparatus with bleed slot and supplemental flange |
| US11179516B2 (en) | 2017-06-22 | 2021-11-23 | Baxter International Inc. | Systems and methods for incorporating patient pressure into medical fluid delivery |
| KR20240085798A (ko) | 2020-04-03 | 2024-06-17 | 비스테라, 인크. | 항체 분자-약물 접합체 및 이의 용도 |
| CU24750B1 (es) * | 2020-11-19 | 2025-06-11 | Centro De Investig Y Desarrollo De Medicamentos Cidem | Entidades peptídicas con actividad antimicrobiana frente a patógenos multi-drogoresistentes |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206154A (en) | 1985-01-28 | 1993-04-27 | Xoma Corporation | Method of producing cecropins by microbiological techniques |
| US5166321A (en) | 1985-01-28 | 1992-11-24 | International Genetic Engineering, Inc. | Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria |
| US5028530A (en) | 1985-01-28 | 1991-07-02 | Xoma Corporation | AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques |
| US4810777A (en) | 1987-03-04 | 1989-03-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antimicrobial compounds |
| US4822608A (en) | 1987-09-14 | 1989-04-18 | Vespa Laboratories, Inc. | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof |
| KR900701295A (ko) | 1988-05-27 | 1990-12-01 | 원본미기재 | 양극성 펩타이드류와 그것에 관한 용도 |
| SE8802939D0 (sv) | 1988-08-19 | 1988-08-19 | Kabigen Ab | A method for the production and isolation of a fusion protein in eukaryotic cells |
| US5217956A (en) | 1988-10-21 | 1993-06-08 | The Children's Hospital Of Philadelphia | Composition and treatment with biologically active peptides and certain anions |
| JPH04502901A (ja) | 1988-10-21 | 1992-05-28 | マゲイニン サイエンセス インコーポレーテッド | シーピーエフペプチド組成物およびその用途 |
| HUT57992A (en) | 1988-10-21 | 1992-01-28 | Magainin Sciences Inc | Process for producing composition comprising biologically active peptides and certain anions |
| CA2007913A1 (en) | 1989-01-30 | 1990-07-30 | Michael Zasloff | Composition and treatment with peptide combinations |
| US5254535A (en) | 1989-04-17 | 1993-10-19 | The Children's Hospital Of Pennsylvania | Composition and treatment with biologically active peptides and antibiotic |
| FR2646777B1 (fr) | 1989-05-12 | 1993-09-03 | Bio Serae Lab | Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications |
| US5073542A (en) | 1989-06-07 | 1991-12-17 | Magainin Sciences Inc. | CPF peptide compositions and their use in inhibiting growth of target cells or a virus |
| US5045531A (en) | 1989-12-18 | 1991-09-03 | Magainin Sciences Inc. | Wound treatment employing biologically active ion channel forming peptides and proteins |
| WO1991012015A1 (en) | 1990-02-08 | 1991-08-22 | Magainin Sciences Inc. | Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell |
| US5227469A (en) | 1990-02-14 | 1993-07-13 | Genentech, Inc. | Platelet aggregation inhibitors from the leech |
| WO1991016066A1 (en) | 1990-04-23 | 1991-10-31 | Magainin Sciences Inc. | Composition and treatment with biologically active peptides and toxic cations |
| WO1991016918A1 (en) | 1990-04-27 | 1991-11-14 | Magainin Sciences Inc. | Composition and treatment with biologically active peptides and anti-parasitic agents or anti-fungal agents |
| JPH05507273A (ja) | 1990-05-14 | 1993-10-21 | マゲイニン サイエンセズ インコーポレーテッド | Dアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法 |
| US5208220A (en) | 1990-06-27 | 1993-05-04 | Magainin Pharmaceuticals, Inc. | Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase |
| US5202420A (en) | 1990-10-25 | 1993-04-13 | The Children's Hospital Of Philadelphia | Tracheal antimicrobial peptides, dna sequences and methods for the production and use thereof |
| US5235038A (en) | 1991-01-22 | 1993-08-10 | Torry Pines Institute For Molecular Studies | Deletion and substitution analogues of melittin peptide |
| CA2107674A1 (en) | 1991-04-08 | 1992-10-09 | W. Lee Maloy | Novel peptide compositions and uses therefor |
| EP0590044A4 (en) | 1991-06-12 | 1996-06-12 | Magainin Pharma | Composition and treatment with biologically active peptides having c-terminal substitutions |
| US5547939A (en) * | 1991-06-14 | 1996-08-20 | The Regents Of The University Of California | Broad spectrum antimicrobial compounds and methods of use |
| US5324716A (en) * | 1991-06-14 | 1994-06-28 | Regents Of The University Of California | Broad spectrum antimicrobial compounds and methods of use |
| JPH07502979A (ja) | 1991-07-25 | 1995-03-30 | マゲイニン ファーマス−ティカルズ,インコーポレーテッド | 生物活性ペプチドを利用する口腔内の有害な状態の予防と治療 |
| JPH07501519A (ja) | 1991-09-13 | 1995-02-16 | マゲイニン ファーマスーティカルズ,インコーポレーテッド | 生物活性両親媒性ペプチド組成物およびその用途 |
| AU3236293A (en) | 1991-12-09 | 1993-07-19 | Magainin Pharmaceuticals, Inc. | Composition and treatment with biologically active peptides and chelating agents |
| WO1993024138A1 (en) | 1992-06-01 | 1993-12-09 | Magainin Pharmaceuticals, Inc. | Biologically active peptides having n-terminal substitutions |
| EP0656952B1 (en) * | 1992-08-21 | 2003-03-05 | The University Of British Columbia | Cationic peptides and method for production |
| CA2106720C (en) | 1992-09-23 | 1997-12-16 | Charles L. Deschenes | Needle for use as part of a plastic fastener dispensing tool |
| US5635594A (en) * | 1994-03-11 | 1997-06-03 | University Of California, Los Angeles | Gallinacins - antibiotic peptides |
| US5877274A (en) * | 1995-06-02 | 1999-03-02 | University Of British Columbia | Antimicrobial cationic peptides |
-
1996
- 1996-08-23 AU AU69407/96A patent/AU6940796A/en not_active Abandoned
- 1996-08-23 AT AT96930303T patent/ATE412668T1/de not_active IP Right Cessation
- 1996-08-23 WO PCT/IB1996/000996 patent/WO1997008199A2/en not_active Ceased
- 1996-08-23 JP JP51006897A patent/JP3860838B2/ja not_active Expired - Fee Related
- 1996-08-23 EP EP96930303A patent/EP0846128B1/en not_active Expired - Lifetime
- 1996-08-23 CA CA002230160A patent/CA2230160A1/en not_active Abandoned
- 1996-08-23 DE DE69637731T patent/DE69637731D1/de not_active Expired - Lifetime
- 1996-08-23 US US08/702,054 patent/US6191254B1/en not_active Expired - Fee Related
- 1996-08-23 ES ES96930303T patent/ES2316154T3/es not_active Expired - Lifetime
-
2003
- 2003-03-28 US US10/403,104 patent/US7390873B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6191254B1 (en) | 2001-02-20 |
| JP3860838B2 (ja) | 2006-12-20 |
| HK1011867A1 (en) | 1999-07-23 |
| WO1997008199A3 (en) | 1997-09-12 |
| EP0846128A2 (en) | 1998-06-10 |
| EP0846128B1 (en) | 2008-10-29 |
| WO1997008199A2 (en) | 1997-03-06 |
| DE69637731D1 (de) | 2008-12-11 |
| JPH11511971A (ja) | 1999-10-19 |
| US20040019181A1 (en) | 2004-01-29 |
| CA2230160A1 (en) | 1997-03-06 |
| ES2316154T3 (es) | 2009-04-01 |
| ATE412668T1 (de) | 2008-11-15 |
| US7390873B2 (en) | 2008-06-24 |
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